Standard name | |
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Human Ortholog | |
Description | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; relocalizes to the cytosol in response to hypoxia |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 1 |
Bud | 2 | 0 | 9 | 10 | 2 | 6 | – | 31 | 11 | 18 | 19 | 11 | 0 | 0 | 0 | 1 | 0 | 0 | 14 | 5 | 11 | 13 | 13 | 13 |
Bud Neck | 0 | 0 | 1 | 0 | 1 | 3 | – | 0 | 3 | 3 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 2 | 2 | 5 | 3 |
Bud Site | 0 | 1 | 3 | 15 | 9 | 29 | – | 28 | 14 | 32 | 21 | 27 | 0 | 0 | 2 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 1 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 58 | 21 | 61 | 37 | 28 | 36 | – | 63 | 62 | 79 | 80 | 107 | 56 | 80 | 124 | 26 | 30 | 25 | 24 | 15 | 21 | 36 | 30 | 31 |
Endoplasmic Reticulum | 3 | 0 | 0 | 1 | 0 | 0 | – | 0 | 0 | 1 | 0 | 2 | 1 | 1 | 0 | 8 | 5 | 4 | 1 | 0 | 3 | 1 | 1 | 1 |
Endosome | 8 | 7 | 3 | 12 | 41 | 12 | – | 13 | 1 | 9 | 2 | 4 | 10 | 20 | 24 | 20 | 9 | 13 | 21 | 6 | 21 | 8 | 13 | 12 |
Golgi | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 4 | 1 | 2 | 2 | 0 | 2 |
Mitochondria | 152 | 24 | 293 | 205 | 84 | 260 | – | 496 | 402 | 416 | 337 | 404 | 11 | 8 | 6 | 17 | 17 | 36 | 15 | 2 | 21 | 9 | 17 | 19 |
Nucleus | 439 | 117 | 283 | 164 | 127 | 213 | – | 319 | 219 | 205 | 109 | 123 | 175 | 175 | 179 | 144 | 141 | 149 | 416 | 124 | 270 | 120 | 123 | 102 |
Nuclear Periphery | 4 | 1 | 2 | 7 | 6 | 10 | – | 10 | 8 | 4 | 2 | 2 | 2 | 8 | 9 | 5 | 3 | 4 | 6 | 1 | 11 | 1 | 2 | 2 |
Nucleolus | 18 | 14 | 42 | 81 | 76 | 130 | – | 158 | 66 | 78 | 43 | 37 | 36 | 41 | 37 | 42 | 24 | 41 | 46 | 16 | 49 | 12 | 10 | 20 |
Peroxisomes | 0 | 0 | 0 | 0 | 5 | 3 | – | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
SpindlePole | 10 | 3 | 23 | 33 | 58 | 69 | – | 54 | 24 | 44 | 23 | 19 | 6 | 14 | 6 | 23 | 13 | 21 | 61 | 20 | 85 | 25 | 29 | 33 |
Vac/Vac Membrane | 43 | 31 | 19 | 9 | 24 | 26 | – | 46 | 41 | 34 | 23 | 21 | 19 | 24 | 31 | 14 | 22 | 11 | 91 | 25 | 95 | 42 | 59 | 60 |
Unique Cell Count | 631 | 196 | 523 | 383 | 350 | 556 | 894 | 610 | 631 | 475 | 547 | 290 | 334 | 380 | 234 | 219 | 239 | 728 | 226 | 616 | 286 | 313 | 320 | |
Labelled Cell Count | 738 | 219 | 739 | 575 | 461 | 797 | 1219 | 851 | 924 | 660 | 761 | 316 | 373 | 423 | 301 | 265 | 306 | 728 | 226 | 616 | 286 | 313 | 320 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.4 | 5.2 | 3.8 | 4.0 | 4.9 | 4.0 | – | 3.8 | 3.4 | 3.6 | 3.5 | 3.1 | 5.3 | 5.7 | 5.5 | 7.4 | 7.1 | 7.0 | 5.3 | 5.3 | 5.1 |
Std Deviation (1e-4) | 0.8 | 1.1 | 0.9 | 1.6 | 1.5 | 1.1 | – | 1.2 | 1.1 | 1.2 | 1.2 | 0.7 | 1.2 | 1.4 | 1.5 | 1.9 | 1.9 | 1.9 | 1.4 | 1.2 | 1.6 |
