Standard name | |
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Human Ortholog | |
Description | Subunit of the Cop9 signalosome; Cop9 signalosome is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 2 |
Bud | 1 | 0 | 5 | 0 | 0 | 1 | – | 5 | 6 | 3 | 7 | 11 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 2 | 1 | 1 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 3 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 1 | 0 | 1 | 1 | 2 | – | 1 | 2 | 2 | 3 | 1 | 0 | 0 | 2 | 5 | 2 | 3 | 0 | 0 | 1 | 0 | 1 | 0 |
Cytoplasm | 179 | 308 | 212 | 154 | 157 | 180 | – | 225 | 175 | 186 | 234 | 252 | 352 | 425 | 390 | 288 | 211 | 235 | 170 | 300 | 195 | 238 | 255 | 250 |
Endoplasmic Reticulum | 0 | 0 | 1 | 1 | 0 | 0 | – | 0 | 0 | 0 | 2 | 2 | 3 | 2 | 0 | 14 | 5 | 6 | 0 | 0 | 1 | 0 | 1 | 1 |
Endosome | 0 | 0 | 0 | 0 | 1 | 0 | – | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 4 | 21 | 11 | 9 | 1 | 0 | 3 | 4 | 2 | 6 |
Golgi | 0 | 1 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 1 | 1 | 1 | 1 |
Mitochondria | 4 | 8 | 23 | 60 | 21 | 85 | – | 190 | 160 | 204 | 239 | 272 | 0 | 1 | 1 | 4 | 10 | 2 | 1 | 4 | 7 | 3 | 4 | 2 |
Nucleus | 0 | 1 | 2 | 0 | 2 | 4 | – | 12 | 5 | 4 | 11 | 12 | 0 | 1 | 3 | 2 | 8 | 4 | 0 | 3 | 0 | 1 | 1 | 4 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 1 | – | 1 | 6 | 3 | 2 | 7 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 1 | 0 | 0 | 0 | – | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 4 | 0 | 1 | 1 |
Vac/Vac Membrane | 3 | 7 | 1 | 4 | 2 | 6 | – | 17 | 15 | 11 | 12 | 18 | 2 | 0 | 8 | 134 | 105 | 90 | 2 | 5 | 2 | 5 | 4 | 6 |
Unique Cell Count | 183 | 317 | 225 | 170 | 172 | 223 | 353 | 280 | 326 | 380 | 437 | 358 | 430 | 395 | 375 | 288 | 294 | 179 | 319 | 229 | 261 | 283 | 284 | |
Labelled Cell Count | 187 | 326 | 245 | 220 | 184 | 279 | 452 | 369 | 417 | 511 | 581 | 359 | 434 | 408 | 473 | 353 | 354 | 179 | 319 | 229 | 261 | 283 | 284 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.6 | 5.4 | 3.7 | 3.7 | 4.6 | 3.8 | – | 3.8 | 3.7 | 3.9 | 3.7 | 3.6 | 5.1 | 5.1 | 5.5 | 8.6 | 8.6 | 8.3 | 5.1 | 5.2 | 5.4 |
Std Deviation (1e-4) | 1.3 | 0.8 | 0.9 | 1.2 | 1.2 | 0.8 | – | 1.2 | 1.5 | 1.0 | 1.1 | 0.8 | 0.8 | 0.8 | 5.4 | 1.9 | 2.4 | 2.2 | 1.2 | 1.1 | 1.6 |
Intensity Change (Log2) | – | – | – | 0.01 | 0.3 | 0.04 | – | 0.04 | 0.0 | 0.06 | 0.01 | -0.02 | 0.48 | 0.48 | 0.59 | 1.23 | 1.22 | 1.18 | 0.47 | 0.51 | 0.56 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -1.4 | -1.1 | -4.3 | – | -8.3 | -8.4 | -9.6 | -8.8 | -9.7 | 2.7 | 3.4 | 3.2 | -5.5 | -6.2 | -4.7 |
