Standard name | |
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Human Ortholog | |
Description | DNA-dependent ATPase; DNA recombination/repair translocase, supercoils DNA and promotes DNA strand opening; stimulates strand exchange by modifying dsDNA topology; involved in recombinational repair of DNA double-strand breaks (DSBs) during mitosis and meiosis; phosphorylated in Mec1p-, Rad53p-dependent way in response to one DSB; contributes to remodelling of nucleosomes; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 1 | 2 | 8 | 7 | 8 | 9 | 9 | 12 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 3 | 2 | 2 | 2 | 5 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Bud Site | 0 | 0 | 0 | 3 | 2 | 14 | 11 | 32 | 15 | 21 | 20 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 2 | 7 | 17 | 20 | 31 | 32 | 84 | 138 | 69 | 79 | 96 | 106 | 10 | 29 | 42 | 17 | 26 | 25 | 0 | 2 | 3 | 0 | 1 | 2 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 6 | 7 | 8 | 0 | 0 | 2 | 0 | 1 | 1 |
Endosome | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4 | 4 | 2 | 3 | 1 | 1 | 1 | 1 | 1 | 3 | 11 |
Golgi | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 |
Mitochondria | 4 | 38 | 117 | 136 | 99 | 294 | 361 | 496 | 279 | 310 | 293 | 406 | 11 | 9 | 38 | 11 | 3 | 13 | 1 | 1 | 7 | 0 | 4 | 8 |
Nucleus | 191 | 115 | 258 | 223 | 290 | 316 | 298 | 416 | 153 | 158 | 167 | 178 | 109 | 170 | 124 | 316 | 223 | 216 | 178 | 114 | 247 | 58 | 91 | 67 |
Nuclear Periphery | 1 | 2 | 2 | 3 | 5 | 6 | 8 | 4 | 1 | 5 | 5 | 3 | 2 | 7 | 1 | 4 | 6 | 4 | 1 | 0 | 2 | 0 | 1 | 4 |
Nucleolus | 2 | 2 | 4 | 10 | 11 | 21 | 19 | 34 | 10 | 16 | 15 | 17 | 5 | 6 | 8 | 24 | 13 | 23 | 13 | 1 | 7 | 1 | 4 | 14 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 1 | 2 | 2 | 3 | 3 | 16 | 5 | 6 | 2 | 10 | 0 | 2 | 1 | 2 | 3 | 1 | 2 | 2 | 3 | 1 | 1 | 2 |
Vac/Vac Membrane | 6 | 8 | 6 | 2 | 13 | 12 | 19 | 31 | 6 | 4 | 4 | 25 | 3 | 8 | 14 | 27 | 17 | 21 | 7 | 9 | 41 | 18 | 35 | 70 |
Unique Cell Count | 200 | 141 | 315 | 282 | 370 | 466 | 545 | 830 | 374 | 418 | 422 | 520 | 125 | 217 | 211 | 377 | 278 | 282 | 211 | 141 | 323 | 90 | 150 | 197 |
Labelled Cell Count | 208 | 172 | 407 | 399 | 454 | 702 | 812 | 1177 | 546 | 610 | 613 | 786 | 140 | 237 | 237 | 411 | 303 | 313 | 211 | 141 | 323 | 90 | 150 | 197 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 6.6 | 4.4 | 4.3 | 4.2 | 5.3 | 3.7 | 3.6 | 3.5 | 2.9 | 2.9 | 3.0 | 2.6 | 5.7 | 5.7 | 5.0 | 8.6 | 9.6 | 9.7 | 5.1 | 5.5 | 6.2 |
Std Deviation (1e-4) | 1.1 | 1.0 | 1.1 | 1.5 | 3.6 | 1.2 | 1.6 | 1.2 | 1.2 | 1.3 | 1.3 | 1.1 | 1.4 | 1.6 | 1.7 | 2.1 | 2.4 | 2.2 | 0.8 | 1.3 | 1.8 |
Intensity Change (Log2) | – | – | – | -0.03 | 0.3 | -0.19 | -0.26 | -0.31 | -0.56 | -0.56 | -0.52 | -0.71 | 0.41 | 0.43 | 0.22 | 1.01 | 1.17 | 1.18 | 0.25 | 0.38 | 0.55 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | 3.2 | 2.6 | 3.3 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 1.8282 | 3.0531 | 3.269 | 2.6616 | 2.1146 | 2.3995 | 2.4085 | 3.7218 | 3.8598 | 2.6745 | 3.0012 | 2.9131 | 2.5487 | 4.3065 | 4.1218 | 3.5422 | 3.2973 | 3.5906 |
Actin | 0.0176 | 0 | 0.0078 | 0 | 0.0096 | 0.0001 | 0.0312 | 0.0002 | 0.0109 | 0 | 0.0026 | 0.0015 | 0.0068 | 0.0001 | 0.0001 | 0.0002 | 0 | 0.0005 |
Bud | 0.0002 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0004 | 0.0002 | 0.0004 | 0 | 0.0004 | 0.0002 | 0.0001 | 0 | 0 | 0 | 0 | 0.0001 |
Bud Neck | 0.0012 | 0.0002 | 0.0006 | 0.0003 | 0.0003 | 0.0018 | 0.0041 | 0.0008 | 0.0009 | 0.0002 | 0.001 | 0.0017 | 0.0007 | 0.0002 | 0.0005 | 0.0002 | 0.0007 | 0.0029 |
