Standard name | |
---|---|
Human Ortholog | |
Description | Nucleolar protein that binds nuclear localization sequences; required for pre-rRNA processing and ribosome biogenesis; binds to single stranded telomeric DNA and mRNA; methylated by Hmt1p; interaction with Top1p and nucleolar localization are negatively regulated by polyphosphorylation |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 2 | 0 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 2 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 4 | 14 | 12 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 4 | 8 |
Bud Site | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 0 | 4 | 6 | 3 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 0 | 2 | 6 | 10 | 8 | 12 | 13 | 10 | 4 | 4 | 9 | 42 | 74 | 93 | 27 | 22 | 40 | 0 | 0 | 3 | 0 | 0 | 2 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 15 | 17 | 19 | 0 | 0 | 0 | 0 | 0 | 3 |
Endosome | 0 | 0 | 2 | 1 | 0 | 2 | 0 | 1 | 2 | 9 | 1 | 6 | 2 | 2 | 5 | 1 | 0 | 0 | 0 | 10 | 8 | 7 | 8 | 21 |
Golgi | 0 | 1 | 8 | 2 | 35 | 0 | 1 | 8 | 1 | 2 | 2 | 1 | 22 | 22 | 7 | 13 | 4 | 10 | 1 | 3 | 6 | 10 | 3 | 15 |
Mitochondria | 68 | 54 | 135 | 107 | 103 | 249 | 283 | 210 | 162 | 203 | 151 | 155 | 128 | 119 | 176 | 29 | 17 | 26 | 1 | 0 | 0 | 5 | 2 | 7 |
Nucleus | 1 | 5 | 4 | 0 | 2 | 7 | 10 | 7 | 7 | 7 | 10 | 8 | 30 | 22 | 14 | 54 | 48 | 47 | 11 | 24 | 13 | 33 | 33 | 28 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 5 | 8 | 17 |
Nucleolus | 132 | 216 | 267 | 232 | 301 | 393 | 510 | 532 | 368 | 386 | 281 | 302 | 519 | 539 | 595 | 144 | 154 | 177 | 104 | 156 | 194 | 364 | 438 | 500 |
Peroxisomes | 0 | 0 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 3 | 3 | 0 | 0 | 1 | 0 | 0 | 6 | 3 | 1 | 7 |
SpindlePole | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 2 | 1 | 4 | 3 | 1 | 0 | 0 | 0 | 9 | 24 | 42 | 31 | 36 | 79 |
Vac/Vac Membrane | 3 | 9 | 6 | 3 | 13 | 6 | 12 | 18 | 14 | 16 | 13 | 10 | 2 | 5 | 13 | 12 | 8 | 7 | 3 | 12 | 10 | 16 | 17 | 25 |
Unique Cell Count | 135 | 230 | 287 | 247 | 340 | 421 | 551 | 588 | 409 | 446 | 328 | 356 | 600 | 650 | 724 | 236 | 220 | 273 | 141 | 247 | 306 | 502 | 583 | 754 |
Labelled Cell Count | 204 | 285 | 425 | 354 | 467 | 666 | 832 | 801 | 573 | 641 | 469 | 505 | 752 | 794 | 910 | 295 | 270 | 327 | 141 | 247 | 306 | 502 | 583 | 754 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 72.1 | 70.0 | 71.1 | 72.5 | 62.0 | 41.7 | 39.2 | 36.8 | 33.5 | 30.1 | 31.0 | 30.3 | 87.3 | 81.3 | 71.3 | 148.0 | 132.0 | 139.5 | 103.2 | 98.8 | 93.9 |
Std Deviation (1e-4) | 21.8 | 18.4 | 19.4 | 20.6 | 24.3 | 11.9 | 12.2 | 11.4 | 10.5 | 9.8 | 9.4 | 9.5 | 28.6 | 31.8 | 29.2 | 46.5 | 42.5 | 48.1 | 31.6 | 32.3 | 29.2 |
