Standard name | |
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Human Ortholog | |
Description | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 5 | 4 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 1 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 1 | – | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 2 | 4 | – | 3 | 9 | 10 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 3 | 7 | 0 | 14 | 12 | 16 | 24 | – | 14 | 26 | 6 | 20 | 8 | 21 | 49 | 23 | 27 | 15 | 0 | 0 | 2 | 0 | 1 | 7 |
Endoplasmic Reticulum | 0 | 0 | 0 | 1 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 8 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 1 |
Endosome | 0 | 2 | 0 | 0 | 1 | 2 | 8 | – | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 7 | 7 | 6 | 1 | 2 | 1 | 1 | 3 | 4 |
Golgi | 0 | 0 | 0 | 1 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
Mitochondria | 15 | 1 | 0 | 5 | 3 | 38 | 55 | – | 69 | 80 | 179 | 131 | 0 | 0 | 0 | 12 | 11 | 5 | 0 | 1 | 0 | 2 | 2 | 5 |
Nucleus | 174 | 207 | 22 | 151 | 173 | 174 | 324 | – | 154 | 191 | 191 | 232 | 56 | 129 | 190 | 207 | 168 | 129 | 178 | 204 | 52 | 37 | 145 | 136 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 1 | 1 | 3 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 4 | 3 | 0 | 1 | 4 | 19 | 17 | – | 9 | 15 | 21 | 15 | 0 | 1 | 2 | 13 | 18 | 12 | 6 | 4 | 0 | 0 | 7 | 7 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 2 | 2 | 8 | 10 | – | 5 | 6 | 3 | 7 | 0 | 2 | 3 | 3 | 2 | 4 | 2 | 1 | 0 | 2 | 8 | 2 |
Vac/Vac Membrane | 9 | 27 | 1 | 7 | 9 | 17 | 12 | – | 6 | 17 | 6 | 14 | 1 | 0 | 4 | 39 | 29 | 11 | 8 | 11 | 11 | 5 | 18 | 36 |
Unique Cell Count | 188 | 230 | 23 | 173 | 197 | 234 | 405 | 194 | 279 | 263 | 323 | 64 | 152 | 245 | 284 | 238 | 167 | 205 | 230 | 73 | 51 | 191 | 209 | |
Labelled Cell Count | 205 | 247 | 23 | 182 | 204 | 276 | 455 | 270 | 351 | 417 | 439 | 65 | 155 | 252 | 316 | 269 | 186 | 205 | 230 | 73 | 51 | 191 | 209 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.1 | 6.8 | 6.1 | 6.4 | 6.5 | 5.2 | 5.4 | – | 4.4 | 4.9 | 4.0 | 4.5 | 6.9 | 6.7 | 6.2 | 9.0 | 8.7 | 8.6 | 5.2 | 6.2 | 6.6 |
Std Deviation (1e-4) | 0.6 | 0.9 | 1.0 | 1.7 | 1.1 | 1.0 | 1.3 | – | 1.2 | 1.1 | 0.6 | 1.2 | 1.2 | 1.4 | 1.5 | 1.8 | 1.9 | 2.3 | 1.1 | 1.2 | 1.4 |
Intensity Change (Log2) | – | – | – | 0.07 | 0.09 | -0.23 | -0.18 | – | -0.46 | -0.33 | -0.62 | -0.44 | 0.18 | 0.13 | 0.03 | 0.55 | 0.51 | 0.5 | -0.23 | 0.02 | 0.11 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | -1.2 | -1.1 | -2.3 | -1.9 | – | -1.9 | -2.7 | -2.4 | -2.5 | -1.1 | -1.4 | -2.0 | -2.4 | -2.6 | -2.0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | -0.0139 | 0.6641 | 0.5753 | -0.2649 | -0.0402 | 0.5269 | 1.369 | 2.1158 | 1.8289 | 1.4486 | 1.4732 | 1.5718 | 0.5178 | 1.0257 | 0.968 | 0.8694 | 0.7005 | 0.7315 |
Actin | 0.0158 | 0 | 0.0115 | 0.0003 | 0.0075 | 0.0014 | 0.014 | 0.0001 | 0.004 | 0 | 0.0015 | 0.0022 | 0.0093 | 0 | 0.0002 | 0 | 0.0003 | 0 |
Bud | 0.0002 | 0 | 0.0005 | 0.0001 | 0.0029 | 0.0001 | 0.0002 | 0.0005 | 0.0002 | 0 | 0.0003 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0 | 0 |
Bud Neck | 0.0008 | 0.0001 | 0.0016 | 0.0002 | 0.0013 | 0.0035 | 0.0014 | 0.0003 | 0.0006 | 0.0002 | 0.0011 | 0.0011 | 0.0022 | 0 | 0.0002 | 0 | 0.0049 | 0.0014 |
