Standard name | |
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Human Ortholog | |
Description | D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate with a minor role in lactate catabolism; located in the mitochondrial matrix |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 2 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 5 | 1 | 2 | 2 | 1 | 4 | 5 | 1 | 11 | 10 |
Bud | 0 | 0 | 4 | 2 | 2 | 0 | 8 | 8 | 3 | 2 | 3 | 3 | 1 | 0 | 0 | 5 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Bud Site | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 2 | 1 | – | – | – | – | – | – |
Cell Periphery | 1 | 5 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 3 | 5 | 10 | 6 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 2 | 0 | 4 | 2 | 3 | 2 | 4 | 3 | 2 | 6 | 2 | 5 | 2 | 7 | 5 | 25 | 6 | 10 | 0 | 0 | 1 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 2 | 1 | 3 | 4 | 1 | 1 | 2 | 1 | 6 | 1 | 1 | 0 | 2 | 2 | 6 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 1 |
Endosome | 1 | 2 | 2 | 4 | 1 | 3 | 4 | 3 | 0 | 2 | 0 | 1 | 0 | 4 | 7 | 11 | 7 | 7 | 7 | 4 | 5 | 2 | 10 | 4 |
Golgi | 2 | 8 | 12 | 7 | 7 | 0 | 2 | 3 | 2 | 3 | 2 | 1 | 5 | 11 | 27 | 22 | 36 | 20 | 5 | 23 | 15 | 10 | 26 | 22 |
Mitochondria | 162 | 197 | 114 | 132 | 128 | 181 | 226 | 273 | 209 | 238 | 100 | 136 | 103 | 262 | 215 | 16 | 13 | 9 | 150 | 174 | 102 | 89 | 189 | 118 |
Nucleus | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 4 | 5 | 9 | 2 | 4 | 24 | 23 | 38 | 19 | 30 | 15 | 10 | 4 | 10 | 9 | 16 | 10 | 4 | 2 | 0 | 2 | 0 | 1 | 3 |
Nucleolus | 23 | 10 | 14 | 9 | 12 | 24 | 44 | 44 | 21 | 20 | 12 | 18 | 7 | 12 | 4 | 19 | 14 | 10 | 2 | 1 | 1 | 2 | 2 | 2 |
Peroxisomes | 5 | 6 | 1 | 1 | 1 | 6 | 5 | 7 | 0 | 1 | 1 | 1 | 5 | 13 | 7 | 21 | 12 | 5 | 7 | 4 | 8 | 15 | 13 | 12 |
SpindlePole | 0 | 0 | 2 | 1 | 1 | 2 | 3 | 4 | 1 | 0 | 1 | 2 | 0 | 0 | 0 | 4 | 3 | 4 | 1 | 0 | 1 | 1 | 1 | 1 |
Vac/Vac Membrane | 18 | 28 | 2 | 2 | 7 | 6 | 4 | 14 | 6 | 8 | 3 | 8 | 7 | 16 | 15 | 19 | 20 | 17 | 2 | 13 | 1 | 0 | 4 | 4 |
Unique Cell Count | 180 | 218 | 136 | 143 | 144 | 208 | 262 | 321 | 220 | 263 | 111 | 153 | 112 | 292 | 242 | 141 | 116 | 83 | 184 | 230 | 148 | 127 | 267 | 188 |
Labelled Cell Count | 218 | 264 | 169 | 167 | 172 | 252 | 326 | 402 | 267 | 318 | 141 | 188 | 135 | 341 | 299 | 173 | 141 | 102 | 184 | 230 | 148 | 127 | 267 | 188 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 14.1 | 13.3 | 12.3 | 13.3 | 13.8 | 12.4 | 11.0 | 10.7 | 11.7 | 10.7 | 9.8 | 10.8 | 16.2 | 15.9 | 15.5 | 10.8 | 12.9 | 13.7 | 14.1 | 15.8 | 16.1 |
