Standard name | |
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Human Ortholog | |
Description | Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | 1 | 6 | 6 | 3 | 4 | 7 |
Bud | 0 | 1 | 1 | 1 | 0 | 1 | 4 | 7 | – | 8 | 11 | 17 | 0 | 2 | 0 | – | – | – | 0 | 1 | 4 | 3 | 5 | 14 |
Bud Neck | 2 | 1 | 1 | 2 | 3 | 4 | 5 | 11 | – | 6 | 1 | 4 | 0 | 1 | 0 | – | – | – | 0 | 1 | 4 | 2 | 4 | 6 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 2 | 2 | 2 | 0 | 0 | 0 | – | – | – | – | – | – | – | – | – |
Cell Periphery | 1 | 2 | 3 | 3 | 3 | 0 | 2 | 0 | – | 2 | 3 | 1 | 7 | 10 | 0 | – | – | – | 1 | 0 | 5 | 4 | 7 | 8 |
Cytoplasm | 192 | 141 | 299 | 240 | 287 | 290 | 387 | 453 | – | 349 | 267 | 296 | 152 | 296 | 347 | – | – | – | 172 | 117 | 195 | 248 | 406 | 378 |
Endoplasmic Reticulum | 4 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | 0 | 0 | 2 | – | – | – | 0 | 0 | 5 | 3 | 3 | 3 |
Endosome | 0 | 0 | 1 | 0 | 2 | 0 | 2 | 1 | – | 1 | 0 | 2 | 0 | 0 | 1 | – | – | – | 3 | 3 | 2 | 2 | 2 | 5 |
Golgi | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 1 | 2 | 1 | 3 |
Mitochondria | 1 | 15 | 7 | 8 | 10 | 84 | 99 | 132 | – | 213 | 209 | 199 | 0 | 0 | 0 | – | – | – | 14 | 16 | 46 | 45 | 52 | 54 |
Nucleus | 0 | 0 | 0 | 1 | 2 | 1 | 2 | 2 | – | 3 | 1 | 2 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | – | 1 | 0 | 0 | 0 | 0 | 0 | – | – | – | 0 | 1 | 1 | 0 | 0 | 1 |
Nucleolus | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | – | 1 | 2 | 1 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | 1 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 2 | 1 | 2 | 9 | 9 | – | 13 | 8 | 19 | 0 | 0 | 0 | – | – | – | 2 | 2 | 5 | 3 | 7 | 13 |
Vac/Vac Membrane | 0 | 0 | 1 | 0 | 2 | 0 | 4 | 0 | – | 5 | 2 | 0 | 0 | 0 | 2 | – | – | – | 1 | 4 | 2 | 5 | 8 | 12 |
Unique Cell Count | 197 | 154 | 306 | 247 | 299 | 331 | 455 | 525 | 459 | 396 | 428 | 152 | 297 | 351 | 204 | 163 | 292 | 333 | 514 | 524 | ||||
Labelled Cell Count | 202 | 163 | 314 | 257 | 312 | 383 | 514 | 615 | 604 | 506 | 544 | 159 | 309 | 352 | 204 | 163 | 292 | 333 | 514 | 524 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 3.5 | 3.6 | 3.1 | 3.0 | 3.2 | 2.5 | 2.5 | 2.8 | – | 2.2 | 2.3 | 2.3 | 4.6 | 4.8 | 5.1 | 3.2 | 3.7 | 4.4 | 4.8 | 4.8 | 5.1 |
Std Deviation (1e-4) | 0.5 | 1.0 | 0.7 | 0.9 | 1.5 | 0.9 | 1.1 | 1.3 | – | 0.8 | 0.7 | 0.9 | 0.7 | 0.8 | 1.6 | 0.7 | 0.9 | 2.0 | 1.4 | 1.0 | 1.6 |
