Standard name | |
---|---|
Human Ortholog | |
Description | Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 5 | 3 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 14 | 3 | 5 | – | 2 | 0 | 0 | 3 | 3 | 0 | 1 | 2 |
Bud | 0 | 4 | 0 | 3 | 4 | 4 | 13 | 13 | 21 | 20 | 17 | 18 | 3 | 1 | 2 | – | 1 | 0 | 1 | 2 | 3 | 0 | 0 | 1 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4 | 1 | 2 | – | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | – | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 5 | 0 | 3 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 27 | 228 | 232 | 179 | 243 | 283 | 345 | 332 | 284 | 372 | 283 | 364 | 204 | 360 | 335 | – | 348 | 157 | 6 | 16 | 9 | 3 | 15 | 17 |
Endoplasmic Reticulum | 1 | 17 | 7 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 17 | 3 | 5 | – | 25 | 16 | 0 | 3 | 9 | 0 | 5 | 6 |
Endosome | 0 | 26 | 62 | 34 | 31 | 3 | 8 | 7 | 3 | 5 | 1 | 3 | 9 | 18 | 20 | – | 28 | 26 | 14 | 102 | 100 | 20 | 21 | 22 |
Golgi | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | – | 1 | 0 | 1 | 15 | 12 | 2 | 4 | 6 |
Mitochondria | 9 | 38 | 11 | 13 | 27 | 115 | 150 | 127 | 149 | 186 | 155 | 155 | 0 | 0 | 1 | – | 20 | 5 | 10 | 46 | 41 | 23 | 34 | 27 |
Nucleus | 1 | 2 | 0 | 0 | 0 | 1 | 1 | 1 | 3 | 1 | 1 | 0 | 1 | 1 | 1 | – | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 2 | 1 | 0 | 0 | 0 | – | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 1 | 1 | 2 | 0 | 1 | 2 | 0 | 2 | 0 | 2 | 0 | 1 | 0 | – | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 |
SpindlePole | 0 | 2 | 7 | 5 | 2 | 3 | 9 | 5 | 9 | 9 | 9 | 19 | 0 | 7 | 4 | – | 5 | 1 | 2 | 1 | 2 | 0 | 2 | 1 |
Vac/Vac Membrane | 15 | 119 | 98 | 31 | 44 | 13 | 12 | 7 | 4 | 12 | 4 | 8 | 7 | 14 | 8 | – | 78 | 63 | 49 | 250 | 195 | 33 | 100 | 79 |
Unique Cell Count | 46 | 378 | 361 | 235 | 318 | 354 | 443 | 423 | 360 | 465 | 364 | 470 | 250 | 404 | 372 | 433 | 217 | 89 | 450 | 391 | 88 | 193 | 172 | |
Labelled Cell Count | 54 | 442 | 425 | 267 | 355 | 424 | 542 | 498 | 476 | 609 | 477 | 571 | 264 | 409 | 387 | 511 | 268 | 89 | 450 | 391 | 88 | 193 | 172 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.7 | 5.5 | 5.2 | 4.8 | 4.7 | 3.5 | 3.3 | 3.7 | 3.1 | 3.1 | 3.1 | 3.0 | 5.8 | 5.6 | 5.7 | 4.7 | 5.4 | 5.9 | 5.7 | 6.6 | 6.9 |
Std Deviation (1e-4) | 0.7 | 0.8 | 1.4 | 1.5 | 2.0 | 1.2 | 1.1 | 1.3 | 0.8 | 1.4 | 1.1 | 0.9 | 0.7 | 0.8 | 0.8 | 0.8 | 0.9 | 1.6 | 0.8 | 1.5 | 2.4 |
