Standard name | |
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Human Ortholog | |
Description | Subunit of Snt2C complex, RING finger ubiquitin ligase (E3); physically associates with Ecm5p and Rpd3p; along with Ecm5p, recruits Rpd3p to small number of promoters; colocalizes with Ecm5p, independently of Rpd3p, to promoters of stress response genes upon oxidative stress; involved in ubiquitination, degradation of excess histones; interacts with Ubc4p; role in regulating genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 1 | 0 | 0 | – | 0 | 0 | 0 | – | – | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 3 | 0 | 2 | 4 |
Bud | 0 | 0 | 1 | 3 | 0 | 8 | – | 10 | 18 | 6 | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 3 | 2 | 3 | 4 |
Bud Neck | 0 | 1 | 0 | 1 | 1 | 0 | – | 0 | 0 | 0 | – | – | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 1 | 1 | 3 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 2 | – | 3 | 5 | 9 | – | – | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | – | – | 0 | 0 | 1 | 1 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 2 |
Cytoplasm | 4 | 189 | 77 | 94 | 126 | 115 | – | 133 | 53 | 80 | – | – | 108 | 115 | 224 | 159 | 168 | 156 | 38 | 189 | 74 | 103 | 160 | 252 |
Endoplasmic Reticulum | 1 | 1 | 1 | 0 | 0 | 1 | – | 2 | 0 | 0 | – | – | 5 | 1 | 7 | 9 | 6 | 12 | 0 | 0 | 4 | 4 | 5 | 6 |
Endosome | 0 | 1 | 9 | 15 | 28 | 3 | – | 15 | 2 | 4 | – | – | 5 | 2 | 5 | 1 | 2 | 1 | 1 | 5 | 2 | 1 | 1 | 4 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Mitochondria | 8 | 113 | 12 | 39 | 40 | 148 | – | 242 | 271 | 268 | – | – | 0 | 0 | 0 | 5 | 3 | 6 | 4 | 15 | 25 | 22 | 34 | 34 |
Nucleus | 2 | 17 | 1 | 5 | 6 | 23 | – | 48 | 61 | 92 | – | – | 29 | 8 | 22 | 1 | 2 | 0 | 18 | 48 | 5 | 9 | 7 | 7 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | – | – | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | – | – | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 2 | 1 | 1 | 1 | – | 4 | 5 | 3 | – | – | 0 | 2 | 0 | 0 | 0 | 1 | 4 | 20 | 8 | 4 | 12 | 12 |
Vac/Vac Membrane | 6 | 27 | 30 | 39 | 78 | 61 | – | 43 | 75 | 54 | – | – | 65 | 67 | 100 | 10 | 6 | 9 | 24 | 67 | 15 | 65 | 49 | 85 |
Unique Cell Count | 20 | 298 | 110 | 163 | 238 | 286 | 407 | 358 | 391 | 199 | 183 | 333 | 170 | 183 | 169 | 96 | 373 | 158 | 223 | 288 | 432 | |||