Bud Periphery | 0.0003 | 0 | 0.0007 | 0.0004 | 0.0073 | 0.0002 | 0.0007 | 0.0013 | 0.0004 | 0.0002 | 0.0007 | 0.0001 | 0.0004 | 0 | 0.0001 | 0 | 0 | 0 |
Bud Site | 0.0025 | 0 | 0.0126 | 0.0006 | 0.0027 | 0.0004 | 0.0011 | 0.0086 | 0.0005 | 0.0001 | 0.002 | 0.0001 | 0.0009 | 0 | 0.0001 | 0 | 0.0002 | 0.0001 |
Cell Periphery | 0.0003 | 0 | 0.0002 | 0.0003 | 0.0006 | 0 | 0.0002 | 0.0003 | 0.0001 | 0.0001 | 0.0009 | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.0111 | 0.0001 | 0.0013 | 0.0009 | 0.0079 | 0.0021 | 0.0045 | 0.0005 | 0.0012 | 0 | 0.0042 | 0.001 | 0.001 | 0.0001 | 0.001 | 0.0001 | 0.0019 | 0.0009 |
Cytoplasmic Foci | 0.0155 | 0 | 0.0139 | 0.003 | 0.0038 | 0.0046 | 0.0051 | 0.0001 | 0.0038 | 0 | 0.0009 | 0.0011 | 0.0004 | 0 | 0 | 0 | 0.0135 | 0.0008 |
Eisosomes | 0.0004 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0021 | 0 | 0.0002 | 0.0025 | 0.0063 | 0.0003 | 0.0012 | 0.0002 | 0.0013 | 0 | 0.0056 | 0.0003 | 0.0014 | 0 | 0.0003 | 0 | 0.0003 | 0 |
Endosome | 0.0211 | 0 | 0.0099 | 0.0196 | 0.0361 | 0.0024 | 0.0097 | 0.0004 | 0.0112 | 0 | 0.0074 | 0.0017 | 0.0033 | 0 | 0.0003 | 0 | 0.0019 | 0.0002 |
Golgi | 0.0057 | 0 | 0.0066 | 0.0028 | 0.0079 | 0.0016 | 0.0035 | 0 | 0.002 | 0 | 0.0017 | 0.0007 | 0.0009 | 0 | 0 | 0 | 0.0002 | 0 |
Lipid Particles | 0.0195 | 0 | 0.0183 | 0.0483 | 0.0246 | 0.0044 | 0.0166 | 0.0001 | 0.0081 | 0 | 0.0027 | 0.0014 | 0.0009 | 0 | 0 | 0 | 0.0025 | 0 |
Mitochondria | 0.0099 | 0.0001 | 0.0142 | 0.0079 | 0.0606 | 0.0012 | 0.0111 | 0.0002 | 0.0031 | 0.0026 | 0.0022 | 0.0009 | 0.001 | 0.0001 | 0.0005 | 0.0001 | 0.0002 | 0.0001 |
None | 0.0466 | 0 | 0.001 | 0.0007 | 0.0068 | 0.0003 | 0.0022 | 0.0004 | 0.0017 | 0 | 0.0005 | 0.0011 | 0.001 | 0 | 0.0002 | 0 | 0.0046 | 0.0001 |
Nuclear Periphery | 0.017 | 0.0014 | 0.0087 | 0.011 | 0.055 | 0.0062 | 0.0077 | 0.0026 | 0.0062 | 0.0008 | 0.0132 | 0.0029 | 0.0071 | 0.0042 | 0.0068 | 0.0026 | 0.0061 | 0.0028 |
Nucleolus | 0.017 | 0.0107 | 0.0105 | 0.0142 | 0.0431 | 0.0261 | 0.0194 | 0.013 | 0.0088 | 0.0294 | 0.0253 | 0.0225 | 0.0154 | 0.006 | 0.0087 | 0.0039 | 0.0316 | 0.0199 |
Nucleus | 0.7575 | 0.9859 | 0.8724 | 0.8703 | 0.6881 | 0.9204 | 0.881 | 0.9692 | 0.9395 | 0.9653 | 0.9208 | 0.9508 | 0.9485 | 0.9768 | 0.9798 | 0.9929 | 0.9051 | 0.9524 |
Peroxisomes | 0.0202 | 0 | 0.0108 | 0.0007 | 0.0031 | 0.0068 | 0.0046 | 0 | 0.0012 | 0 | 0.0002 | 0.0018 | 0.0002 | 0 | 0 | 0 | 0.0004 | 0 |
Punctate Nuclear | 0.0324 | 0.0013 | 0.0023 | 0.0025 | 0.0221 | 0.0165 | 0.0118 | 0.0012 | 0.003 | 0.0004 | 0.0054 | 0.01 | 0.003 | 0.0125 | 0.0008 | 0.0002 | 0.0258 | 0.0208 |
Vacuole | 0.0027 | 0 | 0.0019 | 0.009 | 0.0065 | 0.0009 | 0.0025 | 0.001 | 0.0021 | 0.0003 | 0.0026 | 0.0002 | 0.0018 | 0 | 0.0005 | 0 | 0.0003 | 0.0002 |
Vacuole Periphery | 0.0012 | 0 | 0.0007 | 0.0048 | 0.0057 | 0.0004 | 0.0012 | 0.0001 | 0.0009 | 0.0006 | 0.0009 | 0.0002 | 0.0006 | 0 | 0.0002 | 0 | 0.0001 | 0 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 7.6259 | 7.8658 | 3.8912 | 8.5903 | 11.7887 | 2.9314 | 9.9414 | 8.9464 | 10.4607 | 9.9486 |
Translational Efficiency | 1.3052 | 1.0353 | 1.4241 | 0.7109 | 0.7015 | 2.6868 | 0.9228 | 0.9792 | 0.7017 | 0.7435 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
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37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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