Standard name | |
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Human Ortholog | |
Description | TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70); stimulates ATPase activity of Ssa1p; ts mutants reduce Hsp82p function, overexpression suppresses phenotypes of HSP82 ts allele and cpr7 deletion; human homolog TTC4 complements yeast cns1 mutant |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Bud | 0 | 0 | 3 | 5 | 1 | 2 | 8 | 5 | 5 | 4 | 7 | 9 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 2 | 22 | 5 | 5 | 4 | 16 | 11 | 3 | 17 | 13 | 18 | 7 | 5 | 2 | 13 | 17 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 239 | 173 | 336 | 278 | 316 | 301 | 345 | 358 | 229 | 293 | 260 | 231 | 364 | 530 | 575 | 182 | 225 | 119 | 231 | 164 | 318 | 302 | 398 | 415 |
Endoplasmic Reticulum | 1 | 0 | 12 | 2 | 2 | 4 | 7 | 7 | 1 | 13 | 1 | 3 | 0 | 4 | 2 | 6 | 10 | 5 | 2 | 1 | 18 | 0 | 3 | 5 |
Endosome | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 2 | 5 |
Golgi | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 2 |
Mitochondria | 1 | 1 | 4 | 13 | 14 | 68 | 132 | 126 | 84 | 178 | 175 | 158 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 5 | 0 | 0 | 2 |
Nucleus | 2 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 6 | 0 | 4 | 1 | 0 | 2 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 2 | 1 | 2 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 3 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 1 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Vac/Vac Membrane | 1 | 0 | 0 | 4 | 4 | 9 | 12 | 37 | 29 | 29 | 42 | 28 | 1 | 1 | 0 | 4 | 1 | 4 | 2 | 1 | 4 | 2 | 5 | 7 |
Unique Cell Count | 244 | 174 | 351 | 289 | 334 | 347 | 451 | 488 | 321 | 457 | 412 | 388 | 365 | 537 | 577 | 188 | 233 | 123 | 243 | 169 | 359 | 316 | 419 | 453 |
Labelled Cell Count | 245 | 176 | 378 | 309 | 345 | 390 | 522 | 551 | 362 | 535 | 505 | 455 | 374 | 542 | 581 | 209 | 258 | 136 | 243 | 169 | 359 | 316 | 419 | 453 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 10.3 | 13.9 | 11.4 | 10.4 | 9.1 | 7.9 | 7.4 | 7.2 | 6.4 | 6.6 | 6.3 | 6.3 | 12.0 | 11.8 | 10.7 | 21.6 | 22.4 | 22.0 | 12.4 | 12.6 | 12.5 |
Std Deviation (1e-4) | 1.5 | 1.9 | 1.6 | 1.8 | 1.7 | 1.5 | 1.4 | 1.4 | 1.8 | 1.6 | 1.3 | 1.6 | 1.9 | 1.6 | 1.6 | 6.0 | 5.3 | 4.7 | 2.0 | 2.1 | 2.2 |