Bud Periphery | 0.0004 | 0 | 0.0003 | 0 | 0.0001 | 0.0001 | 0.0012 | 0.0006 | 0.002 | 0 | 0.0004 | 0.0006 | 0.0002 | 0 | 0.0001 | 0.0001 | 0 | 0.0002 |
Bud Site | 0.0007 | 0.0001 | 0.0003 | 0 | 0.0002 | 0.0001 | 0.0019 | 0.0022 | 0.0017 | 0 | 0.013 | 0.0004 | 0.0004 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0003 |
Cell Periphery | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0.0004 | 0.0002 | 0.0002 | 0 | 0.0002 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0001 |
Cytoplasm | 0.003 | 0.0009 | 0.0014 | 0.0001 | 0.0001 | 0.0001 | 0.0036 | 0.0007 | 0.0013 | 0.0001 | 0.0109 | 0.0018 | 0.0081 | 0.0016 | 0.0013 | 0.0004 | 0.0013 | 0.0016 |
Cytoplasmic Foci | 0.0055 | 0 | 0.0009 | 0 | 0.0021 | 0 | 0.0103 | 0.001 | 0.0022 | 0 | 0.0234 | 0.0021 | 0.0019 | 0 | 0.0016 | 0 | 0 | 0.0002 |
Eisosomes | 0.0002 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0003 | 0 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0018 | 0.0001 | 0.001 | 0 | 0.0001 | 0.0001 | 0.0012 | 0.0003 | 0.0022 | 0 | 0.0033 | 0.001 | 0.001 | 0.0002 | 0.0002 | 0.0002 | 0.0001 | 0.0002 |
Endosome | 0.0138 | 0.0001 | 0.0044 | 0.0001 | 0.0011 | 0.0006 | 0.0092 | 0.0142 | 0.0108 | 0 | 0.0089 | 0.0111 | 0.0056 | 0.0002 | 0.0005 | 0.0004 | 0.0002 | 0.0017 |
Golgi | 0.0041 | 0 | 0.0015 | 0 | 0.0045 | 0 | 0.0029 | 0.0011 | 0.0033 | 0 | 0.0021 | 0.0018 | 0.0007 | 0 | 0.0003 | 0 | 0 | 0.0002 |
Lipid Particles | 0.0059 | 0 | 0.0042 | 0 | 0.011 | 0.0001 | 0.0037 | 0.0007 | 0.0089 | 0 | 0.0182 | 0.0074 | 0.0008 | 0 | 0.014 | 0.0001 | 0 | 0.0003 |
Mitochondria | 0.0056 | 0.0001 | 0.0049 | 0.0001 | 0.0052 | 0.0022 | 0.0175 | 0.0033 | 0.0137 | 0.0002 | 0.0015 | 0.0086 | 0.001 | 0.0004 | 0.0005 | 0.0006 | 0.0002 | 0.0009 |
None | 0.0133 | 0.0004 | 0.001 | 0 | 0.0001 | 0.0001 | 0.0045 | 0.0001 | 0.0017 | 0.0001 | 0.0042 | 0.0002 | 0.0135 | 0.0002 | 0.0014 | 0.0002 | 0.0014 | 0.0022 |
Nuclear Periphery | 0.0321 | 0.0094 | 0.0317 | 0.011 | 0.0056 | 0.0061 | 0.0268 | 0.0106 | 0.0285 | 0.0046 | 0.0167 | 0.0066 | 0.0122 | 0.0238 | 0.0255 | 0.0441 | 0.0034 | 0.0046 |
Nucleolus | 0.0429 | 0.0313 | 0.0506 | 0.0701 | 0.0403 | 0.0549 | 0.0424 | 0.04 | 0.0513 | 0.0446 | 0.0418 | 0.0547 | 0.0432 | 0.0369 | 0.0418 | 0.0401 | 0.0393 | 0.0915 |
Nucleus | 0.8087 | 0.9442 | 0.8742 | 0.9049 | 0.8838 | 0.9265 | 0.8008 | 0.909 | 0.844 | 0.9466 | 0.8348 | 0.8801 | 0.8489 | 0.9212 | 0.9026 | 0.9034 | 0.9454 | 0.8793 |
Peroxisomes | 0.0064 | 0 | 0.0006 | 0 | 0.0217 | 0 | 0.0031 | 0.0002 | 0.0036 | 0 | 0.0081 | 0.0015 | 0.0007 | 0 | 0.0002 | 0 | 0 | 0.0002 |
Punctate Nuclear | 0.032 | 0.0126 | 0.0125 | 0.0128 | 0.0135 | 0.0058 | 0.0275 | 0.0088 | 0.0079 | 0.0034 | 0.0064 | 0.0124 | 0.0529 | 0.0139 | 0.0084 | 0.0089 | 0.0072 | 0.0111 |
Vacuole | 0.0024 | 0.0003 | 0.0008 | 0.0002 | 0.0002 | 0.0005 | 0.004 | 0.0047 | 0.0021 | 0.0001 | 0.0018 | 0.0036 | 0.0009 | 0.0003 | 0.0004 | 0.0003 | 0.0002 | 0.0017 |
Vacuole Periphery | 0.0021 | 0.0002 | 0.0013 | 0.0002 | 0.0004 | 0.0006 | 0.0029 | 0.0013 | 0.0021 | 0.0001 | 0.0007 | 0.0024 | 0.0005 | 0.0006 | 0.0004 | 0.0006 | 0.0001 | 0.0003 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 58.6795 | 22.628 | 16.0277 | 27.5135 | 44.7532 | 37.1814 | 22.8792 | 17.8986 | 20.3956 | 43.9408 |
Translational Efficiency | 0.6725 | 0.6792 | 0.611 | 0.5458 | 0.6349 | 1.0165 | 0.6322 | 0.5999 | 0.5597 | 0.6429 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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