Standard name | |
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Human Ortholog | |
Description | Transcriptional repressor that regulates middle-sporulation genes; required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 2 | 1 | 9 | 2 | 4 | 2 | 0 | 1 | 0 | 0 | 0 | 1 | 6 | 0 | 0 | 4 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Bud Site | 0 | 1 | 3 | 4 | 3 | 10 | 13 | 13 | 8 | 14 | 10 | 10 | 1 | 0 | 2 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1 | 4 | 0 | 3 | 9 | 10 | 7 | 7 | 3 | 6 | 5 | 3 | 12 | 66 | 75 | 21 | 8 | 9 | 0 | 0 | 0 | 0 | 0 | 1 |
Endoplasmic Reticulum | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 0 | 1 | 2 | 2 | 2 | 1 | 0 | 1 | 2 | 9 |
Golgi | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 3 | 2 | 1 | 0 | 0 | 0 | 1 |
Mitochondria | 2 | 71 | 90 | 85 | 91 | 192 | 275 | 280 | 243 | 322 | 263 | 308 | 11 | 6 | 49 | 16 | 1 | 18 | 2 | 2 | 1 | 0 | 2 | 4 |
Nucleus | 175 | 247 | 145 | 182 | 347 | 304 | 419 | 409 | 251 | 296 | 277 | 263 | 228 | 381 | 381 | 146 | 118 | 137 | 166 | 236 | 125 | 187 | 327 | 249 |
Nuclear Periphery | 4 | 3 | 1 | 0 | 13 | 4 | 15 | 9 | 12 | 12 | 17 | 10 | 0 | 7 | 9 | 4 | 3 | 4 | 2 | 0 | 2 | 0 | 0 | 2 |
Nucleolus | 44 | 48 | 31 | 24 | 54 | 79 | 103 | 90 | 96 | 120 | 122 | 129 | 58 | 73 | 93 | 22 | 16 | 26 | 42 | 22 | 23 | 40 | 72 | 110 |
Peroxisomes | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 2 | 1 | 2 | 0 | 2 | 2 | 3 | 4 | 2 | 6 | 1 | 0 | 1 | 4 | 2 | 0 | 2 | 1 | 1 | 3 | 1 | 0 | 3 | 7 |
Vac/Vac Membrane | 1 | 4 | 0 | 1 | 2 | 0 | 2 | 1 | 2 | 0 | 0 | 1 | 1 | 0 | 3 | 4 | 2 | 3 | 3 | 12 | 6 | 7 | 26 | 32 |
Unique Cell Count | 202 | 280 | 164 | 211 | 408 | 405 | 549 | 563 | 388 | 481 | 411 | 437 | 259 | 481 | 509 | 189 | 144 | 173 | 227 | 291 | 162 | 241 | 444 | 432 |
Labelled Cell Count | 230 | 380 | 273 | 301 | 524 | 603 | 840 | 816 | 618 | 786 | 698 | 731 | 315 | 543 | 618 | 217 | 156 | 204 | 227 | 291 | 162 | 241 | 444 | 432 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 7.1 | 5.3 | 4.2 | 4.6 | 4.6 | 4.1 | 3.8 | 4.0 | 3.6 | 3.5 | 3.6 | 3.3 | 6.6 | 6.6 | 5.6 | 7.7 | 8.6 | 8.8 | 6.5 | 6.3 | 7.1 |
Std Deviation (1e-4) | 1.5 | 1.2 | 0.5 | 1.1 | 1.0 | 0.8 | 0.7 | 0.7 | 0.7 | 0.7 | 0.8 | 0.6 | 1.5 | 1.7 | 1.5 | 1.8 | 2.0 | 2.0 | 1.5 | 1.4 | 1.6 |
