Standard name | |
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Human Ortholog | |
Description | Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | – | 3 | 4 | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 2 | 0 | 7 | 0 | 0 | 0 | – | 0 | 1 | 3 | 0 | 2 | 3 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 3 | 0 | 11 | 14 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 3 | 1 | 0 | 2 | 3 | 2 | – | 7 | 13 | 10 | 8 | 16 | 0 | 3 | 3 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 480 | 295 | 251 | 262 | 307 | 274 | – | 339 | 256 | 279 | 242 | 246 | 387 | 392 | 501 | 64 | 86 | 56 | 472 | 271 | 241 | 202 | 304 | 308 |
Endoplasmic Reticulum | 0 | 2 | 0 | 4 | 2 | 3 | – | 21 | 13 | 23 | 17 | 22 | 3 | 3 | 2 | 4 | 6 | 2 | 0 | 0 | 0 | 0 | 3 | 3 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | – | 2 | 3 | 6 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Mitochondria | 0 | 1 | 0 | 1 | 0 | 1 | – | 8 | 10 | 7 | 14 | 19 | 0 | 1 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nucleus | 19 | 2 | 0 | 0 | 0 | 1 | – | 7 | 5 | 5 | 5 | 7 | 1 | 0 | 3 | 3 | 0 | 1 | 11 | 8 | 3 | 4 | 9 | 7 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 2 | 0 | 2 | – | 0 | 2 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Vac/Vac Membrane | 1 | 1 | 3 | 9 | 23 | 16 | – | 75 | 33 | 28 | 17 | 24 | 2 | 6 | 8 | 3 | 6 | 2 | 6 | 6 | 5 | 5 | 15 | 9 |
Unique Cell Count | 489 | 299 | 253 | 274 | 329 | 293 | 441 | 317 | 347 | 300 | 329 | 391 | 402 | 509 | 65 | 91 | 59 | 497 | 292 | 262 | 218 | 353 | 353 | |
Labelled Cell Count | 505 | 302 | 261 | 280 | 335 | 299 | 462 | 340 | 365 | 310 | 340 | 396 | 406 | 519 | 76 | 103 | 63 | 497 | 292 | 262 | 218 | 353 | 353 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 18.8 | 20.5 | 14.8 | 20.5 | 25.2 | 24.9 | – | 27.6 | 28.6 | 29.9 | 28.9 | 29.9 | 23.6 | 27.4 | 30.7 | 24.8 | 27.3 | 28.6 | 19.3 | 22.3 | 25.4 |
Std Deviation (1e-4) | 3.9 | 5.0 | 4.3 | 6.1 | 6.2 | 6.9 | – | 9.2 | 10.2 | 9.8 | 10.7 | 17.6 | 5.6 | 8.3 | 9.4 | 14.3 | 12.2 | 16.5 | 4.7 | 8.1 | 8.4 |
Intensity Change (Log2) | – | – | – | 0.47 | 0.77 | 0.76 | – | 0.9 | 0.95 | 1.02 | 0.97 | 1.02 | 0.67 | 0.89 | 1.06 | 0.75 | 0.89 | 0.95 | 0.39 | 0.59 | 0.78 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | – | 0 | 3.3 | 0 | 0 | 3.6 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -2.6 | -3.5 | -3.5 | – | -7.9 | -7.0 | -7.1 | -7.0 | -8.3 | -0.3 | -1.6 | -0.9 | -0.6 | -2.7 | -2.4 |
Endoplasmic Reticulum | 0 | 0 | 0 | – | 3.5 | 3.3 | 4.2 | 3.8 | 4.2 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | – | 0 | 0 | 0 | 3.5 | 3.9 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 1.6 | 3.4 | 2.7 | – | 6.4 | 4.5 | 3.8 | 2.8 | 3.5 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 14.8185 | 16.9052 | 15.8306 | 14.9846 | 12.1456 | 15.868 | 12.6965 | 17.0334 | 14.1907 | 12.3926 | 12.9742 | 14.6351 | 13.6895 | 17.3835 | 15.0966 | 16.1348 | 14.8081 | 16.5723 |
Actin | 0.0059 | 0.0059 | 0.0207 | 0.0285 | 0.0533 | 0.0019 | 0.0109 | 0.0011 | 0.0041 | 0.0062 | 0.0016 | 0.0007 | 0.0141 | 0.0002 | 0.0049 | 0.0002 | 0.0001 | 0.0006 |
Bud | 0.0003 | 0.0002 | 0.0004 | 0.0001 | 0.0004 | 0.0003 | 0.0011 | 0.0032 | 0.0002 | 0.0008 | 0.0001 | 0.0001 | 0.0004 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0001 |
Bud Neck | 0.0005 | 0.0002 | 0.001 | 0.0005 | 0.0015 | 0.0011 | 0.0011 | 0.0003 | 0.0005 | 0.002 | 0.0008 | 0.0009 | 0.0012 | 0.0002 | 0.0007 | 0.0005 | 0.0006 | 0.0016 |
