Standard name | |
---|---|
Human Ortholog | |
Description | Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx1p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases under DNA replication stress; TRX2 has a paralog, TRX1, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | – | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 1 | – | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 1 | 4 | 4 | 0 | 1 | 2 | 7 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 4 | – | 5 | 0 | 8 | 0 | 0 | 1 | 2 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 386 | 349 | 161 | 138 | 185 | 161 | 134 | 154 | – | 152 | 162 | 228 | 257 | 265 | 285 | 313 | 351 | 261 | 370 | 332 | 144 | 127 | 230 | 211 |
Endoplasmic Reticulum | 0 | 2 | 1 | 0 | 4 | 5 | 15 | 12 | – | 11 | 9 | 25 | 5 | 3 | 0 | 5 | 18 | 8 | 1 | 2 | 0 | 6 | 1 | 3 |
Endosome | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | – | 0 | 1 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | – | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5 | 5 | 2 | 3 | 5 | 7 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | – | 2 | 0 | 4 | 1 | 1 | 1 | 0 | 0 | 1 | 2 | 1 | 0 | 2 | 6 | 8 |
Unique Cell Count | 388 | 354 | 163 | 139 | 189 | 167 | 148 | 174 | 170 | 173 | 263 | 262 | 269 | 286 | 314 | 351 | 262 | 390 | 353 | 149 | 150 | 253 | 246 | |
Labelled Cell Count | 390 | 356 | 163 | 141 | 190 | 167 | 149 | 177 | 175 | 176 | 274 | 265 | 270 | 287 | 322 | 374 | 273 | 390 | 353 | 149 | 150 | 253 | 246 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 82.3 | 75.3 | 49.9 | 58.3 | 58.4 | 56.4 | 52.9 | 54.3 | – | 53.0 | 50.6 | 52.2 | 91.0 | 99.7 | 99.3 | 81.8 | 79.9 | 80.7 | 58.5 | 68.1 | 70.7 |
Std Deviation (1e-4) | 21.8 | 23.1 | 12.2 | 14.7 | 13.7 | 12.9 | 17.1 | 18.7 | – | 17.1 | 13.5 | 18.0 | 27.3 | 30.9 | 30.9 | 21.8 | 21.0 | 22.5 | 18.4 | 20.9 | 29.9 |
Intensity Change (Log2) | – | – | – | 0.22 | 0.23 | 0.18 | 0.09 | 0.12 | – | 0.09 | 0.02 | 0.07 | 0.87 | 1.0 | 0.99 | 0.72 | 0.68 | 0.69 | 0.23 | 0.45 | 0.5 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.4 | -0.6 | -1.4 | -3.3 | -3.8 | – | -3.6 | -2.4 | -4.3 | -0.5 | -0.2 | 1.1 | 1.2 | 2.1 | 1.0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 3.8 | 3.0 | – | 2.9 | 0 | 3.7 | 0 | 0 | 0 | 0 | 2.5 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | -0.8733 | -0.492 | -0.584 | -0.9632 | -0.754 | -0.4702 | 0.9365 | 1.7869 | 1.3937 | 1.3522 | 1.377 | 1.6734 | -0.6385 | -0.2346 | -0.1238 | -0.159 | 0.0101 | -0.2029 |
Actin | 0.0205 | 0.0003 | 0.0003 | 0.0004 | 0.0047 | 0.0014 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0023 | 0.0001 | 0.0019 | 0.0047 | 0.0011 | 0.016 |
Bud | 0.0062 | 0.0041 | 0.0048 | 0.0075 | 0.0005 | 0.0021 | 0 | 0 | 0.0002 | 0 | 0 | 0.0009 | 0.0004 | 0.0011 | 0.0001 | 0.0003 | 0.0056 | 0.0001 |
Bud Neck | 0.002 | 0.0002 | 0.0011 | 0.0004 | 0.0134 | 0.0005 | 0 | 0 | 0 | 0 | 0 | 0.0002 | 0.0014 | 0.0001 | 0.0002 | 0.0006 | 0.002 | 0.0003 |
Bud Periphery | 0.0033 | 0.0034 | 0.0035 | 0.0103 | 0.0006 | 0.0007 | 0 | 0.0002 | 0.0002 | 0 | 0 | 0.0002 | 0.0009 | 0.0012 | 0.0004 | 0.0005 | 0.0294 | 0.0001 |
Bud Site | 0.0135 | 0.0155 | 0.0048 | 0.0081 | 0.0011 | 0.0011 | 0 | 0.0001 | 0.0004 | 0 | 0 | 0.0002 | 0.0224 | 0.0044 | 0.0003 | 0.0009 | 0.0047 | 0.0002 |
