Standard name | |
---|---|
Human Ortholog | |
Description | Plasma membrane protein involved in maintaining membrane organization; involved in maintaining organization during stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 1 | 0 | 0 | 1 | – | 4 | 1 | 6 | 3 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Bud | 0 | 1 | 12 | 4 | 1 | 4 | – | 19 | 32 | 31 | 22 | 34 | 0 | 1 | 0 | 0 | 0 | 0 | 15 | 10 | 9 | 5 | 5 | 12 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 2 | 1 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 4 | 3 | 4 | 4 | 6 | – | 7 | 15 | 12 | 17 | 23 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 254 | 300 | 252 | 455 | 469 | 488 | – | 434 | 449 | 412 | 340 | 412 | 76 | 199 | 216 | 65 | 110 | 91 | 247 | 284 | 259 | 72 | 152 | 138 |
Endoplasmic Reticulum | 1 | 0 | 0 | 5 | 1 | 2 | – | 7 | 5 | 14 | 23 | 20 | 0 | 0 | 0 | 2 | 0 | 7 | 0 | 0 | 1 | 0 | 0 | 1 |
Endosome | 0 | 0 | 0 | 2 | 1 | 1 | – | 7 | 4 | 4 | 3 | 6 | 0 | 0 | 2 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 5 | 1 |
Golgi | 1 | 1 | 0 | 0 | 0 | 0 | – | 0 | 1 | 5 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4 | 0 |
Mitochondria | 3 | 1 | 3 | 16 | 11 | 70 | – | 79 | 134 | 114 | 111 | 141 | 0 | 0 | 0 | 0 | 5 | 2 | 1 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 2 | 0 | 0 | 2 | 0 | 3 | – | 21 | 22 | 20 | 23 | 28 | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 4 |
Nuclear Periphery | 0 | 0 | 0 | 1 | 0 | 1 | – | 16 | 6 | 19 | 11 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 1 | 0 | 0 | 2 | 0 | 0 | – | 11 | 5 | 6 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 1 | – | 5 | 4 | 0 | 5 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 2 | 0 | 3 |
Vac/Vac Membrane | 4 | 6 | 12 | 17 | 24 | 42 | – | 186 | 126 | 148 | 67 | 91 | 0 | 3 | 10 | 4 | 15 | 8 | 1 | 2 | 1 | 1 | 1 | 1 |
Unique Cell Count | 263 | 304 | 268 | 490 | 492 | 558 | 708 | 682 | 685 | 531 | 683 | 76 | 203 | 228 | 69 | 122 | 99 | 277 | 308 | 286 | 87 | 176 | 169 | |
Labelled Cell Count | 267 | 313 | 283 | 508 | 511 | 619 | 796 | 806 | 792 | 629 | 789 | 76 | 205 | 230 | 71 | 133 | 110 | 277 | 308 | 286 | 87 | 176 | 169 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 21.2 | 18.9 | 13.0 | 12.9 | 12.1 | 9.5 | – | 12.6 | 17.6 | 19.8 | 22.4 | 25.9 | 16.3 | 18.2 | 21.2 | 61.3 | 48.5 | 51.0 | 21.1 | 19.1 | 18.6 |
Std Deviation (1e-4) | 15.5 | 14.8 | 10.5 | 9.5 | 10.4 | 8.8 | – | 12.1 | 21.0 | 21.3 | 26.5 | 31.1 | 9.5 | 23.1 | 41.8 | 53.2 | 52.6 | 55.4 | 16.2 | 12.4 | 13.4 |
