Standard name | |
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Human Ortholog | |
Description | Cyclin-dependent protein kinase regulatory subunit and adaptor; interacts with Cdc28p (aka Cdk1p); required for G1/S and G2/M phase transitions and budding; mediates phosphorylation and degradation of Sic1p; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters; human homologs CKS1B and CKS2 can each complement yeast cks1 null mutant |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | 1 | 0 | 4 | 6 | 6 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
Bud | 1 | 0 | 4 | 0 | 1 | 2 | – | 3 | 3 | 4 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 54 | 15 | 11 | 5 | 1 | 12 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 3 | 0 | 0 | 2 | 2 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 1 | 1 | 1 | 0 | 1 | – | 3 | 0 | 1 | 6 | 6 | 0 | 0 | 2 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 195 | 88 | 56 | 67 | 62 | 111 | – | 170 | 118 | 140 | 115 | 144 | 89 | 120 | 132 | 131 | 80 | 55 | 127 | 58 | 50 | 99 | 210 | 235 |
Endoplasmic Reticulum | 2 | 0 | 0 | 2 | 1 | 0 | – | 5 | 3 | 1 | 3 | 1 | 0 | 2 | 2 | 9 | 2 | 3 | 0 | 0 | 0 | 0 | 1 | 1 |
Endosome | 1 | 0 | 0 | 0 | 8 | 8 | – | 6 | 1 | 0 | 1 | 2 | 7 | 11 | 22 | 0 | 1 | 2 | 7 | 2 | 3 | 1 | 1 | 6 |
Golgi | 0 | 1 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 7 | 1 | 0 | 0 | 0 | 3 | 0 |
Mitochondria | 5 | 0 | 18 | 33 | 12 | 44 | – | 113 | 119 | 126 | 87 | 121 | 0 | 5 | 4 | 6 | 4 | 3 | 2 | 0 | 1 | 0 | 1 | 0 |
Nucleus | 112 | 44 | 49 | 24 | 70 | 65 | – | 99 | 57 | 51 | 48 | 56 | 78 | 155 | 213 | 22 | 16 | 12 | 195 | 101 | 59 | 34 | 49 | 58 |
Nuclear Periphery | 1 | 0 | 0 | 0 | 0 | 3 | – | 1 | 2 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 1 |
Nucleolus | 10 | 4 | 4 | 2 | 13 | 14 | – | 35 | 19 | 22 | 13 | 15 | 3 | 14 | 12 | 1 | 5 | 6 | 12 | 8 | 2 | 1 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 3 | 7 | 20 | 0 | 0 | 0 | 17 | 9 | 7 | 1 | 1 | 4 |
Vac/Vac Membrane | 98 | 73 | 30 | 33 | 57 | 44 | – | 153 | 62 | 75 | 29 | 66 | 87 | 92 | 75 | 96 | 77 | 55 | 20 | 13 | 7 | 14 | 12 | 17 |
Unique Cell Count | 388 | 193 | 128 | 143 | 205 | 253 | 504 | 321 | 369 | 257 | 353 | 241 | 383 | 447 | 241 | 157 | 124 | 455 | 215 | 148 | 163 | 290 | 345 | |
Labelled Cell Count | 426 | 211 | 162 | 162 | 224 | 292 | 588 | 386 | 422 | 308 | 414 | 271 | 414 | 503 | 273 | 188 | 144 | 455 | 215 | 148 | 163 | 290 | 345 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 9.6 | 12.6 | 6.1 | 7.2 | 8.2 | 7.2 | – | 7.2 | 7.1 | 7.4 | 7.5 | 7.7 | 10.4 | 10.7 | 10.4 | 18.4 | 18.5 | 18.0 | 9.7 | 10.6 | 10.5 |
