Standard name | |
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Human Ortholog | |
Description | 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 22 | 40 | 1 | 2 | 5 | 3 | 8 | 10 | 13 | 15 | 6 | 5 | 28 | 44 | 100 | 40 | 77 | 31 | 27 | 28 | 0 | 12 | 8 | 17 |
Cytoplasm | 119 | 75 | 34 | 47 | 50 | 45 | 92 | 119 | 110 | 94 | 80 | 111 | 41 | 46 | 78 | 133 | 66 | 46 | 185 | 179 | 56 | 126 | 136 | 160 |
Endoplasmic Reticulum | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 4 | 6 | 1 | 2 | 2 | 0 | 1 | 0 | 2 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Unique Cell Count | 132 | 111 | 35 | 48 | 50 | 47 | 99 | 124 | 115 | 104 | 86 | 114 | 68 | 85 | 168 | 157 | 133 | 64 | 223 | 219 | 66 | 145 | 150 | 190 |
Labelled Cell Count | 143 | 116 | 36 | 50 | 55 | 48 | 102 | 129 | 123 | 110 | 88 | 116 | 69 | 90 | 182 | 178 | 150 | 79 | 223 | 219 | 66 | 145 | 150 | 190 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 536.9 | 612.0 | 348.9 | 399.9 | 431.5 | 363.8 | 353.1 | 346.3 | 326.4 | 336.2 | 288.3 | 299.4 | 659.8 | 640.8 | 631.8 | 565.8 | 615.5 | 602.3 | 504.4 | 509.5 | 505.7 |
Std Deviation (1e-4) | 101.5 | 116.5 | 177.9 | 132.8 | 100.5 | 116.7 | 114.2 | 121.9 | 108.5 | 95.2 | 104.8 | 88.8 | 113.1 | 153.3 | 142.0 | 156.6 | 163.5 | 166.5 | 154.3 | 152.8 | 177.9 |
Intensity Change (Log2) | – | – | – | 0.2 | 0.31 | 0.06 | 0.02 | -0.01 | -0.1 | -0.05 | -0.28 | -0.22 | 0.92 | 0.88 | 0.86 | 0.7 | 0.82 | 0.79 | 0.53 | 0.55 | 0.54 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.1 | 5.0 | 6.1 | 3.0 | 5.8 | 4.6 |
Cytoplasm | 0.2 | 1.2 | -0.3 | -0.9 | -0.3 | -0.4 | -1.3 | -0.9 | 0.1 | -4.0 | -4.5 | -5.5 | -2.0 | -5.1 | -3.1 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Actin | 0.0153 | 0.0001 | 0.017 | 0.0002 | 0.0094 | 0.0003 | 0.0012 | 0.0001 | 0.0061 | 0.0069 | 0.0056 | 0.0027 | – | – | – | – | – | – |
Bud | 0.0196 | 0 | 0.0059 | 0.0001 | 0.0173 | 0.0002 | 0.0048 | 0.0001 | 0.0139 | 0.0018 | 0.0021 | 0.0016 | – | – | – | – | – | – |
Bud Neck | 0.0018 | 0 | 0.0009 | 0.0001 | 0.0145 | 0.0004 | 0.0004 | 0 | 0.001 | 0.0005 | 0.0008 | 0.0004 | – | – | – | – | – | – |
Bud Periphery | 0.0094 | 0 | 0.003 | 0 | 0.012 | 0 | 0.0025 | 0 | 0.0043 | 0.0031 | 0.0009 | 0.0004 | – | – | – | – | – | – |
Bud Site | 0.0083 | 0 | 0.0015 | 0.0001 | 0.047 | 0 | 0.003 | 0 | 0.0042 | 0.0019 | 0.0015 | 0.0004 | – | – | – | – | – | – |
Cell Periphery | 0.0334 | 0 | 0.0209 | 0.0008 | 0.1518 | 0 | 0.0071 | 0 | 0.0035 | 0.0216 | 0.0077 | 0.0015 | – | – | – | – | – | – |
Cytoplasm | 0.2856 | 0.9778 | 0.3595 | 0.8602 | 0.4209 | 0.9098 | 0.2584 | 0.9799 | 0.6004 | 0.3778 | 0.4739 | 0.7982 | – | – | – | – | – | – |
