Standard name | |
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Human Ortholog | |
Description | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 1 | 0 | 1 | 2 | 1 | 4 | 6 | 2 | 3 | 5 | 9 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 |
Bud | 0 | 0 | 1 | 0 | 1 | 2 | 9 | 4 | 5 | 17 | 12 | 10 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 3 | 13 | 5 | 10 | 17 | 5 | 16 | 15 | 11 | 14 | 11 | 20 | 2 | 5 | 4 | 27 | 24 | 27 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 174 | 418 | 214 | 202 | 300 | 259 | 253 | 273 | 230 | 259 | 212 | 223 | 186 | 198 | 186 | 326 | 284 | 291 | 170 | 403 | 212 | 150 | 245 | 323 |
Endoplasmic Reticulum | 1 | 8 | 2 | 3 | 2 | 7 | 7 | 9 | 8 | 0 | 8 | 5 | 3 | 0 | 1 | 13 | 10 | 6 | 4 | 6 | 10 | 13 | 13 | 15 |
Endosome | 0 | 0 | 1 | 0 | 0 | 2 | 2 | 3 | 0 | 4 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
Golgi | 0 | 1 | 0 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 1 | 3 | 0 | 1 | 0 | 0 | 1 | 0 |
Mitochondria | 2 | 1 | 0 | 1 | 19 | 71 | 143 | 119 | 158 | 188 | 199 | 140 | 1 | 0 | 0 | 3 | 2 | 10 | 0 | 1 | 2 | 3 | 6 | 9 |
Nucleus | 1 | 1 | 0 | 0 | 1 | 1 | 2 | 3 | 2 | 2 | 4 | 1 | 3 | 2 | 2 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Nuclear Periphery | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 1 | 1 | 9 | 3 | 23 | 11 | 21 | 21 | 10 | 21 | 8 | 23 | 0 | 1 | 1 | 38 | 21 | 10 | 1 | 8 | 2 | 6 | 5 | 7 |
Unique Cell Count | 178 | 430 | 225 | 212 | 339 | 313 | 366 | 384 | 348 | 420 | 370 | 356 | 193 | 200 | 189 | 368 | 312 | 311 | 181 | 429 | 237 | 181 | 279 | 364 |
Labelled Cell Count | 183 | 444 | 232 | 220 | 367 | 361 | 458 | 454 | 427 | 510 | 459 | 434 | 196 | 206 | 195 | 413 | 347 | 348 | 181 | 429 | 237 | 181 | 279 | 364 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 10.7 | 13.9 | 10.3 | 9.9 | 9.1 | 7.2 | 6.2 | 6.9 | 6.0 | 5.9 | 5.2 | 6.0 | 11.1 | 11.8 | 11.3 | 16.4 | 16.4 | 16.6 | 12.1 | 11.9 | 12.9 |
Std Deviation (1e-4) | 1.6 | 2.0 | 1.3 | 1.4 | 1.8 | 1.4 | 1.1 | 1.4 | 1.5 | 1.0 | 1.0 | 1.0 | 1.9 | 1.7 | 1.8 | 2.9 | 3.5 | 2.9 | 2.8 | 2.7 | 2.7 |
Intensity Change (Log2) | – | – | – | -0.06 | -0.17 | -0.53 | -0.73 | -0.59 | -0.78 | -0.8 | -0.98 | -0.78 | 0.11 | 0.2 | 0.13 | 0.67 | 0.67 | 0.69 | 0.23 | 0.21 | 0.32 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 2.6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 1.4 | 1.7 | 0 | 1.4 | 1.1 | 0.7 | 0.8 | 0.5 | 2.0 | 0 | 0 | 0 | 2.7 | 2.8 | 3.1 |