Std Deviation (1e-4) | 1.6 | 1.8 | 1.1 | 1.4 | 1.5 | 1.4 | – | 1.4 | 1.7 | 1.7 | 1.7 | 1.9 | 1.9 | 2.4 | 2.5 | 5.8 | 6.0 | 4.8 | 1.9 | 1.8 | 1.8 |
Intensity Change (Log2) | – | – | – | 0.25 | 0.42 | 0.23 | – | 0.24 | 0.22 | 0.28 | 0.3 | 0.34 | 0.77 | 0.81 | 0.78 | 1.6 | 1.6 | 1.56 | 0.67 | 0.8 | 0.78 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.5 | -2.5 | 0 | – | -2.1 | -1.4 | -1.2 | 0.2 | -0.6 | -1.3 | -2.6 | -3.0 | 1.9 | 1.2 | 0.1 |
Endoplasmic Reticulum | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 1.9 | -2.5 | 0.8 | – | 2.1 | 4.8 | 4.3 | 4.1 | 4.3 | -6.0 | -6.0 | 0 | -4.3 | -3.6 | -3.3 |
Nucleus | -4.0 | -0.8 | -2.5 | – | -4.4 | -4.6 | -5.9 | -4.2 | -5.3 | -1.1 | 0.4 | 1.9 | -6.8 | -5.6 | -5.3 |
Nuclear Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 1.3 | 1.0 | – | 1.6 | 1.2 | 1.2 | 0.9 | 0.6 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | -0.1 | 0.9 | -1.4 | – | 1.5 | -1.0 | -0.7 | -3.1 | -1.1 | 2.5 | 0.1 | -1.7 | 3.2 | 4.4 | 3.5 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 5.7496 | 7.5955 | 7.2573 | 6.6186 | 6.3092 | 6.5259 | 4.6288 | 6.6192 | 6.2829 | 5.4695 | 4.8884 | 5.8346 | 6.8671 | 8.7201 | 8.1844 | 8.18 | 8.0455 | 7.896 |
Actin | 0.0294 | 0.0017 | 0.0082 | 0.0249 | 0.0053 | 0.0012 | 0.0105 | 0.0003 | 0.0074 | 0.0128 | 0.0016 | 0.0019 | 0.0101 | 0.0008 | 0.0016 | 0.0077 | 0.0194 | 0.0074 |
Bud | 0.0014 | 0.0005 | 0.0006 | 0.0003 | 0.0011 | 0.0002 | 0.0013 | 0.0007 | 0.0004 | 0.0044 | 0.0005 | 0.0004 | 0.0043 | 0.0009 | 0.0004 | 0.0001 | 0.0006 | 0.0002 |
Bud Neck | 0.0032 | 0.0007 | 0.0015 | 0.0027 | 0.0178 | 0.0034 | 0.0037 | 0.0008 | 0.0021 | 0.0013 | 0.0012 | 0.0068 | 0.0135 | 0.001 | 0.0007 | 0.0006 | 0.0039 | 0.0038 |
Bud Periphery | 0.0013 | 0.0002 | 0.0005 | 0.0005 | 0.002 | 0.0002 | 0.001 | 0.0002 | 0.0003 | 0.0081 | 0.0009 | 0.0002 | 0.0087 | 0.0003 | 0.0003 | 0.0001 | 0.0008 | 0.0001 |
Bud Site | 0.0035 | 0.0023 | 0.0024 | 0.0019 | 0.0104 | 0.0002 | 0.0026 | 0.0023 | 0.0013 | 0.0047 | 0.0034 | 0.0004 | 0.0248 | 0.0062 | 0.0009 | 0.0001 | 0.0024 | 0.0002 |
Cell Periphery | 0.0014 | 0.0001 | 0.0001 | 0.0005 | 0.0006 | 0.0001 | 0.0003 | 0 | 0 | 0.0003 | 0.0004 | 0.0001 | 0.0017 | 0.0001 | 0 | 0 | 0.0001 | 0 |
Cytoplasm | 0.3922 | 0.2488 | 0.0211 | 0.0015 | 0.0079 | 0.2151 | 0.3553 | 0.2009 | 0.0227 | 0.0033 | 0.0203 | 0.2063 | 0.4631 | 0.2774 | 0.0267 | 0.001 | 0.0067 | 0.3333 |
Cytoplasmic Foci | 0.0269 | 0.0031 | 0.0023 | 0.0032 | 0.0178 | 0.0016 | 0.0414 | 0.0008 | 0.0103 | 0.0085 | 0.0255 | 0.0119 | 0.0248 | 0.0012 | 0.0107 | 0.0065 | 0.0031 | 0.0033 |
