Standard name
Human Ortholog
Description Core subunit of the ubiquinol-cytochrome c reductase complex; the ubiquinol-cytochrome c reductase complex (bc1 complex) is a component of the mitochondrial inner membrane electron transport chain
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0.11 – 0 0 0 0 0.08 0.06
Bud 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0.07 0 0 – 0 – 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0.44 – 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0.06 – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0.06 – 0 0 0 0 0 0
Golgi 0.1 0 0 0 0 0 0 0 – 0 0 0 0.34 0.21 0.4 – 0.11 – 0.06 0.08 0 0.1 0.14 0.13
Mitochondria 0.9 0.95 0.92 0.96 0.91 0.91 0.88 0.89 – 0.9 0.94 0.93 0.86 0.8 0.62 – 0 – 0.86 0.79 0.81 0.7 0.63 0.6
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 – 0 0 0 0 0 0
Nuclear Periphery 0.05 0.07 0.06 0 0 0.07 0 0 – 0 0 0 0.09 0 0 – 0 – 0 0 0 0 0 0
Nucleolus 0.12 0 0.07 0 0.07 0.18 0.22 0.24 – 0.21 0.18 0.15 0 0 0 – 0.11 – 0 0 0 0 0 0
Peroxisomes 0 0 0.1 0.08 0 0 0 0 – 0 0 0 0 0 0 – 0.06 – 0 0 0.1 0.07 0.06 0.1
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0.06 – 0 0 0 0 0 0
Vac/Vac Membrane 0.08 0.05 0 0 0.07 0 0 0 – 0 0 0 0.16 0.14 0.27 – 0.11 – 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 2 0 0 2 0 0 2 – 0 0 0 1 2 1 – 2 – 0 4 4 2 13 11
Bud 1 1 7 6 3 2 5 4 – 8 7 5 0 1 0 – 0 – 0 1 1 0 1 1
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 7 4 1 0 0 0 – 0 – – – – – – –
Cell Periphery 2 5 6 2 1 0 1 1 – 1 0 0 4 2 4 – 0 – 0 0 0 1 0 0
Cytoplasm 0 2 5 3 3 9 8 8 – 6 3 6 1 0 4 – 8 – 0 0 0 0 0 1
Endoplasmic Reticulum 0 2 0 0 0 1 2 3 – 2 0 0 0 2 1 – 1 – 0 0 0 0 2 0
Endosome 1 0 3 1 2 0 0 1 – 0 0 0 1 2 2 – 1 – 3 2 5 2 1 5
Golgi 8 3 3 1 3 0 1 3 – 2 2 3 20 15 51 – 2 – 5 11 8 9 26 26
Mitochondria 76 140 298 227 170 256 395 431 – 439 345 385 50 56 80 – 0 – 83 112 271 69 117 118
Nucleus 0 1 0 0 0 0 1 2 – 1 0 0 0 0 0 – 0 – 0 0 0 0 0 0
Nuclear Periphery 4 10 21 8 7 21 13 16 – 15 9 7 5 3 5 – 0 – 0 0 2 0 0 2
Nucleolus 10 5 24 9 13 50 98 118 – 101 65 63 2 1 4 – 2 – 0 0 1 1 0 2
Peroxisomes 0 2 31 19 5 4 6 8 – 11 4 7 2 1 1 – 1 – 2 5 33 7 11 19
SpindlePole 0 0 2 2 0 0 1 1 – 3 5 1 0 1 0 – 1 – 0 0 1 1 0 0
Vac/Vac Membrane 7 8 13 3 13 4 13 4 – 13 5 6 9 10 35 – 2 – 0 1 0 1 3 6
Unique Cell Count 84 148 325 236 187 280 448 486 490 366 414 58 70 129 18 98 143 334 100 185 197
Labelled Cell Count 109 181 413 281 222 347 544 602 609 449 484 95 96 188 20 98 143 334 100 185 197


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.9 11.8 13.5 13.2 16.8 18.9 22.9 24.5 – 25.9 26.3 31.6 12.4 11.2 13.8 – 16.9 – 17.5 22.7 19.8
Std Deviation (1e-4) 2.3 2.8 2.9 3.2 3.8 5.8 7.7 9.0 – 11.9 12.0 13.9 2.1 2.1 2.8 – 8.4 – 20.4 31.1 21.8
Intensity Change (Log2) – – – -0.03 0.32 0.49 0.76 0.86 – 0.94 0.96 1.23 -0.12 -0.26 0.03 – 0.32 – 0.38 0.75 0.56


