Standard name | |
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Human Ortholog | |
Description | Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; relocalizes to the cytosol in response to hypoxia; homolog of human Sm D1; protein abundance increases in response to DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 1 | 0 | 1 | 1 | – | 1 | 0 | 3 | 2 | 2 | 0 | 2 | 1 | 0 | 0 | 0 | 3 | 1 | 1 | 2 | 1 | 6 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 3 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 1 | 2 | 5 | – | 15 | 6 | 20 | 12 | 23 | 0 | 4 | 0 | 2 | 2 | 1 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 10 | 8 | 12 | 17 | 30 | 10 | – | 21 | 6 | 7 | 7 | 8 | 25 | 66 | 85 | 15 | 25 | 21 | 0 | 2 | 2 | 0 | 2 | 2 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 1 |
Endosome | 1 | 0 | 1 | 0 | 3 | 0 | – | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4 | 3 | 1 | 1 | 4 | 0 | 5 | 2 | 2 | 2 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 2 | 0 | 1 | 1 | 0 | 1 |
Mitochondria | 13 | 1 | 36 | 29 | 28 | 60 | – | 70 | 69 | 95 | 67 | 80 | 1 | 3 | 0 | 8 | 8 | 5 | 4 | 2 | 0 | 0 | 4 | 5 |
Nucleus | 518 | 209 | 494 | 354 | 408 | 591 | – | 631 | 299 | 538 | 323 | 369 | 306 | 456 | 450 | 275 | 149 | 271 | 550 | 221 | 500 | 200 | 287 | 301 |
Nuclear Periphery | 1 | 1 | 3 | 4 | 4 | 8 | – | 8 | 3 | 12 | 4 | 8 | 1 | 4 | 3 | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
Nucleolus | 43 | 21 | 83 | 42 | 80 | 177 | – | 291 | 156 | 284 | 168 | 169 | 22 | 36 | 36 | 18 | 10 | 9 | 7 | 5 | 24 | 18 | 46 | 63 |
Peroxisomes | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 10 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 1 | 0 | 1 | 1 | – | 1 | 0 | 0 | 0 | 1 | 2 | 15 | 18 | 0 | 0 | 0 | 1 | 0 | 3 | 1 | 1 | 1 |
Vac/Vac Membrane | 2 | 4 | 7 | 0 | 11 | 4 | – | 11 | 1 | 7 | 5 | 5 | 5 | 2 | 11 | 8 | 6 | 11 | 12 | 5 | 17 | 20 | 47 | 80 |
Unique Cell Count | 551 | 228 | 546 | 394 | 508 | 712 | 863 | 405 | 721 | 439 | 500 | 346 | 554 | 584 | 315 | 192 | 309 | 588 | 243 | 567 | 250 | 398 | 471 | |
Labelled Cell Count | 589 | 244 | 638 | 447 | 568 | 857 | 1052 | 540 | 969 | 588 | 665 | 365 | 593 | 620 | 337 | 205 | 322 | 588 | 243 | 567 | 250 | 398 | 471 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 10.0 | 12.9 | 8.1 | 9.4 | 9.9 | 8.0 | – | 8.5 | 7.9 | 7.9 | 8.1 | 7.9 | 11.3 | 12.2 | 11.8 | 12.8 | 12.0 | 12.5 | 11.7 | 12.6 | 12.7 |
Std Deviation (1e-4) | 2.8 | 3.5 | 2.6 | 3.9 | 4.7 | 2.8 | – | 3.2 | 3.3 | 3.0 | 3.2 | 2.9 | 3.8 | 4.5 | 4.8 | 4.7 | 4.6 | 4.8 | 2.8 | 3.1 | 2.9 |
Intensity Change (Log2) | – | – | – | 0.22 | 0.29 | -0.02 | – | 0.07 | -0.04 | -0.04 | 0.0 | -0.04 | 0.48 | 0.59 | 0.54 | 0.66 | 0.57 | 0.63 | 0.54 | 0.64 | 0.64 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | – | 3.1 | 0 | 3.9 | 3.9 | 5.1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1.9 | 3.1 | -1.1 | – | 0.3 | -0.8 | -1.8 | -0.7 | -0.7 | 3.7 | 6.3 | 7.4 | 2.1 | 5.9 | 3.4 |
Endoplasmic Reticulum | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0.5 | -0.7 | 1.2 | – | 1.1 | 5.1 | 3.8 | 4.4 | 4.8 | -4.6 | -5.4 | -6.3 | -2.6 | -1.2 | -3.3 |
Nucleus | -0.3 | -4.7 | -3.8 | – | -7.9 | -6.8 | -7.2 | -7.0 | -7.1 | -1.0 | -3.9 | -6.1 | -1.5 | -4.6 | -1.3 |
Nuclear Periphery | 0 | 0 | 0 | – | 0 | 0 | 1.8 | 0 | 1.7 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | -2.0 | 0.2 | 4.2 | – | 7.7 | 8.2 | 9.4 | 8.3 | 7.0 | -4.0 | -4.6 | -4.9 | -4.2 | -3.6 | -5.6 |
Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 3.5 | 3.8 | 0 | 0 | 0 |
Vacuole | 0 | 1.1 | 0 | – | 0 | 0 | -0.5 | -0.2 | -0.4 | 0 | 0 | 0.8 | 1.4 | 0 | 2.2 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 9.6943 | 11.3169 | 9.7532 | 9.6872 | 8.7125 | 9.477 | 9.1754 | 8.2872 | 7.9874 | 7.762 | 7.232 | 7.8676 | 10.8895 | 11.3334 | 10.7167 | 10.0933 | 9.8181 | 10.5995 |