Cytoplasm | 0.1 | -2.7 | -4.3 | -7.5 | -7.1 | -8.1 | -9.2 | -9.9 | -8.8 | 0.6 | 2.3 | 1.9 | -2.7 | -1.8 | -0.8 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.0 | 1.8 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 3.6 | 7.7 | 10.8 | 9.3 | 11.9 | 11.9 | 13.5 | 10.8 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | -1.7 | 1.4 | -0.3 | 0.9 | 0.8 | -0.7 | 0.6 | -1.3 | 1.3 | 0 | 0 | 0 | 2.8 | 1.4 | -0.5 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 8.7823 | 11.7631 | 10.167 | 9.5273 | 8.8813 | 10.3138 | 7.7521 | 10.489 | 9.7113 | 8.9405 | 8.7738 | 9.297 | 7.9272 | 11.8307 | 10.3195 | 9.5262 | 9.5554 | 9.9038 |
Actin | 0.012 | 0.0009 | 0.011 | 0.0228 | 0.0127 | 0.0012 | 0.0062 | 0.0015 | 0.0002 | 0.0002 | 0.0034 | 0.0013 | 0.0332 | 0.0003 | 0.0254 | 0.0074 | 0.0004 | 0.0029 |
Bud | 0.0005 | 0.0003 | 0.0007 | 0.002 | 0.0003 | 0.0004 | 0.0009 | 0.0024 | 0.0004 | 0.0006 | 0.0004 | 0.0016 | 0.0011 | 0.0002 | 0.0007 | 0.0006 | 0.0004 | 0.0003 |
Bud Neck | 0.0006 | 0.0003 | 0.0007 | 0.0008 | 0.0013 | 0.0011 | 0.0013 | 0.0003 | 0.0004 | 0.0004 | 0.0008 | 0.0025 | 0.0019 | 0.0002 | 0.002 | 0.0009 | 0.0007 | 0.0012 |
Bud Periphery | 0.0005 | 0.0001 | 0.0005 | 0.002 | 0.0002 | 0.0003 | 0.0006 | 0.0007 | 0.0001 | 0.0001 | 0.0005 | 0.0011 | 0.0016 | 0 | 0.0006 | 0.0003 | 0.0001 | 0.0003 |
Bud Site | 0.0009 | 0.001 | 0.0021 | 0.0029 | 0.0003 | 0.0003 | 0.0009 | 0.0102 | 0.0004 | 0.0007 | 0.0004 | 0.0022 | 0.0051 | 0.0006 | 0.0027 | 0.0012 | 0.0002 | 0.0002 |
Cell Periphery | 0.0005 | 0.0001 | 0.0003 | 0.0002 | 0.0001 | 0.0001 | 0.0005 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0.0011 | 0.0002 | 0.0005 | 0.0002 | 0 | 0.0001 |
Cytoplasm | 0.8375 | 0.967 | 0.8864 | 0.779 | 0.8301 | 0.8996 | 0.8784 | 0.9652 | 0.9439 | 0.858 | 0.8804 | 0.9088 | 0.7167 | 0.9786 | 0.8922 | 0.8781 | 0.8584 | 0.8795 |
Cytoplasmic Foci | 0.0244 | 0.0069 | 0.0139 | 0.0199 | 0.0181 | 0.0145 | 0.0097 | 0.0038 | 0.012 | 0.0133 | 0.0065 | 0.0095 | 0.0311 | 0.0038 | 0.0155 | 0.0153 | 0.0161 | 0.0141 |
Eisosomes | 0.0001 | 0 | 0.0003 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0.0004 | 0 | 0.0002 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0225 | 0.0044 | 0.008 | 0.0151 | 0.015 | 0.016 | 0.021 | 0.0032 | 0.0057 | 0.0037 | 0.012 | 0.029 | 0.0397 | 0.0046 | 0.0084 | 0.0085 | 0.0151 | 0.0217 |