Intensity Change (Log2) | – | – | – | 0.03 | -0.2 | -0.77 | -0.86 | -0.95 | -1.09 | -1.24 | -1.2 | -1.23 | 0.3 | 0.19 | 0.0 | 1.06 | 0.89 | 0.97 | 0.54 | 0.47 | 0.4 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.0 | 5.5 | 6.0 | 5.3 | 4.9 | 6.3 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.3 | 4.8 | 4.5 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 3.7 | 0 | 0 | -1.5 | 0 | 0 | 0 | 0 | 0.7 | 0.5 | 0 | 1.6 | -0.7 | 0.6 |
Mitochondria | -0.9 | -4.3 | 3.2 | 1.2 | -3.2 | -2.0 | -0.4 | -0.2 | -0.9 | -7.8 | -9.1 | -7.1 | -8.5 | -9.6 | -9.8 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.4 | 0.8 | 2.6 | 1.7 | 0.6 | 7.8 | 7.5 | 6.5 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0.4 | -1.9 | 0.2 | -0.2 | -1.3 | -1.4 | -2.7 | -2.9 | -3.2 | -2.9 | -4.1 | -4.4 | -8.9 | -6.8 | -8.2 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 1.3 | 0 | 0.1 | 0.8 | 1.0 | 1.2 | 1.3 | 0.6 | 0 | 0 | -0.3 | 1.9 | 1.1 | 0.4 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 83.7006 | 113.5037 | 98.4218 | 107.5842 | 96.4841 | 99.406 | 72.3758 | 111.6533 | 90.9537 | 89.8632 | 77.2915 | 100.8164 | 89.2073 | 128.6561 | 106.6419 | 101.6233 | 111.6202 | 107.6556 |
Actin | 0.005 | 0 | 0.0022 | 0 | 0.0175 | 0 | 0.0063 | 0 | 0.0005 | 0 | 0.001 | 0.0012 | 0.0119 | 0.0024 | 0.0123 | 0.0002 | 0.0004 | 0.0265 |
Bud | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0004 | 0 | 0.0005 | 0.0001 | 0.0001 | 0 | 0.0005 | 0.0001 | 0.0003 | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0.0001 |
Bud Neck | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0055 | 0.0002 | 0.0002 | 0.0001 | 0.0003 | 0.0002 | 0.0008 | 0.0001 | 0.0003 | 0.0001 | 0.0002 | 0.0002 | 0.0003 | 0.0001 |
Bud Periphery | 0.0001 | 0 | 0 | 0 | 0.0005 | 0 | 0.0003 | 0 | 0.0001 | 0 | 0.0003 | 0.0002 | 0.0004 | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0.0001 |
Bud Site | 0.0006 | 0.0001 | 0.0002 | 0.0001 | 0.0004 | 0.0001 | 0.0011 | 0.0002 | 0.0013 | 0.0003 | 0.0022 | 0.0001 | 0.0015 | 0.0011 | 0.0006 | 0.0005 | 0.0003 | 0.0002 |
Cell Periphery | 0.0005 | 0.0002 | 0.0003 | 0.0016 | 0.0018 | 0.0002 | 0.0004 | 0.0004 | 0.0004 | 0.0006 | 0.0009 | 0.0001 | 0.001 | 0.0002 | 0.0003 | 0.0009 | 0.0008 | 0.0001 |
Cytoplasm | 0.0013 | 0.0002 | 0.0039 | 0.0007 | 0.007 | 0.0001 | 0.0033 | 0.0002 | 0.0006 | 0.0003 | 0.0015 | 0.0002 | 0.0063 | 0.0015 | 0.0021 | 0.0009 | 0.0024 | 0.0002 |
Cytoplasmic Foci | 0.0156 | 0.0001 | 0.0032 | 0.0015 | 0.0118 | 0.0036 | 0.0109 | 0.0055 | 0.0084 | 0.0196 | 0.0895 | 0.0008 | 0.0224 | 0.0057 | 0.0319 | 0.0185 | 0.0271 | 0.0038 |
Eisosomes | 0.0002 | 0 | 0.0001 | 0 | 0.0004 | 0 | 0.0001 | 0 | 0 | 0 | 0.0013 | 0 | 0.0015 | 0 | 0.0002 | 0.0002 | 0.0002 | 0.0001 |
