Standard name | |
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Human Ortholog | |
Description | Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR) |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 2 | 1 | 4 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 15 | 2 | 1 | 4 | 9 | 5 | 1 | 1 | 1 | 3 | 6 | 12 |
Bud | 0 | 4 | 0 | 8 | 4 | 3 | 13 | 6 | 4 | 7 | 5 | 7 | 8 | 2 | 2 | 4 | 3 | 2 | 0 | 1 | 0 | 1 | 5 | 8 |
Bud Neck | 0 | 0 | 2 | 2 | 0 | 1 | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 3 | 5 | 16 |
Bud Site | 0 | 0 | 1 | 1 | 3 | 1 | 11 | 4 | 4 | 5 | 4 | 4 | 1 | 0 | 0 | 0 | 1 | 2 | – | – | – | – | – | – |
Cell Periphery | 0 | 1 | 5 | 2 | 3 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 13 | 8 | 8 | 11 | 14 | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 4 | 3 | 7 | 10 | 10 | 18 | 8 | 6 | 10 | 7 | 8 | 15 | 25 | 32 | 16 | 21 | 18 | 0 | 1 | 0 | 0 | 0 | 3 |
Endoplasmic Reticulum | 1 | 1 | 2 | 0 | 4 | 1 | 1 | 3 | 0 | 2 | 0 | 4 | 2 | 3 | 10 | 4 | 5 | 4 | 0 | 0 | 2 | 0 | 2 | 3 |
Endosome | 0 | 7 | 7 | 7 | 31 | 8 | 8 | 13 | 2 | 8 | 1 | 2 | 27 | 105 | 131 | 20 | 24 | 9 | 2 | 10 | 9 | 36 | 59 | 64 |
Golgi | 0 | 1 | 11 | 14 | 30 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 55 | 80 | 89 | 52 | 36 | 22 | 5 | 6 | 1 | 14 | 16 | 25 |
Mitochondria | 93 | 96 | 52 | 126 | 202 | 154 | 330 | 269 | 221 | 312 | 243 | 246 | 206 | 219 | 134 | 27 | 10 | 20 | 73 | 95 | 92 | 235 | 375 | 459 |
Nucleus | 1 | 10 | 7 | 15 | 12 | 14 | 14 | 23 | 17 | 9 | 14 | 18 | 27 | 45 | 36 | 31 | 33 | 25 | 0 | 6 | 3 | 7 | 10 | 8 |
Nuclear Periphery | 4 | 4 | 0 | 1 | 7 | 12 | 13 | 14 | 13 | 28 | 11 | 14 | 7 | 6 | 3 | 1 | 3 | 2 | 0 | 1 | 0 | 6 | 6 | 9 |
Nucleolus | 11 | 9 | 4 | 16 | 11 | 16 | 41 | 20 | 14 | 16 | 16 | 23 | 23 | 32 | 21 | 69 | 62 | 55 | 0 | 6 | 5 | 15 | 32 | 31 |
Peroxisomes | 1 | 3 | 3 | 1 | 3 | 2 | 6 | 6 | 5 | 3 | 2 | 3 | 17 | 29 | 50 | 7 | 7 | 5 | 5 | 3 | 8 | 20 | 31 | 54 |
SpindlePole | 0 | 4 | 10 | 33 | 28 | 24 | 41 | 35 | 9 | 15 | 6 | 20 | 41 | 64 | 67 | 27 | 24 | 15 | 0 | 5 | 4 | 18 | 51 | 39 |
Vac/Vac Membrane | 9 | 35 | 13 | 11 | 30 | 24 | 21 | 11 | 11 | 24 | 12 | 16 | 59 | 102 | 104 | 36 | 23 | 21 | 1 | 21 | 7 | 15 | 26 | 33 |
Unique Cell Count | 96 | 147 | 92 | 180 | 282 | 222 | 405 | 347 | 249 | 356 | 268 | 288 | 365 | 525 | 516 | 228 | 204 | 166 | 93 | 165 | 141 | 385 | 639 | 783 |
Labelled Cell Count | 120 | 181 | 121 | 248 | 378 | 273 | 522 | 416 | 309 | 442 | 322 | 366 | 516 | 725 | 688 | 309 | 275 | 210 | 93 | 165 | 141 | 385 | 639 | 783 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.9 | 6.0 | 6.8 | 6.3 | 6.9 | 5.8 | 5.4 | 5.7 | 5.2 | 5.5 | 4.8 | 5.2 | 7.2 | 7.0 | 6.9 | 10.1 | 10.4 | 10.1 | 6.4 | 6.5 | 6.9 |
Std Deviation (1e-4) | 0.9 | 1.3 | 1.8 | 1.6 | 1.5 | 1.4 | 1.6 | 1.3 | 1.7 | 1.6 | 1.4 | 1.3 | 1.3 | 1.2 | 1.3 | 3.2 | 3.5 | 3.2 | 1.3 | 1.4 | 1.5 |