Intensity Change (Log2) | – | – | – | -0.04 | 0.08 | -0.27 | -0.27 | -0.13 | – | -0.46 | -0.41 | -0.39 | 0.6 | 0.64 | 0.75 | 0.06 | 0.26 | 0.54 | 0.64 | 0.64 | 0.74 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 1.0043 | 0.317 | 0.3176 | 0.1043 | 0.287 | 0.1805 | -0.7618 | -0.3437 | -0.5884 | -0.4018 | -0.4121 | -0.4913 | -1.3191 | -0.6785 | -1.1222 | -0.8551 | -1.4852 | -0.986 |
Actin | 0.032 | 0.0003 | 0.0256 | 0.0228 | 0.0182 | 0.0081 | 0.0202 | 0 | 0.0011 | 0.0009 | 0.0051 | 0.0029 | 0.0158 | 0.0002 | 0.0002 | 0.0003 | 0 | 0.0003 |
Bud | 0.0021 | 0.0011 | 0.0051 | 0.0228 | 0.0005 | 0.0017 | 0.0023 | 0 | 0.0041 | 0.0002 | 0.0058 | 0.0015 | 0.0002 | 0.0003 | 0.0005 | 0.0018 | 0 | 0.0001 |
Bud Neck | 0.0048 | 0.0002 | 0.0026 | 0.009 | 0.0035 | 0.0023 | 0.0009 | 0 | 0.0001 | 0.0004 | 0.0004 | 0.0003 | 0.0075 | 0.0002 | 0.0001 | 0.0004 | 0 | 0.0007 |
Bud Periphery | 0.0078 | 0.0005 | 0.0075 | 0.0154 | 0.001 | 0.0033 | 0.0101 | 0 | 0.0123 | 0.0004 | 0.0097 | 0.0113 | 0.0003 | 0.0006 | 0.0015 | 0.0017 | 0 | 0.0001 |
Bud Site | 0.004 | 0.011 | 0.0083 | 0.038 | 0.0034 | 0.0005 | 0.0054 | 0 | 0.0029 | 0.0005 | 0.002 | 0.0001 | 0.0017 | 0.0024 | 0.0001 | 0.0006 | 0 | 0.0009 |
Cell Periphery | 0.0016 | 0.0002 | 0.0004 | 0.0008 | 0.0003 | 0.0001 | 0.0005 | 0.0001 | 0.0003 | 0 | 0.0002 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0 |
Cytoplasm | 0.0349 | 0.0146 | 0.0112 | 0.0189 | 0.0048 | 0.0253 | 0.038 | 0.0109 | 0.0137 | 0.0047 | 0.0299 | 0.0325 | 0.0184 | 0.0343 | 0.0242 | 0.0211 | 0.0494 | 0.0422 |
Cytoplasmic Foci | 0.0262 | 0.003 | 0.0065 | 0.0199 | 0.0036 | 0.0051 | 0.049 | 0.0012 | 0.0044 | 0.0323 | 0.0053 | 0.0034 | 0.0117 | 0.0074 | 0.0026 | 0.0021 | 0.0037 | 0.0069 |
Eisosomes | 0.0008 | 0.0001 | 0.0005 | 0.0003 | 0.0005 | 0.0001 | 0.0003 | 0.0001 | 0.0007 | 0.0001 | 0.0001 | 0.0001 | 0.0006 | 0.0004 | 0.0004 | 0.0001 | 0.0001 | 0.0001 |
Endoplasmic Reticulum | 0.0078 | 0.0002 | 0.0013 | 0.0037 | 0.0016 | 0.0008 | 0.002 | 0.0004 | 0.0005 | 0.0001 | 0.0026 | 0.0019 | 0.0004 | 0.0003 | 0.0005 | 0.0003 | 0.0005 | 0.0002 |
Endosome | 0.018 | 0.0005 | 0.0031 | 0.0152 | 0.0055 | 0.0021 | 0.0208 | 0.0001 | 0.0123 | 0.0056 | 0.0287 | 0.0009 | 0.0035 | 0.001 | 0.0005 | 0.0007 | 0.0008 | 0.0003 |