Intensity Change (Log2) | – | – | – | 0.06 | 0.37 | 0.07 | – | 0.01 | -0.15 | -0.1 | -0.14 | -0.28 | 0.49 | 0.58 | 0.53 | 0.96 | 0.91 | 0.87 | 0.49 | 0.48 | 0.43 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -1.0 | -1.8 | -3.0 | – | -3.0 | -0.8 | 0.4 | 2.3 | 3.5 | 3.0 | 4.7 | 7.7 | -0.2 | 0.8 | -0.5 |
Endoplasmic Reticulum | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 7.4 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 4.8 | 5.0 | 5.9 | 0 | 4.3 |
Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | -9.4 | 0 | – | 0 | 0 | 0 | 0 | 0 | -14.7 | -16.0 | -17.2 | -12.6 | -12.2 | -10.6 |
Nucleus | -3.4 | -5.2 | -5.2 | – | -6.8 | -6.2 | -7.4 | -10.1 | -10.7 | 1.7 | -0.5 | -2.1 | 1.9 | 2.6 | 2.1 |
Nuclear Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 5.8 | 0 | – | 0 | 0 | 0 | 0 | 0 | 2.0 | 2.0 | 0.9 | 4.0 | 1.3 | 3.8 |
Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 6.1 | 0 | – | 0 | 0 | 0 | 0 | 0 | -1.7 | -0.1 | -2.4 | 2.9 | 0.9 | 2.4 |
Vacuole | -1.1 | 2.2 | 0.9 | – | 1.3 | 2.3 | 1.4 | 1.0 | 0.2 | 1.9 | 2.3 | 2.9 | 1.5 | 3.5 | 0.6 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.0977 | 1.7018 | 1.7434 | 1.0248 | 1.6973 | 1.5008 | 0.7216 | 0.6208 | 0.7591 | 0.5187 | 1.5625 | 0.767 | 1.3553 | 2.3267 | 1.8923 | 2.074 | 1.6132 | 1.9018 |
Actin | 0.0261 | 0.0002 | 0.0187 | 0.0002 | 0.0324 | 0.0065 | 0.0081 | 0.0001 | 0.0159 | 0.001 | 0.0076 | 0.0023 | 0.0021 | 0.0001 | 0.0002 | 0 | 0.0001 | 0.0003 |
Bud | 0.0008 | 0.0002 | 0.0004 | 0.0001 | 0.0012 | 0.0002 | 0.0002 | 0.0001 | 0.0023 | 0.0002 | 0.0003 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0 | 0.0006 | 0.0001 |
Bud Neck | 0.0045 | 0.0007 | 0.0062 | 0.0013 | 0.0015 | 0.0043 | 0.0014 | 0.0021 | 0.0013 | 0.0006 | 0.0022 | 0.0025 | 0.0008 | 0.0006 | 0.001 | 0.0002 | 0.0005 | 0.0031 |
Bud Periphery | 0.0014 | 0.0001 | 0.0007 | 0.0001 | 0.0031 | 0.0003 | 0.0005 | 0.0001 | 0.0009 | 0.0001 | 0.001 | 0.0002 | 0.0002 | 0.0003 | 0.0001 | 0 | 0.001 | 0.0001 |
Bud Site | 0.005 | 0.0008 | 0.0051 | 0.0002 | 0.0059 | 0.0002 | 0.0007 | 0.0005 | 0.0033 | 0.0009 | 0.0009 | 0.0002 | 0.0003 | 0.0007 | 0.0004 | 0.0001 | 0.0002 | 0.0001 |
Cell Periphery | 0.0003 | 0 | 0.0008 | 0.0001 | 0.0002 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0.0002 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.0234 | 0.0314 | 0.0107 | 0.0205 | 0.0009 | 0.0298 | 0.0218 | 0.0079 | 0.0051 | 0.0127 | 0.0046 | 0.0187 | 0.0153 | 0.0295 | 0.0127 | 0.0027 | 0.0079 | 0.0201 |
Cytoplasmic Foci | 0.0259 | 0.0015 | 0.0057 | 0.0009 | 0.0029 | 0.0013 | 0.0114 | 0.0012 | 0.005 | 0.0065 | 0.0038 | 0.003 | 0.0012 | 0.0018 | 0.0022 | 0 | 0.001 | 0.0012 |