Cell Periphery | 0.0004 | 0.0006 | 0.0001 | 0.0003 | 0.0001 | 0.0001 | 0 | 0.0002 | 0.0001 | 0 | 0 | 0 | 0.001 | 0.0001 | 0.0003 | 0.0002 | 0.0007 | 0 |
Cytoplasm | 0.0127 | 0.0121 | 0.0094 | 0.0129 | 0.0202 | 0.0205 | 0.0354 | 0.0321 | 0.0297 | 0.0096 | 0.019 | 0.0459 | 0.0314 | 0.0341 | 0.0406 | 0.0488 | 0.0267 | 0.0842 |
Cytoplasmic Foci | 0.0213 | 0.0016 | 0.0088 | 0.0022 | 0.0222 | 0.0086 | 0.001 | 0.0023 | 0.0011 | 0.0004 | 0.0014 | 0.0037 | 0.0614 | 0.0028 | 0.0097 | 0.0083 | 0.0129 | 0.0082 |
Eisosomes | 0.0003 | 0.0002 | 0.0001 | 0.0006 | 0.0002 | 0.0001 | 0.0002 | 0.0003 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0014 | 0.0001 | 0.0004 | 0.0009 | 0.0004 | 0.0002 |
Endoplasmic Reticulum | 0.001 | 0.0002 | 0.0002 | 0.0016 | 0.001 | 0.0004 | 0.0002 | 0.0002 | 0.0003 | 0.0001 | 0.0001 | 0.0002 | 0.0019 | 0.0004 | 0.0025 | 0.0025 | 0.0029 | 0.0004 |
Endosome | 0.0054 | 0.0001 | 0.0001 | 0.0003 | 0.0035 | 0.0031 | 0.0001 | 0.0004 | 0.0002 | 0 | 0 | 0.0001 | 0.0546 | 0.0026 | 0.0143 | 0.0037 | 0.0877 | 0.0044 |
Golgi | 0.0015 | 0 | 0 | 0.0001 | 0.0009 | 0.0016 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0.0112 | 0.0007 | 0.0063 | 0.0004 | 0.0051 | 0.01 |
Lipid Particles | 0.0017 | 0.0001 | 0.0003 | 0.0004 | 0.0016 | 0.0012 | 0 | 0.0001 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0147 | 0.0022 | 0.0116 | 0.001 | 0.0043 | 0.0049 |
Mitochondria | 0.0018 | 0.0005 | 0.0003 | 0.0004 | 0.0003 | 0.0011 | 0 | 0.0008 | 0.0003 | 0 | 0.0001 | 0.0002 | 0.0162 | 0.0002 | 0.0235 | 0.0004 | 0.0158 | 0.0043 |
None | 0.8935 | 0.945 | 0.9547 | 0.9462 | 0.9135 | 0.9389 | 0.9626 | 0.9623 | 0.9643 | 0.9896 | 0.9785 | 0.9458 | 0.7558 | 0.948 | 0.8711 | 0.9209 | 0.7731 | 0.8576 |
Nuclear Periphery | 0.0034 | 0.0003 | 0.0003 | 0.0004 | 0.0027 | 0.0013 | 0 | 0 | 0.0003 | 0 | 0.0001 | 0.0001 | 0.0024 | 0.0001 | 0.0022 | 0.0012 | 0.0016 | 0.0001 |
Nucleolus | 0.0007 | 0.0011 | 0.0011 | 0.0008 | 0.0011 | 0.0009 | 0 | 0.0001 | 0.0002 | 0 | 0 | 0.0002 | 0.0031 | 0.0001 | 0.0002 | 0.0003 | 0.0021 | 0 |
Nucleus | 0.0012 | 0.0066 | 0.0018 | 0.0026 | 0.0017 | 0.0021 | 0.0001 | 0.0001 | 0.0006 | 0 | 0.0001 | 0.0008 | 0.0029 | 0.0002 | 0.0013 | 0.0006 | 0.0019 | 0.0001 |
Peroxisomes | 0.002 | 0.0002 | 0.0001 | 0.0002 | 0.0006 | 0.0007 | 0 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0072 | 0.0005 | 0.0072 | 0.001 | 0.0011 | 0.0083 |
Punctate Nuclear | 0.0042 | 0.0073 | 0.0079 | 0.0038 | 0.0096 | 0.0131 | 0.0001 | 0.0001 | 0.0013 | 0 | 0.0002 | 0.001 | 0.0015 | 0.0002 | 0.0009 | 0.0015 | 0.0011 | 0.0003 |
Vacuole | 0.0026 | 0.0003 | 0.0002 | 0.0005 | 0.0005 | 0.0003 | 0.0001 | 0.0003 | 0.0003 | 0 | 0 | 0.0001 | 0.0047 | 0.0006 | 0.0035 | 0.0011 | 0.0159 | 0.0001 |
Vacuole Periphery | 0.0007 | 0 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0.0012 | 0 | 0.0016 | 0.0003 | 0.0038 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 446.6161 | 535.4614 | 594.8413 | 770.076 | 554.0783 | 448.1193 | 683.8793 | 728.6861 | 734.5233 | 644.5424 |
Translational Efficiency | 2.3186 | 2.3509 | 2.5578 | 1.8871 | 2.7477 | 3.043 | 2.3771 | 2.7943 | 2.8368 | 2.4659 |
Dataset | Hit |
---|---|
Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
---|
Gene | Images |
---|
Gene | Images |
---|