Standard name | |
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Human Ortholog | |
Description | Poly(A+) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; relocalizes to the cytosol in response to hypoxia; GBP2 has a paralog, HRB1, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 0 |
Bud | 1 | 0 | 0 | 0 | 2 | 7 | 16 | 10 | 9 | 11 | 14 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 4 | 1 | 2 | 4 |
Bud Neck | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 1 | 0 | 0 | 0 | 4 | 10 | 17 | 26 | 17 | 27 | 19 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 3 | 5 | 14 | 20 | 32 | 26 | 48 | 43 | 31 | 53 | 24 | 35 | 19 | 48 | 72 | 24 | 16 | 24 | 1 | 0 | 0 | 4 | 6 | 3 |
Endoplasmic Reticulum | 0 | 0 | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 2 | 7 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3 | 2 | 4 | 3 | 2 | 1 | 1 | 0 | 5 | 1 | 4 | 3 |
Golgi | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 5 | 0 | 0 | 1 |
Mitochondria | 34 | 32 | 12 | 26 | 54 | 202 | 408 | 334 | 403 | 474 | 378 | 469 | 2 | 2 | 1 | 5 | 7 | 11 | 8 | 2 | 2 | 2 | 4 | 2 |
Nucleus | 231 | 206 | 438 | 282 | 372 | 412 | 478 | 568 | 362 | 419 | 279 | 313 | 221 | 282 | 316 | 115 | 116 | 104 | 225 | 201 | 423 | 218 | 210 | 191 |
Nuclear Periphery | 4 | 0 | 2 | 3 | 2 | 8 | 10 | 13 | 4 | 5 | 3 | 7 | 1 | 3 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 2 |
Nucleolus | 20 | 4 | 7 | 13 | 14 | 30 | 36 | 46 | 29 | 31 | 15 | 18 | 5 | 2 | 8 | 3 | 3 | 3 | 8 | 1 | 18 | 5 | 11 | 14 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 1 | 0 | 0 | 1 | 0 | 2 | 0 | 8 | 6 | 4 | 1 | 5 | 0 | 5 | 5 | 1 | 0 | 0 | 1 | 1 | 2 | 3 | 0 | 5 |
Vac/Vac Membrane | 0 | 7 | 1 | 9 | 7 | 12 | 9 | 14 | 12 | 23 | 12 | 25 | 0 | 2 | 10 | 12 | 9 | 13 | 2 | 18 | 14 | 11 | 27 | 36 |
Unique Cell Count | 250 | 231 | 468 | 319 | 437 | 510 | 698 | 780 | 572 | 710 | 496 | 592 | 247 | 339 | 407 | 155 | 144 | 144 | 253 | 237 | 486 | 254 | 271 | 269 |
Labelled Cell Count | 295 | 254 | 478 | 355 | 491 | 709 | 1025 | 1063 | 873 | 1047 | 745 | 917 | 253 | 348 | 419 | 164 | 156 | 165 | 253 | 237 | 486 | 254 | 271 | 269 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.8 | 6.6 | 6.6 | 5.9 | 5.6 | 4.4 | 4.1 | 3.9 | 3.6 | 3.5 | 3.1 | 3.1 | 8.1 | 7.5 | 7.3 | 8.5 | 8.5 | 8.2 | 8.0 | 8.5 | 8.8 |
Std Deviation (1e-4) | 1.2 | 1.7 | 1.5 | 1.7 | 2.1 | 1.7 | 1.5 | 1.4 | 1.2 | 1.3 | 1.0 | 0.8 | 1.6 | 1.6 | 1.7 | 2.0 | 1.7 | 2.0 | 1.7 | 1.8 | 1.6 |