Labelled Cell Count | 21 | 349 | 133 | 198 | 280 | 362 | 500 | 490 | 518 | 213 | 198 | 359 | 186 | 193 | 187 | 96 | 373 | 158 | 223 | 288 | 432 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 3.5 | 3.3 | 4.4 | 4.0 | 4.2 | 3.5 | – | 3.9 | 3.5 | 3.8 | – | – | 5.5 | 5.4 | 5.4 | 5.4 | 5.0 | 5.1 | 4.7 | 5.0 | 5.3 |
Std Deviation (1e-4) | 0.2 | 0.7 | 1.1 | 0.6 | 0.7 | 0.8 | – | 1.3 | 1.0 | 1.1 | – | – | 1.0 | 1.1 | 1.0 | 1.0 | 0.9 | 1.0 | 0.9 | 1.2 | 1.3 |
Intensity Change (Log2) | – | – | – | -0.12 | -0.07 | -0.34 | – | -0.16 | -0.34 | -0.22 | – | – | 0.32 | 0.31 | 0.3 | 0.31 | 0.19 | 0.23 | 0.11 | 0.19 | 0.28 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | -5.0 | -6.1 | -5.2 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | -1.5071 | -1.3785 | -1.0581 | -1.4994 | -1.5595 | -1.1567 | 0.1314 | 0.0454 | -0.2647 | 0.0991 | -0.4895 | 0.0523 | -1.0551 | -1.0412 | -1.0799 | -0.7693 | -1.2423 | -1.2918 |
Actin | 0.002 | 0.0004 | 0.0056 | 0.0004 | 0.0002 | 0.002 | 0.0403 | 0.0003 | 0.0183 | 0.006 | 0.0641 | 0.002 | 0.0088 | 0.0034 | 0.0002 | 0.0013 | 0.0002 | 0.0003 |
Bud | 0.0004 | 0.0001 | 0.0016 | 0 | 0 | 0.0013 | 0.0017 | 0.0003 | 0.0004 | 0.001 | 0.0402 | 0.0002 | 0.0003 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 |
Bud Neck | 0.0002 | 0.0001 | 0.0008 | 0.0002 | 0.0006 | 0.0018 | 0.0038 | 0.0004 | 0.0035 | 0.0037 | 0.0015 | 0.0032 | 0.0017 | 0.0002 | 0.0002 | 0.0023 | 0.0003 | 0.0015 |
Bud Periphery | 0.0004 | 0 | 0.0018 | 0 | 0 | 0.0023 | 0.0028 | 0.0002 | 0.0005 | 0.0013 | 0.0162 | 0.0006 | 0.0004 | 0 | 0 | 0.0001 | 0 | 0.0001 |
Bud Site | 0.0013 | 0.0005 | 0.0072 | 0.0001 | 0.0001 | 0.0004 | 0.0087 | 0.0024 | 0.0044 | 0.0052 | 0.0047 | 0.0004 | 0.0041 | 0.0006 | 0.0004 | 0.0072 | 0.0001 | 0.0002 |
Cell Periphery | 0 | 0 | 0.0002 | 0 | 0 | 0.0001 | 0.0003 | 0.0001 | 0.0002 | 0.0002 | 0.0004 | 0.0001 | 0.0003 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 |
Cytoplasm | 0.2015 | 0.1907 | 0.2101 | 0.1356 | 0.3368 | 0.2284 | 0.2035 | 0.2195 | 0.2239 | 0.2125 | 0.2368 | 0.2969 | 0.2048 | 0.2532 | 0.2384 | 0.1202 | 0.267 | 0.2388 |
Cytoplasmic Foci | 0.016 | 0.0121 | 0.0145 | 0.0121 | 0.0048 | 0.0114 | 0.0467 | 0.0156 | 0.0128 | 0.0275 | 0.0051 | 0.0128 | 0.0356 | 0.0078 | 0.0065 | 0.0532 | 0.0061 | 0.0046 |
Eisosomes | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0002 | 0.0001 | 0.0003 | 0.0001 | 0.0014 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0001 |
Endoplasmic Reticulum | 0.0028 | 0.0027 | 0.0042 | 0.0029 | 0.0064 | 0.0028 | 0.0052 | 0.0029 | 0.0026 | 0.0022 | 0.0036 | 0.0036 | 0.0048 | 0.0037 | 0.0064 | 0.0041 | 0.0108 | 0.0035 |
