Standard name | |
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Human Ortholog | |
Description | S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 4 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Bud | 2 | 0 | 1 | 3 | 1 | 0 | 5 | 3 | 0 | 4 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 4 | 9 | 9 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 1 | 8 | 4 | 7 | 9 | 24 | 31 | 29 | 21 | 33 | 41 | 5 | 7 | 7 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Cytoplasm | 256 | 114 | 272 | 265 | 293 | 342 | 438 | 364 | 275 | 256 | 299 | 353 | 367 | 585 | 475 | 72 | 70 | 53 | 237 | 103 | 261 | 213 | 375 | 393 |
Endoplasmic Reticulum | 1 | 1 | 1 | 2 | 0 | 6 | 30 | 56 | 34 | 27 | 22 | 47 | 1 | 1 | 3 | 2 | 9 | 3 | 1 | 0 | 6 | 0 | 2 | 1 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3 | 2 | 3 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Vac/Vac Membrane | 0 | 0 | 0 | 1 | 0 | 1 | 2 | 1 | 0 | 2 | 1 | 1 | 0 | 3 | 6 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Unique Cell Count | 257 | 115 | 273 | 271 | 295 | 355 | 483 | 437 | 322 | 290 | 337 | 415 | 367 | 589 | 483 | 72 | 70 | 53 | 245 | 109 | 273 | 226 | 396 | 416 |
Labelled Cell Count | 260 | 116 | 282 | 275 | 302 | 360 | 501 | 459 | 343 | 315 | 357 | 451 | 373 | 597 | 491 | 78 | 79 | 56 | 245 | 109 | 273 | 226 | 396 | 416 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 46.1 | 63.6 | 56.2 | 55.1 | 60.6 | 61.2 | 56.9 | 60.1 | 56.4 | 51.3 | 52.2 | 50.5 | 60.8 | 54.5 | 49.8 | 91.8 | 90.8 | 85.3 | 52.9 | 47.8 | 48.5 |
Std Deviation (1e-4) | 11.3 | 17.5 | 14.5 | 16.2 | 18.2 | 19.0 | 17.2 | 17.5 | 16.6 | 13.3 | 14.0 | 13.8 | 21.7 | 17.9 | 16.5 | 39.6 | 37.8 | 38.2 | 17.4 | 16.9 | 17.2 |
Intensity Change (Log2) | – | – | – | -0.03 | 0.11 | 0.12 | 0.02 | 0.09 | 0.0 | -0.13 | -0.11 | -0.16 | 0.11 | -0.04 | -0.17 | 0.71 | 0.69 | 0.6 | -0.09 | -0.24 | -0.21 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | -1.2 | -0.4 | -0.3 | 1.3 | 2.4 | 3.1 | 2.3 | 3.4 | 3.5 | -1.4 | 0 | -1.4 | 0 | 0 | 0 |
Cytoplasm | -1.9 | -0.5 | -2.8 | -4.9 | -6.9 | -6.4 | -5.6 | -5.5 | -6.5 | 1.2 | -0.6 | -1.6 | 0.5 | 0.5 | 0.4 |
Endoplasmic Reticulum | 0 | 0 | 0 | 3.9 | 5.9 | 5.3 | 4.9 | 4.0 | 5.5 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 45.1486 | 66.7326 | 55.8375 | 51.5324 | 55.4496 | 62.5455 | 61.6883 | 84.9896 | 76.4297 | 66.7324 | 73.4171 | 79.0435 | 62.3891 | 84.8951 | 71.5425 | 70.9266 | 66.6978 | 81.4619 |
Actin | 0.0065 | 0.0001 | 0.0062 | 0 | 0.0165 | 0.0005 | 0.0018 | 0.0001 | 0.0022 | 0 | 0.0006 | 0.0001 | 0.0024 | 0.0001 | 0.0013 | 0.0002 | 0.0018 | 0.0001 |
Bud | 0.0001 | 0 | 0.0001 | 0 | 0.0004 | 0.0001 | 0.0008 | 0 | 0.0002 | 0 | 0.0002 | 0.0001 | 0.0015 | 0 | 0.0023 | 0.0002 | 0.0004 | 0.0001 |
Bud Neck | 0.0007 | 0.0001 | 0.0002 | 0.0002 | 0.0011 | 0.0004 | 0.0012 | 0.0001 | 0.0006 | 0.0001 | 0.0004 | 0.0004 | 0.0004 | 0.0001 | 0.0002 | 0.0001 | 0.0009 | 0.0003 |
Bud Periphery | 0.0001 | 0 | 0.0001 | 0 | 0.0005 | 0.0001 | 0.0006 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0012 | 0 | 0.003 | 0.0001 | 0.0003 | 0.0001 |
Bud Site | 0.0003 | 0 | 0.0002 | 0 | 0.0011 | 0.0001 | 0.0026 | 0 | 0.0023 | 0 | 0.0002 | 0 | 0.0005 | 0 | 0.0005 | 0.0005 | 0.0007 | 0 |
