Standard name | |
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Human Ortholog | |
Description | Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | – | 0 | 2 | 18 | 12 | 9 | 12 | 14 |
Bud | 0 | 3 | 1 | 0 | 1 | 0 | 2 | 8 | 5 | 4 | 14 | 16 | 0 | 0 | 0 | 0 | – | 0 | 2 | 15 | 1 | 4 | 10 | 19 |
Bud Neck | 0 | 2 | 1 | 1 | 2 | 2 | 3 | 2 | 1 | 2 | 1 | 1 | 5 | 3 | 2 | 2 | – | 1 | 0 | 7 | 6 | 8 | 8 | 9 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 1 | 4 | 3 | 0 | 0 | 0 | 0 | – | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 3 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4 | 5 | 3 | 6 | – | 4 | 0 | 8 | 5 | 10 | 15 | 10 |
Cytoplasm | 45 | 539 | 329 | 270 | 239 | 265 | 254 | 453 | 269 | 244 | 229 | 303 | 543 | 461 | 606 | 186 | – | 128 | 42 | 394 | 212 | 221 | 383 | 363 |
Endoplasmic Reticulum | 2 | 6 | 2 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 1 | 1 | 1 | 7 | 2 | 13 | – | 5 | 7 | 34 | 33 | 20 | 17 | 10 |
Endosome | 0 | 4 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 4 | 0 | – | 0 | 0 | 9 | 3 | 4 | 2 | 14 |
Golgi | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | – | 0 | 0 | 9 | 2 | 2 | 3 | 2 |
Mitochondria | 5 | 18 | 8 | 8 | 38 | 92 | 156 | 258 | 188 | 188 | 230 | 345 | 0 | 1 | 0 | 4 | – | 5 | 5 | 50 | 52 | 84 | 83 | 76 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 3 | 1 | 1 | 2 | 0 | 0 | 1 | 0 | – | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 1 | 0 | 1 | 0 | 2 | 10 | 3 | 10 | 12 | 13 | 0 | 0 | 2 | 0 | – | 0 | 0 | 7 | 2 | 5 | 5 | 16 |
Vac/Vac Membrane | 1 | 7 | 1 | 0 | 1 | 0 | 1 | 2 | 6 | 2 | 1 | 2 | 4 | 1 | 5 | 1 | – | 3 | 1 | 11 | 7 | 20 | 33 | 26 |
Unique Cell Count | 48 | 569 | 336 | 274 | 259 | 311 | 321 | 605 | 375 | 373 | 368 | 546 | 550 | 469 | 617 | 191 | 132 | 65 | 585 | 349 | 402 | 586 | 578 | |
Labelled Cell Count | 53 | 586 | 343 | 279 | 289 | 363 | 420 | 739 | 478 | 457 | 494 | 689 | 559 | 478 | 627 | 213 | 146 | 65 | 585 | 349 | 402 | 586 | 578 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.3 | 4.3 | 3.6 | 3.7 | 3.3 | 3.1 | 2.5 | 2.7 | 2.6 | 2.5 | 2.6 | 2.5 | 5.4 | 4.9 | 4.9 | 5.1 | 4.8 | 5.1 | 5.8 | 5.5 | 5.4 |
Std Deviation (1e-4) | 2.7 | 0.9 | 0.8 | 1.1 | 1.4 | 0.9 | 0.6 | 0.7 | 0.8 | 0.7 | 1.1 | 0.6 | 1.2 | 0.8 | 1.0 | 1.1 | 0.9 | 1.2 | 1.5 | 1.1 | 1.3 |
Intensity Change (Log2) | – | – | – | 0.03 | -0.12 | -0.19 | -0.53 | -0.41 | -0.47 | -0.54 | -0.46 | -0.5 | 0.58 | 0.46 | 0.47 | 0.51 | 0.43 | 0.52 | 0.69 | 0.61 | 0.61 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | -0.2098 | 0.2585 | 0.0398 | 0.4169 | -0.078 | 0.1923 | 2.559 | 2.9861 | 2.826 | 3.004 | 3.4543 | 2.8186 | 1.1643 | 1.1378 | 1.1242 | 1.0314 | 0.2985 | 1.5209 |
Actin | 0.0018 | 0.0006 | 0.0003 | 0.0001 | 0.0002 | 0.0005 | 0.0247 | 0.0011 | 0.0046 | 0.0009 | 0.0243 | 0.0046 | 0.018 | 0.0022 | 0.0049 | 0.0013 | 0.0008 | 0.0046 |
Bud | 0.0049 | 0.0099 | 0.0089 | 0.0002 | 0.0034 | 0.0029 | 0.0016 | 0.0026 | 0.0013 | 0.0025 | 0.0027 | 0.0057 | 0.0366 | 0.0872 | 0.069 | 0.0321 | 0.0226 | 0.0593 |
Bud Neck | 0.0018 | 0.0035 | 0.0003 | 0 | 0.0006 | 0.0005 | 0.0083 | 0.0007 | 0.0014 | 0.0017 | 0.051 | 0.0076 | 0.0044 | 0.0013 | 0.0058 | 0.0013 | 0.001 | 0.0076 |
Bud Periphery | 0.001 | 0.0027 | 0.0019 | 0 | 0.0011 | 0.0006 | 0.0024 | 0.0022 | 0.0017 | 0.0054 | 0.0132 | 0.0062 | 0.0162 | 0.0182 | 0.0184 | 0.0113 | 0.0105 | 0.0288 |
Bud Site | 0.0033 | 0.0109 | 0.0028 | 0 | 0.0184 | 0.0004 | 0.0209 | 0.0347 | 0.0096 | 0.0018 | 0.004 | 0.0055 | 0.0247 | 0.0808 | 0.0469 | 0.0022 | 0.0033 | 0.0036 |