Intensity Change (Log2) | – | – | – | -0.1 | 0.02 | -0.23 | -0.33 | -0.24 | -0.38 | -0.3 | -0.48 | -0.39 | 0.09 | 0.04 | 0.03 | 0.58 | 0.61 | 0.57 | -0.08 | -0.06 | 0.02 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.5 | 0 |
Cytoplasm | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.1 | 1.3 | 2.1 | 2.1 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0.9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -0.1 | 2.8 | 3.8 | 0.3 | 1.1 | -0.7 |
Golgi | -1.1 | -0.4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.8 | 0.8 | 1.3 | 2.2 | 1.2 | 0.3 |
Mitochondria | 2.2 | 2.7 | 2.2 | 5.1 | 4.0 | 6.6 | 6.8 | 0 | 5.9 | 0 | -2.6 | -5.9 | -8.4 | -10.1 | -7.6 |
Nucleus | 0.2 | 0 | -0.4 | 0 | -0.3 | -0.3 | 0 | -0.8 | -0.5 | -0.1 | 0.3 | -0.2 | 1.5 | 2.0 | 1.7 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 2.8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 1.4 | 0 | 0.9 | 1.7 | 0.5 | 0 | 0 | 0 | 1.2 | 0.7 | 0.7 | 0 | 5.0 | 5.0 | 5.3 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.0 | 0 | 0 | 0 |
SpindlePole | 1.6 | -0.3 | 0 | -0.2 | -0.2 | -2.6 | -2.5 | 0 | -1.2 | 0.1 | 0.4 | 0.6 | 0.2 | 0.2 | -0.5 |
Vacuole | -2.2 | -0.9 | -0.8 | -3.1 | -4.1 | -3.1 | -2.3 | -3.1 | -2.7 | 0.5 | 1.2 | 1.4 | 0.4 | -0.7 | -0.3 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.3217 | 5.7335 | 4.986 | 4.8846 | 4.0302 | 4.6385 | 6.6309 | 7.3263 | 6.8317 | 6.9124 | 6.0457 | 7.1572 | 7.4417 | 6.7532 | 6.6504 | 6.0197 | 6.0591 | 7.1924 |
Actin | 0.0722 | 0.0101 | 0.0437 | 0.0202 | 0.1825 | 0.0323 | 0.0108 | 0.0144 | 0.0039 | 0.0002 | 0.0044 | 0.0155 | 0.029 | 0.0267 | 0.0313 | 0.0536 | 0.0193 | 0.015 |
Bud | 0.0009 | 0.0037 | 0.0034 | 0.0003 | 0.0002 | 0.0003 | 0.0005 | 0.0037 | 0.002 | 0.003 | 0.0001 | 0.0003 | 0.0015 | 0.0031 | 0.0012 | 0.0009 | 0.0005 | 0.0005 |
Bud Neck | 0.0044 | 0.0009 | 0.0037 | 0.0005 | 0.0003 | 0.0137 | 0.0004 | 0.0007 | 0.0004 | 0.0003 | 0.0001 | 0.0003 | 0.0028 | 0.0006 | 0.0023 | 0.0003 | 0.0003 | 0.0006 |
Bud Periphery | 0.0013 | 0.0057 | 0.0052 | 0.0004 | 0.0002 | 0.0005 | 0.001 | 0.0061 | 0.003 | 0.0038 | 0.0003 | 0.0006 | 0.0016 | 0.0032 | 0.0016 | 0.0011 | 0.0008 | 0.0008 |
Bud Site | 0.0108 | 0.0144 | 0.0069 | 0.0007 | 0.0003 | 0.0005 | 0.0015 | 0.0077 | 0.008 | 0.003 | 0.0001 | 0.0003 | 0.0081 | 0.0084 | 0.0068 | 0.0016 | 0.0009 | 0.0006 |
Cell Periphery | 0.0005 | 0.0012 | 0.0008 | 0.0001 | 0.0001 | 0.0002 | 0.0013 | 0.0011 | 0.0005 | 0.0007 | 0.0001 | 0.0002 | 0.0009 | 0.0008 | 0.001 | 0.0002 | 0.0004 | 0.0004 |
Cytoplasm | 0.0062 | 0.0006 | 0.0045 | 0.0002 | 0.0001 | 0.0006 | 0.0004 | 0.0007 | 0.0017 | 0.0002 | 0.0001 | 0.0001 | 0.019 | 0.0011 | 0.0023 | 0.0018 | 0.0088 | 0.0002 |
Cytoplasmic Foci | 0.0543 | 0.0121 | 0.0294 | 0.023 | 0.0033 | 0.0068 | 0.0265 | 0.0183 | 0.0181 | 0.003 | 0.0035 | 0.0046 | 0.0267 | 0.0228 | 0.0173 | 0.0276 | 0.012 | 0.006 |