Intensity Change (Log2) | – | – | – | 0.14 | 0.13 | -0.03 | -0.13 | -0.08 | -0.24 | -0.26 | -0.22 | -0.36 | 0.66 | 0.66 | 0.43 | 0.88 | 1.03 | 1.07 | 0.64 | 0.58 | 0.77 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.0 | 5.2 | 4.4 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -11.9 | -16.7 | -12.4 | -9.5 | -10.4 | -8.7 |
Nucleus | -0.6 | -1.0 | -3.5 | -3.3 | -4.2 | -5.7 | -6.4 | -5.1 | -6.6 | -0.1 | -2.6 | -3.7 | -2.7 | -1.6 | -2.3 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.9 | -1.1 | -0.2 | -1.9 | -1.9 | -0.9 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 3.9642 | 4.4511 | 3.913 | 3.4708 | 3.5615 | 3.9238 | 5.2787 | 5.5768 | 5.0223 | 5.1386 | 4.8716 | 5.0301 | 3.9422 | 3.8653 | 3.5177 | 3.2275 | 3.1316 | 3.458 |
Actin | 0.0677 | 0 | 0.0066 | 0 | 0.0179 | 0.0026 | 0.0559 | 0 | 0.026 | 0.0003 | 0.029 | 0.0072 | 0 | 0 | 0.0043 | 0.0382 | 0.0001 | 0.002 |
Bud | 0.0009 | 0 | 0.0003 | 0 | 0.0002 | 0.0001 | 0.0003 | 0 | 0.0004 | 0.0001 | 0.0004 | 0.0004 | 0 | 0 | 0.0006 | 0.0004 | 0.0001 | 0.0002 |
Bud Neck | 0.0043 | 0.0001 | 0.0005 | 0 | 0.0015 | 0.0013 | 0.0013 | 0 | 0.0032 | 0.0003 | 0.0005 | 0.0017 | 0.0001 | 0.0001 | 0.0005 | 0.0006 | 0.0007 | 0.001 |
Bud Periphery | 0.0018 | 0 | 0.0006 | 0 | 0.0004 | 0.0001 | 0.0006 | 0 | 0.0011 | 0.0001 | 0.001 | 0.001 | 0 | 0 | 0.0011 | 0.0007 | 0.0003 | 0.0005 |
Bud Site | 0.014 | 0 | 0.0038 | 0 | 0.002 | 0.0001 | 0.0022 | 0 | 0.0021 | 0.0003 | 0.0013 | 0.0018 | 0 | 0 | 0.008 | 0.0012 | 0.0002 | 0.0004 |
Cell Periphery | 0.0007 | 0 | 0.0003 | 0 | 0.0001 | 0 | 0.0003 | 0 | 0.0003 | 0 | 0.0002 | 0.0002 | 0 | 0 | 0.0003 | 0.0002 | 0.0001 | 0.0001 |
Cytoplasm | 0.0041 | 0 | 0.0014 | 0 | 0.0009 | 0.0006 | 0.0162 | 0 | 0.0041 | 0.0021 | 0.0009 | 0.0004 | 0 | 0 | 0.0014 | 0.0006 | 0 | 0.0001 |
Cytoplasmic Foci | 0.0337 | 0 | 0.0041 | 0 | 0.0141 | 0.0008 | 0.0124 | 0 | 0.008 | 0.0083 | 0.0132 | 0.0016 | 0 | 0 | 0.0077 | 0.0088 | 0 | 0.0019 |
Eisosomes | 0.0006 | 0 | 0.0001 | 0 | 0.0004 | 0 | 0.0012 | 0 | 0.0002 | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 |
Endoplasmic Reticulum | 0.0031 | 0 | 0.0013 | 0 | 0.0019 | 0.0006 | 0.0056 | 0 | 0.0048 | 0.0007 | 0.0025 | 0.002 | 0 | 0 | 0.0003 | 0.0006 | 0 | 0.0003 |