Golgi | 0.0022 | 0.0001 | 0.0027 | 0.003 | 0.0023 | 0.0012 | 0.0151 | 0 | 0.0055 | 0.0054 | 0.0022 | 0.0005 | 0.002 | 0.0007 | 0.0001 | 0.0001 | 0 | 0.0001 |
Lipid Particles | 0.0057 | 0.0001 | 0.0037 | 0.019 | 0.0019 | 0.0011 | 0.0079 | 0.0001 | 0.0007 | 0.0033 | 0.0033 | 0.0009 | 0.0042 | 0.0019 | 0.0004 | 0.0002 | 0.0003 | 0.0003 |
Mitochondria | 0.0023 | 0.0002 | 0.0043 | 0.003 | 0.0012 | 0.0009 | 0.0133 | 0.0001 | 0.0018 | 0.008 | 0.0438 | 0.0057 | 0.0015 | 0.0008 | 0.0003 | 0.0004 | 0.0001 | 0.0002 |
None | 0.761 | 0.9582 | 0.8951 | 0.7568 | 0.9412 | 0.9346 | 0.7562 | 0.9864 | 0.9347 | 0.8863 | 0.8022 | 0.9236 | 0.9088 | 0.9306 | 0.9676 | 0.9646 | 0.9444 | 0.9465 |
Nuclear Periphery | 0.0228 | 0.0002 | 0.0036 | 0.0078 | 0.0035 | 0.0022 | 0.003 | 0.0001 | 0.0005 | 0.0001 | 0.0114 | 0.0011 | 0.0002 | 0.0001 | 0.0001 | 0.0004 | 0.0001 | 0.0001 |
Nucleolus | 0.0033 | 0.0006 | 0.0012 | 0.0038 | 0.0007 | 0.0004 | 0.0176 | 0 | 0.0003 | 0.0004 | 0.0005 | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0.0004 | 0 | 0.0001 |
Nucleus | 0.0206 | 0.0031 | 0.0053 | 0.0168 | 0.0017 | 0.004 | 0.0074 | 0.0001 | 0.0025 | 0.0002 | 0.0135 | 0.0005 | 0.0002 | 0.0002 | 0.0002 | 0.0014 | 0.0001 | 0.0001 |
Peroxisomes | 0.0055 | 0.0001 | 0.0036 | 0.0088 | 0.0009 | 0.0007 | 0.0042 | 0 | 0.0004 | 0.0471 | 0.0151 | 0.0107 | 0.0214 | 0.0174 | 0.0001 | 0.0001 | 0 | 0.0003 |
Punctate Nuclear | 0.0256 | 0.0055 | 0.0072 | 0.0108 | 0.0027 | 0.0032 | 0.0228 | 0.0001 | 0.0006 | 0.0037 | 0.0016 | 0.0011 | 0.0009 | 0.0003 | 0.0002 | 0.0024 | 0.0002 | 0.0004 |
Vacuole | 0.0093 | 0.0002 | 0.0008 | 0.0025 | 0.0007 | 0.0015 | 0.0022 | 0.0001 | 0.0004 | 0.0002 | 0.0131 | 0.0004 | 0.0003 | 0.0004 | 0.0002 | 0.0007 | 0.0003 | 0.0001 |
Vacuole Periphery | 0.0016 | 0 | 0.0004 | 0.0008 | 0.0004 | 0.0006 | 0.0008 | 0 | 0.0001 | 0.0001 | 0.0034 | 0.0001 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0 |
R1 | R2 | |||||||||
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G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 13.7339 | 11.379 | 7.9993 | 6.8314 | 12.5949 | 8.0349 | 13.9274 | 10.4218 | 9.2802 | 12.5018 |
Translational Efficiency | – | – | – | – | – | – | – | – | – | – |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | – |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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