Eisosomes | 0.0006 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0002 | 0 | 0 | 0.0001 | 0.0001 | 0 | 0.0002 | 0 | 0 | 0.0001 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0156 | 0.0019 | 0.003 | 0.0003 | 0.0028 | 0.0026 | 0.0111 | 0.0018 | 0.001 | 0.0008 | 0.005 | 0.0028 | 0.0082 | 0.0011 | 0.0007 | 0.0002 | 0.0035 | 0.0021 |
Endosome | 0.0197 | 0.0025 | 0.0065 | 0.0106 | 0.021 | 0.0067 | 0.0701 | 0.0008 | 0.0063 | 0.0107 | 0.1077 | 0.0087 | 0.0217 | 0.0004 | 0.0031 | 0.0016 | 0.0045 | 0.0026 |
Golgi | 0.0051 | 0.0003 | 0.0019 | 0.0039 | 0.0063 | 0.0009 | 0.01 | 0 | 0.0037 | 0.0102 | 0.0149 | 0.0073 | 0.0074 | 0.0001 | 0.0016 | 0.0019 | 0.0032 | 0.0015 |
Lipid Particles | 0.0079 | 0.0006 | 0.0026 | 0.0039 | 0.0121 | 0.0015 | 0.0103 | 0 | 0.0024 | 0.015 | 0.032 | 0.001 | 0.0088 | 0 | 0.0049 | 0.0136 | 0.0051 | 0.0024 |
Mitochondria | 0.0072 | 0.0005 | 0.0042 | 0.0045 | 0.0139 | 0.0007 | 0.0245 | 0.0002 | 0.0028 | 0.024 | 0.0137 | 0.0066 | 0.021 | 0.0003 | 0.0013 | 0.0011 | 0.0036 | 0.0004 |
None | 0.0131 | 0.0019 | 0.0012 | 0.0003 | 0.0009 | 0.0005 | 0.0062 | 0.0014 | 0.0006 | 0.0004 | 0.0013 | 0.0021 | 0.0091 | 0.001 | 0.0007 | 0.0007 | 0.0005 | 0.0008 |
Nuclear Periphery | 0.0466 | 0.0159 | 0.0168 | 0.0077 | 0.0277 | 0.0207 | 0.0558 | 0.0127 | 0.0261 | 0.0088 | 0.0167 | 0.0191 | 0.0275 | 0.0106 | 0.0089 | 0.0092 | 0.0453 | 0.0155 |
Nucleolus | 0.0035 | 0.0052 | 0.0081 | 0.0037 | 0.0115 | 0.0016 | 0.002 | 0.0024 | 0.004 | 0.0034 | 0.0074 | 0.0019 | 0.0085 | 0.0047 | 0.0046 | 0.0028 | 0.0241 | 0.0023 |
Nucleus | 0.3813 | 0.7009 | 0.8928 | 0.911 | 0.7927 | 0.7315 | 0.3538 | 0.7567 | 0.886 | 0.8671 | 0.636 | 0.6862 | 0.3128 | 0.6809 | 0.9037 | 0.9349 | 0.8519 | 0.5956 |
Peroxisomes | 0.0056 | 0.0003 | 0.0038 | 0.005 | 0.0065 | 0.0004 | 0.0082 | 0.0001 | 0.0024 | 0.0062 | 0.0038 | 0.0017 | 0.0027 | 0.0001 | 0.0099 | 0.0149 | 0.0065 | 0.0055 |
Punctate Nuclear | 0.0177 | 0.0113 | 0.0208 | 0.0018 | 0.0326 | 0.0057 | 0.0108 | 0.0162 | 0.0187 | 0.0055 | 0.0945 | 0.0323 | 0.0078 | 0.012 | 0.018 | 0.0027 | 0.0126 | 0.0219 |
Vacuole | 0.0119 | 0.001 | 0.0011 | 0.0099 | 0.007 | 0.0047 | 0.0171 | 0.0013 | 0.0008 | 0.0031 | 0.0096 | 0.0018 | 0.011 | 0.0007 | 0.0012 | 0.0002 | 0.0011 | 0.0007 |
Vacuole Periphery | 0.005 | 0.0002 | 0.0005 | 0.0015 | 0.002 | 0.0007 | 0.0038 | 0.0002 | 0.0006 | 0.0013 | 0.0034 | 0.0004 | 0.0023 | 0.0001 | 0.0003 | 0.0001 | 0.0009 | 0.0002 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 70.6374 | 80.5649 | 45.2409 | 52.0821 | 60.0036 | 68.1638 | 60.5439 | 56.4654 | 38.3944 | 62.0294 |
Translational Efficiency | 1.5077 | 1.0995 | 1.4645 | 1.3001 | 1.7322 | 1.6571 | 1.3614 | 1.7251 | 1.8729 | 1.4471 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✔ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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