Standard name | |
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Human Ortholog | |
Description | Sorting nexin family member; required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 7 | 8 | 5 | 6 | 5 | 1 | 8 | 15 | 3 | 7 | 7 | 5 | 6 | 5 | 0 | 20 | 9 | 18 | 6 | 5 | 3 | 0 | 1 | 2 |
Bud | 7 | 2 | 2 | 1 | 2 | 7 | 9 | 11 | 13 | 19 | 8 | 10 | 2 | 0 | 1 | 2 | 0 | 3 | 1 | 1 | 1 | 0 | 0 | 1 |
Bud Neck | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 1 | 2 | 1 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 2 | 0 | 1 | 0 | 0 | 1 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 58 | 50 | 39 | 25 | 30 | 26 | 48 | 43 | 30 | 40 | 31 | 30 | 23 | 49 | 79 | 36 | 36 | 46 | 27 | 13 | 12 | 11 | 13 | 19 |
Endoplasmic Reticulum | 6 | 9 | 2 | 1 | 2 | 5 | 4 | 3 | 2 | 1 | 1 | 0 | 3 | 3 | 1 | 6 | 8 | 5 | 5 | 2 | 2 | 0 | 2 | 2 |
Endosome | 157 | 109 | 48 | 49 | 66 | 51 | 68 | 44 | 30 | 42 | 28 | 42 | 60 | 69 | 71 | 95 | 75 | 135 | 223 | 157 | 86 | 78 | 100 | 95 |
Golgi | 0 | 5 | 0 | 1 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 13 | 10 | 7 | 2 | 6 | 1 | 0 | 1 | 0 |
Mitochondria | 35 | 2 | 1 | 10 | 3 | 21 | 25 | 27 | 58 | 59 | 73 | 61 | 0 | 0 | 0 | 17 | 8 | 11 | 20 | 5 | 24 | 10 | 13 | 9 |
Nucleus | 0 | 1 | 1 | 0 | 1 | 1 | 2 | 4 | 1 | 0 | 4 | 2 | 1 | 0 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nucleolus | 2 | 3 | 0 | 12 | 6 | 5 | 9 | 13 | 6 | 13 | 12 | 10 | 0 | 1 | 4 | 11 | 7 | 10 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 7 | 2 | 1 | 5 | 7 | 5 | 9 | 2 | 3 | 3 | 4 | 5 | 2 | 3 | 9 | 1 | 1 | 6 | 0 | 1 | 0 | 0 | 0 | 0 |
SpindlePole | 45 | 24 | 19 | 67 | 70 | 31 | 72 | 62 | 18 | 49 | 18 | 50 | 23 | 30 | 30 | 61 | 57 | 76 | 13 | 8 | 6 | 10 | 8 | 13 |
Vac/Vac Membrane | 19 | 18 | 11 | 8 | 11 | 3 | 9 | 4 | 6 | 8 | 2 | 6 | 11 | 7 | 8 | 35 | 31 | 28 | 12 | 14 | 14 | 9 | 21 | 9 |
Unique Cell Count | 272 | 183 | 111 | 146 | 164 | 126 | 201 | 176 | 132 | 182 | 147 | 171 | 105 | 135 | 163 | 212 | 180 | 257 | 319 | 224 | 162 | 127 | 171 | 158 |
Labelled Cell Count | 343 | 233 | 129 | 187 | 205 | 156 | 269 | 229 | 172 | 243 | 191 | 225 | 132 | 167 | 205 | 301 | 246 | 347 | 319 | 224 | 162 | 127 | 171 | 158 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.5 | 7.4 | 7.1 | 6.6 | 7.7 | 6.6 | 6.6 | 7.0 | 5.6 | 6.1 | 5.7 | 6.1 | 7.4 | 7.5 | 7.6 | 10.5 | 11.8 | 9.8 | 6.6 | 6.9 | 7.3 |
Std Deviation (1e-4) | 0.7 | 0.9 | 1.6 | 1.6 | 1.8 | 1.7 | 1.4 | 1.5 | 1.2 | 1.2 | 1.2 | 1.6 | 1.2 | 1.1 | 1.3 | 2.1 | 3.4 | 2.4 | 1.5 | 1.2 | 1.4 |
Intensity Change (Log2) | – | – | – | -0.11 | 0.11 | -0.11 | -0.11 | -0.03 | -0.36 | -0.22 | -0.32 | -0.22 | 0.06 | 0.07 | 0.1 | 0.56 | 0.72 | 0.46 | -0.11 | -0.04 | 0.04 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 1.3 | 0 | 0 | 0.1 | 0 | 0.4 | 0 | 0 | 1.6 | 0.2 | 0.9 |
