Standard name | |
---|---|
Human Ortholog | |
Description | Protein kinase; component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; Pyrococcus Bud32 ortholog functions as a P-loop ATPase rather than a protein kinase in the context of the complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; mutation is functionally complemented by human TP53RK |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2 | 1 | 1 | 4 | 4 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 1 | 2 | 1 | 1 | 3 | 8 | 4 | 6 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 3 | 5 | 3 | 5 | 6 | 7 | 18 | 16 | 8 | 11 | 6 | 8 | 5 | 26 | 43 | 61 | 50 | 58 | 2 | 3 | 1 | 4 | 2 | 2 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 18 | 13 | 19 | 0 | 0 | 0 | 1 | 0 | 0 |
Endosome | 0 | 0 | 0 | 2 | 1 | 0 | 4 | 2 | 1 | 0 | 0 | 0 | 0 | 3 | 2 | 4 | 7 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Golgi | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4 | 1 | 2 | 1 | 0 | 0 | 0 | 0 |
Mitochondria | 2 | 38 | 0 | 6 | 2 | 4 | 6 | 11 | 58 | 25 | 41 | 31 | 1 | 1 | 0 | 10 | 11 | 13 | 0 | 2 | 1 | 0 | 0 | 1 |
Nucleus | 67 | 164 | 49 | 71 | 101 | 141 | 165 | 258 | 168 | 165 | 153 | 159 | 44 | 154 | 153 | 301 | 283 | 250 | 87 | 190 | 77 | 68 | 161 | 137 |
Nuclear Periphery | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 3 | 2 | 1 | 6 | 0 | 2 | 1 | 1 | 17 | 14 | 22 | 17 | 0 | 0 | 1 | 0 | 1 | 4 | 0 | 0 | 1 | 2 | 1 | 11 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2 |
Vac/Vac Membrane | 13 | 25 | 5 | 8 | 12 | 14 | 14 | 8 | 8 | 7 | 7 | 16 | 8 | 16 | 10 | 49 | 71 | 69 | 3 | 10 | 3 | 6 | 10 | 19 |
Unique Cell Count | 80 | 205 | 56 | 88 | 120 | 162 | 200 | 280 | 215 | 194 | 192 | 203 | 54 | 197 | 204 | 400 | 391 | 367 | 102 | 215 | 94 | 89 | 186 | 182 |
Labelled Cell Count | 89 | 234 | 58 | 100 | 125 | 169 | 209 | 299 | 269 | 227 | 235 | 236 | 58 | 202 | 211 | 445 | 441 | 417 | 102 | 215 | 94 | 89 | 186 | 182 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 8.9 | 5.8 | 8.7 | 7.7 | 9.2 | 7.6 | 7.6 | 7.7 | 6.6 | 7.3 | 6.7 | 6.9 | 7.2 | 8.6 | 8.5 | 6.7 | 9.0 | 8.2 | 9.9 | 9.7 | 9.7 |
Std Deviation (1e-4) | 1.9 | 0.9 | 1.7 | 1.6 | 2.2 | 1.7 | 1.8 | 1.6 | 1.5 | 1.7 | 1.6 | 1.8 | 1.5 | 2.0 | 2.0 | 1.6 | 1.9 | 2.0 | 2.7 | 2.1 | 1.6 |