Intensity Change (Log2) | – | – | – | -0.12 | -0.17 | -0.56 | -0.65 | -0.49 | -0.76 | -0.76 | -0.76 | -0.81 | 0.16 | 0.09 | 0.13 | -0.14 | 0.06 | 0.18 | 0.13 | 0.34 | 0.4 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.5 | 0 | 0 | – | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Cytoplasm | 3.1 | 3.4 | 4.7 | 4.3 | 4.4 | 4.4 | 5.1 | 4.0 | 4.2 | 4.7 | 8.2 | 8.3 | – | 5.1 | 2.0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.0 | 0 | -0.6 | – | 2.7 | 3.2 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -5.1 | -5.7 | -5.1 | – | -4.7 | -1.7 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -3.5 | -3.0 | – | 1.1 | -0.5 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -0.2 | -1.0 | – | -0.9 | 0 |
Vacuole | -4.0 | -4.3 | -8.7 | -10.0 | -10.4 | -10.0 | -10.3 | -10.1 | -10.9 | -7.8 | -9.2 | -9.6 | – | -3.1 | 0.5 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 1.0685 | 1.3522 | 1.393 | 1.5778 | 1.492 | 1.2089 | 2.8244 | 3.7528 | 3.7512 | 3.4004 | 3.1815 | 4.0331 | 3.045 | 3.5138 | 3.6417 | 3.5747 | 3.447 | 3.8494 |
Actin | 0.0316 | 0.0009 | 0.0208 | 0.023 | 0.032 | 0.004 | 0.0018 | 0.0031 | 0.0012 | 0.0015 | 0.0003 | 0.0012 | 0.0002 | 0.0002 | 0.0011 | 0.0001 | 0.0001 | 0.0004 |
Bud | 0.0036 | 0.0032 | 0.0007 | 0.0004 | 0.0017 | 0.0002 | 0.0007 | 0.0012 | 0.0012 | 0.0013 | 0.0004 | 0.0004 | 0.0006 | 0.0005 | 0.0003 | 0.0003 | 0.0002 | 0.0002 |
Bud Neck | 0.0029 | 0.0006 | 0.0014 | 0.0018 | 0.0006 | 0.0012 | 0.0053 | 0.0004 | 0.0003 | 0.0005 | 0.0005 | 0.0008 | 0.0003 | 0.0002 | 0.0003 | 0.0074 | 0.0003 | 0.0007 |
Bud Periphery | 0.0062 | 0.0016 | 0.0008 | 0.0005 | 0.0031 | 0.0004 | 0.0008 | 0.0015 | 0.002 | 0.0038 | 0.0005 | 0.0006 | 0.0004 | 0.0007 | 0.0003 | 0.0004 | 0.0002 | 0.0003 |
Bud Site | 0.0046 | 0.0081 | 0.0015 | 0.0009 | 0.0036 | 0.0002 | 0.0069 | 0.0061 | 0.0014 | 0.0011 | 0.0005 | 0.0002 | 0.0018 | 0.0007 | 0.0012 | 0.0004 | 0.0003 | 0.0002 |
Cell Periphery | 0.0004 | 0.0005 | 0.0002 | 0.0002 | 0.0003 | 0.0001 | 0.0004 | 0.0004 | 0.0003 | 0.0003 | 0.0003 | 0.0001 | 0.0003 | 0.0002 | 0.0002 | 0.0002 | 0.0002 | 0.0001 |
Cytoplasm | 0.1396 | 0.247 | 0.1899 | 0.15 | 0.1229 | 0.2613 | 0.1924 | 0.1897 | 0.1879 | 0.0678 | 0.1233 | 0.18 | 0.2278 | 0.2521 | 0.2267 | 0.2022 | 0.2743 | 0.2338 |
Cytoplasmic Foci | 0.1339 | 0.1152 | 0.1442 | 0.1625 | 0.1479 | 0.124 | 0.1489 | 0.1025 | 0.1289 | 0.1059 | 0.1694 | 0.1387 | 0.1253 | 0.1201 | 0.107 | 0.1635 | 0.1095 | 0.1547 |
Eisosomes | 0.0003 | 0.0003 | 0.0002 | 0.0004 | 0.0004 | 0 | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0.0001 |
Endoplasmic Reticulum | 0.007 | 0.0043 | 0.0071 | 0.0061 | 0.0056 | 0.0045 | 0.0069 | 0.0043 | 0.004 | 0.0027 | 0.0038 | 0.0039 | 0.0049 | 0.0057 | 0.0104 | 0.0028 | 0.0064 | 0.0035 |
