Standard name | |
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Human Ortholog | |
Description | Putative protein of unknown function; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5p of TOM (Translocase of the Mitochondrial Outer Membrane) complex; YDR056C is not an essential protein |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 1 | 2 | – | 1 | 9 | 10 | 9 | – | 11 | 13 | 8 | 15 | 9 | 30 | 18 | 16 | 10 | 23 | 0 | 1 | 0 | 4 | 12 | 11 |
Bud | 0 | 0 | – | 0 | 0 | 2 | 1 | – | 1 | 3 | 4 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bud Neck | 0 | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | – | 0 | 3 | 2 | 3 | – | 3 | 10 | 6 | 6 | 27 | 78 | 114 | 54 | 38 | 29 | 0 | 0 | 0 | 2 | 10 | 14 |
Cytoplasm | 3 | 15 | – | 3 | 18 | 22 | 35 | – | 28 | 25 | 9 | 25 | 15 | 26 | 35 | 24 | 21 | 23 | 0 | 2 | 0 | 1 | 4 | 2 |
Endoplasmic Reticulum | 15 | 74 | – | 13 | 111 | 55 | 109 | – | 101 | 105 | 30 | 100 | 212 | 460 | 511 | 1 | 5 | 4 | 61 | 97 | 26 | 275 | 391 | 441 |
Endosome | 0 | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 |
Golgi | 0 | 0 | – | 1 | 8 | 0 | 4 | – | 0 | 5 | 0 | 0 | 10 | 23 | 11 | 34 | 38 | 65 | 0 | 0 | 0 | 0 | 6 | 4 |
Mitochondria | 1 | 2 | – | 5 | 0 | 19 | 6 | – | 25 | 22 | 26 | 35 | 2 | 7 | 1 | 14 | 3 | 27 | 0 | 1 | 0 | 4 | 4 | 5 |
Nucleus | 0 | 0 | – | 0 | 0 | 4 | 2 | – | 4 | 1 | 2 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Nuclear Periphery | 3 | 0 | – | 1 | 0 | 2 | 0 | – | 5 | 2 | 2 | 2 | 7 | 7 | 12 | 3 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 1 |
Nucleolus | 0 | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | – | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 1 | 3 | – | 0 | 12 | 10 | 40 | – | 15 | 20 | 13 | 16 | 2 | 0 | 3 | 5 | 14 | 11 | 0 | 4 | 0 | 1 | 1 | 2 |
Unique Cell Count | 19 | 92 | 16 | 136 | 100 | 189 | 158 | 172 | 77 | 167 | 235 | 518 | 582 | 131 | 112 | 143 | 65 | 115 | 29 | 295 | 441 | 489 | ||
Labelled Cell Count | 24 | 96 | 24 | 161 | 126 | 209 | 193 | 206 | 100 | 200 | 285 | 633 | 705 | 152 | 129 | 182 | 65 | 115 | 29 | 295 | 441 | 489 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 15.8 | 17.1 | – | 13.1 | 16.1 | 9.2 | 12.7 | – | 10.5 | 11.2 | 9.9 | 10.8 | 18.7 | 18.8 | 19.3 | 21.2 | 21.6 | 21.3 | 17.4 | 17.8 | 18.2 |
Std Deviation (1e-4) | 2.3 | 3.9 | – | 2.3 | 2.6 | 2.2 | 2.2 | – | 1.9 | 2.0 | 1.9 | 2.2 | 3.2 | 3.2 | 3.1 | 3.8 | 4.3 | 4.1 | 2.9 | 3.3 | 3.1 |
Intensity Change (Log2) | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 9.5952 | 10.2806 | 10.0905 | 9.0796 | 9.2545 | 9.8306 | 11.7706 | 13.6025 | 12.3641 | 12.5363 | 9.3181 | 13.464 | 14.6972 | 14.8162 | 14.1831 | 12.6783 | 13.0237 | 14.3646 |
Actin | 0.0289 | 0.0003 | 0.0018 | 0.0003 | 0.0004 | 0.0061 | 0.0315 | 0.0113 | 0.0171 | 0.0001 | 0.0064 | 0.0001 | 0.0103 | 0.0091 | 0.0086 | 0.0001 | 0.0412 | 0.0059 |
Bud | 0.0003 | 0 | 0.0025 | 0 | 0.0001 | 0.0001 | 0.0006 | 0.0001 | 0.0005 | 0 | 0.0005 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 |
Bud Neck | 0.0029 | 0.0001 | 0.0004 | 0.0001 | 0.0002 | 0.0002 | 0.0009 | 0.0001 | 0.0015 | 0 | 0.0003 | 0.0002 | 0.0005 | 0.0006 | 0.0003 | 0.0001 | 0.0001 | 0.0004 |
Bud Periphery | 0.0006 | 0 | 0.0014 | 0.0002 | 0.0001 | 0.0001 | 0.0012 | 0.0002 | 0.0006 | 0 | 0.0006 | 0 | 0.0004 | 0.0001 | 0.0002 | 0 | 0.0001 | 0 |