Endosome | 0.0151 | 0 | 0.0056 | 0 | 0.009 | 0.0034 | 0.0131 | 0 | 0.0111 | 0.0161 | 0.0202 | 0.0089 | 0 | 0 | 0.0053 | 0.0117 | 0 | 0.0041 |
Golgi | 0.0103 | 0 | 0.0011 | 0 | 0.0084 | 0.0017 | 0.0064 | 0 | 0.0079 | 0.0011 | 0.02 | 0.0043 | 0 | 0 | 0.003 | 0.014 | 0 | 0.0026 |
Lipid Particles | 0.0389 | 0 | 0.0042 | 0 | 0.017 | 0.0033 | 0.0169 | 0 | 0.0066 | 0.0047 | 0.0396 | 0.0029 | 0 | 0 | 0.0039 | 0.0058 | 0 | 0.0067 |
Mitochondria | 0.0078 | 0.0001 | 0.0116 | 0.0001 | 0.0061 | 0.0007 | 0.0057 | 0.0004 | 0.0167 | 0.0009 | 0.0492 | 0.0037 | 0.0003 | 0.0001 | 0.0048 | 0.0179 | 0.0029 | 0.0127 |
None | 0.0097 | 0 | 0.0016 | 0 | 0.0024 | 0.0004 | 0.0068 | 0 | 0.0015 | 0.0009 | 0.0005 | 0.0002 | 0 | 0 | 0.0002 | 0.0006 | 0.0001 | 0.0001 |
Nuclear Periphery | 0.0116 | 0.0008 | 0.0132 | 0.0002 | 0.0336 | 0.0064 | 0.0283 | 0.0018 | 0.0047 | 0.0126 | 0.0051 | 0.0047 | 0.0002 | 0.0005 | 0.0039 | 0.0051 | 0.0019 | 0.003 |
Nucleolus | 0.0815 | 0.0535 | 0.0417 | 0.0381 | 0.2377 | 0.1493 | 0.0496 | 0.0355 | 0.04 | 0.0477 | 0.1392 | 0.0888 | 0.043 | 0.0515 | 0.0522 | 0.037 | 0.3169 | 0.1347 |
Nucleus | 0.6242 | 0.9439 | 0.8882 | 0.9614 | 0.5998 | 0.8238 | 0.7569 | 0.9614 | 0.8497 | 0.8645 | 0.6656 | 0.8657 | 0.956 | 0.9468 | 0.89 | 0.8426 | 0.5878 | 0.8219 |
Peroxisomes | 0.0307 | 0 | 0.0019 | 0 | 0.0112 | 0.0009 | 0.0078 | 0 | 0.0037 | 0.001 | 0.0027 | 0.0006 | 0 | 0 | 0.0075 | 0.0101 | 0 | 0.0012 |
Punctate Nuclear | 0.0318 | 0.0013 | 0.0081 | 0.0002 | 0.0326 | 0.0029 | 0.0096 | 0.0005 | 0.0049 | 0.0374 | 0.0053 | 0.0012 | 0.0003 | 0.0009 | 0.0036 | 0.002 | 0.0882 | 0.005 |
Vacuole | 0.0056 | 0.0001 | 0.0021 | 0 | 0.0009 | 0.0004 | 0.0013 | 0.0001 | 0.0015 | 0.0005 | 0.0012 | 0.0018 | 0 | 0 | 0.001 | 0.001 | 0.0002 | 0.0007 |
Vacuole Periphery | 0.0019 | 0 | 0.0017 | 0 | 0.0019 | 0.0005 | 0.0015 | 0.0001 | 0.0016 | 0.0004 | 0.002 | 0.001 | 0 | 0 | 0.0003 | 0.0006 | 0.0002 | 0.0007 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 21.6252 | 13.6095 | 16.7548 | 20.0345 | 26.9165 | 19.7113 | 18.0607 | 18.0471 | 20.7691 | 29.2853 |
Translational Efficiency | 0.9768 | 1.5167 | 1.0154 | 1.218 | 0.6438 | 1.1208 | 1.3144 | 1.0118 | 0.8442 | 0.6828 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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