Intensity Change (Log2) | – | – | – | -0.16 | -0.23 | -0.59 | -0.69 | -0.74 | -0.88 | -0.9 | -1.09 | -1.09 | 0.3 | 0.2 | 0.16 | 0.37 | 0.36 | 0.31 | 0.28 | 0.37 | 0.42 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 2.2 | 3.0 | 1.7 | 2.9 | 2.1 | 1.9 | 3.2 | 1.5 | 2.2 | 2.8 | 5.9 | 7.3 | 5.6 | 3.9 | 5.9 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 3.6 | 5.7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2.1 | -2.8 | 0 | 0 | 2.8 |
Nucleus | -2.6 | -4.2 | -5.9 | -10.2 | -9.0 | -11.5 | -13.0 | -13.3 | -14.5 | -1.9 | -4.7 | -6.8 | -6.6 | -4.7 | -7.0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 2.3 | 1.7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.5 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 2.9 | 0 | 2.5 | 2.7 | 3.6 | 3.0 | 4.2 | 0 | 0 | 3.0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.6029 | 5.1382 | 4.9114 | 4.9157 | 3.8619 | 4.906 | 1.8209 | 3.2973 | 2.3766 | 2.1674 | 2.5292 | 2.2806 | 2.0702 | 2.6172 | 2.0138 | 2.0309 | 1.7183 | 1.9578 |
Actin | 0.0128 | 0.0202 | 0.004 | 0 | 0 | 0 | 0.0101 | 0.0083 | 0.0215 | 0.0484 | 0 | 0.0226 | 0.0185 | 0 | 0.0058 | 0.0439 | 0.0003 | 0.0007 |
Bud | 0.0002 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0009 | 0.0001 | 0.0003 | 0.0013 | 0 | 0.001 | 0.0006 | 0.0001 | 0.0001 | 0.0002 | 0.0002 | 0.0007 |
Bud Neck | 0.0006 | 0.0002 | 0.0003 | 0 | 0.0008 | 0.0005 | 0.001 | 0.0001 | 0.0003 | 0.0004 | 0.0004 | 0.0016 | 0.0027 | 0 | 0.0002 | 0.0003 | 0.0009 | 0.0006 |
Bud Periphery | 0.0007 | 0.0001 | 0.0002 | 0 | 0 | 0 | 0.0009 | 0.0001 | 0.0003 | 0.002 | 0 | 0.0017 | 0.0013 | 0 | 0.0001 | 0.0003 | 0.0003 | 0.0008 |
Bud Site | 0.0009 | 0.0006 | 0.001 | 0 | 0.0001 | 0 | 0.0146 | 0.0006 | 0.0029 | 0.0029 | 0.0001 | 0.0008 | 0.0047 | 0 | 0.0009 | 0.0009 | 0.0007 | 0.0034 |
Cell Periphery | 0.0003 | 0 | 0.0006 | 0 | 0 | 0 | 0.0004 | 0 | 0.0001 | 0.0002 | 0 | 0.0001 | 0.0005 | 0 | 0 | 0.0001 | 0.0002 | 0.0001 |
Cytoplasm | 0.0019 | 0.0001 | 0.0001 | 0 | 0.0006 | 0.0001 | 0.0533 | 0.0002 | 0.0074 | 0.0064 | 0.0001 | 0.0009 | 0.0056 | 0.0002 | 0.0028 | 0.0021 | 0.0005 | 0.0002 |
Cytoplasmic Foci | 0.0048 | 0.0003 | 0 | 0 | 0 | 0 | 0.0394 | 0.0021 | 0.0152 | 0.0215 | 0.0617 | 0.0016 | 0.0217 | 0.0001 | 0.0115 | 0.0041 | 0.0001 | 0.0007 |
Eisosomes | 0.0001 | 0.0003 | 0.0046 | 0 | 0 | 0 | 0.0002 | 0 | 0.0001 | 0.0002 | 0 | 0.0001 | 0.0004 | 0 | 0 | 0.0003 | 0 | 0 |