Endosome | 0.0457 | 0.0105 | 0.0362 | 0.0775 | 0.047 | 0.0331 | 0.0294 | 0.0048 | 0.0202 | 0.0453 | 0.0287 | 0.0226 | 0.0594 | 0.0046 | 0.0246 | 0.0253 | 0.0718 | 0.0396 |
Golgi | 0.0069 | 0.0016 | 0.0044 | 0.0047 | 0.0032 | 0.0064 | 0.0028 | 0.0004 | 0.0009 | 0.0008 | 0.0018 | 0.0023 | 0.0076 | 0.0008 | 0.0047 | 0.0032 | 0.004 | 0.0138 |
Lipid Particles | 0.0028 | 0 | 0.0018 | 0.0052 | 0.0029 | 0.002 | 0.0017 | 0 | 0.0001 | 0.0001 | 0.0009 | 0.0001 | 0.0081 | 0.0001 | 0.0019 | 0.0043 | 0.0004 | 0.002 |
Mitochondria | 0.0077 | 0.0004 | 0.0103 | 0.0053 | 0.0438 | 0.0101 | 0.0022 | 0.0002 | 0.0004 | 0.0002 | 0.005 | 0.0029 | 0.0145 | 0.0002 | 0.0043 | 0.0008 | 0.0019 | 0.0109 |
None | 0.0088 | 0.0007 | 0.003 | 0.003 | 0.0016 | 0.0009 | 0.0065 | 0.0008 | 0.0011 | 0.0011 | 0.0014 | 0.0008 | 0.0026 | 0.0005 | 0.0008 | 0.0016 | 0.0007 | 0.0005 |
Nuclear Periphery | 0.0082 | 0.0006 | 0.0033 | 0.01 | 0.0026 | 0.0011 | 0.0081 | 0.0006 | 0.0011 | 0.0023 | 0.0315 | 0.0055 | 0.0154 | 0.0006 | 0.0015 | 0.0048 | 0.0053 | 0.0036 |
Nucleolus | 0.0005 | 0 | 0.0005 | 0.0005 | 0 | 0 | 0.0007 | 0 | 0 | 0.0001 | 0.0006 | 0.0001 | 0.0066 | 0 | 0.0001 | 0.0003 | 0 | 0 |
Nucleus | 0.0051 | 0.001 | 0.0025 | 0.0092 | 0.0018 | 0.0014 | 0.009 | 0.001 | 0.0012 | 0.0034 | 0.0095 | 0.0029 | 0.0199 | 0.0009 | 0.0011 | 0.0026 | 0.0031 | 0.0013 |
Peroxisomes | 0.0016 | 0.0001 | 0.0017 | 0.0049 | 0.0046 | 0.0016 | 0.0005 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0076 | 0 | 0.0021 | 0.0025 | 0.0002 | 0.0012 |
Punctate Nuclear | 0.003 | 0.0001 | 0.0031 | 0.0019 | 0.0005 | 0.0002 | 0.0042 | 0.0001 | 0.0001 | 0.0003 | 0.0014 | 0.0002 | 0.0033 | 0.0001 | 0.0013 | 0.0102 | 0.0005 | 0.0002 |
Vacuole | 0.0085 | 0.0032 | 0.0078 | 0.0276 | 0.0116 | 0.0078 | 0.0131 | 0.004 | 0.0103 | 0.0638 | 0.0088 | 0.005 | 0.0185 | 0.0036 | 0.008 | 0.0291 | 0.0164 | 0.0044 |
Vacuole Periphery | 0.0017 | 0.0005 | 0.0016 | 0.0053 | 0.0023 | 0.0019 | 0.0023 | 0.0005 | 0.0013 | 0.0057 | 0.0058 | 0.0013 | 0.0046 | 0.0003 | 0.0014 | 0.0027 | 0.0042 | 0.0022 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 51.1773 | 43.2357 | 51.4816 | 42.7446 | 43.0204 | 42.7178 | 33.8033 | 31.9066 | 34.7427 | 45.0882 |
Translational Efficiency | 1.6573 | 1.699 | 1.4016 | 1.4218 | 1.4144 | 1.528 | 2.0102 | 1.6952 | 1.5171 | 1.4382 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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