Standard name | |
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Human Ortholog | |
Description | UBX domain-containing substrate adaptor for Cdc48p; ubiquitin regulatory X domain-containing protein that acts as a substrate recruiting cofactor for Cdc48p; positively regulates Glc7p PPase activity to promote growth and mitotic progression in complex with Cdc48p; ubiquitinated protein interactor involved in ER-associated degradation (ERAD); regulated by nuclear Ub-dependent degradation (INMAD pathway) independent of the Asi and Doa10 complexes; homolog of human p47 (NSFL1C) |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 1 | 0 | 0 | 0 | 0 | 1 | 8 | 6 | 5 | 10 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 4 | 3 | 7 | 13 | 17 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 2 | 5 | 1 | 3 | 0 | 0 | 1 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 66 | 57 | 87 | 66 | 79 | 189 | 168 | 162 | 178 | 196 | 75 | 105 | 142 | 163 | 190 | 114 | 100 | 114 | 152 | 32 | 103 | 60 | 63 | 55 |
Endoplasmic Reticulum | 1 | 0 | 0 | 0 | 0 | 1 | 6 | 3 | 6 | 11 | 1 | 4 | 3 | 6 | 3 | 10 | 7 | 8 | 6 | 0 | 8 | 0 | 2 | 2 |
Endosome | 10 | 0 | 4 | 3 | 5 | 1 | 6 | 1 | 2 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 1 | 0 | 7 | 1 | 9 | 3 | 2 | 8 |
Golgi | 0 | 0 | 2 | 2 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 5 | 13 | 5 | 5 | 0 | 0 | 2 | 0 | 1 | 1 |
Mitochondria | 2 | 1 | 3 | 5 | 5 | 25 | 77 | 44 | 41 | 105 | 42 | 66 | 0 | 0 | 2 | 2 | 4 | 0 | 1 | 0 | 4 | 0 | 4 | 1 |
Nucleus | 24 | 3 | 25 | 15 | 22 | 28 | 31 | 28 | 48 | 45 | 18 | 27 | 41 | 28 | 75 | 25 | 14 | 20 | 165 | 55 | 109 | 107 | 172 | 192 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 10 | 0 | 3 | 4 |
Nucleolus | 2 | 0 | 1 | 0 | 1 | 0 | 3 | 3 | 1 | 3 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 4 | 0 | 1 | 5 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 6 | 3 | 2 | 7 |
Vac/Vac Membrane | 259 | 56 | 203 | 153 | 258 | 217 | 271 | 324 | 220 | 273 | 96 | 87 | 100 | 199 | 165 | 151 | 165 | 146 | 37 | 16 | 54 | 27 | 32 | 45 |
Unique Cell Count | 333 | 98 | 289 | 218 | 342 | 403 | 507 | 529 | 440 | 563 | 201 | 255 | 245 | 338 | 358 | 257 | 251 | 246 | 399 | 116 | 327 | 215 | 308 | 353 |
Labelled Cell Count | 365 | 117 | 325 | 244 | 372 | 464 | 572 | 574 | 504 | 649 | 241 | 294 | 286 | 402 | 441 | 317 | 296 | 294 | 399 | 116 | 327 | 215 | 308 | 353 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 10.4 | 12.7 | 12.2 | 12.0 | 12.6 | 11.6 | 10.9 | 10.8 | 10.5 | 10.0 | 9.3 | 9.3 | 14.0 | 14.8 | 14.3 | 16.2 | 15.0 | 16.1 | 12.7 | 13.5 | 14.9 |
Std Deviation (1e-4) | 1.7 | 2.0 | 2.4 | 2.2 | 2.4 | 2.4 | 2.5 | 2.4 | 2.4 | 2.3 | 2.6 | 2.4 | 2.6 | 3.0 | 3.2 | 4.3 | 3.1 | 3.9 | 3.2 | 2.9 | 3.1 |
Intensity Change (Log2) | – | – | – | -0.03 | 0.04 | -0.08 | -0.17 | -0.18 | -0.22 | -0.3 | -0.39 | -0.4 | 0.2 | 0.28 | 0.23 | 0.41 | 0.29 | 0.4 | 0.05 | 0.14 | 0.29 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | -2.0 | 4.4 | 0.9 | 0.2 | 2.8 | 1.4 | 1.7 | 2.7 | 6.5 | 4.6 | 5.9 | 3.4 | 2.4 | 3.9 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.1 | 0 | 0 |
Mitochondria | 0 | 0 | 3.4 | 6.4 | 4.3 | 4.6 | 7.3 | 7.5 | 8.7 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | -0.7 | -1.1 | -0.8 | -1.3 | -1.9 | 1.0 | -0.3 | 0.1 | 0.8 | 2.8 | -0.2 | 4.3 | 0.4 | -1.4 | -0.2 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 1.5 | -4.4 | -4.6 | -2.6 | -5.4 | -6.1 | -5.0 | -8.4 | -6.8 | -3.0 | -6.2 | -2.8 | -1.1 | -2.6 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Actin | – | – | – | – | – | – | 0.0639 | 0.0002 | 0.0039 | 0.0053 | 0.0409 | 0.0017 | 0.0021 | 0.0001 | 0.0043 | 0.0047 | 0.0001 | 0.0001 |