Std Deviation (1e-4) | 3.8 | 4.2 | 4.2 | 3.9 | 5.3 | 3.5 | 4.0 | 3.1 | 3.7 | 4.1 | 3.2 | 3.1 | 3.8 | 4.1 | 3.9 | 3.2 | 3.6 | 4.3 | 3.7 | 4.4 | 5.0 |
Intensity Change (Log2) | – | – | – | 0.11 | 0.17 | 0.0 | -0.17 | -0.2 | -0.08 | -0.2 | -0.33 | -0.2 | 0.39 | 0.37 | 0.33 | -0.19 | 0.07 | 0.16 | 0.2 | 0.36 | 0.38 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.0 | 0 | 2.7 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.5 | 0 | 0 |
Golgi | -1.3 | -1.3 | 0 | 0 | 0 | -3.7 | -3.8 | -2.4 | -3.3 | -1.4 | -2.2 | 0.7 | 1.7 | 4.5 | 3.1 |
Mitochondria | 2.2 | 1.2 | 0.8 | 0.7 | 0.3 | 3.5 | 2.0 | 1.4 | 1.3 | 1.9 | 1.7 | 1.4 | -12.1 | -11.5 | -10.6 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | -2.2 | -1.5 | 1.5 | 0.8 | 1.7 | 0.7 | 1.5 | 1.8 | 0 | -1.1 | -1.5 | -1.3 | 1.4 | 0.6 | 0 |
Nucleolus | -1.2 | -0.6 | 0.4 | 1.7 | 1.0 | -0.2 | -0.9 | 0.1 | 0.4 | -1.1 | -2.5 | -3.8 | 0.8 | 0.4 | 0.4 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.4 | 3.4 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.9 | 2.1 | 3.8 | 4.4 | 4.8 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 23.5353 | 22.6804 | 23.7014 | 19.731 | 17.6762 | 22.3758 | 16.9184 | 21.4437 | 18.9262 | 17.3409 | 17.3829 | 18.7664 | 20.6884 | 22.0993 | 21.8388 | 20.637 | 20.941 | 20.5093 |
Actin | 0.304 | 0.0034 | 0.0066 | 0.0254 | 0.0001 | 0.0125 | 0.0055 | 0.0032 | 0.0105 | 0.0068 | 0.0007 | 0.0011 | 0.0256 | 0.0078 | 0.0066 | 0.0005 | 0.0034 | 0.002 |
Bud | 0.0007 | 0.0002 | 0.0005 | 0 | 0 | 0.0001 | 0.0005 | 0 | 0.0001 | 0.0001 | 0 | 0 | 0.0003 | 0.0002 | 0.0001 | 0 | 0 | 0 |
Bud Neck | 0.0005 | 0.0006 | 0.0005 | 0.0001 | 0 | 0.0001 | 0.0002 | 0 | 0 | 0 | 0 | 0 | 0.0003 | 0.0001 | 0 | 0 | 0 | 0 |
Bud Periphery | 0.001 | 0.0004 | 0.0019 | 0.0001 | 0 | 0.0001 | 0.0012 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0004 | 0.0003 | 0.0003 | 0 | 0.0001 | 0.0001 |
Bud Site | 0.0053 | 0.0003 | 0.0008 | 0.0002 | 0 | 0.0001 | 0.0019 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0018 | 0.0013 | 0.0003 | 0 | 0.0001 | 0.0001 |
Cell Periphery | 0.0002 | 0.0014 | 0.0015 | 0.0001 | 0 | 0.0002 | 0.0006 | 0.0003 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0006 | 0.0001 | 0.0002 | 0 | 0.0001 | 0 |
Cytoplasm | 0 | 0.1075 | 0 | 0 | 0 | 0 | 0.0034 | 0 | 0 | 0 | 0 | 0 | 0.0005 | 0 | 0.0001 | 0 | 0 | 0 |
Cytoplasmic Foci | 0.0003 | 0.0017 | 0.0002 | 0.0001 | 0 | 0.0002 | 0.0117 | 0.0002 | 0.001 | 0.0021 | 0.0018 | 0.0002 | 0.0083 | 0.0004 | 0.0032 | 0.0003 | 0.0003 | 0.0012 |