Endosome | 0.0087 | 0.0068 | 0.0105 | 0.0049 | 0.0152 | 0.0048 | 0.0213 | 0.0059 | 0.0081 | 0.0363 | 0.009 | 0.0076 | 0.0271 | 0.0085 | 0.0193 | 0.0039 | 0.0055 | 0.0053 |
Golgi | 0.0016 | 0.0036 | 0.0005 | 0.0002 | 0.0001 | 0.0004 | 0.0058 | 0.0003 | 0.0066 | 0.0217 | 0.0128 | 0.0022 | 0.0184 | 0.0123 | 0.0014 | 0.001 | 0.0001 | 0.0001 |
Lipid Particles | 0.0018 | 0.0006 | 0.0012 | 0.0008 | 0.0008 | 0.0008 | 0.0091 | 0.0003 | 0.0027 | 0.0118 | 0.0072 | 0.003 | 0.0202 | 0.0007 | 0.0003 | 0.0049 | 0.0005 | 0.0005 |
Mitochondria | 0.0008 | 0.0017 | 0.001 | 0.0011 | 0.0008 | 0.0007 | 0.0021 | 0.0008 | 0.0083 | 0.0067 | 0.0171 | 0.0079 | 0.0156 | 0.0008 | 0.0008 | 0.0009 | 0.0008 | 0.0009 |
None | 0.5962 | 0.6769 | 0.5226 | 0.5541 | 0.4524 | 0.5586 | 0.4389 | 0.5549 | 0.4435 | 0.3853 | 0.431 | 0.3876 | 0.5654 | 0.593 | 0.5749 | 0.6715 | 0.5388 | 0.5045 |
Nuclear Periphery | 0.0088 | 0.0056 | 0.0133 | 0.0153 | 0.025 | 0.0068 | 0.0134 | 0.0083 | 0.0136 | 0.0131 | 0.0067 | 0.0081 | 0.0039 | 0.0076 | 0.0106 | 0.0123 | 0.0139 | 0.0154 |
Nucleolus | 0.0011 | 0.001 | 0.003 | 0.0012 | 0.0013 | 0.0018 | 0.0035 | 0.0026 | 0.002 | 0.005 | 0.0016 | 0.0028 | 0.0032 | 0.0005 | 0.0009 | 0.0018 | 0.0013 | 0.0024 |
Nucleus | 0.1341 | 0.0867 | 0.17 | 0.2551 | 0.1263 | 0.1448 | 0.1229 | 0.1641 | 0.2067 | 0.2195 | 0.1259 | 0.2215 | 0.0603 | 0.1009 | 0.122 | 0.0942 | 0.1387 | 0.2002 |
Peroxisomes | 0.0018 | 0.0007 | 0.0006 | 0.0003 | 0.0001 | 0.0008 | 0.0208 | 0.0011 | 0.0104 | 0.0044 | 0.0057 | 0.0088 | 0.0158 | 0.0001 | 0.0002 | 0.0014 | 0.0001 | 0.0001 |
Punctate Nuclear | 0.0178 | 0.0083 | 0.028 | 0.014 | 0.0224 | 0.0288 | 0.0454 | 0.0163 | 0.0286 | 0.0317 | 0.0068 | 0.0277 | 0.0034 | 0.0041 | 0.0153 | 0.0179 | 0.0127 | 0.0183 |
Vacuole | 0.002 | 0.001 | 0.0026 | 0.0011 | 0.006 | 0.001 | 0.0028 | 0.0032 | 0.002 | 0.0037 | 0.0014 | 0.0022 | 0.0051 | 0.0019 | 0.0014 | 0.0009 | 0.0027 | 0.0024 |
Vacuole Periphery | 0.0004 | 0.0002 | 0.0005 | 0.0005 | 0.0008 | 0.0002 | 0.0007 | 0.0005 | 0.0005 | 0.0012 | 0.0008 | 0.0006 | 0.0007 | 0.0004 | 0.0005 | 0.0004 | 0.0004 | 0.0006 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 9.8238 | 5.152 | 7.9936 | 10.8616 | 8.4913 | 9.1638 | 12.0759 | 12.1457 | 10.7612 | 12.3676 |
Translational Efficiency | – | – | – | – | – | – | – | – | – | – |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | – |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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