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 – 0 –
Bud 0.3 0 0 -1.2 0 – -0.5 -0.2 -1.0 0 0 0 – 0 –
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 – 0 –
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 – 0 –
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 0 – 0 –
Cytoplasm 0 0 1.4 0.3 0.1 – 0 0 0 0 0 0 – 0 –
Endoplasmic Reticulum 0 0 0 0 0 – 0 0 0 0 0 0 – 0 –
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 – 0 –
Golgi 0 0 0 0 0 – 0 0 0 0 0 11.5 – 0 –
Mitochondria 2.1 -0.3 -0.1 -1.6 -1.4 – -1.0 1.3 0.7 -1.3 -2.9 -7.6 – -11.2 –
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 – 0 –
Nuclear Periphery -1.6 -1.3 0.5 -2.4 -2.1 – -2.3 -2.6 -3.4 0 0 -1.1 – 0 –
Nucleolus -1.8 -0.2 3.9 5.5 6.2 – 5.1 4.1 3.3 0 0 -1.7 – 0 –
Peroxisomes -0.6 -2.9 -4.3 -5.3 -5.1 – -4.6 -5.1 -4.8 0 -2.3 -3.3 – 0 –
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 – 0 –
Vacuole -1.9 1.5 -1.9 -0.8 -3.1 – -1.1 -2.2 -2.2 0 0 7.2 – 0 –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 20.308 19.1096 19.5181 19.8619 16.5161 19.2032 23.3721 28.1915 24.144 24.7296 21.6164 24.907 26.0248 29.9699 27.7932 28.2968 29.7554 24.111
Actin 0.0133 0.0101 0.0027 0.0061 0.0021 0.0012 0.0093 0.0009 0.0042 0.0001 0.0136 0.0004 0.0009 0.0016 0.0141 0.0001 0.0003 0.0003
Bud 0.0001 0.0001 0.0001 0.0004 0 0 0.0002 0 0.0001 0 0.0002 0 0 0 0.0006 0 0 0
Bud Neck 0.0001 0.0001 0.0001 0.0011 0 0 0.0001 0 0.0002 0 0.0008 0 0 0 0 0 0 0
Bud Periphery 0.0001 0.0001 0.0001 0.0008 0 0 0.0002 0 0.0002 0 0.0005 0 0 0 0.0014 0 0 0
Bud Site 0.0002 0.0002 0.0006 0.0016 0 0 0.0007 0 0.0006 0 0.0014 0 0 0.0002 0.0009 0 0 0
Cell Periphery 0.0002 0.0002 0.0001 0.0003 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0003 0 0 0 0.0002 0 0 0
Cytoplasm 0.0005 0 0.0001 0.0003 0 0 0.0003 0 0.0001 0 0 0 0 0 0 0 0 0
Cytoplasmic Foci 0.0021 0.0023 0.0011 0.0017 0.0016 0.0005 0.0118 0.0001 0.0121 0 0.0039 0.0005 0.0002 0.0135 0.0003 0 0 0
Eisosomes 0.0004 0.002 0.0002 0.0016 0.0003 0.0003 0.0003 0.0003 0.0004 0.0001 0.0007 0.0001 0.0001 0.0002 0.0006 0.0001 0.0002 0.0001
Endoplasmic Reticulum 0.0008 0.0001 0 0.0005 0.0001 0.0001 0.0003 0 0.0001 0 0.0001 0 0 0 0 0 0 0
Endosome 0.006 0.0036 0.0026 0.0181 0.002 0.0033 0.0069 0.0003 0.0023 0.0002 0.004 0.0002 0 0.0002 0.0002 0 0 0.0001
Golgi 0.008 0.0261 0.0126 0.0028 0.0345 0.033 0.0074 0.0012 0.0061 0.0003 0.0097 0.0087 0.0001 0.0003 0.0005 0 0.0004 0.0004
Lipid Particles 0.0141 0.0128 0.0132 0.0116 0.0246 0.0151 0.03 0.004 0.0181 0.0015 0.0255 0.0065 0.0022 0.0352 0.0154 0.0004 0.0094 0.0024
Mitochondria 0.9268 0.9264 0.9576 0.9342 0.9207 0.9315 0.901 0.9774 0.9247 0.9932 0.9229 0.9774 0.9807 0.9409 0.9567 0.9979 0.9867 0.9923
None 0.0012 0 0.0001 0.0016 0 0 0.0007 0 0.0001 0 0.0001 0 0 0.0001 0 0 0 0
Nuclear Periphery 0.0027 0.0001 0.0001 0.0023 0.0001 0.0002 0.0006 0 0.0001 0 0.0002 0 0 0 0 0 0 0
Nucleolus 0.0037 0.0002 0.0003 0.0025 0.0003 0.0001 0.0007 0.0001 0.0003 0 0.0005 0 0 0.0007 0.0004 0 0 0
Nucleus 0.0015 0.0001 0.0001 0.0015 0.0001 0 0.0004 0 0.0001 0 0.0002 0 0 0 0.0001 0 0 0
Peroxisomes 0.0064 0.0047 0.0041 0.0028 0.0055 0.0017 0.0135 0.0019 0.0221 0.0012 0.0083 0.0028 0.0154 0.0061 0.0034 0.001 0.0009 0.0017
Punctate Nuclear 0.001 0 0.0003 0.0014 0 0 0.002 0 0.0006 0 0.0004 0 0 0.0004 0 0 0 0
Vacuole 0.0015 0.0014 0.0005 0.0046 0.0005 0.0008 0.0018 0.0024 0.0027 0.0002 0.0013 0.0001 0 0.0001 0.001 0 0.0001 0.0001
Vacuole Periphery 0.0093 0.0094 0.0034 0.0022 0.0074 0.012 0.0117 0.0112 0.0048 0.0029 0.0053 0.0032 0.0002 0.0004 0.0041 0.0004 0.0019 0.0026

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 41.7591 39.4838 52.2049 65.7988 52.5807 56.1831 43.1883 51.6847 56.0038 52.3864
Translational Efficiency 1.3851 1.4771 1.3517 1.2696 1.635 1.3029 1.688 1.5097 1.5864 1.6685

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

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Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cor1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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Images are not yet available