Standard name
Human Ortholog
Description Protein that localizes to chromatin; has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; relocalizes to the cytosol in response to hypoxia; potentially phosphorylated by Cdc28p
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.06 0 0 0 0 0 0 0 0.11 0.14 0.12 0.14 0.17 0.11 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.16 0.27 0.38 0.18 0.46 0.38 0.39 0.6 0.58 0.61 0.57 0 0 0.05 0 0 0.11 0 0 0 0 0 0
Nucleus 0.84 0.87 0.85 0.86 0.81 0.79 0.73 0.75 0.7 0.66 0.67 0.67 0.84 0.79 0.78 0.76 0.7 0.76 0.64 0.8 0.72 0.72 0.61 0.59
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.19 0.09 0.09 0.1 0.1 0.12 0.16 0.16 0.2 0.24 0.25 0.28 0.1 0.08 0.09 0 0 0.07 0.24 0.11 0.15 0.13 0.22 0.23
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.05 0 0 0.05 0.06 0.07 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 1 0 0 0 0 0 0 2 0 0 0 0 0 0 1 5 1
Bud 0 2 2 0 0 0 2 4 6 1 9 2 0 0 1 0 0 0 3 2 2 2 2 1
Bud Neck 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 0 0 0 0 1 0 3 2
Bud Site 0 0 1 4 3 12 10 7 15 16 7 23 0 1 5 0 0 0 – – – – – –
Cell Periphery 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 9 6 10 7 21 15 20 22 14 14 5 3 40 69 65 14 21 16 1 2 0 2 0 1
Endoplasmic Reticulum 1 1 3 1 1 1 1 1 0 0 0 0 0 0 2 2 2 4 0 0 0 2 1 1
Endosome 0 2 0 0 3 0 3 1 0 0 0 0 4 5 2 2 2 6 5 5 5 1 9 12
Golgi 2 0 0 0 0 0 0 0 0 0 0 0 0 0 2 2 0 0 2 2 3 1 5 6
Mitochondria 1 75 118 111 63 219 233 233 287 257 187 223 4 5 24 1 3 16 3 4 3 1 5 9
Nucleus 276 415 375 252 277 382 441 442 335 295 204 263 307 396 412 74 85 111 236 418 325 199 308 300
Nuclear Periphery 3 8 3 2 5 5 12 10 8 16 10 7 6 4 8 1 1 0 2 1 1 2 1 1
Nucleolus 62 44 41 30 34 56 99 92 96 108 78 111 35 41 47 1 4 10 90 56 70 36 112 116
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 3 8 7 1 0 0 0 0 0 0 0 0
SpindlePole 9 3 13 0 6 6 4 7 0 3 2 4 3 7 14 3 2 4 8 6 8 3 7 12
Vac/Vac Membrane 6 7 2 1 4 1 2 3 0 3 0 0 5 2 6 4 8 7 14 22 25 16 34 41
Unique Cell Count 328 478 439 292 344 481 607 592 480 445 306 394 365 500 530 97 121 146 371 525 455 278 505 513
Labelled Cell Count 369 564 568 408 417 697 829 824 761 713 503 636 407 538 597 105 128 174 371 525 455 278 505 513


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.8 5.6 4.7 4.6 5.0 4.2 4.3 4.4 3.9 3.9 3.8 3.9 6.8 6.5 5.8 8.2 9.2 8.0 6.9 6.9 7.4
Std Deviation (1e-4) 1.2 1.0 0.8 1.1 1.5 1.1 1.4 1.3 1.1 1.4 0.9 1.0 1.6 1.7 1.5 2.2 2.7 2.4 1.9 1.5 1.6
Intensity Change (Log2) – – – -0.02 0.11 -0.13 -0.13 -0.07 -0.26 -0.25 -0.29 -0.27 0.54 0.49 0.32 0.82 0.98 0.78 0.57 0.57 0.67


