Standard name | |
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Human Ortholog | |
Description | Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress; homologous to the human Treslin/Ticrr protein |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 1 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 2 | 2 |
Bud | 0 | 0 | 0 | 0 | 1 | 1 | 2 | – | 3 | 1 | 11 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 4 |
Bud Neck | 0 | 0 | 0 | 0 | 4 | 1 | 4 | – | 6 | 2 | 2 | 11 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 6 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 5 | 2 | 12 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 11 | 62 | 34 | 11 | 104 | 161 | 189 | – | 142 | 136 | 88 | 141 | 68 | 122 | 140 | 32 | 36 | 27 | 26 | 55 | 33 | 21 | 96 | 109 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 1 | 0 | 1 | – | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 10 | 13 | 8 | 0 | 0 | 1 | 0 | 1 | 0 |
Endosome | 0 | 12 | 2 | 2 | 4 | 12 | 7 | – | 6 | 3 | 1 | 2 | 5 | 8 | 6 | 26 | 38 | 30 | 9 | 13 | 2 | 2 | 5 | 9 |
Golgi | 0 | 0 | 1 | 0 | 0 | 1 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Mitochondria | 31 | 5 | 0 | 2 | 3 | 56 | 67 | – | 112 | 110 | 231 | 153 | 3 | 2 | 0 | 9 | 6 | 5 | 8 | 15 | 20 | 3 | 17 | 14 |
Nucleus | 0 | 26 | 0 | 4 | 8 | 19 | 28 | – | 20 | 18 | 28 | 19 | 38 | 41 | 29 | 25 | 30 | 24 | 10 | 42 | 10 | 7 | 14 | 18 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 1 | – | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 0 | 2 | 0 | 4 | 0 | 0 | 5 | 1 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 1 | – | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 1 | 8 | 0 | 0 | 7 | 4 | 23 | – | 16 | 25 | 16 | 35 | 9 | 10 | 0 | 5 | 14 | 18 | 12 | 28 | 13 | 16 | 53 | 48 |
Vac/Vac Membrane | 5 | 65 | 5 | 4 | 23 | 33 | 19 | – | 5 | 13 | 10 | 10 | 18 | 39 | 38 | 50 | 44 | 40 | 27 | 55 | 36 | 8 | 30 | 44 |
Unique Cell Count | 41 | 156 | 40 | 22 | 148 | 254 | 303 | 268 | 272 | 319 | 314 | 130 | 208 | 199 | 134 | 152 | 123 | 102 | 228 | 132 | 68 | 245 | 276 | |
Labelled Cell Count | 48 | 178 | 42 | 23 | 156 | 288 | 342 | 315 | 313 | 402 | 386 | 143 | 223 | 216 | 163 | 182 | 157 | 102 | 228 | 132 | 68 | 245 | 276 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 3.3 | 4.7 | 5.5 | 5.3 | 5.6 | 4.2 | 4.5 | – | 3.7 | 4.0 | 3.3 | 3.8 | 5.2 | 5.1 | 5.3 | 6.4 | 6.2 | 6.2 | – | 5.0 | 5.2 |
Std Deviation (1e-4) | 0.3 | 0.6 | 1.5 | 1.5 | 1.8 | 1.1 | 1.9 | – | 1.1 | 1.4 | 0.7 | 1.4 | 1.1 | 1.2 | 1.6 | 1.8 | 1.9 | 2.0 | – | 1.4 | 1.2 |
Intensity Change (Log2) | – | – | – | -0.05 | 0.03 | -0.37 | -0.27 | – | -0.56 | -0.47 | -0.73 | -0.54 | -0.08 | -0.11 | -0.05 | 0.23 | 0.18 | 0.19 | – | -0.13 | -0.07 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | 3.0 | 2.1 | 2.5 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | -1.1469 | -1.3413 | -1.2872 | -1.8047 | -1.2975 | -1.25 | -0.3862 | -0.0423 | -0.2115 | -0.2857 | -0.2262 | -0.3275 | -1.0642 | -0.9626 | -0.9777 | -0.9267 | -1.0847 | -0.8934 |
Actin | 0.0289 | 0.0021 | 0.0149 | 0.0006 | 0.0012 | 0.0139 | 0.0156 | 0.0002 | 0.0011 | 0.0022 | 0.0077 | 0.0012 | 0.0252 | 0.0002 | 0.0008 | 0.0005 | 0.0046 | 0.003 |
Bud | 0.0009 | 0.0024 | 0.0003 | 0.0001 | 0.0001 | 0.0005 | 0.0025 | 0.0002 | 0.0019 | 0.0004 | 0.0002 | 0.002 | 0.0004 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 |
Bud Neck | 0.0022 | 0.0007 | 0.0006 | 0.0003 | 0.0005 | 0.0045 | 0.0037 | 0.0005 | 0.0012 | 0.0005 | 0.0009 | 0.0033 | 0.0093 | 0.0005 | 0.0008 | 0.0009 | 0.0013 | 0.0055 |