Intensity Change (Log2) | – | – | – | -0.16 | 0.08 | -0.19 | -0.18 | -0.17 | -0.4 | -0.25 | -0.37 | -0.32 | -0.26 | -0.01 | -0.03 | -0.37 | 0.05 | -0.07 | 0.19 | 0.17 | 0.17 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.6 | 2.7 | 2.0 | 1.6 | 2.1 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 4.4 | 2.8 | 3.8 | 3.1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | -1.1 | -0.6 | -0.1 | -0.9 | 1.1 | -1.6 | -0.5 | -1.3 | -1.5 | -0.9 | -1.5 | -2.0 | -2.0 | -2.4 | -3.0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.0 | 0 | 0 | 0.7 | 1.7 | 1.8 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 3.034 | 3.2255 | 2.9653 | 1.9922 | 2.6268 | 2.7427 | 5.7404 | 6.9868 | 6.1838 | 5.7754 | 5.7256 | 6.3386 | 2.8415 | 3.4893 | 2.8965 | 3.2593 | 3.1121 | 3.182 |
Actin | 0.0229 | 0 | 0.0122 | 0.0001 | 0.0152 | 0.0051 | 0.0122 | 0 | 0.0094 | 0.0162 | 0.0049 | 0.0113 | 0.0374 | 0.0001 | 0.0041 | 0.0015 | 0.0137 | 0.0058 |
Bud | 0.0002 | 0 | 0.0001 | 0 | 0.0008 | 0.0001 | 0.0003 | 0.0001 | 0.001 | 0.0003 | 0 | 0.0003 | 0.0009 | 0.0003 | 0.0004 | 0.0001 | 0.0018 | 0.0003 |
Bud Neck | 0.001 | 0.0001 | 0.0003 | 0.0002 | 0.0014 | 0.0009 | 0.0029 | 0.0002 | 0.0009 | 0.0009 | 0.001 | 0.0018 | 0.0024 | 0.0003 | 0.0018 | 0.0007 | 0.0009 | 0.0018 |
Bud Periphery | 0.0005 | 0 | 0.0001 | 0 | 0.0017 | 0.0001 | 0.0004 | 0 | 0.002 | 0.0007 | 0.0001 | 0.0005 | 0.0012 | 0.0002 | 0.0008 | 0.0001 | 0.0024 | 0.0006 |
Bud Site | 0.0005 | 0.0001 | 0.0007 | 0.0001 | 0.0052 | 0.0001 | 0.003 | 0.0004 | 0.0043 | 0.0007 | 0.0001 | 0.0005 | 0.0027 | 0.0009 | 0.0027 | 0.0004 | 0.004 | 0.0006 |
Cell Periphery | 0.0001 | 0 | 0 | 0 | 0.0003 | 0 | 0.0002 | 0 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0.0002 | 0.0001 |
Cytoplasm | 0.0052 | 0.0055 | 0.0193 | 0.0052 | 0.0024 | 0.001 | 0.0078 | 0.0291 | 0.0091 | 0.0017 | 0.0046 | 0.0072 | 0.0057 | 0.0198 | 0.0055 | 0.0035 | 0.0061 | 0.014 |
Cytoplasmic Foci | 0.0017 | 0.0005 | 0.0023 | 0.0289 | 0.0058 | 0.0003 | 0.0059 | 0.0003 | 0.0044 | 0.0015 | 0.0055 | 0.0015 | 0.0169 | 0.0001 | 0.004 | 0.0007 | 0.0157 | 0.0005 |
Eisosomes | 0.0003 | 0 | 0.0001 | 0 | 0.0003 | 0 | 0.0002 | 0 | 0.0001 | 0.0002 | 0 | 0.0001 | 0.0002 | 0 | 0 | 0 | 0.0001 | 0.0001 |
Endoplasmic Reticulum | 0.0031 | 0.0002 | 0.0016 | 0.0001 | 0.0052 | 0.0002 | 0.0018 | 0.0006 | 0.0012 | 0.0003 | 0.002 | 0.0008 | 0.0013 | 0.0005 | 0.001 | 0.0002 | 0.0042 | 0.0074 |