Eisosomes | 0.0014 | 0.0003 | 0.0004 | 0.0002 | 0.0002 | 0.0004 | 0.0003 | 0.0003 | 0.0002 | 0.0001 | 0.0002 | 0.0002 | 0.0005 | 0.0003 | 0.0006 | 0.0003 | 0.0003 | 0.0003 |
Endoplasmic Reticulum | 0.0039 | 0.0003 | 0.0008 | 0.0001 | 0.0002 | 0.002 | 0.0046 | 0.0011 | 0.0004 | 0.0001 | 0.0001 | 0.0003 | 0.0017 | 0.0005 | 0.0011 | 0.0018 | 0.004 | 0.0002 |
Endosome | 0.0689 | 0.0379 | 0.037 | 0.0099 | 0.0196 | 0.0109 | 0.0391 | 0.045 | 0.0471 | 0.0192 | 0.0144 | 0.0109 | 0.0361 | 0.0519 | 0.0417 | 0.0382 | 0.0537 | 0.0214 |
Golgi | 0.0687 | 0.0591 | 0.0486 | 0.0653 | 0.0589 | 0.0217 | 0.04 | 0.0751 | 0.0674 | 0.0093 | 0.1331 | 0.0396 | 0.0595 | 0.1011 | 0.0821 | 0.0799 | 0.0513 | 0.0957 |
Lipid Particles | 0.053 | 0.0227 | 0.036 | 0.0055 | 0.0585 | 0.0234 | 0.054 | 0.0477 | 0.0164 | 0.0038 | 0.004 | 0.0135 | 0.0725 | 0.0511 | 0.0243 | 0.0439 | 0.048 | 0.0128 |
Mitochondria | 0.512 | 0.7546 | 0.7087 | 0.8104 | 0.6562 | 0.8084 | 0.7351 | 0.6786 | 0.7616 | 0.9166 | 0.8293 | 0.8849 | 0.6578 | 0.6602 | 0.733 | 0.6844 | 0.7048 | 0.8291 |
None | 0.019 | 0.0002 | 0.0004 | 0.0001 | 0.0001 | 0.021 | 0.0006 | 0.0002 | 0.0023 | 0.0001 | 0 | 0.0002 | 0.0138 | 0.0003 | 0.0018 | 0.0037 | 0.0056 | 0.0001 |
Nuclear Periphery | 0.0131 | 0.0005 | 0.0025 | 0 | 0.0005 | 0.0108 | 0.006 | 0.0028 | 0.0008 | 0 | 0 | 0.0009 | 0.0023 | 0.0013 | 0.0005 | 0.0018 | 0.012 | 0.0002 |
Nucleolus | 0.0044 | 0.0135 | 0.0199 | 0.0001 | 0.0001 | 0.0009 | 0.0066 | 0.0101 | 0.0061 | 0.0025 | 0 | 0.0012 | 0.0133 | 0.0069 | 0.0021 | 0.001 | 0.0079 | 0.0013 |
Nucleus | 0.0071 | 0.0013 | 0.002 | 0 | 0 | 0.0006 | 0.0017 | 0.0079 | 0.0013 | 0.0004 | 0 | 0.0004 | 0.0023 | 0.0013 | 0.0008 | 0.0007 | 0.0101 | 0.0002 |
Peroxisomes | 0.0566 | 0.0188 | 0.0291 | 0.0603 | 0.0023 | 0.0321 | 0.0435 | 0.0397 | 0.0443 | 0.0112 | 0.0077 | 0.0194 | 0.0241 | 0.0196 | 0.0261 | 0.0492 | 0.0273 | 0.0079 |
Punctate Nuclear | 0.0184 | 0.0015 | 0.0011 | 0.0007 | 0 | 0.0009 | 0.0024 | 0.0003 | 0.002 | 0 | 0 | 0.0005 | 0.0017 | 0.0002 | 0.0007 | 0.0016 | 0.0015 | 0 |
Vacuole | 0.0097 | 0.0247 | 0.01 | 0.0005 | 0.0016 | 0.0025 | 0.0102 | 0.0229 | 0.0071 | 0.0169 | 0.0009 | 0.0015 | 0.012 | 0.0176 | 0.0075 | 0.0031 | 0.0126 | 0.0019 |
Vacuole Periphery | 0.0129 | 0.0157 | 0.0057 | 0.0016 | 0.0147 | 0.0094 | 0.0135 | 0.0157 | 0.0054 | 0.0056 | 0.0017 | 0.0046 | 0.0127 | 0.0209 | 0.0138 | 0.0034 | 0.0179 | 0.0051 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 65.6366 | 53.9177 | 61.9751 | 101.6811 | 65.9339 | 79.1931 | 100.4807 | 125.5348 | 132.9393 | 107.3278 |
Translational Efficiency | 1.6073 | 1.6046 | 1.6612 | 1.0289 | 1.4008 | 1.7032 | 1.3548 | 1.2745 | 1.2246 | 1.1741 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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