Standard name | |
---|---|
Human Ortholog | |
Description | Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; relocalizes to the cytosol in response to hypoxia |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 1 | 1 | – | 1 | 0 | 2 | 1 | – | – | – | 2 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 2 | 0 | 4 | 2 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 3 | – | 9 | 9 | 7 | 10 | – | – | – | 0 | 0 | 1 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1 | 5 | 12 | 17 | 14 | 15 | 11 | – | 8 | 8 | 11 | 6 | – | – | – | 14 | 8 | 6 | 0 | 0 | 0 | 0 | 0 | 1 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 1 | – | 0 | 0 | 0 | 0 | – | – | – | 3 | 1 | 2 | 0 | 1 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 1 | 0 | 2 | 0 | 1 | – | 0 | 1 | 0 | 0 | – | – | – | 2 | 1 | 3 | 1 | 1 | 1 | 0 | 0 | 1 |
Golgi | 0 | 0 | 1 | 1 | 0 | 0 | 2 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
Mitochondria | 25 | 3 | 1 | 6 | 1 | 15 | 24 | – | 35 | 31 | 49 | 53 | – | – | – | 6 | 5 | 5 | 1 | 1 | 3 | 0 | 0 | 0 |
Nucleus | 156 | 250 | 171 | 214 | 250 | 189 | 298 | – | 169 | 196 | 195 | 199 | – | – | – | 135 | 138 | 94 | 145 | 254 | 165 | 7 | 7 | 13 |
Nuclear Periphery | 1 | 0 | 0 | 0 | 2 | 1 | 2 | – | 2 | 3 | 0 | 4 | – | – | – | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 6 | 4 | 0 | 1 | 12 | 8 | 19 | – | 34 | 46 | 79 | 67 | – | – | – | 4 | 1 | 2 | 7 | 5 | 5 | 0 | 1 | 1 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 2 | 1 | 3 | 2 | 3 | – | 0 | 4 | 0 | 4 | – | – | – | 1 | 2 | 0 | 1 | 1 | 1 | 0 | 1 | 0 |
Vac/Vac Membrane | 2 | 7 | 2 | 5 | 2 | 1 | 1 | – | 1 | 3 | 0 | 1 | – | – | – | 6 | 9 | 7 | 2 | 10 | 7 | 0 | 0 | 5 |
Unique Cell Count | 167 | 262 | 184 | 236 | 270 | 216 | 336 | 207 | 241 | 252 | 259 | 165 | 159 | 111 | 162 | 281 | 195 | 10 | 15 | 25 | ||||
Labelled Cell Count | 191 | 269 | 190 | 245 | 286 | 232 | 366 | 261 | 301 | 347 | 347 | 174 | 167 | 121 | 162 | 281 | 195 | 10 | 15 | 25 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.7 | 7.7 | 7.2 | 7.2 | 7.7 | 6.3 | 6.5 | – | 6.3 | 6.2 | 5.7 | 5.8 | – | – | – | 8.0 | 7.9 | 7.4 | – | – | – |
Std Deviation (1e-4) | 0.8 | 1.2 | 2.0 | 2.0 | 2.4 | 1.9 | 1.8 | – | 6.8 | 1.9 | 1.8 | 1.7 | – | – | – | 2.2 | 2.1 | 2.2 | – | – | – |
Intensity Change (Log2) | – | – | – | -0.0 | 0.1 | -0.2 | -0.15 | – | -0.21 | -0.21 | -0.34 | -0.32 | – | – | – | 0.14 | 0.12 | 0.03 | – | – | – |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 |
Cytoplasm | 0.3 | -0.6 | 0.2 | -1.7 | – | -1.2 | -1.5 | -1.0 | -2.2 | – | – | – | 0.7 | -0.6 | -0.4 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 3.3 | 3.4 | – | 5.6 | 4.8 | 6.1 | 6.3 | – | – | – | 0 | 0 | 0 |
Nucleus | -0.8 | -0.1 | -1.8 | -1.6 | – | -3.3 | -3.5 | -4.4 | -4.5 | – | – | – | -3.2 | -1.9 | -2.3 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 3.3 | – | 5.8 | 6.3 | 8.4 | 7.5 | – | – | – | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | – | 0 | 2.4 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 1.137 | 1.4164 | 1.1657 | 0.9117 | 0.9102 | 0.9329 | 1.7695 | 1.8745 | 1.6912 | 1.5418 | 1.5812 | 1.6108 | 2.4217 | 2.347 | 2.0624 | 2.156 | 2.1583 | 2.0285 |
Actin | 0.0043 | 0 | 0.006 | 0.0228 | 0.0018 | 0.0012 | 0.0283 | 0 | 0.0098 | 0 | 0.0093 | 0.0029 | 0.0006 | 0 | 0.0014 | 0.0037 | 0.0011 | 0.0005 |
Bud | 0.0008 | 0 | 0.0001 | 0.0006 | 0.001 | 0 | 0.0006 | 0 | 0 | 0 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 |