Bud | – | – | – | – | – | – | 0.0005 | 0.0001 | 0.0006 | 0.0002 | 0.0019 | 0.0001 | 0.0005 | 0 | 0.0003 | 0.0003 | 0 | 0.0001 |
Bud Neck | – | – | – | – | – | – | 0.001 | 0.0002 | 0.0011 | 0.0005 | 0.0005 | 0.0006 | 0.002 | 0.0001 | 0.0005 | 0.001 | 0.0006 | 0.0011 |
Bud Periphery | – | – | – | – | – | – | 0.0006 | 0 | 0.0012 | 0.0002 | 0.0022 | 0 | 0.0003 | 0 | 0.0002 | 0.0002 | 0 | 0 |
Bud Site | – | – | – | – | – | – | 0.0016 | 0.0002 | 0.0006 | 0.0005 | 0.0033 | 0 | 0.0137 | 0.0001 | 0.0019 | 0.0006 | 0.0001 | 0.0001 |
Cell Periphery | – | – | – | – | – | – | 0.0001 | 0 | 0.0007 | 0.0001 | 0.0001 | 0 | 0.0002 | 0 | 0.0001 | 0.0001 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | 0.0285 | 0.072 | 0.0492 | 0.0496 | 0.1182 | 0.0513 | 0.0803 | 0.0936 | 0.0655 | 0.0989 | 0.0835 | 0.0786 |
Cytoplasmic Foci | – | – | – | – | – | – | 0.0326 | 0.0001 | 0.0049 | 0.0084 | 0.0071 | 0.0026 | 0.0117 | 0.0002 | 0.0084 | 0.0136 | 0.0001 | 0.0078 |
Eisosomes | – | – | – | – | – | – | 0.0004 | 0 | 0 | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 |
Endoplasmic Reticulum | – | – | – | – | – | – | 0.0086 | 0.0003 | 0.0033 | 0.0012 | 0.0011 | 0.0003 | 0.0063 | 0.0006 | 0.0031 | 0.0059 | 0.0005 | 0.0013 |
Endosome | – | – | – | – | – | – | 0.0381 | 0.0001 | 0.0132 | 0.0085 | 0.0079 | 0.0062 | 0.0141 | 0.0004 | 0.0196 | 0.0158 | 0.0002 | 0.0142 |
Golgi | – | – | – | – | – | – | 0.0148 | 0 | 0.0034 | 0.0165 | 0.016 | 0.0031 | 0.0012 | 0 | 0.0042 | 0.0022 | 0 | 0.0006 |
Lipid Particles | – | – | – | – | – | – | 0.0169 | 0 | 0.0033 | 0.0071 | 0.0101 | 0.002 | 0.0022 | 0 | 0.0073 | 0.007 | 0 | 0.0036 |
Mitochondria | – | – | – | – | – | – | 0.0079 | 0.0004 | 0.0033 | 0.0105 | 0.054 | 0.0011 | 0.0013 | 0.0001 | 0.0078 | 0.0019 | 0.0001 | 0.0004 |
None | – | – | – | – | – | – | 0.0159 | 0.0001 | 0.0004 | 0.0015 | 0.0006 | 0.0001 | 0.0177 | 0.0012 | 0.0016 | 0.0428 | 0.0001 | 0.0037 |
Nuclear Periphery | – | – | – | – | – | – | 0.0522 | 0.0189 | 0.0226 | 0.0191 | 0.0212 | 0.0238 | 0.04 | 0.0194 | 0.0266 | 0.03 | 0.0317 | 0.023 |
Nucleolus | – | – | – | – | – | – | 0.0023 | 0.0012 | 0.001 | 0.0006 | 0.001 | 0.0006 | 0.0039 | 0.0005 | 0.0011 | 0.003 | 0.0006 | 0.0012 |
Nucleus | – | – | – | – | – | – | 0.6758 | 0.9045 | 0.8807 | 0.8633 | 0.7068 | 0.8994 | 0.7777 | 0.8807 | 0.8323 | 0.7442 | 0.8773 | 0.8515 |
Peroxisomes | – | – | – | – | – | – | 0.0118 | 0 | 0.0019 | 0.0022 | 0.0034 | 0.0046 | 0.0008 | 0 | 0.0026 | 0.0009 | 0 | 0.0006 |
Punctate Nuclear | – | – | – | – | – | – | 0.0179 | 0.001 | 0.0013 | 0.0035 | 0.0011 | 0.0016 | 0.0167 | 0.0021 | 0.0092 | 0.0203 | 0.0045 | 0.0062 |
Vacuole | – | – | – | – | – | – | 0.0054 | 0.0003 | 0.0027 | 0.0007 | 0.001 | 0.0005 | 0.0057 | 0.0005 | 0.0027 | 0.0049 | 0.0004 | 0.0047 |
Vacuole Periphery | – | – | – | – | – | – | 0.0032 | 0.0002 | 0.0007 | 0.0004 | 0.0016 | 0.0003 | 0.0016 | 0.0001 | 0.0008 | 0.0018 | 0.0001 | 0.0009 |
R1 | R2 | |||||||||
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G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 81.9746 | 79.0962 | 90.9163 | 97.6504 | 73.6675 | 79.7618 | 93.1071 | 109.2772 | 115.3267 | 77.1098 |
Translational Efficiency | 2.4463 | 2.1719 | 2.0624 | 2.2436 | 2.3986 | 2.7125 | 1.7583 | 1.8881 | 1.9087 | 2.0808 |
Dataset | Hit |
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Protein Concentration | – |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✔ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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