Standard name | |
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Human Ortholog | |
Description | Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 1 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 3 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 4 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 3 | 5 | 3 | 2 | 4 | 7 | 10 | 6 | 7 | 9 | 9 | 12 | 10 | 11 | 8 | 18 | 16 | 18 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 263 | 220 | 162 | 174 | 218 | 238 | 280 | 242 | 240 | 236 | 205 | 192 | 446 | 515 | 518 | 207 | 309 | 224 | 263 | 212 | 149 | 251 | 465 | 398 |
Endoplasmic Reticulum | 0 | 5 | 3 | 5 | 5 | 4 | 19 | 7 | 17 | 24 | 11 | 14 | 2 | 4 | 3 | 4 | 6 | 10 | 0 | 0 | 3 | 0 | 5 | 1 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
Mitochondria | 2 | 0 | 0 | 0 | 2 | 10 | 30 | 39 | 47 | 68 | 71 | 51 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Nucleus | 0 | 0 | 0 | 0 | 1 | 0 | 4 | 0 | 2 | 4 | 4 | 3 | 0 | 1 | 0 | 5 | 0 | 0 | 1 | 1 | 0 | 3 | 1 | 2 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Nucleolus | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 3 | 0 | 0 | 0 | 5 | 7 | 16 | 46 | 28 | 21 | 25 | 12 | 0 | 0 | 1 | 4 | 1 | 9 | 0 | 0 | 2 | 1 | 4 | 3 |
Unique Cell Count | 269 | 225 | 164 | 179 | 231 | 258 | 345 | 332 | 321 | 336 | 295 | 261 | 448 | 519 | 521 | 220 | 315 | 235 | 277 | 219 | 161 | 263 | 490 | 420 |
Labelled Cell Count | 273 | 230 | 168 | 181 | 235 | 266 | 368 | 345 | 344 | 367 | 331 | 288 | 458 | 531 | 531 | 240 | 336 | 263 | 277 | 219 | 161 | 263 | 490 | 420 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 19.5 | 27.5 | 20.4 | 19.6 | 16.2 | 13.7 | 12.3 | 11.5 | 10.7 | 10.5 | 9.7 | 9.5 | 25.0 | 24.1 | 22.2 | 31.0 | 29.2 | 29.5 | 24.2 | 24.4 | 23.7 |
Std Deviation (1e-4) | 4.2 | 4.3 | 4.2 | 3.3 | 2.5 | 2.7 | 2.4 | 2.4 | 2.3 | 2.3 | 2.3 | 2.0 | 4.6 | 3.9 | 3.8 | 8.9 | 7.3 | 8.5 | 4.6 | 5.2 | 6.1 |
Intensity Change (Log2) | – | – | – | -0.05 | -0.33 | -0.58 | -0.73 | -0.82 | -0.93 | -0.95 | -1.07 | -1.1 | 0.29 | 0.24 | 0.13 | 0.6 | 0.52 | 0.53 | 0.25 | 0.26 | 0.22 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.5 | 0 | 0 | 0 | 2.7 | 1.7 | 2.6 |
Cytoplasm | -1.0 | -2.3 | -2.9 | -5.5 | -7.0 | -6.6 | -7.4 | -7.5 | -6.8 | 1.1 | 0.5 | 0.8 | -2.3 | -0.6 | -1.9 |
Endoplasmic Reticulum | 0 | 0 | 0 | 1.9 | 0 | 1.8 | 2.5 | 1.1 | 1.8 | 0 | 0 | 0 | 0 | 0 | 1.3 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 3.9 | 4.6 | 5.2 | 6.2 | 6.8 | 6.0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 2.8 | 5.0 | 3.9 | 3.3 | 3.8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 17.2321 | 24.0017 | 20.8983 | 19.1795 | 20.2142 | 21.2687 | 15.2775 | 25.6351 | 23.2428 | 20.1661 | 13.6025 | 22.1177 | 21.8983 | 29.4186 | 25.1908 | 24.5226 | 20.4974 | 26.1611 |
Actin | 0.0113 | 0.0003 | 0.0075 | 0.0172 | 0.0478 | 0.0037 | 0.0618 | 0.0001 | 0.0091 | 0.0036 | 0.1382 | 0.0009 | 0.002 | 0.0006 | 0.004 | 0 | 0.0246 | 0.0025 |
Bud | 0.0002 | 0.0001 | 0.0002 | 0.0006 | 0.0003 | 0.0001 | 0.0033 | 0 | 0.0005 | 0.0149 | 0.0006 | 0.0002 | 0.0005 | 0.0003 | 0.0002 | 0.0003 | 0.0009 | 0.0003 |
Bud Neck | 0.0042 | 0.0002 | 0.0004 | 0.0012 | 0.003 | 0.0007 | 0.0017 | 0.0001 | 0.0003 | 0.0005 | 0.0009 | 0.0007 | 0.0003 | 0.0001 | 0.0017 | 0.0004 | 0.0012 | 0.0007 |
Bud Periphery | 0.0001 | 0 | 0.0002 | 0.0007 | 0.0005 | 0.0001 | 0.0034 | 0 | 0.0006 | 0.0028 | 0.0006 | 0.0001 | 0.0005 | 0.0002 | 0.0005 | 0.0001 | 0.0014 | 0.0004 |