Cytoplasmic Foci | 0.0455 | 0 | 0.0673 | 0.0079 | 0.006 | 0.0001 | 0.0559 | 0.0029 | 0.0432 | 0.0254 | 0.0358 | 0.0047 | – | – | – | – | – | – |
Eisosomes | 0.0043 | 0 | 0.0037 | 0.0016 | 0.0081 | 0 | 0.0028 | 0 | 0.0012 | 0.0216 | 0.0237 | 0.0006 | – | – | – | – | – | – |
Endoplasmic Reticulum | 0.0099 | 0 | 0.003 | 0 | 0.0247 | 0.0001 | 0.0031 | 0 | 0.002 | 0.0007 | 0.0019 | 0.0003 | – | – | – | – | – | – |
Endosome | 0.0204 | 0 | 0.0042 | 0 | 0.0052 | 0 | 0.0044 | 0 | 0.0111 | 0.0008 | 0.0033 | 0.0003 | – | – | – | – | – | – |
Golgi | 0.0018 | 0 | 0.0113 | 0 | 0.0021 | 0 | 0.0004 | 0 | 0.0015 | 0.0011 | 0.001 | 0.0002 | – | – | – | – | – | – |
Lipid Particles | 0.005 | 0 | 0.0181 | 0.002 | 0.0036 | 0 | 0.0053 | 0 | 0.0071 | 0.0071 | 0.0099 | 0.0009 | – | – | – | – | – | – |
Mitochondria | 0.1001 | 0.0002 | 0.1515 | 0.0184 | 0.0504 | 0.0014 | 0.0963 | 0.0006 | 0.0411 | 0.196 | 0.191 | 0.0099 | – | – | – | – | – | – |
None | 0.0409 | 0.0002 | 0.0976 | 0.0037 | 0.0417 | 0.0009 | 0.0332 | 0.0031 | 0.0501 | 0.154 | 0.0501 | 0.0076 | – | – | – | – | – | – |
Nuclear Periphery | 0.0497 | 0.0013 | 0.0026 | 0.0012 | 0.0156 | 0.0079 | 0.0556 | 0.001 | 0.0384 | 0.0042 | 0.0683 | 0.0497 | – | – | – | – | – | – |
Nucleolus | 0.1693 | 0 | 0.162 | 0.0846 | 0.01 | 0.0003 | 0.2362 | 0.0007 | 0.0568 | 0.0576 | 0.0303 | 0.0167 | – | – | – | – | – | – |
Nucleus | 0.1304 | 0.0201 | 0.038 | 0.0154 | 0.0389 | 0.0777 | 0.1305 | 0.0101 | 0.0682 | 0.017 | 0.0581 | 0.0906 | – | – | – | – | – | – |
Peroxisomes | 0.0034 | 0 | 0.0063 | 0.0008 | 0.001 | 0 | 0.0024 | 0 | 0.0025 | 0.0032 | 0.0034 | 0.0005 | – | – | – | – | – | – |
Punctate Nuclear | 0.0041 | 0 | 0.0019 | 0.0002 | 0.0015 | 0.0002 | 0.0194 | 0.0013 | 0.0178 | 0.0021 | 0.0023 | 0.0025 | – | – | – | – | – | – |
Vacuole | 0.0265 | 0 | 0.0194 | 0.0009 | 0.1149 | 0.0002 | 0.0529 | 0 | 0.0152 | 0.0214 | 0.0163 | 0.0035 | – | – | – | – | – | – |
Vacuole Periphery | 0.0153 | 0 | 0.0044 | 0.0016 | 0.0033 | 0.0003 | 0.0241 | 0.0001 | 0.0103 | 0.0743 | 0.0122 | 0.0068 | – | – | – | – | – | – |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 656.0377 | 686.4373 | 628.8655 | 528.9018 | 532.83 | 759.2021 | 767.8377 | 674.9581 | 752.6892 | 571.62 |
Translational Efficiency | 1.665 | 1.6205 | 1.4971 | 2.0861 | 1.7736 | 1.5291 | 1.7303 | 1.875 | 1.6756 | 1.7745 |
Dataset | Hit |
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Protein Concentration | – |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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