Actin | 0.0039 | 0.0008 | 0.0119 | 0.0026 | 0.0072 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0 | 0.0091 | 0 | 0.0001 | 0.0016 | 0.0004 | 0 |
Bud | 0.0008 | 0.0001 | 0.0003 | 0.0001 | 0.0002 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0.0002 | 0 | 0.0001 | 0.0005 | 0.0007 | 0 |
Bud Neck | 0.0014 | 0.0001 | 0.0002 | 0 | 0.0003 | 0.0004 | 0 | 0 | 0 | 0.0002 | 0.0001 | 0.0004 | 0.0006 | 0 | 0.0001 | 0.0002 | 0.0005 | 0.0003 |
Bud Periphery | 0.0013 | 0.0001 | 0.0005 | 0.0002 | 0.0004 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0.0002 | 0 | 0.0001 | 0.0006 | 0.0005 | 0 |
Bud Site | 0.0019 | 0.0008 | 0.0008 | 0.0003 | 0.0004 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0.0008 | 0 | 0.0002 | 0.0008 | 0.0019 | 0 |
Cell Periphery | 0.0007 | 0 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0002 | 0 | 0.0002 | 0.0004 | 0.0006 | 0 |
Cytoplasm | 0.0154 | 0.0003 | 0.0088 | 0.0001 | 0.0003 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0.0039 | 0 | 0.0077 | 0.0018 | 0.0075 | 0 |
Cytoplasmic Foci | 0.022 | 0.0002 | 0.0047 | 0.009 | 0.0106 | 0.0001 | 0.0014 | 0 | 0 | 0 | 0 | 0 | 0.0144 | 0 | 0.0029 | 0.0017 | 0.0058 | 0 |
Eisosomes | 0.0002 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0002 | 0 | 0 | 0 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0013 | 0.0002 | 0.0004 | 0.0001 | 0.0005 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0013 | 0 | 0.0006 | 0.0007 | 0.0011 | 0 |
Endosome | 0.0172 | 0.0013 | 0.0028 | 0.005 | 0.0383 | 0 | 0.0003 | 0 | 0 | 0 | 0 | 0 | 0.0079 | 0 | 0.002 | 0.0059 | 0.001 | 0 |
Golgi | 0.0059 | 0.0006 | 0.0034 | 0.0089 | 0.0215 | 0 | 0.0003 | 0 | 0 | 0 | 0 | 0 | 0.0019 | 0 | 0.0002 | 0.0007 | 0.0002 | 0 |
Lipid Particles | 0.0217 | 0.0012 | 0.0066 | 0.0325 | 0.0213 | 0 | 0.0043 | 0 | 0 | 0 | 0 | 0 | 0.0163 | 0 | 0.0027 | 0.0014 | 0.0052 | 0 |
Mitochondria | 0.0171 | 0.0035 | 0.0055 | 0.0152 | 0.0653 | 0.0003 | 0.0007 | 0 | 0 | 0.0005 | 0.0002 | 0.0005 | 0.0021 | 0.0001 | 0.0011 | 0.003 | 0.0021 | 0.0001 |
None | 0.0018 | 0 | 0.0008 | 0.0002 | 0.0002 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.006 | 0 | 0.0007 | 0.0005 | 0.0041 | 0 |
Nuclear Periphery | 0.0097 | 0.0016 | 0.0037 | 0.0009 | 0.0035 | 0.0003 | 0.0007 | 0.0015 | 0.0003 | 0.0009 | 0.0006 | 0.0004 | 0.0149 | 0.0008 | 0.0057 | 0.0106 | 0.0055 | 0.0002 |
Nucleolus | 0.0553 | 0.0113 | 0.0209 | 0.0094 | 0.117 | 0.1076 | 0.0199 | 0.0151 | 0.0086 | 0.0162 | 0.1459 | 0.0909 | 0.0522 | 0.011 | 0.0279 | 0.0418 | 0.1452 | 0.0639 |
Nucleus | 0.7905 | 0.9771 | 0.9129 | 0.9079 | 0.7053 | 0.8877 | 0.9532 | 0.9831 | 0.9909 | 0.9808 | 0.8494 | 0.9073 | 0.836 | 0.9876 | 0.9373 | 0.9076 | 0.8065 | 0.9351 |
Peroxisomes | 0.0054 | 0.0002 | 0.008 | 0.0043 | 0.0039 | 0 | 0.015 | 0 | 0 | 0 | 0 | 0 | 0.0035 | 0 | 0.0001 | 0.001 | 0.0002 | 0 |
Punctate Nuclear | 0.0168 | 0.0002 | 0.0041 | 0.0005 | 0.0009 | 0.0028 | 0.0029 | 0.0001 | 0.0001 | 0.0003 | 0.0036 | 0.0002 | 0.0251 | 0.0004 | 0.006 | 0.0143 | 0.007 | 0.0001 |
Vacuole | 0.0054 | 0.0002 | 0.0014 | 0.0008 | 0.0012 | 0.0002 | 0.0005 | 0 | 0 | 0.0002 | 0.0001 | 0.0001 | 0.0017 | 0 | 0.0024 | 0.0026 | 0.0025 | 0.0001 |
Vacuole Periphery | 0.0041 | 0.0003 | 0.0019 | 0.002 | 0.0016 | 0.0001 | 0.0004 | 0 | 0 | 0.0002 | 0.0001 | 0.0001 | 0.0014 | 0 | 0.0018 | 0.0023 | 0.0013 | 0 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 36.2797 | 40.2603 | 28.2151 | 26.1877 | 22.7081 | 55.0146 | 39.5763 | 28.2377 | 29.4797 | 27.0034 |
Translational Efficiency | 1.552 | 1.7647 | 1.5759 | 2.065 | 2.3029 | 0.9734 | 1.506 | 2.1073 | 1.8741 | 1.9075 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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