Bud Site | 0.001 | 0.0005 | 0.0003 | 0.001 | 0.0007 | 0.0001 | 0.0086 | 0.0001 | 0.0067 | 0.0014 | 0.0016 | 0.0001 | 0.0008 | 0.0009 | 0.0008 | 0.0001 | 0.0034 | 0.0002 |
Cell Periphery | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0004 | 0 | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0.0003 | 0 | 0.0003 | 0.0001 | 0.0004 | 0 |
Cytoplasm | 0.918 | 0.9875 | 0.9644 | 0.9409 | 0.9233 | 0.9778 | 0.7248 | 0.9948 | 0.9594 | 0.8736 | 0.6678 | 0.9596 | 0.8989 | 0.9953 | 0.9555 | 0.9597 | 0.7619 | 0.9679 |
Cytoplasmic Foci | 0.0128 | 0.0014 | 0.0022 | 0.0024 | 0.0015 | 0.002 | 0.0291 | 0.0004 | 0.0026 | 0.0071 | 0.0272 | 0.0045 | 0.0146 | 0.0005 | 0.0038 | 0.0126 | 0.0133 | 0.0028 |
Eisosomes | 0.0001 | 0 | 0.0001 | 0.0002 | 0.0003 | 0 | 0.0005 | 0 | 0.0001 | 0 | 0.0003 | 0 | 0 | 0 | 0.0001 | 0 | 0.0003 | 0 |
Endoplasmic Reticulum | 0.0057 | 0.0011 | 0.002 | 0.0055 | 0.0011 | 0.0047 | 0.0067 | 0.0003 | 0.0029 | 0.0006 | 0.0231 | 0.0055 | 0.0043 | 0.0004 | 0.0015 | 0.0009 | 0.0314 | 0.0037 |
Endosome | 0.0128 | 0.002 | 0.005 | 0.0063 | 0.005 | 0.0016 | 0.0415 | 0.0001 | 0.0021 | 0.0269 | 0.0551 | 0.0139 | 0.0197 | 0.0002 | 0.0074 | 0.0118 | 0.0414 | 0.0052 |
Golgi | 0.0022 | 0.0003 | 0.0008 | 0.0019 | 0.0045 | 0.0008 | 0.0167 | 0 | 0.0015 | 0.0148 | 0.0122 | 0.0029 | 0.0041 | 0.0001 | 0.005 | 0.0003 | 0.0229 | 0.0023 |
Lipid Particles | 0.0024 | 0.001 | 0.0009 | 0.0006 | 0.002 | 0.0015 | 0.0215 | 0 | 0.0008 | 0.0338 | 0.0161 | 0.0005 | 0.0065 | 0 | 0.0051 | 0.0011 | 0.0259 | 0.0023 |
Mitochondria | 0.0005 | 0.0004 | 0.0035 | 0.0015 | 0.0011 | 0.0012 | 0.0247 | 0 | 0.0057 | 0.0084 | 0.0115 | 0.001 | 0.0166 | 0.0002 | 0.0039 | 0.0001 | 0.0163 | 0.0035 |
None | 0.004 | 0.0003 | 0.0006 | 0.0021 | 0.0004 | 0.0005 | 0.0058 | 0.0001 | 0.0004 | 0.0004 | 0.0042 | 0.0004 | 0.0013 | 0.0001 | 0.0003 | 0.0024 | 0.0029 | 0.0003 |
Nuclear Periphery | 0.0067 | 0.001 | 0.0026 | 0.0069 | 0.0027 | 0.0011 | 0.0137 | 0.0007 | 0.0014 | 0.0008 | 0.0111 | 0.0017 | 0.0054 | 0.0002 | 0.0027 | 0.0006 | 0.0164 | 0.0016 |
Nucleolus | 0.0008 | 0.0004 | 0.0007 | 0.0003 | 0.0003 | 0 | 0.0019 | 0 | 0.0001 | 0.0002 | 0.0003 | 0 | 0.0005 | 0 | 0.0001 | 0.0004 | 0.002 | 0.0001 |
Nucleus | 0.0079 | 0.0019 | 0.0036 | 0.0054 | 0.0019 | 0.0023 | 0.0067 | 0.0028 | 0.002 | 0.0021 | 0.0067 | 0.0028 | 0.0116 | 0.0007 | 0.0027 | 0.0025 | 0.0089 | 0.0023 |
Peroxisomes | 0.0011 | 0.0001 | 0.0002 | 0.0002 | 0.0005 | 0.0005 | 0.0128 | 0 | 0.0024 | 0.0049 | 0.0097 | 0.0001 | 0.0022 | 0 | 0.001 | 0.0001 | 0.0051 | 0.0021 |
Punctate Nuclear | 0.0047 | 0.0008 | 0.001 | 0.0023 | 0.0013 | 0.0004 | 0.004 | 0.0001 | 0.0002 | 0.0005 | 0.0065 | 0.0003 | 0.0028 | 0 | 0.0014 | 0.0009 | 0.0052 | 0.0005 |
Vacuole | 0.0029 | 0.0006 | 0.0024 | 0.0019 | 0.0011 | 0.0007 | 0.0077 | 0.0001 | 0.0007 | 0.0016 | 0.0045 | 0.0036 | 0.0053 | 0.0002 | 0.0014 | 0.0053 | 0.01 | 0.0007 |
Vacuole Periphery | 0.0007 | 0.0001 | 0.0013 | 0.0008 | 0.0005 | 0.0003 | 0.0028 | 0 | 0.0004 | 0.0009 | 0.0018 | 0.0012 | 0.0018 | 0.0001 | 0.0005 | 0.0005 | 0.004 | 0.0005 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 63.4436 | 58.2475 | 50.0467 | 58.7701 | 62.8046 | 36.8455 | 65.2871 | 64.3314 | 52.5548 | 69.5107 |
Translational Efficiency | 1.2664 | 1.4341 | 1.4146 | 1.1114 | 1.0091 | 2.0206 | 1.1848 | 0.95 | 1.0979 | 1.0482 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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