Intensity Change (Log2) | – | – | – | -0.01 | -0.11 | -0.46 | – | -0.05 | 0.43 | 0.6 | 0.78 | 0.99 | 0.32 | 0.48 | 0.7 | 2.23 | 1.89 | 1.97 | 0.69 | 0.55 | 0.51 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | -3.4 | 0 | -3.7 | – | -1.4 | 0.1 | 0 | -0.2 | 0.3 | 0 | -2.6 | -3.2 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | – | 0 | 1.1 | 0 | 1.8 | 1.9 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -0.6 | 0.8 | -2.9 | – | -10.0 | -8.9 | -10.2 | -9.1 | -10.2 | 2.2 | 2.1 | 0.3 | 0.1 | -1.4 | -0.7 |
Endoplasmic Reticulum | 0 | 0 | 0 | – | 0 | 0 | 0 | 3.5 | 2.8 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 1.8 | 0 | 5.4 | – | 5.0 | 7.3 | 6.6 | 7.5 | 7.6 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | – | 2.9 | 3.0 | 2.8 | 3.5 | 3.4 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | – | 0 | 0 | 2.8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | -0.7 | 0.2 | 1.7 | – | 7.6 | 5.5 | 6.4 | 3.6 | 3.9 | 0 | -1.8 | 0 | 0 | 2.8 | 1.3 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 147.1001 | 140.8925 | 146.6995 | 185.6852 | 122.0993 | 167.1872 | 69.9479 | 90.5747 | 75.5569 | 87.2527 | 74.8531 | 100.2537 | 63.783 | 80.7772 | 83.0577 | 59.2074 | 66.6158 | 99.707 |
Actin | 0.0042 | 0.0009 | 0.0008 | 0.0002 | 0.0007 | 0.0003 | 0.0072 | 0.0024 | 0.0033 | 0.0013 | 0.001 | 0.0113 | 0.0287 | 0.0045 | 0.0011 | 0.0483 | 0.0006 | 0.0006 |
Bud | 0.0009 | 0.0011 | 0.0039 | 0.0014 | 0.0034 | 0.0003 | 0.0015 | 0.0073 | 0.0007 | 0.0003 | 0.0001 | 0.0006 | 0.0064 | 0.0064 | 0.0022 | 0.0024 | 0.0005 | 0.0002 |
Bud Neck | 0.0003 | 0.0001 | 0.0003 | 0.0003 | 0.0005 | 0.0004 | 0.0005 | 0.0001 | 0.0002 | 0.0005 | 0.0004 | 0.0011 | 0.0034 | 0.0002 | 0.0001 | 0.0048 | 0.0002 | 0.0003 |
Bud Periphery | 0.0003 | 0.0002 | 0.0013 | 0.0004 | 0.0008 | 0.0001 | 0.0012 | 0.002 | 0.0006 | 0.0001 | 0 | 0.0003 | 0.0031 | 0.001 | 0.0003 | 0.002 | 0.0001 | 0.0001 |
Bud Site | 0.0006 | 0.0005 | 0.0004 | 0.0001 | 0.001 | 0 | 0.0013 | 0.0033 | 0.0007 | 0.0001 | 0 | 0.0004 | 0.0065 | 0.0028 | 0.0006 | 0.0061 | 0.0001 | 0.0003 |
Cell Periphery | 0.0006 | 0.0002 | 0.0005 | 0.0001 | 0.0014 | 0.0002 | 0.0008 | 0.0005 | 0.0005 | 0.0001 | 0.0001 | 0.0002 | 0.001 | 0.0002 | 0.0002 | 0.0007 | 0.0001 | 0 |
Cytoplasm | 0.9241 | 0.9807 | 0.9521 | 0.9742 | 0.861 | 0.9584 | 0.8479 | 0.9595 | 0.9494 | 0.9275 | 0.9752 | 0.9239 | 0.798 | 0.9635 | 0.9502 | 0.8196 | 0.9824 | 0.9455 |
Cytoplasmic Foci | 0.0069 | 0.002 | 0.0018 | 0.0003 | 0.0288 | 0.0046 | 0.018 | 0.0081 | 0.0163 | 0.0125 | 0.0026 | 0.0041 | 0.03 | 0.0021 | 0.0106 | 0.0256 | 0.0055 | 0.0034 |
Eisosomes | 0.0001 | 0 | 0.0001 | 0 | 0.0003 | 0 | 0.0002 | 0 | 0.0005 | 0 | 0 | 0 | 0.0005 | 0 | 0 | 0.0008 | 0 | 0 |