Endoplasmic Reticulum | 0.0008 | 0 | 0.0001 | 0 | 0.0003 | 0 | 0.0008 | 0 | 0.0078 | 0.0001 | 0 | 0.0017 | 0.0037 | 0.0001 | 0.0005 | 0.0003 | 0.0002 | 0.0004 |
Endosome | 0.0031 | 0 | 0.0006 | 0.0002 | 0.0023 | 0.0001 | 0.0067 | 0 | 0.0056 | 0.0105 | 0.0013 | 0.016 | 0.01 | 0.0005 | 0.0028 | 0.0011 | 0.0006 | 0.0027 |
Golgi | 0.001 | 0 | 0.0005 | 0 | 0.004 | 0.0001 | 0.0019 | 0 | 0.0027 | 0.002 | 0.0013 | 0.0058 | 0.007 | 0.0003 | 0.0026 | 0.0004 | 0.0006 | 0.0022 |
Lipid Particles | 0.0084 | 0.0001 | 0.0032 | 0.0003 | 0.0104 | 0.0012 | 0.009 | 0.0005 | 0.0167 | 0.0138 | 0.0218 | 0.0011 | 0.0094 | 0.0007 | 0.0121 | 0.0084 | 0.0104 | 0.0044 |
Mitochondria | 0.0058 | 0.0003 | 0.0024 | 0.0003 | 0.0052 | 0.0011 | 0.0112 | 0.0016 | 0.0023 | 0.0013 | 0.0338 | 0.0019 | 0.0129 | 0.0036 | 0.0044 | 0.0075 | 0.007 | 0.0027 |
None | 0.003 | 0 | 0.0024 | 0 | 0.001 | 0.0001 | 0.0053 | 0.0002 | 0.0001 | 0.0001 | 0.0063 | 0.0001 | 0.0096 | 0.0003 | 0.0049 | 0.0043 | 0.0064 | 0.0008 |
Nuclear Periphery | 0.0019 | 0.0004 | 0.0011 | 0.0002 | 0.0062 | 0.0008 | 0.0098 | 0.0001 | 0.0013 | 0.0003 | 0.0006 | 0.0089 | 0.0077 | 0.0011 | 0.0003 | 0.001 | 0.0067 | 0.0022 |
Nucleolus | 0.818 | 0.8203 | 0.8524 | 0.8 | 0.779 | 0.8816 | 0.7751 | 0.8496 | 0.8741 | 0.8261 | 0.7549 | 0.868 | 0.7852 | 0.8702 | 0.8332 | 0.8883 | 0.7965 | 0.8316 |
Nucleus | 0.1112 | 0.1771 | 0.1124 | 0.1049 | 0.1229 | 0.0955 | 0.1308 | 0.1386 | 0.0688 | 0.1076 | 0.0633 | 0.0794 | 0.0897 | 0.1096 | 0.0827 | 0.0586 | 0.1065 | 0.1158 |
Peroxisomes | 0.0017 | 0 | 0.008 | 0 | 0.004 | 0.0001 | 0.004 | 0.0001 | 0.002 | 0.0008 | 0.0049 | 0.0001 | 0.0051 | 0.0003 | 0.0056 | 0.0012 | 0.0005 | 0.0023 |
Punctate Nuclear | 0.016 | 0.0007 | 0.0037 | 0.0131 | 0.0121 | 0.0117 | 0.0195 | 0.0012 | 0.0048 | 0.0109 | 0.0084 | 0.0119 | 0.0115 | 0.0009 | 0.0016 | 0.0033 | 0.0296 | 0.0026 |
Vacuole | 0.0025 | 0.0003 | 0.0017 | 0.0573 | 0.0033 | 0.0008 | 0.0012 | 0.0009 | 0.0011 | 0.0025 | 0.0022 | 0.0008 | 0.0012 | 0.0006 | 0.0009 | 0.0019 | 0.0012 | 0.0004 |
Vacuole Periphery | 0.0028 | 0.0004 | 0.0012 | 0.0194 | 0.0039 | 0.0025 | 0.0017 | 0.0005 | 0.0009 | 0.0031 | 0.003 | 0.0016 | 0.0015 | 0.0004 | 0.0008 | 0.0018 | 0.0021 | 0.0006 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 401.0366 | 503.8837 | 405.0621 | 198.5808 | 357.3658 | 311.7939 | 236.9145 | 134.8956 | 147.461 | 205.3423 |
Translational Efficiency | 2.6263 | 2.278 | 2.0896 | 3.0783 | 2.0396 | 1.8077 | 1.9912 | 2.7492 | 1.5932 | 2.0158 |
Dataset | Hit |
---|---|
Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
---|
Gene | Images |
---|
Gene | Images |
---|