Endoplasmic Reticulum | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.5 | 0 | 0 |
Endosome | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.6 | 0 | 0 |
Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | -6.2 | -6.5 | -6.2 | -5.2 | -3.1 | -5.0 |
Nucleus | 0 | 0 | 0 | – | 1.9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | – | 3.0 | 3.1 | 0 | 0 | 2.7 | 0 | 0 | 0 | 10.0 | 10.0 | 9.0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | -0.5661 | 1.1976 | 0.4207 | 0.4768 | -0.4488 | 0.2381 | 0.3845 | -0.0777 | 0.1612 | -0.5505 | 0.2396 | -0.0588 | 1.8523 | 1.3511 | 1.461 | 2.1013 | 1.0109 | 1.5233 |
Actin | 0.0028 | 0.0003 | 0.002 | 0.0022 | 0.0272 | 0.0034 | 0.059 | 0.0037 | 0.0213 | 0.0345 | 0.0297 | 0.0068 | 0.0523 | 0.001 | 0.0031 | 0.0625 | 0.0009 | 0.0007 |
Bud | 0.0003 | 0.0002 | 0.0009 | 0.0005 | 0.0007 | 0.0012 | 0.0017 | 0.0108 | 0.0015 | 0.0173 | 0.0008 | 0.0006 | 0.0033 | 0.0066 | 0.0052 | 0.0022 | 0.0001 | 0.0013 |
Bud Neck | 0.0007 | 0.0027 | 0.0001 | 0.0001 | 0.0009 | 0.0027 | 0.0042 | 0.0002 | 0.0006 | 0.0004 | 0.0005 | 0.0006 | 0.004 | 0.0001 | 0.0002 | 0.0009 | 0.0002 | 0.0009 |
Bud Periphery | 0.0013 | 0.0001 | 0.0013 | 0.0013 | 0.0013 | 0.0008 | 0.0031 | 0.0046 | 0.002 | 0.0079 | 0.0013 | 0.0005 | 0.0087 | 0.0022 | 0.001 | 0.0088 | 0.0001 | 0.0021 |
Bud Site | 0.0004 | 0.0052 | 0.0016 | 0.0001 | 0.001 | 0.0011 | 0.0041 | 0.0076 | 0.0036 | 0.0068 | 0.0041 | 0.0001 | 0.0052 | 0.0058 | 0.004 | 0.0016 | 0 | 0.0001 |
Cell Periphery | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0005 | 0.0002 | 0.0001 | 0.0003 | 0.0011 | 0.0001 | 0.0006 | 0.0001 | 0.0001 | 0.0002 | 0 | 0.0001 |
Cytoplasm | 0.2753 | 0.4428 | 0.3618 | 0.3548 | 0.4718 | 0.4492 | 0.1547 | 0.3191 | 0.2375 | 0.289 | 0.257 | 0.4248 | 0.2678 | 0.3411 | 0.3364 | 0.3263 | 0.416 | 0.373 |
Cytoplasmic Foci | 0.012 | 0.0075 | 0.0145 | 0.0082 | 0.0129 | 0.0113 | 0.0177 | 0.0101 | 0.0233 | 0.0145 | 0.0414 | 0.0137 | 0.0143 | 0.0075 | 0.0122 | 0.0135 | 0.0085 | 0.0066 |
Eisosomes | 0.0001 | 0 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0008 | 0.0001 | 0.0001 | 0.0001 | 0.0004 | 0.0001 | 0.0005 | 0.0001 | 0.0001 | 0.0003 | 0 | 0 |
Endoplasmic Reticulum | 0.0022 | 0.0028 | 0.0023 | 0.0015 | 0.0042 | 0.0015 | 0.0092 | 0.0017 | 0.0023 | 0.0016 | 0.0033 | 0.0033 | 0.0037 | 0.0014 | 0.0018 | 0.0031 | 0.0014 | 0.0011 |