Bud | 0 | 0 | 0 | 0 | 1.8 | 2.6 | 2.8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -3.3 | -3.2 | -2.5 | -2.1 | -2.0 | -2.1 | -2.5 | -2.5 | -3.4 | -2.1 | 0.2 | 2.2 | -3.7 | -2.9 | -3.6 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | -1.6 | -0.5 | -0.4 | -1.6 | -3.2 | -3.4 | -3.6 | -4.2 | -3.3 | 2.0 | 1.2 | 0.1 | 0.3 | -0.3 | 1.6 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 4.2 | 3.5 | 4.0 | 7.8 | 6.5 | 8.6 | 6.9 | 0 | 0 | 0 | 2.6 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 3.1 | 0 | 0 | 0 | 2.9 | 0 | 0 | 3.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 4.8 | 4.4 | 1.4 | 3.5 | 3.3 | -0.8 | 1.9 | -1.1 | 2.3 | 0.9 | 1.0 | 0.3 | 2.3 | 2.7 | 2.5 |
Vacuole | -1.3 | -1.0 | -2.5 | -1.9 | -2.8 | -1.6 | -1.9 | -3.1 | -2.2 | 0.1 | -1.4 | -1.6 | 1.6 | 1.7 | 0.3 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 1.2617 | 0.9006 | 0.8532 | 0.5274 | 0.3132 | 0.864 | 1.2562 | 1.509 | 1.395 | 1.2742 | 1.0872 | 1.5482 | 1.3483 | 1.6877 | 1.2594 | 1.3175 | 2.0967 | 1.387 |
Actin | 0.021 | 0.0034 | 0.004 | 0.0001 | 0.0008 | 0.0021 | 0.0032 | 0.001 | 0.0016 | 0.0036 | 0.0146 | 0.0038 | 0.0284 | 0.0002 | 0.022 | 0 | 0.0683 | 0.029 |
Bud | 0.0006 | 0.0029 | 0.0043 | 0.0002 | 0.0001 | 0.0007 | 0.0003 | 0.0009 | 0.0021 | 0.0005 | 0.0006 | 0.0003 | 0.0035 | 0.0006 | 0.0017 | 0.0002 | 0.0026 | 0.0003 |
Bud Neck | 0.0011 | 0.001 | 0.0006 | 0.0002 | 0.0004 | 0.001 | 0.0007 | 0.0005 | 0.0011 | 0.0019 | 0.0005 | 0.0022 | 0.0021 | 0.0004 | 0.0011 | 0.0003 | 0.0106 | 0.001 |
Bud Periphery | 0.0006 | 0.0013 | 0.0021 | 0.0001 | 0.0001 | 0.0007 | 0.0003 | 0.0009 | 0.0032 | 0.0008 | 0.0007 | 0.0004 | 0.0022 | 0.0003 | 0.0017 | 0.0001 | 0.0035 | 0.0004 |
Bud Site | 0.0049 | 0.0242 | 0.0028 | 0.0004 | 0.0004 | 0.0005 | 0.0028 | 0.0053 | 0.0047 | 0.0006 | 0.0009 | 0.0007 | 0.0142 | 0.0025 | 0.0087 | 0.0002 | 0.0408 | 0.0007 |
Cell Periphery | 0.0003 | 0.0005 | 0.0002 | 0 | 0 | 0.0001 | 0.0002 | 0.0002 | 0.0004 | 0.0001 | 0.0001 | 0.0001 | 0.0011 | 0.0001 | 0.0002 | 0 | 0.0011 | 0.0001 |
Cytoplasm | 0.1258 | 0.2878 | 0.1846 | 0.1636 | 0.1081 | 0.2274 | 0.1196 | 0.1029 | 0.1626 | 0.1503 | 0.051 | 0.1411 | 0.1529 | 0.3051 | 0.1835 | 0.1538 | 0.0524 | 0.2009 |
Cytoplasmic Foci | 0.258 | 0.2429 | 0.2618 | 0.2235 | 0.224 | 0.3097 | 0.2317 | 0.3364 | 0.2671 | 0.228 | 0.2254 | 0.2968 | 0.2109 | 0.2619 | 0.2563 | 0.1782 | 0.1998 | 0.3382 |
Eisosomes | 0.0003 | 0.0001 | 0.0002 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0 | 0.0001 | 0 | 0.0004 | 0.0002 |
