Standard name | |
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Human Ortholog | |
Description | GTPase activating protein (GAP) for Rho1p; regulator of a Tor2p-mediated, Rho1p GTPase switch that controls organization of the actin cytoskeleton; negative regulator of the RHO1-PKC1-MAPK cell integrity (CWI) and membrane fluidity homeostasis signaling pathways; potential Cdc28p substrate; SAC7 has a paralog, BAG7, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 3 | 3 | 1 | 2 | 2 | 5 | 5 | 1 | 10 | 12 | 12 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 6 | 11 | 1 | 3 | 8 |
Bud | 2 | 3 | 1 | 1 | 1 | 8 | 7 | 11 | 8 | 5 | 10 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Bud Neck | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 6 | 4 | 2 | 3 | 6 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 38 | 76 | 49 | 52 | 31 | 57 | 54 | 64 | 53 | 63 | 52 | 64 | 16 | 15 | 30 | 53 | 52 | 49 | 16 | 12 | 10 | 4 | 5 | 10 |
Cytoplasm | 341 | 547 | 417 | 379 | 397 | 570 | 596 | 654 | 547 | 569 | 373 | 396 | 200 | 296 | 399 | 344 | 321 | 392 | 299 | 507 | 372 | 242 | 253 | 289 |
Endoplasmic Reticulum | 6 | 4 | 1 | 6 | 6 | 7 | 11 | 17 | 17 | 17 | 9 | 18 | 1 | 1 | 0 | 11 | 9 | 15 | 9 | 7 | 8 | 0 | 3 | 4 |
Endosome | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4 | 1 | 1 | 6 | 4 | 1 | 1 | 3 | 3 |
Golgi | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 1 | 3 | 0 | 2 | 0 | 1 | 2 |
Mitochondria | 2 | 0 | 0 | 1 | 0 | 6 | 12 | 6 | 35 | 22 | 83 | 40 | 0 | 1 | 0 | 2 | 0 | 5 | 2 | 3 | 2 | 2 | 2 | 2 |
Nucleus | 0 | 1 | 0 | 0 | 2 | 2 | 4 | 6 | 0 | 2 | 1 | 3 | 0 | 2 | 1 | 5 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 1 |
Nuclear Periphery | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 3 | 0 | 3 | 3 | 4 | 0 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 2 | 2 | 0 | 2 | 2 | 1 | 9 | 6 | 19 | 6 | 10 | 0 | 1 | 1 | 14 | 15 | 8 | 1 | 3 | 1 | 0 | 1 | 2 |
Unique Cell Count | 352 | 560 | 423 | 390 | 409 | 592 | 632 | 704 | 605 | 631 | 453 | 482 | 203 | 299 | 400 | 369 | 335 | 408 | 357 | 560 | 423 | 260 | 284 | 339 |
Labelled Cell Count | 395 | 638 | 475 | 441 | 447 | 657 | 695 | 774 | 680 | 710 | 547 | 554 | 220 | 316 | 431 | 437 | 402 | 478 | 357 | 560 | 423 | 260 | 284 | 339 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 6.7 | 8.4 | 7.9 | 7.4 | 7.9 | 7.4 | 7.7 | 8.2 | 7.7 | 8.2 | 7.3 | 8.0 | 8.2 | 8.0 | 8.2 | 10.4 | 10.8 | 9.6 | 7.6 | 7.9 | 8.5 |
Std Deviation (1e-4) | 0.7 | 1.0 | 1.1 | 1.3 | 1.2 | 1.1 | 1.2 | 1.2 | 1.2 | 1.4 | 1.3 | 1.4 | 1.0 | 0.9 | 1.0 | 2.0 | 2.1 | 1.8 | 1.0 | 1.3 | 1.4 |