Intensity Change (Log2) | – | – | – | -0.13 | -0.33 | -0.54 | -0.63 | -0.66 | -0.83 | -0.79 | -0.86 | -0.87 | 0.07 | 0.05 | -0.09 | 0.92 | 0.97 | 0.94 | 0.11 | 0.14 | 0.13 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.6 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | -2.8 | -3.2 | -3.6 | -1.8 | -3.0 | -3.6 | -1.7 | -2.0 | -1.0 | -3.0 | -4.5 | -5.5 | 0.3 | 0.5 | 0.1 |
Cytoplasm | 0.3 | -0.7 | -4.2 | -7.5 | -8.5 | -8.6 | -10.7 | -10.9 | -11.6 | 3.6 | 2.8 | 4.3 | 0.6 | 0.5 | 0.5 |
Endoplasmic Reticulum | -2.3 | -2.6 | -2.0 | -1.7 | -1.9 | -2.9 | -0.5 | -3.4 | -2.5 | -3.6 | -2.9 | -3.7 | -0.1 | 0.5 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 2.6 | 2.5 | 8.0 | 10.5 | 9.7 | 9.6 | 12.8 | 13.4 | 13.0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 3.1 | 5.3 | 5.8 | 4.8 | 6.2 | 5.1 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 5.5895 | 8.3172 | 7.1529 | 5.9739 | 6.6452 | 7.312 | 6.7653 | 9.7179 | 8.8193 | 7.5691 | 7.5862 | 9.15 | 6.3341 | 9.4972 | 7.9604 | 6.3604 | 6.844 | 7.455 |
Actin | 0.0064 | 0.0073 | 0.0005 | 0.0001 | 0.0043 | 0.0004 | 0.0235 | 0.0016 | 0.0101 | 0.0093 | 0.0134 | 0.0016 | 0.0077 | 0.0009 | 0.0077 | 0.0314 | 0.0066 | 0.0016 |
Bud | 0.0002 | 0.0003 | 0.0002 | 0.0002 | 0.0281 | 0.0003 | 0.0012 | 0.0003 | 0.0006 | 0.0009 | 0.001 | 0.0004 | 0.0006 | 0.0027 | 0.0002 | 0.0012 | 0.0003 | 0.0013 |
Bud Neck | 0.0002 | 0.0002 | 0.0003 | 0.0003 | 0.0004 | 0.0008 | 0.003 | 0.0003 | 0.0011 | 0.0007 | 0.0006 | 0.0008 | 0.0007 | 0.0002 | 0.0004 | 0.0012 | 0.0005 | 0.0021 |
Bud Periphery | 0.0001 | 0.0001 | 0 | 0 | 0.0146 | 0.0003 | 0.0013 | 0.0003 | 0.0005 | 0.0011 | 0.0007 | 0.0004 | 0.0007 | 0.0007 | 0.0001 | 0.0015 | 0.0003 | 0.0007 |
Bud Site | 0.0004 | 0.0006 | 0.0002 | 0.0001 | 0.0057 | 0.0001 | 0.006 | 0.0015 | 0.0073 | 0.0045 | 0.0067 | 0.0003 | 0.0019 | 0.0034 | 0.0002 | 0.0052 | 0.0003 | 0.0005 |
Cell Periphery | 0.0001 | 0 | 0 | 0 | 0.0001 | 0.0001 | 0.0004 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0002 | 0.0002 | 0 | 0.0003 | 0.0001 | 0.0001 |
Cytoplasm | 0.9233 | 0.9722 | 0.9607 | 0.9139 | 0.915 | 0.9316 | 0.7255 | 0.9665 | 0.9344 | 0.8173 | 0.9001 | 0.9542 | 0.8849 | 0.982 | 0.9515 | 0.7923 | 0.8899 | 0.9466 |
Cytoplasmic Foci | 0.0141 | 0.0066 | 0.0091 | 0.0246 | 0.0129 | 0.0143 | 0.039 | 0.0075 | 0.0093 | 0.0147 | 0.0094 | 0.0112 | 0.0219 | 0.0029 | 0.0045 | 0.0218 | 0.0148 | 0.0118 |
Eisosomes | 0 | 0 | 0 | 0 | 0 | 0 | 0.0003 | 0 | 0 | 0.0001 | 0.0001 | 0 | 0.0002 | 0 | 0.0001 | 0.0003 | 0 | 0 |
Endoplasmic Reticulum | 0.0068 | 0.0013 | 0.004 | 0.0017 | 0.0028 | 0.0037 | 0.0112 | 0.0015 | 0.0029 | 0.0097 | 0.0011 | 0.0034 | 0.0096 | 0.0011 | 0.0029 | 0.0027 | 0.0025 | 0.0036 |