Endosome | 0.009 | 0.0003 | 0.0068 | 0.0002 | 0.0422 | 0.0018 | 0.0068 | 0.0003 | 0.0074 | 0.0028 | 0.0125 | 0.0033 | 0.0155 | 0.0006 | 0.0059 | 0.0052 | 0.0362 | 0.0051 |
Golgi | 0.0051 | 0 | 0.0012 | 0.0003 | 0.0102 | 0.0014 | 0.0021 | 0 | 0.004 | 0.0013 | 0.0028 | 0.0028 | 0.0078 | 0 | 0.0015 | 0.0071 | 0.0208 | 0.001 |
Lipid Particles | 0.0073 | 0 | 0.003 | 0.0014 | 0.021 | 0.0005 | 0.005 | 0 | 0.009 | 0.0031 | 0.0271 | 0.0037 | 0.015 | 0 | 0.0071 | 0.0131 | 0.0128 | 0.001 |
Mitochondria | 0.0116 | 0.0001 | 0.0008 | 0.0002 | 0.0278 | 0.0004 | 0.0028 | 0.0001 | 0.0102 | 0.0101 | 0.0008 | 0.0024 | 0.0057 | 0.0004 | 0.0023 | 0.0101 | 0.0039 | 0.0056 |
None | 0.0013 | 0.0031 | 0.003 | 0.0001 | 0.0015 | 0.0001 | 0.0047 | 0.0035 | 0.003 | 0.0012 | 0.0023 | 0.0047 | 0.0019 | 0.0002 | 0.0014 | 0.0002 | 0.002 | 0.0167 |
Nuclear Periphery | 0.0216 | 0.009 | 0.0167 | 0.0033 | 0.0491 | 0.002 | 0.0197 | 0.0035 | 0.0062 | 0.0024 | 0.0181 | 0.0036 | 0.0136 | 0.0079 | 0.007 | 0.0032 | 0.0121 | 0.0127 |
Nucleolus | 0.0028 | 0.0021 | 0.0013 | 0.0013 | 0.004 | 0.004 | 0.0053 | 0.0024 | 0.0044 | 0.0026 | 0.0039 | 0.0039 | 0.0035 | 0.0022 | 0.003 | 0.0027 | 0.0033 | 0.0056 |
Nucleus | 0.896 | 0.9719 | 0.9164 | 0.9257 | 0.7738 | 0.9808 | 0.8985 | 0.9541 | 0.9093 | 0.9442 | 0.8811 | 0.9464 | 0.8396 | 0.9622 | 0.941 | 0.9491 | 0.8459 | 0.9162 |
Peroxisomes | 0.0029 | 0 | 0.0091 | 0.0311 | 0.0128 | 0.0002 | 0.0092 | 0 | 0.0064 | 0.0062 | 0.0084 | 0.0016 | 0.016 | 0 | 0.0052 | 0.0005 | 0.0025 | 0.0003 |
Punctate Nuclear | 0.0037 | 0.0065 | 0.0029 | 0.0015 | 0.0052 | 0.0005 | 0.0089 | 0.0051 | 0.0033 | 0.0022 | 0.0234 | 0.0026 | 0.0094 | 0.0025 | 0.0031 | 0.0006 | 0.0049 | 0.0021 |
Vacuole | 0.0017 | 0.0004 | 0.0017 | 0.0001 | 0.0059 | 0.0003 | 0.0016 | 0.0003 | 0.0028 | 0.001 | 0.0005 | 0.0005 | 0.0023 | 0.0015 | 0.0012 | 0.0004 | 0.0047 | 0.0014 |
Vacuole Periphery | 0.0015 | 0.0001 | 0.0004 | 0 | 0.008 | 0.0001 | 0.0008 | 0 | 0.0011 | 0.0005 | 0.0008 | 0.0003 | 0.0008 | 0.0003 | 0.0006 | 0.0006 | 0.0018 | 0.0012 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 26.6726 | 13.8042 | 17.6931 | 22.7018 | 19.1112 | 11.2244 | 20.3018 | 29.1174 | 24.8102 | 22.8381 |
Translational Efficiency | 1.3427 | 2.0965 | 1.7443 | 1.0944 | 1.5088 | 3.0924 | 1.5862 | 0.8212 | 1.0768 | 1.4461 |
Dataset | Hit |
---|---|
Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
---|
Gene | Images |
---|
Gene | Images |
---|