Eisosomes | 0.0091 | 0.0005 | 0.0003 | 0.0013 | 0.0001 | 0.0008 | 0.0004 | 0.0003 | 0.0003 | 0.0002 | 0.0001 | 0.0001 | 0.0008 | 0.0004 | 0.0003 | 0.0003 | 0.0003 | 0.0001 |
Endoplasmic Reticulum | 0 | 0.0001 | 0.0001 | 0 | 0 | 0.0001 | 0.0016 | 0 | 0 | 0 | 0.0001 | 0 | 0.0007 | 0 | 0.0001 | 0 | 0 | 0.0001 |
Endosome | 0.0001 | 0.0085 | 0.0025 | 0.0001 | 0 | 0.0009 | 0.0105 | 0.0005 | 0.0005 | 0.001 | 0.0023 | 0.0007 | 0.0128 | 0.0004 | 0.0017 | 0.0002 | 0.0002 | 0.0025 |
Golgi | 0.001 | 0.008 | 0.0019 | 0.0003 | 0.0001 | 0.0069 | 0.0107 | 0.001 | 0.0023 | 0.0065 | 0.0025 | 0.0039 | 0.0088 | 0.0022 | 0.0036 | 0.0006 | 0.0014 | 0.0051 |
Lipid Particles | 0.0016 | 0.0337 | 0.0024 | 0.0004 | 0.0013 | 0.0018 | 0.041 | 0.0122 | 0.013 | 0.0449 | 0.0704 | 0.0195 | 0.0323 | 0.0033 | 0.0097 | 0.0053 | 0.0037 | 0.0025 |
Mitochondria | 0.6656 | 0.7841 | 0.947 | 0.9688 | 0.9973 | 0.9727 | 0.8604 | 0.9528 | 0.9409 | 0.9187 | 0.9117 | 0.9566 | 0.8645 | 0.9773 | 0.9525 | 0.9876 | 0.9807 | 0.9826 |
None | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0028 | 0 | 0 | 0 | 0.0001 | 0 | 0.0018 | 0 | 0.0003 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0.0006 | 0.0001 | 0 | 0 | 0.0001 | 0.0136 | 0.0001 | 0 | 0 | 0.0004 | 0.0002 | 0.001 | 0 | 0.0002 | 0 | 0 | 0.0001 |
Nucleolus | 0.0001 | 0.0011 | 0.0006 | 0 | 0 | 0 | 0.0025 | 0.0013 | 0.0006 | 0.0001 | 0.0001 | 0.0001 | 0.0172 | 0.0002 | 0.0014 | 0 | 0 | 0 |
Nucleus | 0.0001 | 0.0032 | 0.0004 | 0 | 0 | 0 | 0.0057 | 0.0003 | 0.0002 | 0 | 0.0001 | 0 | 0.0017 | 0.0001 | 0.0003 | 0 | 0 | 0 |
Peroxisomes | 0.0099 | 0.0051 | 0.0027 | 0.003 | 0.0005 | 0.0003 | 0.0118 | 0.0065 | 0.0145 | 0.0184 | 0.006 | 0.0013 | 0.0106 | 0.0037 | 0.0051 | 0.0042 | 0.0074 | 0.0026 |
Punctate Nuclear | 0 | 0 | 0 | 0 | 0 | 0 | 0.0022 | 0 | 0 | 0 | 0.0001 | 0 | 0.0015 | 0 | 0.0001 | 0 | 0 | 0.0001 |
Vacuole | 0.0001 | 0.019 | 0.015 | 0 | 0.0001 | 0.0003 | 0.0054 | 0.0044 | 0.0035 | 0.0002 | 0.0006 | 0.0005 | 0.0031 | 0.0005 | 0.003 | 0.0001 | 0.0002 | 0.0001 |
Vacuole Periphery | 0.0002 | 0.0204 | 0.0148 | 0.0002 | 0.0003 | 0.0026 | 0.0064 | 0.0165 | 0.0122 | 0.0006 | 0.0026 | 0.0158 | 0.0053 | 0.0019 | 0.011 | 0.0007 | 0.0019 | 0.0007 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 36.7109 | 24.1486 | 33.0817 | 31.1457 | 27.8399 | 34.6137 | 28.6425 | 33.8042 | 35.4013 | 30.3439 |
Translational Efficiency | 1.1767 | 1.3031 | 1.0533 | 1.175 | 1.0498 | 1.0761 | 1.2118 | 1.0465 | 1.0165 | 1.0892 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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