Endosome | 0.2744 | 0.2954 | 0.352 | 0.4156 | 0.3644 | 0.3337 | 0.3214 | 0.2442 | 0.3032 | 0.5206 | 0.4077 | 0.3219 | 0.3476 | 0.357 | 0.3427 | 0.4634 | 0.3644 | 0.3628 |
Golgi | 0.0191 | 0.0123 | 0.0183 | 0.015 | 0.0208 | 0.0082 | 0.0119 | 0.0096 | 0.0129 | 0.0212 | 0.014 | 0.0139 | 0.0202 | 0.0189 | 0.0123 | 0.0203 | 0.0222 | 0.0137 |
Lipid Particles | 0.0236 | 0.0064 | 0.0091 | 0.0116 | 0.0139 | 0.007 | 0.0078 | 0.0095 | 0.0076 | 0.0054 | 0.0054 | 0.0113 | 0.0044 | 0.0057 | 0.0037 | 0.0041 | 0.0029 | 0.0065 |
Mitochondria | 0.013 | 0.0077 | 0.0131 | 0.0105 | 0.019 | 0.0045 | 0.0032 | 0.0152 | 0.008 | 0.0392 | 0.0082 | 0.016 | 0.0114 | 0.0063 | 0.0066 | 0.0066 | 0.0064 | 0.0045 |
None | 0.2583 | 0.2424 | 0.1922 | 0.0877 | 0.2296 | 0.1925 | 0.2392 | 0.3382 | 0.2845 | 0.1587 | 0.2012 | 0.2588 | 0.2189 | 0.1873 | 0.2375 | 0.0517 | 0.1658 | 0.184 |
Nuclear Periphery | 0.0091 | 0.0018 | 0.0054 | 0.0151 | 0.0041 | 0.0047 | 0.0053 | 0.0027 | 0.0032 | 0.0035 | 0.0019 | 0.0067 | 0.0013 | 0.0031 | 0.0038 | 0.0012 | 0.0022 | 0.0011 |
Nucleolus | 0.0008 | 0.0012 | 0.0007 | 0.0013 | 0.0005 | 0.0004 | 0.0012 | 0.0005 | 0.0009 | 0.0004 | 0.0005 | 0.0005 | 0.0004 | 0.0003 | 0.0003 | 0.0003 | 0.0002 | 0.0002 |
Nucleus | 0.0122 | 0.0023 | 0.0024 | 0.0126 | 0.0022 | 0.0037 | 0.0036 | 0.0016 | 0.0019 | 0.001 | 0.0012 | 0.0025 | 0.0013 | 0.0017 | 0.0018 | 0.001 | 0.0013 | 0.0008 |
Peroxisomes | 0.013 | 0.0051 | 0.004 | 0.005 | 0.0053 | 0.0024 | 0.0025 | 0.0041 | 0.0093 | 0.003 | 0.0242 | 0.0026 | 0.002 | 0.0018 | 0.0026 | 0.0033 | 0.0022 | 0.0035 |
Punctate Nuclear | 0.0077 | 0.0016 | 0.0021 | 0.0083 | 0.003 | 0.0042 | 0.002 | 0.0011 | 0.0043 | 0.0005 | 0.0012 | 0.0014 | 0.0006 | 0.0007 | 0.0008 | 0.0017 | 0.0004 | 0.0011 |
Vacuole | 0.0326 | 0.0359 | 0.0273 | 0.0602 | 0.0151 | 0.0336 | 0.0325 | 0.0543 | 0.0265 | 0.0418 | 0.0281 | 0.0288 | 0.0252 | 0.0301 | 0.0305 | 0.0538 | 0.0345 | 0.0212 |
Vacuole Periphery | 0.006 | 0.0063 | 0.0067 | 0.0113 | 0.0042 | 0.0092 | 0.0052 | 0.0098 | 0.0103 | 0.0197 | 0.0073 | 0.0096 | 0.005 | 0.0065 | 0.0097 | 0.0154 | 0.0062 | 0.0068 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 15.4465 | 16.153 | 6.9597 | 14.4795 | 10.5803 | 12.2338 | 12.6444 | 14.0457 | 13.1786 | 16.5792 |
Translational Efficiency | 0.3904 | 0.375 | 0.7632 | 0.449 | 0.5157 | 0.4622 | 0.5614 | 0.4114 | 0.3864 | 0.3166 |
Dataset | Hit |
---|---|
Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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