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.1 2.7 0.8 1.0 1.3 0.6 0.8 -0.6 -1.8 5.1 6.3 5.8 0 6.4 4.4
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 -2.8 0 0 0 0 0 0 0 -10.1 -11.7 -9.8 -5.5 -5.8 -4.0
Nucleus 0.3 -1.8 -2.4 -4.9 -4.2 -5.6 -6.6 -6.1 -6.4 -0.5 -2.5 -3.0 -2.2 -3.9 -2.6
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0.3 0 0 0 0 0 0 0 0.1 -0.6 -0.3 -2.8 -2.2 -0.9
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 -1.1 0 0 0 0 0 0 0 -2.2 -1.7 -0.3 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0 0 0 0 0.0001 0 – – – – – – 0.0064 0 0.0009 0 0 0
Bud 0 0 0 0 0 0 – – – – – – 0 0 0 0 0 0
Bud Neck 0.0001 0.0001 0.0001 0 0.0015 0.0008 – – – – – – 0.0004 0.0001 0 0.0001 0.0006 0.0005
Bud Periphery 0 0 0 0 0.0001 0 – – – – – – 0.0001 0 0 0 0.0001 0.0001
Bud Site 0 0 0 0 0.0001 0 – – – – – – 0.0003 0 0 0 0.0001 0.0001
Cell Periphery 0 0 0 0 0 0 – – – – – – 0 0 0 0 0 0
Cytoplasm 0.0001 0 0 0 0 0 – – – – – – 0.0001 0 0 0 0.0001 0
Cytoplasmic Foci 0 0 0 0 0 0 – – – – – – 0.0003 0 0.0002 0 0 0
Eisosomes 0 0 0 0 0 0 – – – – – – 0.0002 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – – – – – – 0.0002 0 0 0 0 0
Endosome 0 0 0 0 0.0001 0 – – – – – – 0.0005 0 0 0 0 0
Golgi 0 0 0 0 0 0 – – – – – – 0.0004 0 0.0001 0 0 0
Lipid Particles 0 0 0.0001 0 0.0001 0 – – – – – – 0.001 0 0.0007 0 0 0
Mitochondria 0.0004 0 0.0001 0 0.0003 0 – – – – – – 0.0003 0.0001 0.0003 0.0001 0.0002 0.0002
None 0 0 0 0 0.0001 0 – – – – – – 0.0004 0 0 0 0.0001 0
Nuclear Periphery 0.0004 0.0021 0.0013 0.0005 0.0012 0.0004 – – – – – – 0.0012 0.0009 0.0035 0.0009 0.0018 0.0004
Nucleolus 0.0592 0.0455 0.0366 0.0234 0.1681 0.132 – – – – – – 0.0514 0.05 0.0358 0.0301 0.2352 0.0969
Nucleus 0.9376 0.9478 0.9591 0.9747 0.8221 0.8634 – – – – – – 0.9344 0.9426 0.9474 0.9678 0.7197 0.8931
Peroxisomes 0 0 0 0 0 0 – – – – – – 0.0003 0 0.0069 0 0 0
Punctate Nuclear 0.0019 0.0042 0.0025 0.0014 0.0058 0.0033 – – – – – – 0.0019 0.0063 0.004 0.001 0.0419 0.0086
Vacuole 0.0001 0 0 0 0.0001 0 – – – – – – 0.0001 0 0 0 0.0001 0
Vacuole Periphery 0.0001 0 0 0 0.0001 0 – – – – – – 0.0001 0 0 0 0 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 28.5179 20.9665 28.6409 34.3487 34.7286 36.7598 30.5942 33.9002 37.895 37.0821
Translational Efficiency 0.6355 0.5678 0.5369 0.5695 0.5834 0.4993 0.4553 0.4827 0.4197 0.4756

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘
Standard name
Human Ortholog
Description Protein that localizes to chromatin; has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; relocalizes to the cytosol in response to hypoxia; potentially phosphorylated by Cdc28p
Localization
Cell Percentages nucleus (85%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Yta7

Yta7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Yta7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available