Endoplasmic Reticulum | 0.0017 | 0.0003 | 0.0004 | 0.0001 | 0.0004 | 0.0004 | 0.006 | 0.0002 | 0.0003 | 0.0069 | 0.0005 | 0.0012 | 0.0058 | 0.0002 | 0.0006 | 0.0038 | 0.0003 | 0.0003 |
Endosome | 0.0046 | 0 | 0.0001 | 0 | 0.0009 | 0.0001 | 0.0172 | 0.0029 | 0.0003 | 0.0289 | 0.0003 | 0.0044 | 0.0132 | 0.0009 | 0.0023 | 0.011 | 0.0003 | 0.0283 |
Golgi | 0.0004 | 0 | 0.0001 | 0 | 0.0003 | 0 | 0.0065 | 0.0011 | 0.0002 | 0.0022 | 0.0001 | 0.007 | 0.0036 | 0.0011 | 0.0005 | 0.0014 | 0.0001 | 0.0095 |
Lipid Particles | 0.0009 | 0.0001 | 0.001 | 0 | 0.0045 | 0.0001 | 0.007 | 0.0003 | 0.0006 | 0.0006 | 0.0002 | 0.0009 | 0.0132 | 0.0015 | 0.0025 | 0.0037 | 0.0001 | 0.0008 |
Mitochondria | 0.0013 | 0.0002 | 0.0026 | 0.0001 | 0.0151 | 0.0003 | 0.0158 | 0.0006 | 0.0044 | 0.0005 | 0.0001 | 0.0017 | 0.0098 | 0.0053 | 0.0019 | 0.006 | 0.0001 | 0.0027 |
None | 0.0064 | 0.0027 | 0.0036 | 0.0008 | 0.023 | 0.0026 | 0.0085 | 0.0046 | 0.0075 | 0.0038 | 0.0019 | 0.0011 | 0.015 | 0.0012 | 0.0021 | 0.036 | 0.0031 | 0.0004 |
Nuclear Periphery | 0.0073 | 0.0017 | 0.0035 | 0.0026 | 0.0027 | 0.0049 | 0.0204 | 0.0012 | 0.0012 | 0.0036 | 0.0036 | 0.0041 | 0.0093 | 0.0011 | 0.0037 | 0.004 | 0.0011 | 0.0008 |
Nucleolus | 0.0072 | 0.0008 | 0.0025 | 0.0001 | 0.0234 | 0.0048 | 0.0021 | 0.0005 | 0.0047 | 0.0003 | 0.0001 | 0.002 | 0.0058 | 0.0001 | 0.0011 | 0.0035 | 0.0001 | 0 |
Nucleus | 0.0242 | 0.0069 | 0.0195 | 0.0183 | 0.0179 | 0.0204 | 0.0223 | 0.0036 | 0.0048 | 0.0075 | 0.0107 | 0.0315 | 0.0263 | 0.0046 | 0.0148 | 0.0084 | 0.0032 | 0.005 |
Peroxisomes | 0.0002 | 0 | 0.0001 | 0 | 0.0013 | 0 | 0.0018 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0.0004 | 0.0079 | 0.002 | 0.0006 | 0.0013 | 0 | 0.0003 |
Punctate Nuclear | 0.0021 | 0.0008 | 0.0007 | 0.0002 | 0.0026 | 0.0004 | 0.0023 | 0.0005 | 0.0012 | 0.0015 | 0.0026 | 0.0024 | 0.0045 | 0.0006 | 0.0028 | 0.0029 | 0.0005 | 0.0003 |
Vacuole | 0.0049 | 0.0008 | 0.0033 | 0.0007 | 0.006 | 0.0014 | 0.0071 | 0.0008 | 0.0017 | 0.0011 | 0.0004 | 0.0011 | 0.005 | 0.0006 | 0.0011 | 0.0066 | 0.0013 | 0.0007 |
Vacuole Periphery | 0.0008 | 0.0001 | 0.0014 | 0.0002 | 0.004 | 0.0003 | 0.0046 | 0.0002 | 0.0008 | 0.0005 | 0.0001 | 0.0003 | 0.0028 | 0.0002 | 0.0006 | 0.0013 | 0.0004 | 0.0006 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 10.0309 | 8.9671 | 6.6539 | 6.6087 | 6.5028 | 36.7598 | 22.6665 | 14.2784 | 10.6475 | 7.2884 |
Translational Efficiency | 1.3813 | 1.3448 | 1.9179 | 2.8937 | 2.1972 | 1.4925 | 1.0829 | 2.6065 | 3.1232 | 2.7889 |
Dataset | Hit |
---|---|
Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✔ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
---|
Gene | Images |
---|
Gene | Images |
---|