Standard name | |
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Human Ortholog | |
Description | Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases; involved in tRNA delivery, stimulating catalysis, and ensuring localization; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress; methionyl-tRNA synthetase is Mes1p; glutamyl-tRNA synthetase is Gus1p |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 1 | 4 | 18 | 13 | 22 | 33 | 19 | 34 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 |
Bud | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 5 | 14 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 2 | 7 | 13 | 21 | 17 | 49 | 29 | 23 | 35 | 21 | 28 | 5 | 6 | 11 | 2 | 4 | 5 | 0 | 0 | 2 | 0 | 0 | 1 |
Cytoplasm | 347 | 358 | 412 | 372 | 489 | 329 | 307 | 351 | 246 | 276 | 189 | 190 | 425 | 530 | 563 | 65 | 99 | 108 | 321 | 348 | 412 | 382 | 469 | 601 |
Endoplasmic Reticulum | 2 | 5 | 7 | 12 | 47 | 43 | 113 | 96 | 68 | 65 | 34 | 55 | 12 | 6 | 9 | 2 | 4 | 5 | 10 | 4 | 15 | 26 | 39 | 34 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 8 | 17 | 7 | 12 | 12 | 4 | 15 | 1 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 4 | 13 | 7 | 17 | 8 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 1 | 1 | 1 | 1 | 2 |
Nucleus | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 3 | 2 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 1 | 2 | 0 | 0 | 3 | 3 | 3 | 0 | 5 | 4 | 5 | 2 | 4 | 2 | 0 | 1 | 0 | 0 | 5 | 4 | 1 | 4 | 6 |
Unique Cell Count | 350 | 365 | 423 | 383 | 539 | 387 | 463 | 472 | 344 | 388 | 258 | 288 | 443 | 538 | 572 | 66 | 103 | 113 | 340 | 371 | 445 | 424 | 537 | 677 |
Labelled Cell Count | 350 | 368 | 428 | 397 | 559 | 404 | 514 | 504 | 387 | 434 | 290 | 337 | 447 | 550 | 587 | 69 | 109 | 120 | 340 | 371 | 445 | 424 | 537 | 677 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 65.5 | 84.3 | 61.7 | 58.1 | 51.6 | 45.4 | 41.5 | 40.3 | 36.8 | 35.9 | 33.3 | 34.2 | 69.0 | 70.7 | 72.1 | 90.6 | 91.3 | 87.9 | 72.2 | 75.0 | 79.3 |
Std Deviation (1e-4) | 12.0 | 18.7 | 12.2 | 9.7 | 11.0 | 10.4 | 9.0 | 9.7 | 8.9 | 8.2 | 8.3 | 9.5 | 17.2 | 17.3 | 16.1 | 33.2 | 31.2 | 26.4 | 16.1 | 19.8 | 21.4 |
Intensity Change (Log2) | – | – | – | -0.09 | -0.26 | -0.44 | -0.57 | -0.62 | -0.75 | -0.78 | -0.89 | -0.85 | 0.16 | 0.2 | 0.22 | 0.55 | 0.56 | 0.51 | 0.22 | 0.28 | 0.36 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 4.1 | 3.4 | 5.3 | 6.1 | 5.7 | 7.2 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 1.6 | 2.1 | 2.3 | 5.5 | 3.4 | 3.6 | 4.7 | 4.1 | 4.9 | -0.7 | -0.7 | 0.3 | 0 | 0 | 0 |
Cytoplasm | -0.2 | -4.2 | -6.3 | -11.8 | -9.7 | -10.2 | -10.4 | -9.5 | -11.4 | -1.2 | 1.2 | 1.1 | 0.5 | -0.7 | -1.0 |
Endoplasmic Reticulum | 1.4 | 4.7 | 5.6 | 9.9 | 8.7 | 8.4 | 7.6 | 6.1 | 8.1 | 1.1 | -0.7 | -0.1 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 4.0 | 0 | 3.9 | 3.6 | 0 | 4.7 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 4.0 | 0 | 5.3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 49.2997 | 58.5061 | 55.7707 | 52.3236 | 56.1446 | 54.4446 | 48.2226 | 62.2591 | 56.3437 | 51.9583 | 49.9907 | 56.304 | 45.6609 | 69.0663 | 66.2322 | 49.7689 | 57.6166 | 59.9553 |
Actin | 0.0005 | 0.0004 | 0.0007 | 0.0004 | 0.0003 | 0.0006 | 0.0072 | 0.0003 | 0.0034 | 0.0002 | 0.0011 | 0.0005 | 0.0092 | 0.0002 | 0.0009 | 0.0023 | 0.0044 | 0.0008 |
Bud | 0.0006 | 0.0003 | 0.0004 | 0.0012 | 0.0002 | 0.0003 | 0.0008 | 0.0002 | 0.0009 | 0.0015 | 0.001 | 0.0004 | 0.0021 | 0.0002 | 0.0009 | 0.002 | 0.0032 | 0.0007 |
Bud Neck | 0.0005 | 0.0003 | 0.0005 | 0.0005 | 0.0007 | 0.001 | 0.0007 | 0.0003 | 0.0032 | 0.0005 | 0.0007 | 0.001 | 0.0082 | 0.0003 | 0.0007 | 0.0014 | 0.0019 | 0.0018 |