Cell Periphery | 0.0002 | 0.0006 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0008 | 0.0013 | 0.0012 | 0.0006 | 0.0005 | 0.0004 | 0.0016 | 0.0015 | 0.0014 | 0.0004 | 0.0012 | 0.0013 |
Cytoplasm | 0.0146 | 0.0239 | 0.019 | 0.0237 | 0.0429 | 0.0334 | 0.0811 | 0.1679 | 0.1059 | 0.2358 | 0.0874 | 0.1665 | 0.1112 | 0.1361 | 0.1193 | 0.1606 | 0.1568 | 0.2534 |
Cytoplasmic Foci | 0.0048 | 0.0036 | 0.0029 | 0.001 | 0.0055 | 0.0058 | 0.0156 | 0.0062 | 0.0106 | 0.0086 | 0.0192 | 0.009 | 0.0567 | 0.0129 | 0.0205 | 0.0137 | 0.0225 | 0.0343 |
Eisosomes | 0.0002 | 0.0002 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0003 | 0.0002 | 0.001 | 0.0001 | 0.0005 | 0.0002 | 0.0006 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0001 |
Endoplasmic Reticulum | 0.0002 | 0.0007 | 0.0003 | 0.0001 | 0.0007 | 0.0004 | 0.0083 | 0.0059 | 0.0067 | 0.0145 | 0.0069 | 0.0103 | 0.0056 | 0.0041 | 0.0031 | 0.0024 | 0.0049 | 0.0046 |
Endosome | 0.0002 | 0.0008 | 0.0002 | 0.0001 | 0.0017 | 0.0003 | 0.0095 | 0.0019 | 0.0052 | 0.0027 | 0.0198 | 0.0032 | 0.0093 | 0.0014 | 0.0042 | 0.0038 | 0.0035 | 0.0034 |
Golgi | 0.0001 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0.0025 | 0.0002 | 0.0011 | 0.0005 | 0.0035 | 0.0004 | 0.0027 | 0.0002 | 0.0023 | 0.0001 | 0.0002 | 0.0008 |
Lipid Particles | 0.0002 | 0.0004 | 0.0002 | 0 | 0.0002 | 0.0001 | 0.0057 | 0.0005 | 0.0016 | 0.0012 | 0.0023 | 0.0015 | 0.0072 | 0.0007 | 0.002 | 0.0002 | 0.0015 | 0.0033 |
Mitochondria | 0.0005 | 0.0004 | 0.0006 | 0.0001 | 0.0004 | 0.0003 | 0.0015 | 0.0004 | 0.0089 | 0.0016 | 0.0035 | 0.0009 | 0.03 | 0.0078 | 0.0117 | 0.0013 | 0.001 | 0.0028 |
None | 0.9574 | 0.9222 | 0.9329 | 0.9392 | 0.9138 | 0.9315 | 0.7875 | 0.7429 | 0.8208 | 0.6942 | 0.7261 | 0.759 | 0.6027 | 0.5424 | 0.5434 | 0.6533 | 0.6755 | 0.4427 |
Nuclear Periphery | 0.0003 | 0.0008 | 0.0012 | 0.0004 | 0.0005 | 0.0006 | 0.0093 | 0.0017 | 0.0032 | 0.0076 | 0.0066 | 0.0032 | 0.0094 | 0.0043 | 0.0056 | 0.0074 | 0.011 | 0.0062 |
Nucleolus | 0.001 | 0.002 | 0.0024 | 0.0007 | 0.0007 | 0.0014 | 0.0011 | 0.0018 | 0.0011 | 0.0014 | 0.0041 | 0.0009 | 0.0116 | 0.0046 | 0.007 | 0.0038 | 0.0031 | 0.0043 |
Nucleus | 0.0015 | 0.0064 | 0.0106 | 0.009 | 0.003 | 0.005 | 0.0075 | 0.0106 | 0.0039 | 0.0082 | 0.0055 | 0.005 | 0.0171 | 0.0419 | 0.0458 | 0.0372 | 0.028 | 0.0507 |
Peroxisomes | 0.0009 | 0.0003 | 0.0004 | 0 | 0.0003 | 0.0001 | 0.0029 | 0.0002 | 0.0014 | 0.0005 | 0.0093 | 0.0004 | 0.0088 | 0.0004 | 0.002 | 0.0002 | 0.0003 | 0.0065 |
Punctate Nuclear | 0.0046 | 0.0093 | 0.0143 | 0.0252 | 0.0059 | 0.0157 | 0.0054 | 0.0156 | 0.0069 | 0.0074 | 0.0065 | 0.0083 | 0.018 | 0.049 | 0.0829 | 0.0642 | 0.0456 | 0.0768 |
Vacuole | 0.0004 | 0.0007 | 0.0004 | 0.0001 | 0.0004 | 0.0003 | 0.0023 | 0.0013 | 0.0015 | 0.0023 | 0.0023 | 0.001 | 0.0053 | 0.0023 | 0.0028 | 0.0024 | 0.0056 | 0.0041 |
Vacuole Periphery | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0007 | 0.0001 | 0.0005 | 0.0004 | 0.0008 | 0.0003 | 0.0023 | 0.0004 | 0.0007 | 0.0006 | 0.0011 | 0.0009 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 19.1442 | 16.5952 | 14.6233 | 16.3134 | 18.804 | 22.0327 | 11.2736 | 12.3867 | 9.4215 | 15.3596 |
Translational Efficiency | 1.064 | 1.0313 | 1.4535 | 0.8881 | 1.2552 | 0.8621 | 1.1145 | 1.0835 | 1.2484 | 1.0573 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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