Standard name | |
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Human Ortholog | |
Description | Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3 | 2 | 2 | 1 | 5 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 7 | 2 | 0 | 0 | 7 | 9 | 19 | 33 | 17 | 33 | 3 | 15 | 1 | 0 | 3 | 3 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 372 | 94 | 188 | 196 | 314 | 263 | 388 | 429 | 215 | 312 | 50 | 114 | 219 | 186 | 196 | 228 | 127 | 176 | 364 | 92 | 182 | 125 | 162 | 251 |
Endoplasmic Reticulum | 1 | 1 | 1 | 1 | 3 | 9 | 32 | 78 | 23 | 44 | 5 | 8 | 3 | 2 | 3 | 7 | 3 | 8 | 2 | 0 | 4 | 0 | 2 | 11 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 4 | 4 | 8 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 14 | 7 | 3 | 0 | 0 | 3 | 1 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 1 | 2 | 1 | 1 | 0 | 2 | 0 | 6 | 2 | 2 | 0 | 0 | 2 | 0 | 2 | 2 |
Unique Cell Count | 374 | 95 | 190 | 197 | 319 | 280 | 425 | 519 | 251 | 370 | 60 | 138 | 221 | 190 | 201 | 249 | 140 | 182 | 372 | 95 | 197 | 132 | 173 | 277 |
Labelled Cell Count | 380 | 97 | 190 | 197 | 324 | 286 | 440 | 547 | 261 | 399 | 64 | 155 | 225 | 191 | 203 | 260 | 147 | 193 | 372 | 95 | 197 | 132 | 173 | 277 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 109.1 | 96.1 | 76.7 | 69.6 | 76.3 | 68.7 | 64.3 | 59.0 | 52.2 | 52.8 | 46.2 | 48.4 | 99.5 | 91.9 | 77.1 | 113.4 | 130.8 | 117.8 | 125.6 | 115.3 | 121.1 |
Std Deviation (1e-4) | 26.1 | 24.0 | 21.9 | 19.3 | 20.0 | 18.8 | 17.5 | 17.0 | 16.9 | 16.2 | 19.9 | 22.8 | 28.5 | 27.5 | 25.9 | 58.9 | 63.4 | 54.9 | 38.5 | 38.1 | 40.8 |
Intensity Change (Log2) | – | – | – | -0.14 | -0.01 | -0.16 | -0.25 | -0.38 | -0.55 | -0.54 | -0.73 | -0.66 | 0.38 | 0.26 | 0.01 | 0.56 | 0.77 | 0.62 | 0.71 | 0.59 | 0.66 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 3.0 | 3.6 | 3.7 | 4.2 | 0 | 4.7 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.6 | -0.5 | -2.7 | -3.6 | -5.7 | -4.9 | -5.3 | -4.9 | -5.4 | 0.2 | -0.8 | -1.1 | -3.4 | -3.5 | -1.5 |
Endoplasmic Reticulum | 0 | 0 | 0 | 3.6 | 5.4 | 4.0 | 4.7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.3 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 68.7857 | 93.7456 | 83.2584 | 76.6538 | 73.3574 | 81.2876 | 181.5346 | 262.4547 | 236.599 | 193.4113 | 192.1365 | 241.7126 | 139.3227 | 176.31 | 163.0641 | 136.9116 | 135.0935 | 130.9777 |
Actin | 0.001 | 0.0008 | 0.0038 | 0.0004 | 0.0013 | 0.002 | 0.025 | 0.0018 | 0.0003 | 0.0009 | 0.004 | 0.0002 | 0.0064 | 0.0002 | 0.0047 | 0.0362 | 0.0002 | 0.0004 |
Bud | 0.0015 | 0.0025 | 0.0019 | 0.0034 | 0.003 | 0.0021 | 0.0016 | 0.0009 | 0.0007 | 0.0018 | 0.0008 | 0.0004 | 0.001 | 0.0004 | 0.0009 | 0.0029 | 0.001 | 0.0013 |
Bud Neck | 0.0011 | 0.0012 | 0.0012 | 0.0022 | 0.003 | 0.0118 | 0.001 | 0.0008 | 0.0008 | 0.001 | 0.0016 | 0.0018 | 0.0006 | 0.0005 | 0.0008 | 0.0017 | 0.0007 | 0.0007 |
Bud Periphery | 0.0021 | 0.0017 | 0.002 | 0.0035 | 0.005 | 0.0031 | 0.0021 | 0.001 | 0.0003 | 0.0007 | 0.0005 | 0.0004 | 0.001 | 0.0001 | 0.0003 | 0.0025 | 0.0001 | 0.0008 |
Bud Site | 0.0008 | 0.0023 | 0.0035 | 0.0008 | 0.0003 | 0.0006 | 0.001 | 0.0015 | 0.0004 | 0.0007 | 0.0002 | 0.0001 | 0.0008 | 0.0004 | 0.0006 | 0.0062 | 0.0001 | 0.0003 |