Bud Neck | 0.0007 | 0 | 0.0002 | 0.0029 | 0.0013 | 0.0006 | 0.0018 | 0 | 0.0001 | 0 | 0.0009 | 0.0006 | 0.001 | 0 | 0.0003 | 0.0002 | 0.0005 | 0.0008 |
Bud Periphery | 0.0019 | 0 | 0.0002 | 0.0008 | 0.0022 | 0.0001 | 0.0011 | 0 | 0 | 0 | 0.0002 | 0.0002 | 0.0006 | 0.0001 | 0.0002 | 0 | 0.0003 | 0.0001 |
Bud Site | 0.002 | 0 | 0.0004 | 0.0016 | 0.0052 | 0.0001 | 0.0039 | 0 | 0.0001 | 0 | 0.0004 | 0.0002 | 0.0014 | 0.0002 | 0.0014 | 0.0001 | 0.0006 | 0.0001 |
Cell Periphery | 0.0005 | 0 | 0.0001 | 0.0002 | 0.0005 | 0 | 0.0003 | 0 | 0 | 0 | 0 | 0.0001 | 0.0002 | 0 | 0.0001 | 0 | 0.0001 | 0 |
Cytoplasm | 0.0017 | 0.0092 | 0.0004 | 0.0029 | 0.0011 | 0.0003 | 0.0014 | 0 | 0.0001 | 0 | 0.0003 | 0.0001 | 0.0019 | 0.0021 | 0.0032 | 0.0001 | 0.0003 | 0.0002 |
Cytoplasmic Foci | 0.0056 | 0 | 0.0057 | 0.031 | 0.0115 | 0.0011 | 0.023 | 0 | 0.0001 | 0 | 0.0241 | 0.0015 | 0.0114 | 0.0005 | 0.0123 | 0.0061 | 0.0011 | 0.0002 |
Eisosomes | 0.0002 | 0 | 0.001 | 0.0001 | 0.0001 | 0 | 0.0003 | 0 | 0 | 0 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0019 | 0.0002 | 0.0003 | 0.0034 | 0.0005 | 0.0009 | 0.0022 | 0 | 0 | 0 | 0.0004 | 0.0003 | 0.0016 | 0.0009 | 0.0014 | 0 | 0.0011 | 0.0005 |
Endosome | 0.0157 | 0.0001 | 0.0041 | 0.0368 | 0.0599 | 0.0064 | 0.0071 | 0 | 0.0001 | 0 | 0.0049 | 0.0025 | 0.0228 | 0.0031 | 0.0207 | 0.012 | 0.0038 | 0.002 |
Golgi | 0.0035 | 0 | 0.0036 | 0.0236 | 0.0097 | 0.0058 | 0.0048 | 0 | 0.0004 | 0 | 0.0044 | 0.0042 | 0.0035 | 0.0001 | 0.0033 | 0.0251 | 0.0031 | 0.0005 |
Lipid Particles | 0.0161 | 0 | 0.0114 | 0.0216 | 0.0409 | 0.0126 | 0.0088 | 0 | 0.0001 | 0 | 0.0335 | 0.003 | 0.0066 | 0.0001 | 0.0045 | 0.001 | 0.0167 | 0.0004 |
Mitochondria | 0.0121 | 0.0002 | 0.0244 | 0.0209 | 0.0505 | 0.0031 | 0.0039 | 0.0001 | 0.0003 | 0 | 0.0022 | 0.0026 | 0.0047 | 0.0002 | 0.0016 | 0.0071 | 0.0039 | 0.0072 |
None | 0.0009 | 0.0026 | 0.005 | 0.003 | 0.0004 | 0.0002 | 0.0024 | 0 | 0 | 0 | 0.0009 | 0.0003 | 0.0012 | 0.0001 | 0.0038 | 0 | 0.0003 | 0 |
Nuclear Periphery | 0.0063 | 0.0021 | 0.0008 | 0.0249 | 0.0054 | 0.0223 | 0.0043 | 0.0005 | 0.0003 | 0.0001 | 0.009 | 0.0022 | 0.0157 | 0.0017 | 0.0043 | 0.0001 | 0.0129 | 0.0017 |
Nucleolus | 0.0152 | 0.0094 | 0.0104 | 0.0058 | 0.0201 | 0.0336 | 0.0155 | 0.0097 | 0.0101 | 0.0112 | 0.0592 | 0.022 | 0.0126 | 0.0095 | 0.0095 | 0.0024 | 0.0834 | 0.0449 |
Nucleus | 0.8947 | 0.9753 | 0.9165 | 0.7592 | 0.7405 | 0.9085 | 0.8433 | 0.9894 | 0.9768 | 0.9885 | 0.8061 | 0.9524 | 0.8953 | 0.9778 | 0.9243 | 0.9022 | 0.8632 | 0.9375 |
Peroxisomes | 0.008 | 0 | 0.0079 | 0.0176 | 0.03 | 0.0009 | 0.023 | 0 | 0.0001 | 0 | 0.0316 | 0.002 | 0.0023 | 0 | 0.0023 | 0.0394 | 0.0005 | 0.0001 |
Punctate Nuclear | 0.0008 | 0.0005 | 0.0009 | 0.0162 | 0.001 | 0.0008 | 0.0219 | 0.0003 | 0.0014 | 0.0001 | 0.0119 | 0.0022 | 0.0049 | 0.0009 | 0.0016 | 0.0001 | 0.0035 | 0.0029 |
Vacuole | 0.005 | 0.0001 | 0.0003 | 0.002 | 0.011 | 0.0004 | 0.0014 | 0 | 0 | 0 | 0.0001 | 0.0003 | 0.0084 | 0.0017 | 0.0032 | 0.0001 | 0.0016 | 0.0002 |
Vacuole Periphery | 0.002 | 0.0001 | 0.0003 | 0.002 | 0.0053 | 0.0009 | 0.0006 | 0 | 0 | 0 | 0.0004 | 0.0004 | 0.0033 | 0.0004 | 0.0007 | 0.0002 | 0.0018 | 0.0003 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 9.2631 | 11.2033 | 8.3133 | 13.242 | 10.2439 | 12.5256 | 15.1445 | 10.1384 | 14.0547 | 15.9041 |
Translational Efficiency | 1.1186 | 0.8517 | 1.0104 | 0.5888 | 0.9738 | 0.9636 | 0.7162 | 1.1106 | 0.8273 | 0.8304 |
Dataset | Hit |
---|---|
Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
---|
Gene | Images |
---|
Gene | Images |
---|