Eisosomes | 0.0002 | 0 | 0.0006 | 0 | 0.0003 | 0 | 0.0003 | 0 | 0.0005 | 0 | 0.0003 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0046 | 0.0021 | 0.002 | 0.0017 | 0.0014 | 0.0015 | 0.0056 | 0.0006 | 0.0014 | 0.0087 | 0.0039 | 0.0007 | 0.0012 | 0.0017 | 0.0006 | 0.0001 | 0.0004 | 0.0005 |
Endosome | 0.0314 | 0.0024 | 0.007 | 0.0023 | 0.0077 | 0.0063 | 0.0164 | 0.001 | 0.0043 | 0.0219 | 0.0228 | 0.0049 | 0.0015 | 0.0009 | 0.0013 | 0 | 0.0004 | 0.0012 |
Golgi | 0.0095 | 0.0001 | 0.003 | 0.0001 | 0.0041 | 0.0017 | 0.0033 | 0.0001 | 0.0021 | 0.007 | 0.0049 | 0.0026 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0 |
Lipid Particles | 0.0182 | 0.0009 | 0.0071 | 0.0004 | 0.0051 | 0.0012 | 0.0174 | 0.0004 | 0.0048 | 0.0011 | 0.0221 | 0.0054 | 0.0005 | 0.0004 | 0.0004 | 0 | 0.0001 | 0.0001 |
Mitochondria | 0.0084 | 0.0005 | 0.0021 | 0.0004 | 0.0095 | 0.0008 | 0.0074 | 0.0002 | 0.003 | 0.0081 | 0.0065 | 0.0031 | 0.0012 | 0.0003 | 0.0002 | 0.0002 | 0.0008 | 0.0002 |
None | 0.0216 | 0.019 | 0.027 | 0.0042 | 0.0009 | 0.0137 | 0.0321 | 0.0106 | 0.0233 | 0.0073 | 0.0748 | 0.0234 | 0.0423 | 0.0812 | 0.0142 | 0.0021 | 0.0815 | 0.01 |
Nuclear Periphery | 0.0404 | 0.0178 | 0.0439 | 0.0273 | 0.0345 | 0.0123 | 0.0554 | 0.0201 | 0.0445 | 0.0178 | 0.0724 | 0.0092 | 0.0193 | 0.0097 | 0.0276 | 0.0031 | 0.0031 | 0.0083 |
Nucleolus | 0.0279 | 0.0354 | 0.047 | 0.0194 | 0.0727 | 0.053 | 0.0518 | 0.0695 | 0.0735 | 0.0168 | 0.0798 | 0.0712 | 0.0387 | 0.0448 | 0.0424 | 0.0085 | 0.0286 | 0.046 |
Nucleus | 0.5887 | 0.7435 | 0.6299 | 0.8378 | 0.7383 | 0.7913 | 0.5627 | 0.7204 | 0.6309 | 0.7461 | 0.6144 | 0.7544 | 0.6697 | 0.6732 | 0.6202 | 0.9734 | 0.6723 | 0.7981 |
Peroxisomes | 0.0167 | 0.0001 | 0.0047 | 0.0001 | 0.0029 | 0.0003 | 0.0052 | 0.0001 | 0.0048 | 0.0018 | 0.0125 | 0.0031 | 0.0001 | 0.0001 | 0.0002 | 0 | 0.0001 | 0.0001 |
Punctate Nuclear | 0.1375 | 0.1404 | 0.1752 | 0.0808 | 0.0673 | 0.0726 | 0.1923 | 0.164 | 0.1711 | 0.1395 | 0.059 | 0.0939 | 0.203 | 0.1527 | 0.2748 | 0.0093 | 0.2004 | 0.1097 |
Vacuole | 0.0049 | 0.0025 | 0.0014 | 0.0016 | 0.0031 | 0.0022 | 0.0039 | 0.0008 | 0.0012 | 0.0012 | 0.0031 | 0.0006 | 0.0015 | 0.0016 | 0.0009 | 0.0001 | 0.0007 | 0.0006 |
Vacuole Periphery | 0.0026 | 0.0004 | 0.0009 | 0.0005 | 0.0042 | 0.0004 | 0.0021 | 0.0002 | 0.0007 | 0.0007 | 0.0033 | 0.0003 | 0.0006 | 0.0003 | 0.0002 | 0 | 0.0003 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 13.2409 | 13.1517 | 1.9518 | 8.327 | 13.3524 | 17.6447 | 6.6488 | 8.975 | 7.0273 | 10.3246 |
Translational Efficiency | – | – | – | – | – | – | – | – | – | – |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | – |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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