Intensity Change (Log2) | – | – | – | -0.08 | 0.01 | -0.08 | -0.03 | 0.07 | -0.04 | 0.07 | -0.11 | 0.03 | 0.07 | 0.03 | 0.07 | 0.4 | 0.45 | 0.29 | -0.04 | 0.0 | 0.12 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 2.4 | 3.0 | 2.7 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0.8 | -2.0 | -1.0 | -1.6 | -1.3 | -1.5 | -0.8 | 0 | 0.8 | -1.4 | -3.1 | -2.0 | 1.2 | 1.6 | 0.2 |
Cytoplasm | -1.4 | -1.5 | -2.2 | -3.5 | -4.3 | -5.3 | -5.4 | -8.1 | -8.2 | -0.1 | 0.5 | 1.8 | -3.9 | -2.4 | -2.2 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 2.8 | 3.1 | 3.0 | 0 | 3.7 | 0 | 0 | 0 | 3.2 | 0 | 3.6 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 5.0 | 3.9 | 9.3 | 6.1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 2.9 | 0 | 2.1 | 0 | 0 | 0 | 3.3 | 3.7 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.7029 | 3.3409 | 3.0933 | 2.6279 | 2.304 | 2.927 | 3.0617 | 3.5982 | 3.7292 | 3.3804 | 3.2434 | 3.4882 | 4.7025 | 5.3268 | 5.0397 | 4.2577 | 4.5084 | 4.6518 |
Actin | 0.0314 | 0.0035 | 0.0105 | 0.0124 | 0.0178 | 0.0132 | 0.0394 | 0.0084 | 0.0226 | 0.0112 | 0.006 | 0.0146 | 0.0298 | 0.0082 | 0.0122 | 0.0511 | 0.0053 | 0.0097 |
Bud | 0.003 | 0.0041 | 0.0079 | 0.0046 | 0.0175 | 0.0011 | 0.003 | 0.002 | 0.0028 | 0.0022 | 0.0005 | 0.0025 | 0.0038 | 0.0129 | 0.0065 | 0.0011 | 0.0174 | 0.0057 |
Bud Neck | 0.0107 | 0.0011 | 0.001 | 0.0025 | 0.0021 | 0.0091 | 0.0113 | 0.0007 | 0.0021 | 0.001 | 0.0019 | 0.0092 | 0.0022 | 0.0023 | 0.0021 | 0.0009 | 0.0047 | 0.0149 |
Bud Periphery | 0.0055 | 0.0021 | 0.0033 | 0.0039 | 0.0154 | 0.0047 | 0.004 | 0.0019 | 0.003 | 0.0034 | 0.0008 | 0.0093 | 0.0044 | 0.0043 | 0.0041 | 0.0012 | 0.0082 | 0.0075 |
Bud Site | 0.0091 | 0.0323 | 0.0249 | 0.0227 | 0.007 | 0.0089 | 0.0085 | 0.0319 | 0.0319 | 0.0024 | 0.0019 | 0.0033 | 0.0119 | 0.042 | 0.0164 | 0.0014 | 0.0171 | 0.0016 |
Cell Periphery | 0.0044 | 0.0055 | 0.0032 | 0.0008 | 0.0017 | 0.0072 | 0.0079 | 0.0046 | 0.004 | 0.0004 | 0.0007 | 0.0056 | 0.0059 | 0.0054 | 0.0021 | 0.0006 | 0.0008 | 0.0059 |
Cytoplasm | 0.568 | 0.8691 | 0.8436 | 0.8562 | 0.8007 | 0.8648 | 0.6799 | 0.8917 | 0.7695 | 0.754 | 0.6485 | 0.8424 | 0.7704 | 0.8797 | 0.8745 | 0.87 | 0.9119 | 0.8614 |
Cytoplasmic Foci | 0.0584 | 0.007 | 0.0124 | 0.0081 | 0.0208 | 0.0106 | 0.0313 | 0.0053 | 0.0247 | 0.0223 | 0.0567 | 0.0082 | 0.0145 | 0.0031 | 0.0078 | 0.0061 | 0.0063 | 0.0092 |
Eisosomes | 0.0004 | 0.0002 | 0.0001 | 0.0002 | 0 | 0.0001 | 0.0003 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0.0001 | 0.0001 | 0 | 0 | 0.0001 |