Bud Site | 0.0036 | 0 | 0.0049 | 0 | 0.0001 | 0.0001 | 0.003 | 0.001 | 0.0097 | 0 | 0.0007 | 0 | 0.0005 | 0.0012 | 0.0004 | 0 | 0.0002 | 0 |
Cell Periphery | 0.0024 | 0.0027 | 0.0029 | 0.0038 | 0.0006 | 0.0006 | 0.0015 | 0.0023 | 0.0019 | 0.0003 | 0.0014 | 0.0003 | 0.001 | 0.0101 | 0.0028 | 0.0008 | 0.0006 | 0.0006 |
Cytoplasm | 0.0162 | 0.0164 | 0.0136 | 0.0025 | 0.0114 | 0.0085 | 0.0035 | 0.0068 | 0.0092 | 0.0008 | 0.0023 | 0.0057 | 0.0145 | 0.0116 | 0.0088 | 0.0023 | 0.0022 | 0.0064 |
Cytoplasmic Foci | 0.0158 | 0.0015 | 0.0013 | 0.0003 | 0.0008 | 0.002 | 0.0175 | 0.0012 | 0.0089 | 0.0001 | 0.014 | 0.0004 | 0.0062 | 0.0009 | 0.0013 | 0.0001 | 0.0008 | 0.0014 |
Eisosomes | 0.0037 | 0 | 0.0003 | 0.0003 | 0 | 0 | 0.0014 | 0.0001 | 0.0003 | 0 | 0.0001 | 0 | 0.0002 | 0.0003 | 0.0002 | 0 | 0.0001 | 0.0001 |
Endoplasmic Reticulum | 0.7941 | 0.9478 | 0.9393 | 0.9438 | 0.9398 | 0.9494 | 0.7633 | 0.9564 | 0.9218 | 0.9874 | 0.693 | 0.9756 | 0.8917 | 0.9478 | 0.9475 | 0.9774 | 0.9448 | 0.971 |
Endosome | 0.0254 | 0.0102 | 0.0044 | 0.0042 | 0.0224 | 0.0061 | 0.034 | 0.002 | 0.0046 | 0.0036 | 0.0766 | 0.0012 | 0.0066 | 0.0011 | 0.0066 | 0.0011 | 0.0012 | 0.0012 |
Golgi | 0.0109 | 0.0052 | 0.0021 | 0.0021 | 0.0085 | 0.0023 | 0.0257 | 0.0014 | 0.0068 | 0.0009 | 0.0882 | 0.0003 | 0.0064 | 0.0023 | 0.0029 | 0.0002 | 0.0015 | 0.0013 |
Lipid Particles | 0.0164 | 0.0068 | 0.0025 | 0.011 | 0.0009 | 0.005 | 0.0289 | 0.0097 | 0.0053 | 0.0003 | 0.0257 | 0.0022 | 0.0076 | 0.0091 | 0.0097 | 0.0003 | 0.0014 | 0.0007 |
Mitochondria | 0.0165 | 0.0005 | 0.001 | 0.0183 | 0.0034 | 0.0013 | 0.0168 | 0.0001 | 0.0005 | 0.0002 | 0.033 | 0 | 0.0025 | 0.0001 | 0.0006 | 0 | 0.0004 | 0.0004 |
None | 0.0071 | 0.0001 | 0.0032 | 0.0001 | 0.0001 | 0.0009 | 0.0077 | 0.0001 | 0.0013 | 0 | 0.0003 | 0 | 0.0067 | 0 | 0.0005 | 0.0001 | 0.0002 | 0.0045 |
Nuclear Periphery | 0.0309 | 0.0051 | 0.0052 | 0.0062 | 0.0045 | 0.0112 | 0.0239 | 0.0052 | 0.0034 | 0.0046 | 0.004 | 0.0121 | 0.0245 | 0.0034 | 0.0054 | 0.0149 | 0.0024 | 0.0034 |
Nucleolus | 0.001 | 0 | 0.0015 | 0 | 0 | 0.0001 | 0.0012 | 0 | 0.0003 | 0 | 0.0001 | 0 | 0.0008 | 0 | 0.0001 | 0 | 0 | 0 |
Nucleus | 0.0031 | 0.0003 | 0.0022 | 0.0002 | 0.0004 | 0.0007 | 0.0015 | 0.0002 | 0.0004 | 0.0001 | 0.0003 | 0.0004 | 0.0024 | 0.0001 | 0.0006 | 0.001 | 0.0001 | 0.0007 |
Peroxisomes | 0.0051 | 0 | 0.0001 | 0 | 0 | 0.0004 | 0.0175 | 0.0001 | 0.0013 | 0 | 0.0457 | 0 | 0.0016 | 0 | 0.0001 | 0 | 0.0014 | 0.0001 |
Punctate Nuclear | 0.0047 | 0.0001 | 0.0013 | 0 | 0.0001 | 0.0014 | 0.0036 | 0 | 0.0003 | 0 | 0.0004 | 0 | 0.0123 | 0 | 0.0002 | 0 | 0.0004 | 0.0004 |
Vacuole | 0.0075 | 0.0026 | 0.0073 | 0.0041 | 0.0032 | 0.0026 | 0.0114 | 0.0014 | 0.0039 | 0.0011 | 0.0042 | 0.0011 | 0.0019 | 0.0019 | 0.0026 | 0.0013 | 0.0009 | 0.0013 |
Vacuole Periphery | 0.0028 | 0.0003 | 0.0006 | 0.0022 | 0.0028 | 0.0009 | 0.0033 | 0.0002 | 0.0003 | 0.0005 | 0.0023 | 0.0004 | 0.0013 | 0.0001 | 0.0005 | 0.0003 | 0.0001 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 43.7434 | 36.7098 | 43.8213 | 47.6407 | 53.2428 | 46.3958 | 45.1862 | 36.4882 | 52.5913 | 46.9869 |
Translational Efficiency | 1.9698 | 1.8835 | 1.3372 | 1.47 | 0.9975 | 1.5514 | 1.3688 | 1.3877 | 1.142 | 1.241 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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