Endosome | 0.019 | 0.0056 | 0.0175 | 0.0429 | 0.0086 | 0.0218 | 0.0796 | 0.0045 | 0.0091 | 0.0548 | 0.0108 | 0.012 | 0.0289 | 0.0017 | 0.0158 | 0.0409 | 0.0161 | 0.016 |
Golgi | 0.0026 | 0.0008 | 0.0014 | 0.0013 | 0.0005 | 0.0017 | 0.0209 | 0.0018 | 0.0021 | 0.0181 | 0.0072 | 0.0018 | 0.0071 | 0.0001 | 0.0078 | 0.0211 | 0.0098 | 0.0022 |
Lipid Particles | 0.0003 | 0 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0093 | 0.0004 | 0.0028 | 0.0038 | 0.0007 | 0.0013 | 0.0038 | 0 | 0.0014 | 0.0199 | 0.0051 | 0.0012 |
Mitochondria | 0.0005 | 0.0003 | 0.0004 | 0.0005 | 0.0007 | 0.009 | 0.0226 | 0.0078 | 0.0008 | 0.039 | 0.0407 | 0.0024 | 0.008 | 0.0001 | 0.003 | 0.0199 | 0.0187 | 0.0019 |
None | 0.0148 | 0.0017 | 0.0012 | 0.0075 | 0.0018 | 0.0106 | 0.0072 | 0.0012 | 0.0085 | 0.0025 | 0.0013 | 0.0013 | 0.0064 | 0.0022 | 0.0011 | 0.0013 | 0.0013 | 0.0012 |
Nuclear Periphery | 0.0014 | 0.0005 | 0.0006 | 0.0005 | 0.0007 | 0.0005 | 0.0093 | 0.0005 | 0.0009 | 0.008 | 0.0005 | 0.0015 | 0.0023 | 0.0003 | 0.0008 | 0.0053 | 0.0012 | 0.0014 |
Nucleolus | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0.0005 | 0 | 0.0001 | 0.0002 | 0 | 0.0004 | 0.0005 | 0 | 0 | 0.0005 | 0 | 0.0005 |
Nucleus | 0.0057 | 0.0009 | 0.0011 | 0.001 | 0.0012 | 0.0011 | 0.0115 | 0.0011 | 0.0015 | 0.0036 | 0.0019 | 0.0028 | 0.0043 | 0.0008 | 0.0009 | 0.0026 | 0.0018 | 0.0017 |
Peroxisomes | 0.0008 | 0.0001 | 0.0001 | 0.0002 | 0.0004 | 0.0001 | 0.012 | 0.0017 | 0.0054 | 0.0013 | 0.0016 | 0.0012 | 0.0041 | 0 | 0.0004 | 0.0114 | 0.0217 | 0.0007 |
Punctate Nuclear | 0.0003 | 0.0001 | 0.0001 | 0.0002 | 0.0004 | 0.0014 | 0.0067 | 0.0001 | 0.0007 | 0.0011 | 0.0003 | 0.0008 | 0.0014 | 0.0002 | 0.0002 | 0.0117 | 0.0068 | 0.0018 |
Vacuole | 0.0024 | 0.0011 | 0.0015 | 0.0036 | 0.0013 | 0.0015 | 0.0069 | 0.0009 | 0.0014 | 0.006 | 0.0013 | 0.0015 | 0.0038 | 0.0006 | 0.0007 | 0.0054 | 0.0018 | 0.0023 |
Vacuole Periphery | 0.0005 | 0.0003 | 0.0007 | 0.0011 | 0.0004 | 0.0007 | 0.0023 | 0.0002 | 0.0003 | 0.0029 | 0.0005 | 0.0006 | 0.001 | 0.0001 | 0.0004 | 0.0021 | 0.0007 | 0.001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 38.5906 | 29.8128 | 32.8675 | 27.1797 | 41.3864 | 19.0465 | 21.3159 | 27.611 | 24.1223 | 32.0668 |
Translational Efficiency | 2.635 | 2.7202 | 2.2075 | 2.0362 | 1.7838 | 3.4716 | 2.2625 | 1.6345 | 1.9344 | 1.9817 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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