Endoplasmic Reticulum | 0.0075 | 0.0039 | 0.0033 | 0.0024 | 0.0017 | 0.0026 | 0.0099 | 0.0039 | 0.004 | 0.0073 | 0.0041 | 0.0028 | 0.0064 | 0.0021 | 0.0042 | 0.002 | 0.0021 | 0.0036 |
Endosome | 0.0498 | 0.0052 | 0.0066 | 0.0083 | 0.0104 | 0.0063 | 0.0299 | 0.0027 | 0.0212 | 0.0518 | 0.0746 | 0.0095 | 0.0253 | 0.0006 | 0.0105 | 0.0016 | 0.0107 | 0.0116 |
Golgi | 0.0191 | 0.0012 | 0.0042 | 0.0123 | 0.0035 | 0.0035 | 0.0098 | 0.0011 | 0.0108 | 0.0204 | 0.0365 | 0.0113 | 0.0124 | 0.0005 | 0.0033 | 0.0016 | 0.0012 | 0.0067 |
Lipid Particles | 0.0182 | 0.0005 | 0.0081 | 0.0019 | 0.0007 | 0.0049 | 0.0109 | 0.0005 | 0.0067 | 0.0184 | 0.0379 | 0.0025 | 0.0093 | 0.0002 | 0.0023 | 0.0002 | 0.0004 | 0.0083 |
Mitochondria | 0.0184 | 0.0065 | 0.0125 | 0.0032 | 0.0076 | 0.0027 | 0.0081 | 0.0003 | 0.0053 | 0.0483 | 0.014 | 0.0088 | 0.0076 | 0.0002 | 0.0016 | 0.0002 | 0.0003 | 0.0033 |
None | 0.0944 | 0.0532 | 0.0391 | 0.0541 | 0.0528 | 0.0421 | 0.0876 | 0.0416 | 0.0781 | 0.0279 | 0.0754 | 0.0537 | 0.0588 | 0.035 | 0.0411 | 0.0597 | 0.007 | 0.0344 |
Nuclear Periphery | 0.0172 | 0.0005 | 0.0031 | 0.0003 | 0.0006 | 0.0028 | 0.0117 | 0.0004 | 0.0005 | 0.0032 | 0.0095 | 0.0003 | 0.0092 | 0.0005 | 0.0022 | 0.0002 | 0.0009 | 0.0073 |
Nucleolus | 0.0033 | 0.0002 | 0.0002 | 0.0002 | 0.0011 | 0.0011 | 0.0016 | 0.0001 | 0.0006 | 0.0004 | 0.0006 | 0.0001 | 0.0016 | 0.0001 | 0.0005 | 0 | 0.0002 | 0.0002 |
Nucleus | 0.0273 | 0.0012 | 0.0038 | 0.0007 | 0.0026 | 0.0016 | 0.0118 | 0.0008 | 0.0011 | 0.005 | 0.0014 | 0.0005 | 0.0064 | 0.0012 | 0.0032 | 0.0004 | 0.0022 | 0.0016 |
Peroxisomes | 0.0231 | 0.0002 | 0.0096 | 0.0031 | 0.0142 | 0.0101 | 0.0168 | 0.0005 | 0.0059 | 0.0119 | 0.0187 | 0.0129 | 0.0053 | 0.0002 | 0.0013 | 0.0003 | 0.0002 | 0.0034 |
Punctate Nuclear | 0.0222 | 0.0006 | 0.0008 | 0.0002 | 0.0009 | 0.0006 | 0.0066 | 0.0003 | 0.0014 | 0.0013 | 0.0014 | 0.0004 | 0.0095 | 0.0007 | 0.0016 | 0.0003 | 0.0014 | 0.0015 |
Vacuole | 0.0062 | 0.0017 | 0.0016 | 0.0017 | 0.0187 | 0.0015 | 0.0085 | 0.0011 | 0.0033 | 0.005 | 0.0047 | 0.0015 | 0.0039 | 0.0006 | 0.0021 | 0.0011 | 0.0016 | 0.0015 |
Vacuole Periphery | 0.0024 | 0.0001 | 0.0004 | 0.0003 | 0.0021 | 0.0005 | 0.0013 | 0.0001 | 0.0004 | 0.0022 | 0.004 | 0.0004 | 0.0011 | 0 | 0.0004 | 0.0001 | 0.0002 | 0.0006 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 21.8996 | 25.6006 | 29.0539 | 35.1373 | 18.9292 | 32.5507 | 31.3408 | 39.3942 | 33.2591 | 31.6748 |
Translational Efficiency | 0.7715 | 0.7651 | 0.7208 | 0.5275 | 0.5901 | 0.7735 | 0.7137 | 0.5248 | 0.6733 | 0.6908 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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