Endoplasmic Reticulum | 0.0009 | 0 | 0.0001 | 0 | 0 | 0 | 0.0056 | 0 | 0.0008 | 0.0065 | 0 | 0.0018 | 0.0033 | 0 | 0.0036 | 0.0015 | 0.0002 | 0.0002 |
Endosome | 0.0147 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0.0858 | 0.0005 | 0.0098 | 0.0123 | 0.0047 | 0.0114 | 0.0167 | 0 | 0.0079 | 0.0077 | 0.0003 | 0.0019 |
Golgi | 0.0057 | 0.0002 | 0.0001 | 0 | 0 | 0 | 0.0174 | 0.001 | 0.0031 | 0.0072 | 0.0034 | 0.0039 | 0.0057 | 0 | 0.0048 | 0.004 | 0.0001 | 0.0005 |
Lipid Particles | 0.0124 | 0.0004 | 0.0001 | 0 | 0 | 0 | 0.0354 | 0.0008 | 0.0036 | 0.012 | 0.0557 | 0.0013 | 0.0168 | 0 | 0.0045 | 0.008 | 0.0001 | 0.0015 |
Mitochondria | 0.0028 | 0.0031 | 0.003 | 0 | 0.0002 | 0.0001 | 0.0072 | 0.0006 | 0.0016 | 0.0858 | 0.0006 | 0.023 | 0.0176 | 0.0002 | 0.0017 | 0.0055 | 0.0025 | 0.0013 |
None | 0.0012 | 0 | 0.0002 | 0 | 0.0002 | 0 | 0.0188 | 0.0001 | 0.0015 | 0.0018 | 0 | 0.0003 | 0.014 | 0 | 0.0005 | 0.0006 | 0.0002 | 0.0001 |
Nuclear Periphery | 0.0144 | 0.0011 | 0.0004 | 0.0002 | 0.0013 | 0.0004 | 0.0328 | 0.0005 | 0.0023 | 0.0414 | 0.0018 | 0.0119 | 0.0189 | 0.0007 | 0.0031 | 0.0139 | 0.0023 | 0.0009 |
Nucleolus | 0.0265 | 0.0085 | 0.012 | 0.0042 | 0.0418 | 0.0333 | 0.0156 | 0.0103 | 0.0049 | 0.0051 | 0.0109 | 0.0287 | 0.0176 | 0.0106 | 0.0086 | 0.0042 | 0.0627 | 0.0196 |
Nucleus | 0.8588 | 0.9584 | 0.9724 | 0.9359 | 0.9492 | 0.9632 | 0.5899 | 0.9699 | 0.9134 | 0.7003 | 0.82 | 0.8822 | 0.7903 | 0.9869 | 0.9303 | 0.86 | 0.9244 | 0.9653 |
Peroxisomes | 0.0204 | 0.0059 | 0.0001 | 0 | 0 | 0 | 0.0117 | 0.0037 | 0.0055 | 0.0283 | 0.0386 | 0.0009 | 0.0123 | 0 | 0.0105 | 0.0015 | 0.0001 | 0.0007 |
Punctate Nuclear | 0.0144 | 0.0002 | 0.0006 | 0.0595 | 0.0054 | 0.0022 | 0.0507 | 0.0007 | 0.0025 | 0.0067 | 0.0016 | 0.0018 | 0.0224 | 0.001 | 0.0016 | 0.0395 | 0.0028 | 0.0006 |
Vacuole | 0.0042 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0059 | 0.0001 | 0.0022 | 0.0045 | 0.0002 | 0.0011 | 0.0051 | 0 | 0.001 | 0.0004 | 0.0007 | 0.0002 |
Vacuole Periphery | 0.0012 | 0.0001 | 0 | 0 | 0 | 0 | 0.0025 | 0.0001 | 0.0009 | 0.0049 | 0.0001 | 0.0014 | 0.0033 | 0 | 0.0004 | 0.0009 | 0.0004 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 69.1776 | 80.6616 | 129.3995 | 100.8297 | 97.4911 | 74.722 | 84.6638 | 95.6741 | 103.0292 | 88.3592 |
Translational Efficiency | 1.2963 | 1.4886 | 0.8618 | 1.2489 | 1.0653 | 1.3711 | 1.1678 | 1.3981 | 1.0678 | 1.1132 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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