Cell Periphery | 0.0169 | 0.0185 | 0.0194 | 0.012 | 0.0256 | 0.0057 | 0.0241 | 0.0304 | 0.013 | 0.0158 | 0.0076 | 0.0271 | 0.0143 | 0.0089 | 0.0126 | 0.0104 | 0.0006 | 0.0051 |
Cytoplasm | 0.6177 | 0.8237 | 0.7912 | 0.6122 | 0.6689 | 0.7192 | 0.7291 | 0.9075 | 0.9134 | 0.6651 | 0.8103 | 0.8631 | 0.8052 | 0.9593 | 0.9093 | 0.7296 | 0.9204 | 0.8061 |
Cytoplasmic Foci | 0.0011 | 0.0012 | 0.0013 | 0.0013 | 0.0021 | 0.0052 | 0.0077 | 0.0003 | 0.0007 | 0.0024 | 0.0018 | 0.0012 | 0.0051 | 0.0006 | 0.0062 | 0.0039 | 0.004 | 0.0022 |
Eisosomes | 0.0003 | 0 | 0 | 0 | 0.0001 | 0.0001 | 0.0017 | 0.0002 | 0.0001 | 0.004 | 0 | 0 | 0.0001 | 0 | 0 | 0.0007 | 0 | 0 |
Endoplasmic Reticulum | 0.05 | 0.0185 | 0.0164 | 0.0106 | 0.0484 | 0.067 | 0.0194 | 0.0012 | 0.0041 | 0.0009 | 0.002 | 0.0025 | 0.0159 | 0.0024 | 0.007 | 0.004 | 0.0006 | 0.0063 |
Endosome | 0.0059 | 0.0022 | 0.0035 | 0.0067 | 0.0156 | 0.0172 | 0.002 | 0.0003 | 0.0005 | 0.0023 | 0.0295 | 0.0014 | 0.0065 | 0.0006 | 0.0022 | 0.0054 | 0.0058 | 0.0022 |
Golgi | 0.0007 | 0.0006 | 0.0004 | 0.0002 | 0.002 | 0.0076 | 0.0012 | 0.0001 | 0.0001 | 0.0003 | 0.0475 | 0.0001 | 0.0027 | 0.0001 | 0.0012 | 0.0022 | 0.0003 | 0.0001 |
Lipid Particles | 0.0005 | 0.0015 | 0.0011 | 0.0004 | 0.0014 | 0.0003 | 0.0063 | 0.0013 | 0.0005 | 0.0027 | 0.0005 | 0.0006 | 0.0027 | 0.0005 | 0.0009 | 0.0028 | 0.0002 | 0.0007 |
Mitochondria | 0.0053 | 0.0046 | 0.001 | 0.0009 | 0.0426 | 0.0886 | 0.0074 | 0.0038 | 0.0006 | 0.0114 | 0.0292 | 0.0004 | 0.0109 | 0.0001 | 0.004 | 0.0067 | 0.0016 | 0.005 |
None | 0.0008 | 0.0005 | 0.0005 | 0.0003 | 0.0005 | 0.0005 | 0.0062 | 0.0006 | 0.0007 | 0.0074 | 0.0003 | 0.0004 | 0.0043 | 0.0002 | 0.0004 | 0.0016 | 0.0011 | 0.0009 |
Nuclear Periphery | 0.0547 | 0.0082 | 0.0094 | 0.0105 | 0.0186 | 0.0053 | 0.0665 | 0.0069 | 0.0083 | 0.0115 | 0.0077 | 0.0082 | 0.0301 | 0.0022 | 0.0043 | 0.0104 | 0.0031 | 0.0172 |
Nucleolus | 0.0004 | 0.0008 | 0.0005 | 0.0019 | 0.0003 | 0.0001 | 0.0061 | 0.0015 | 0.0027 | 0.0508 | 0.0011 | 0.0029 | 0.0101 | 0.0004 | 0.0015 | 0.002 | 0.0006 | 0.0679 |
Nucleus | 0.0127 | 0.0047 | 0.0052 | 0.0086 | 0.0058 | 0.0034 | 0.0306 | 0.006 | 0.0067 | 0.0255 | 0.0084 | 0.0091 | 0.0128 | 0.0019 | 0.0034 | 0.01 | 0.0052 | 0.0196 |
Peroxisomes | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0002 | 0.0043 | 0.0001 | 0.0001 | 0.0003 | 0.0001 | 0 | 0.0007 | 0 | 0.0007 | 0.0031 | 0.0001 | 0.0002 |
Punctate Nuclear | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0017 | 0 | 0.0001 | 0.0009 | 0.0001 | 0.0001 | 0.0008 | 0 | 0.0001 | 0.0008 | 0.0001 | 0.0001 |
Vacuole | 0.1728 | 0.0926 | 0.1146 | 0.2665 | 0.1066 | 0.0459 | 0.0404 | 0.0312 | 0.0378 | 0.12 | 0.0328 | 0.0687 | 0.0535 | 0.0192 | 0.0337 | 0.1227 | 0.0344 | 0.039 |
Vacuole Periphery | 0.0535 | 0.0138 | 0.0228 | 0.0576 | 0.0488 | 0.0141 | 0.015 | 0.0025 | 0.0081 | 0.0737 | 0.0142 | 0.0114 | 0.0144 | 0.0018 | 0.0052 | 0.0343 | 0.0198 | 0.0238 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 234.1264 | 119.6368 | 97.8809 | 126.023 | 83.3209 | 284.9741 | 109.8269 | 118.9437 | 163.3651 | 101.1211 |
Translational Efficiency | 0.6566 | 0.5716 | 0.5002 | 0.6213 | 0.5377 | 0.578 | 0.5751 | 0.463 | 0.4431 | 0.4477 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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