Bud Periphery | 0.0007 | 0.0003 | 0.0002 | 0.0025 | 0.0001 | 0.0002 | 0.0008 | 0.0001 | 0.0009 | 0.0024 | 0.0005 | 0.0003 | 0.0027 | 0.0001 | 0.0005 | 0.0019 | 0.0076 | 0.0018 |
Bud Site | 0.0002 | 0.0004 | 0.0002 | 0.0001 | 0 | 0 | 0.0007 | 0.0003 | 0.0007 | 0.0004 | 0.0008 | 0.0001 | 0.0037 | 0.0002 | 0.0058 | 0.0023 | 0.0057 | 0.0001 |
Cell Periphery | 0.0075 | 0.0036 | 0.0029 | 0.0025 | 0.0005 | 0.001 | 0.0073 | 0.0058 | 0.008 | 0.0085 | 0.0027 | 0.0018 | 0.0143 | 0.0098 | 0.0016 | 0.0022 | 0.0194 | 0.0044 |
Cytoplasm | 0.8105 | 0.9536 | 0.9219 | 0.8425 | 0.9362 | 0.8929 | 0.7818 | 0.9315 | 0.8748 | 0.8249 | 0.8523 | 0.8573 | 0.7055 | 0.9377 | 0.937 | 0.7038 | 0.7546 | 0.8403 |
Cytoplasmic Foci | 0.0024 | 0.0017 | 0.0028 | 0.0025 | 0.0046 | 0.0043 | 0.0055 | 0.0012 | 0.0053 | 0.0022 | 0.0072 | 0.0036 | 0.007 | 0.0008 | 0.0024 | 0.005 | 0.009 | 0.005 |
Eisosomes | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0003 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0028 | 0 | 0 | 0 | 0.0002 | 0 |
Endoplasmic Reticulum | 0.0871 | 0.0109 | 0.0209 | 0.0255 | 0.0187 | 0.0702 | 0.067 | 0.0288 | 0.0214 | 0.0244 | 0.0039 | 0.1046 | 0.0536 | 0.0056 | 0.004 | 0.0093 | 0.0071 | 0.0261 |
Endosome | 0.0121 | 0.0029 | 0.0068 | 0.0145 | 0.0104 | 0.01 | 0.0136 | 0.0016 | 0.0084 | 0.0063 | 0.0119 | 0.0092 | 0.0154 | 0.0014 | 0.0046 | 0.0599 | 0.0154 | 0.031 |
Golgi | 0.0023 | 0.0009 | 0.0017 | 0.0017 | 0.002 | 0.0028 | 0.0015 | 0.0005 | 0.002 | 0.0002 | 0.0009 | 0.0018 | 0.0032 | 0.0003 | 0.0009 | 0.004 | 0.0024 | 0.0118 |
Lipid Particles | 0.0006 | 0.0026 | 0.0007 | 0.0008 | 0.0002 | 0.0006 | 0.0048 | 0.0019 | 0.0033 | 0.0013 | 0.0019 | 0.0005 | 0.0046 | 0.0007 | 0.0003 | 0.0045 | 0.0051 | 0.001 |
Mitochondria | 0.0037 | 0.0009 | 0.0006 | 0.0021 | 0.0005 | 0.0018 | 0.0059 | 0.0001 | 0.0012 | 0.0016 | 0.0023 | 0.0013 | 0.0115 | 0.0001 | 0.0004 | 0.0063 | 0.021 | 0.0016 |
None | 0.0008 | 0.0002 | 0.0004 | 0.0002 | 0.0001 | 0.0003 | 0.0025 | 0.0001 | 0.0032 | 0.0013 | 0.0063 | 0.0003 | 0.0073 | 0.0001 | 0.0003 | 0.0009 | 0.0045 | 0.0011 |
Nuclear Periphery | 0.0105 | 0.0011 | 0.0022 | 0.0028 | 0.0013 | 0.002 | 0.0143 | 0.0019 | 0.0051 | 0.0056 | 0.0116 | 0.0034 | 0.0354 | 0.0013 | 0.0023 | 0.0195 | 0.0108 | 0.0119 |
Nucleolus | 0.0001 | 0 | 0.0003 | 0.0001 | 0 | 0 | 0.003 | 0 | 0.0004 | 0.0005 | 0.004 | 0 | 0.0052 | 0.0001 | 0.0001 | 0.0018 | 0.0124 | 0.0003 |
Nucleus | 0.0028 | 0.0009 | 0.0018 | 0.0016 | 0.0008 | 0.001 | 0.0146 | 0.001 | 0.0025 | 0.0052 | 0.0126 | 0.0013 | 0.0091 | 0.0013 | 0.002 | 0.0247 | 0.0252 | 0.0047 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0.0017 | 0 | 0.0008 | 0.0001 | 0.0002 | 0 | 0.0005 | 0 | 0 | 0.0004 | 0.0009 | 0.0001 |
Punctate Nuclear | 0.0001 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0.0013 | 0 | 0.0039 | 0.0001 | 0.0116 | 0.0001 | 0.0043 | 0 | 0.0001 | 0.0009 | 0.0056 | 0.0002 |
Vacuole | 0.0493 | 0.018 | 0.0311 | 0.0778 | 0.0191 | 0.0094 | 0.0575 | 0.0233 | 0.0467 | 0.101 | 0.0594 | 0.0106 | 0.082 | 0.0379 | 0.0327 | 0.118 | 0.0646 | 0.0459 |
Vacuole Periphery | 0.0073 | 0.0012 | 0.0037 | 0.0208 | 0.0041 | 0.0014 | 0.0072 | 0.0008 | 0.004 | 0.0119 | 0.0071 | 0.0019 | 0.0123 | 0.002 | 0.0025 | 0.029 | 0.019 | 0.0096 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 416.5815 | 443.0408 | 412.2385 | 403.7557 | 417.42 | 402.7 | 363.7455 | 347.5737 | 355.0945 | 347.1512 |
Translational Efficiency | 1.9054 | 1.8639 | 1.9715 | 2.1888 | 2.1575 | 1.8485 | 1.7963 | 2.044 | 1.8502 | 1.9215 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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