Endoplasmic Reticulum | 0.0071 | 0.0046 | 0.0034 | 0.0036 | 0.002 | 0.0032 | 0.0045 | 0.0025 | 0.0029 | 0.0041 | 0.0022 | 0.0029 | 0.0132 | 0.0043 | 0.0037 | 0.0028 | 0.0041 | 0.0042 |
Endosome | 0.2982 | 0.2854 | 0.3413 | 0.3186 | 0.4566 | 0.3079 | 0.4303 | 0.4289 | 0.3683 | 0.4372 | 0.5393 | 0.4189 | 0.3632 | 0.3269 | 0.3785 | 0.5635 | 0.409 | 0.2981 |
Golgi | 0.0252 | 0.011 | 0.0168 | 0.0074 | 0.0321 | 0.0173 | 0.0361 | 0.0294 | 0.0265 | 0.0282 | 0.0573 | 0.0348 | 0.0265 | 0.015 | 0.0367 | 0.0164 | 0.0765 | 0.0256 |
Lipid Particles | 0.0493 | 0.0137 | 0.0295 | 0.0522 | 0.0367 | 0.0327 | 0.0465 | 0.0243 | 0.0408 | 0.0056 | 0.0133 | 0.0216 | 0.0558 | 0.0176 | 0.0183 | 0.0059 | 0.0422 | 0.0337 |
Mitochondria | 0.0138 | 0.0058 | 0.0044 | 0.0017 | 0.0311 | 0.0026 | 0.0084 | 0.0024 | 0.0208 | 0.0467 | 0.0138 | 0.0151 | 0.0064 | 0.0018 | 0.0052 | 0.0007 | 0.0176 | 0.0112 |
None | 0.0764 | 0.0801 | 0.0858 | 0.1792 | 0.0776 | 0.0586 | 0.0653 | 0.0238 | 0.0532 | 0.0201 | 0.0127 | 0.0212 | 0.0412 | 0.0248 | 0.0355 | 0.0318 | 0.0088 | 0.025 |
Nuclear Periphery | 0.021 | 0.0014 | 0.0027 | 0.0026 | 0.0012 | 0.0007 | 0.0092 | 0.0008 | 0.0008 | 0.0025 | 0.001 | 0.0007 | 0.0107 | 0.001 | 0.0011 | 0.0013 | 0.0088 | 0.0026 |
Nucleolus | 0.0019 | 0.0021 | 0.0038 | 0.0005 | 0.0002 | 0.0002 | 0.0005 | 0.0003 | 0.0005 | 0.0002 | 0.0002 | 0.0001 | 0.0077 | 0.0002 | 0.0002 | 0.0001 | 0.0075 | 0.0004 |
Nucleus | 0.0081 | 0.0024 | 0.0084 | 0.0013 | 0.0006 | 0.0008 | 0.0024 | 0.0005 | 0.0008 | 0.0015 | 0.0005 | 0.0004 | 0.0096 | 0.0008 | 0.0005 | 0.0007 | 0.0029 | 0.0006 |
Peroxisomes | 0.0307 | 0.0062 | 0.0176 | 0.0156 | 0.0143 | 0.0204 | 0.0192 | 0.0244 | 0.0237 | 0.0418 | 0.0523 | 0.0279 | 0.0196 | 0.0126 | 0.0292 | 0.0016 | 0.0208 | 0.0153 |
Punctate Nuclear | 0.0181 | 0.0025 | 0.0076 | 0.0028 | 0.0028 | 0.0046 | 0.0024 | 0.0016 | 0.0014 | 0.0008 | 0.0007 | 0.0012 | 0.0083 | 0.0023 | 0.0019 | 0.0007 | 0.0061 | 0.0056 |
Vacuole | 0.0272 | 0.0194 | 0.0157 | 0.0223 | 0.0077 | 0.0071 | 0.0138 | 0.011 | 0.0146 | 0.0201 | 0.0095 | 0.0077 | 0.0189 | 0.0191 | 0.0112 | 0.036 | 0.0133 | 0.0052 |
Vacuole Periphery | 0.0104 | 0.0014 | 0.0027 | 0.0039 | 0.0031 | 0.0015 | 0.0023 | 0.0019 | 0.0028 | 0.0053 | 0.0033 | 0.002 | 0.0033 | 0.0024 | 0.0028 | 0.0057 | 0.003 | 0.0018 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 10.3283 | 11.2846 | 11.038 | 13.1969 | 11.9032 | 10.3226 | 11.7988 | 13.6516 | 14.7088 | 12.5684 |
Translational Efficiency | 0.8102 | 0.871 | 0.8504 | 0.8352 | 0.7337 | 1.0108 | 0.9151 | 0.8435 | 0.8463 | 0.7834 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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