Bud Periphery | 0.0009 | 0.0037 | 0.0008 | 0.0001 | 0.0001 | 0.0006 | 0.0018 | 0.0002 | 0.0007 | 0.0012 | 0.0004 | 0.0042 | 0.0008 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0002 |
Bud Site | 0.0067 | 0.0036 | 0.0008 | 0.0001 | 0.0001 | 0.0006 | 0.0121 | 0.0023 | 0.011 | 0.0005 | 0.0002 | 0.0003 | 0.0044 | 0.0012 | 0.0006 | 0.0002 | 0.0002 | 0.0002 |
Cell Periphery | 0.0003 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0007 | 0.0001 | 0.0003 | 0 | 0.0001 | 0.0001 | 0.0003 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.1248 | 0.168 | 0.1408 | 0.2468 | 0.1253 | 0.1726 | 0.1373 | 0.121 | 0.1165 | 0.0923 | 0.1038 | 0.1367 | 0.1599 | 0.2467 | 0.147 | 0.1431 | 0.1944 | 0.1663 |
Cytoplasmic Foci | 0.0488 | 0.0097 | 0.0323 | 0.0074 | 0.0176 | 0.0354 | 0.0496 | 0.0174 | 0.011 | 0.0292 | 0.0103 | 0.0165 | 0.0237 | 0.0148 | 0.0101 | 0.0074 | 0.0064 | 0.0109 |
Eisosomes | 0.0003 | 0.0002 | 0.0004 | 0.0002 | 0.0001 | 0.0001 | 0.0006 | 0.0001 | 0.0002 | 0.0001 | 0.0003 | 0.0001 | 0.0003 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0093 | 0.0134 | 0.0096 | 0.0067 | 0.0035 | 0.0053 | 0.0044 | 0.0032 | 0.0033 | 0.0027 | 0.0043 | 0.003 | 0.0055 | 0.0031 | 0.0032 | 0.0035 | 0.0031 | 0.003 |
Endosome | 0.0376 | 0.0082 | 0.0245 | 0.0061 | 0.0048 | 0.0154 | 0.0294 | 0.0052 | 0.0189 | 0.0189 | 0.0179 | 0.0052 | 0.0168 | 0.0062 | 0.0052 | 0.0058 | 0.0078 | 0.0069 |
Golgi | 0.0202 | 0.0004 | 0.0055 | 0.0001 | 0.0003 | 0.007 | 0.0126 | 0.0002 | 0.0028 | 0.0039 | 0.0016 | 0.0013 | 0.003 | 0.0002 | 0.0003 | 0.0001 | 0.0012 | 0.0005 |
Lipid Particles | 0.022 | 0.0029 | 0.0086 | 0.0006 | 0.0009 | 0.0072 | 0.0254 | 0.0012 | 0.011 | 0.0052 | 0.0026 | 0.007 | 0.0081 | 0.0005 | 0.0023 | 0.0004 | 0.0045 | 0.0018 |
Mitochondria | 0.0126 | 0.0007 | 0.003 | 0.0011 | 0.0006 | 0.0176 | 0.0057 | 0.0014 | 0.0064 | 0.0068 | 0.0144 | 0.0022 | 0.0028 | 0.0007 | 0.0081 | 0.0011 | 0.0011 | 0.0008 |
None | 0.3712 | 0.4953 | 0.3788 | 0.5813 | 0.6099 | 0.3677 | 0.4272 | 0.5797 | 0.5314 | 0.4436 | 0.5718 | 0.458 | 0.342 | 0.3823 | 0.4188 | 0.4001 | 0.3431 | 0.3025 |
Nuclear Periphery | 0.0199 | 0.0257 | 0.0429 | 0.0233 | 0.043 | 0.0158 | 0.0202 | 0.012 | 0.0243 | 0.0378 | 0.0183 | 0.0117 | 0.0179 | 0.0148 | 0.0237 | 0.015 | 0.0323 | 0.0176 |
Nucleolus | 0.0062 | 0.0037 | 0.003 | 0.0008 | 0.0013 | 0.0052 | 0.0056 | 0.0061 | 0.0055 | 0.005 | 0.0031 | 0.007 | 0.0072 | 0.0043 | 0.0046 | 0.0042 | 0.0044 | 0.0058 |
Nucleus | 0.1629 | 0.1808 | 0.2418 | 0.1072 | 0.1244 | 0.2206 | 0.1432 | 0.181 | 0.196 | 0.2352 | 0.1808 | 0.248 | 0.2413 | 0.2807 | 0.302 | 0.3231 | 0.2981 | 0.3617 |
Peroxisomes | 0.0163 | 0.0004 | 0.015 | 0.0002 | 0.0013 | 0.0114 | 0.0157 | 0.0005 | 0.006 | 0.0187 | 0.0031 | 0.004 | 0.0056 | 0.0003 | 0.0004 | 0.0003 | 0.0025 | 0.0011 |
Punctate Nuclear | 0.1016 | 0.0745 | 0.0727 | 0.0137 | 0.0642 | 0.0956 | 0.0808 | 0.0646 | 0.045 | 0.0933 | 0.0558 | 0.0864 | 0.1208 | 0.04 | 0.0697 | 0.0926 | 0.0924 | 0.1101 |
Vacuole | 0.0048 | 0.0028 | 0.0028 | 0.0026 | 0.0006 | 0.002 | 0.004 | 0.0024 | 0.004 | 0.001 | 0.0013 | 0.0014 | 0.0036 | 0.0027 | 0.0015 | 0.0012 | 0.0013 | 0.0015 |
Vacuole Periphery | 0.0016 | 0.0006 | 0.0009 | 0.0007 | 0.0003 | 0.0008 | 0.0018 | 0.0006 | 0.0014 | 0.0015 | 0.0009 | 0.0004 | 0.001 | 0.0004 | 0.0005 | 0.0004 | 0.0008 | 0.0004 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 10.1709 | 6.3891 | 5.4704 | 9.3599 | 12.8306 | 6.5937 | 10.6838 | 9.3909 | 9.1912 | 11.487 |
Translational Efficiency | 0.3632 | 0.3751 | 0.3674 | 0.3169 | 0.169 | 0.368 | 0.2277 | 0.2291 | 0.2391 | 0.2128 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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