Bud Periphery | 0.0002 | 0.0001 | 0.0007 | 0.0001 | 0.0005 | 0.0002 | 0.0015 | 0.0004 | 0.0001 | 0.0005 | 0.0001 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0 | 0 |
Bud Site | 0.0003 | 0.0006 | 0.0005 | 0.0003 | 0.0012 | 0.0004 | 0.0037 | 0.0016 | 0.0009 | 0.0004 | 0.0002 | 0.0001 | 0.0003 | 0.0001 | 0.0008 | 0 | 0 | 0 |
Cell Periphery | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0003 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.8893 | 0.9519 | 0.9237 | 0.9089 | 0.7955 | 0.8826 | 0.7946 | 0.9624 | 0.892 | 0.8007 | 0.8461 | 0.8979 | 0.8468 | 0.9866 | 0.9031 | 0.9167 | 0.8958 | 0.9223 |
Cytoplasmic Foci | 0.0028 | 0.0019 | 0.0019 | 0.0042 | 0.0103 | 0.0022 | 0.0188 | 0.0031 | 0.0119 | 0.0378 | 0.0088 | 0.0051 | 0.0181 | 0.0006 | 0.0085 | 0.001 | 0.0005 | 0.0017 |
Eisosomes | 0.0001 | 0.0002 | 0.0003 | 0.0001 | 0.0004 | 0.0016 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0039 | 0.0005 | 0.0008 | 0.0005 | 0.0067 | 0.0032 | 0.0067 | 0.0016 | 0.0019 | 0.0024 | 0.0025 | 0.0017 | 0.0037 | 0.0006 | 0.0025 | 0.0016 | 0.0019 | 0.0023 |
Endosome | 0.0103 | 0.0004 | 0.0032 | 0.0017 | 0.0147 | 0.007 | 0.0239 | 0.0012 | 0.0156 | 0.0313 | 0.0351 | 0.0098 | 0.0141 | 0.0001 | 0.0044 | 0.0004 | 0.0004 | 0.001 |
Golgi | 0.0013 | 0.0004 | 0.0012 | 0.0024 | 0.0127 | 0.0006 | 0.0074 | 0.0004 | 0.0088 | 0.0271 | 0.0206 | 0.0043 | 0.005 | 0 | 0.0017 | 0 | 0 | 0 |
Lipid Particles | 0.0009 | 0.0025 | 0.002 | 0.0038 | 0.0239 | 0.0004 | 0.0055 | 0.0008 | 0.0067 | 0.0045 | 0.0143 | 0.001 | 0.0031 | 0 | 0.0045 | 0 | 0 | 0 |
Mitochondria | 0.0012 | 0.0021 | 0.0022 | 0.0005 | 0.0035 | 0.003 | 0.0165 | 0.0002 | 0.0023 | 0.008 | 0.0039 | 0.0008 | 0.0015 | 0 | 0.0009 | 0.0001 | 0.0001 | 0.0002 |
None | 0.0063 | 0.0012 | 0.0042 | 0.0008 | 0.0028 | 0.0138 | 0.002 | 0.0012 | 0.0021 | 0.0018 | 0.0007 | 0.0005 | 0.0037 | 0.0005 | 0.0024 | 0.0005 | 0.0004 | 0.0007 |
Nuclear Periphery | 0.0121 | 0.0018 | 0.0031 | 0.003 | 0.0128 | 0.0078 | 0.0152 | 0.002 | 0.0038 | 0.0045 | 0.0075 | 0.0079 | 0.009 | 0.0012 | 0.0061 | 0.0059 | 0.0086 | 0.0069 |
Nucleolus | 0.0007 | 0.0001 | 0.0006 | 0 | 0.0003 | 0.0006 | 0.0006 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0005 | 0 | 0.0002 | 0 | 0 | 0 |
Nucleus | 0.0546 | 0.0265 | 0.0263 | 0.0374 | 0.0444 | 0.067 | 0.063 | 0.019 | 0.0432 | 0.0588 | 0.0528 | 0.0631 | 0.0501 | 0.0095 | 0.0496 | 0.0719 | 0.0899 | 0.0608 |
Peroxisomes | 0.0002 | 0.003 | 0.0008 | 0.0054 | 0.0082 | 0.0002 | 0.0083 | 0.0003 | 0.0033 | 0.0044 | 0.001 | 0.0026 | 0.0112 | 0 | 0.0049 | 0 | 0 | 0 |
Punctate Nuclear | 0.0071 | 0.0005 | 0.001 | 0.0014 | 0.0051 | 0.0015 | 0.0046 | 0.0005 | 0.0011 | 0.007 | 0.0012 | 0.0015 | 0.0156 | 0.0002 | 0.0039 | 0.0006 | 0.0008 | 0.001 |
Vacuole | 0.0014 | 0.0002 | 0.0042 | 0.0002 | 0.0008 | 0.0033 | 0.0109 | 0.0005 | 0.001 | 0.0008 | 0.0017 | 0.0016 | 0.0008 | 0.0001 | 0.0004 | 0.0003 | 0.0006 | 0.0005 |
Vacuole Periphery | 0.0006 | 0.0001 | 0.0011 | 0.0001 | 0.001 | 0.0013 | 0.0032 | 0.0001 | 0.0003 | 0.0005 | 0.0009 | 0.0004 | 0.0004 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 140.8249 | 74.0523 | 72.534 | 125.9234 | 79.4784 | 139.0911 | 119.7987 | 135.4338 | 145.6113 | 147.2728 |
Translational Efficiency | 2.8776 | 3.9848 | 3.6285 | 2.369 | 4.5895 | 3.8385 | 3.1216 | 2.7013 | 3.0629 | 3.0992 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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