Endosome | 0.0028 | 0.0033 | 0.0048 | 0.0037 | 0.0111 | 0.0042 | 0.0394 | 0.0034 | 0.022 | 0.0016 | 0.0407 | 0.0053 | 0.0164 | 0.0013 | 0.0044 | 0.01 | 0.0106 | 0.0016 |
Golgi | 0.0004 | 0.0002 | 0.0008 | 0.0031 | 0.0023 | 0.0014 | 0.0152 | 0.0006 | 0.0123 | 0.0008 | 0.0162 | 0.0006 | 0.0064 | 0.0003 | 0.0011 | 0.0066 | 0.0003 | 0.0001 |
Lipid Particles | 0.001 | 0.0002 | 0.0004 | 0.0095 | 0.0004 | 0.0004 | 0.0205 | 0.0004 | 0.0022 | 0.0003 | 0.0148 | 0.0005 | 0.0096 | 0.0002 | 0.0024 | 0.003 | 0.0003 | 0.0001 |
Mitochondria | 0.0002 | 0.0003 | 0.0026 | 0.0097 | 0.0028 | 0.0006 | 0.0131 | 0.0054 | 0.0039 | 0.0014 | 0.0075 | 0.0005 | 0.0045 | 0.0006 | 0.0069 | 0.0057 | 0.0017 | 0.0004 |
None | 0.6867 | 0.5247 | 0.5933 | 0.5926 | 0.4493 | 0.5071 | 0.5842 | 0.6238 | 0.6502 | 0.5911 | 0.5477 | 0.5347 | 0.5672 | 0.6229 | 0.5864 | 0.5363 | 0.5141 | 0.5964 |
Nuclear Periphery | 0.0014 | 0.0022 | 0.0015 | 0.0011 | 0.0052 | 0.0015 | 0.0315 | 0.0006 | 0.004 | 0.0019 | 0.0011 | 0.0012 | 0.0078 | 0.0007 | 0.0036 | 0.0024 | 0.0252 | 0.001 |
Nucleolus | 0.0002 | 0.0002 | 0.0003 | 0.0001 | 0.0002 | 0.0017 | 0.0013 | 0.0003 | 0.0003 | 0.0021 | 0.0015 | 0.0001 | 0.0011 | 0.0003 | 0.0011 | 0.0002 | 0.0005 | 0.0003 |
Nucleus | 0.0051 | 0.0035 | 0.0045 | 0.0027 | 0.0032 | 0.006 | 0.0106 | 0.0029 | 0.0015 | 0.008 | 0.002 | 0.0037 | 0.0043 | 0.0021 | 0.013 | 0.0027 | 0.0123 | 0.0062 |
Peroxisomes | 0.0005 | 0.0002 | 0.001 | 0.0049 | 0.0013 | 0.0003 | 0.0151 | 0.0004 | 0.0039 | 0.0027 | 0.0026 | 0.0008 | 0.0082 | 0.0007 | 0.0022 | 0.0086 | 0.0003 | 0.0004 |
Punctate Nuclear | 0.0054 | 0.0019 | 0.0051 | 0.0022 | 0.0023 | 0.0046 | 0.0039 | 0.0032 | 0.0063 | 0.0164 | 0.0122 | 0.0017 | 0.0115 | 0.0045 | 0.0138 | 0.0026 | 0.0048 | 0.0069 |
Vacuole | 0.0008 | 0.0015 | 0.0008 | 0.001 | 0.0009 | 0.0006 | 0.0065 | 0.0009 | 0.0008 | 0.001 | 0.0111 | 0.0005 | 0.0017 | 0.0005 | 0.0007 | 0.002 | 0.0013 | 0.0005 |
Vacuole Periphery | 0.0001 | 0.0003 | 0.0002 | 0.0003 | 0.0009 | 0.0001 | 0.0035 | 0.0002 | 0.0005 | 0.0003 | 0.0028 | 0.0001 | 0.0008 | 0.0001 | 0.0004 | 0.0005 | 0.0013 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 5.6411 | 10.0856 | 1.4968 | 4.3585 | 7.314 | 11.276 | 9.6877 | 9.6358 | 7.904 | 14.7556 |
Translational Efficiency | – | – | – | – | – | – | – | – | – | – |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | – |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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