Cell Periphery | 0.0001 | 0 | 0 | 0 | 0.0007 | 0.0003 | 0.0015 | 0.0001 | 0.0002 | 0 | 0.0004 | 0 | 0.0004 | 0 | 0.0005 | 0.0005 | 0.0003 | 0.0001 |
Cytoplasm | 0.9226 | 0.9987 | 0.9627 | 0.9978 | 0.897 | 0.9727 | 0.9072 | 0.9973 | 0.9731 | 0.9972 | 0.9499 | 0.9843 | 0.9337 | 0.9985 | 0.944 | 0.9541 | 0.9396 | 0.9868 |
Cytoplasmic Foci | 0.0056 | 0.0001 | 0.001 | 0.0004 | 0.009 | 0.0026 | 0.0115 | 0.0002 | 0.0011 | 0.0001 | 0.0111 | 0.0041 | 0.0072 | 0.0003 | 0.0097 | 0.0101 | 0.0033 | 0.0004 |
Eisosomes | 0.0003 | 0 | 0.0003 | 0 | 0.0003 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0.0002 | 0 | 0 |
Endoplasmic Reticulum | 0.0018 | 0.0001 | 0.0002 | 0.0001 | 0.0032 | 0.0025 | 0.0033 | 0.0002 | 0.0007 | 0.0001 | 0.0029 | 0.0003 | 0.0021 | 0.0001 | 0.0005 | 0.0004 | 0.0009 | 0.0005 |
Endosome | 0.0077 | 0 | 0.0023 | 0.0001 | 0.0142 | 0.0022 | 0.0075 | 0 | 0.0025 | 0 | 0.0059 | 0.0004 | 0.0072 | 0 | 0.0035 | 0.0008 | 0.0086 | 0.0004 |
Golgi | 0.0021 | 0 | 0.0013 | 0 | 0.0059 | 0.0004 | 0.0016 | 0 | 0.0006 | 0 | 0.0004 | 0 | 0.0019 | 0 | 0.0015 | 0.0002 | 0.0048 | 0 |
Lipid Particles | 0.0068 | 0 | 0.0047 | 0 | 0.005 | 0.0018 | 0.0075 | 0 | 0.0008 | 0 | 0.0038 | 0.0005 | 0.0053 | 0 | 0.0069 | 0.0089 | 0.0026 | 0.0001 |
Mitochondria | 0.0011 | 0 | 0.0012 | 0 | 0.0032 | 0.0015 | 0.0067 | 0 | 0.0038 | 0 | 0.0008 | 0.0003 | 0.0041 | 0 | 0.004 | 0.003 | 0.0035 | 0.0002 |
None | 0.0087 | 0.0001 | 0.0037 | 0.0001 | 0.0089 | 0.0019 | 0.0058 | 0.0001 | 0.0006 | 0.0001 | 0.0088 | 0.0018 | 0.0038 | 0.0001 | 0.0044 | 0.0044 | 0.0097 | 0.0005 |
Nuclear Periphery | 0.0137 | 0.0002 | 0.0035 | 0.0002 | 0.0134 | 0.0027 | 0.0087 | 0.0003 | 0.0009 | 0.0004 | 0.0033 | 0.0011 | 0.0047 | 0.0001 | 0.001 | 0.0012 | 0.0025 | 0.0008 |
Nucleolus | 0.002 | 0 | 0.0018 | 0 | 0.0032 | 0.0005 | 0.0045 | 0 | 0.0016 | 0 | 0.0003 | 0.0008 | 0.0021 | 0 | 0.0027 | 0.0049 | 0.0016 | 0.0002 |
Nucleus | 0.0095 | 0.0006 | 0.005 | 0.0009 | 0.0071 | 0.0037 | 0.0083 | 0.001 | 0.0035 | 0.0016 | 0.003 | 0.004 | 0.0075 | 0.0005 | 0.0037 | 0.0029 | 0.0068 | 0.007 |
Peroxisomes | 0.0017 | 0 | 0.0025 | 0 | 0.0007 | 0.0001 | 0.002 | 0 | 0.0002 | 0 | 0.0003 | 0.0001 | 0.0012 | 0 | 0.0032 | 0.0005 | 0.0004 | 0 |
Punctate Nuclear | 0.0067 | 0 | 0.0022 | 0 | 0.0037 | 0.0003 | 0.0025 | 0 | 0.0003 | 0 | 0.0012 | 0.0005 | 0.0028 | 0 | 0.002 | 0.0009 | 0.0005 | 0.0001 |
Vacuole | 0.0014 | 0.0001 | 0.0004 | 0.0001 | 0.0038 | 0.0033 | 0.0109 | 0.0003 | 0.0027 | 0.0003 | 0.0052 | 0.001 | 0.0072 | 0.0001 | 0.0034 | 0.0036 | 0.0079 | 0.0019 |
Vacuole Periphery | 0.0007 | 0 | 0.0004 | 0 | 0.0013 | 0.0022 | 0.0034 | 0 | 0.0018 | 0 | 0.001 | 0.0004 | 0.0027 | 0 | 0.0016 | 0.0024 | 0.0027 | 0.0003 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 301.4061 | 150.3049 | 178.7059 | 231.4348 | 154.2088 | 210.0559 | 134.9194 | 140.1618 | 225.7264 | 177.2572 |
Translational Efficiency | 1.4021 | 1.3886 | 1.3815 | 1.5153 | 1.5015 | 1.9311 | 1.3891 | 1.5443 | 1.5866 | 1.69 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✔ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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