Standard name | |
---|---|
Human Ortholog | |
Description | Subunit of the cohesin complex; which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms; relocalizes to the cytosol in response to hypoxia; essential for viability |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | – | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bud | – | 0 | 0 | – | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 1 | 2 | 3 | 4 |
Bud Neck | – | 0 | 1 | – | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 |
Bud Site | – | 0 | 0 | – | 0 | 1 | 2 | 0 | 3 | 1 | 1 | 4 | 0 | 0 | 2 | 1 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | – | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | – | 8 | 1 | – | 4 | 2 | 1 | 2 | 0 | 2 | 0 | 1 | 14 | 39 | 53 | 15 | 13 | 5 | 0 | 4 | 0 | 0 | 3 | 0 |
Endoplasmic Reticulum | – | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 4 | 4 |
Endosome | – | 1 | 0 | – | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 4 | 0 | 2 | 1 | 1 | 5 | 2 | 6 | 5 | 8 |
Golgi | – | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Mitochondria | – | 38 | 4 | – | 2 | 12 | 18 | 16 | 8 | 22 | 3 | 11 | 1 | 1 | 0 | 2 | 8 | 5 | 0 | 3 | 0 | 5 | 22 | 22 |
Nucleus | – | 149 | 10 | – | 12 | 36 | 52 | 47 | 21 | 50 | 10 | 26 | 160 | 148 | 197 | 81 | 86 | 89 | 15 | 129 | 11 | 65 | 164 | 193 |
Nuclear Periphery | – | 15 | 4 | – | 8 | 21 | 30 | 23 | 8 | 16 | 7 | 11 | 15 | 11 | 13 | 22 | 26 | 13 | 5 | 18 | 15 | 48 | 84 | 59 |
Nucleolus | – | 49 | 8 | – | 12 | 19 | 31 | 37 | 17 | 28 | 2 | 12 | 47 | 67 | 77 | 29 | 16 | 23 | 4 | 46 | 16 | 24 | 15 | 15 |
Peroxisomes | – | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | – | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11 | 14 | 1 | 0 | 0 | 0 | 14 | 2 | 2 | 3 | 4 |
Vac/Vac Membrane | – | 31 | 2 | – | 6 | 29 | 24 | 12 | 8 | 17 | 6 | 6 | 13 | 8 | 10 | 19 | 20 | 19 | 1 | 14 | 4 | 17 | 68 | 131 |
Unique Cell Count | 230 | 25 | 37 | 91 | 116 | 114 | 52 | 101 | 20 | 50 | 220 | 252 | 337 | 140 | 145 | 139 | 29 | 244 | 56 | 177 | 384 | 452 | ||
Labelled Cell Count | 291 | 31 | 44 | 121 | 159 | 139 | 65 | 136 | 30 | 71 | 251 | 290 | 377 | 170 | 174 | 158 | 29 | 244 | 56 | 177 | 384 | 452 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | – | 5.7 | 5.9 | – | 6.6 | 6.1 | 6.2 | 7.2 | 6.4 | 6.2 | 6.4 | 5.7 | 8.4 | 8.6 | 8.7 | 9.8 | 9.5 | 9.9 | 6.6 | 6.5 | 6.8 |
Std Deviation (1e-4) | – | 1.3 | 1.3 | – | 1.3 | 1.4 | 1.4 | 1.7 | 1.6 | 1.3 | 1.4 | 1.2 | 2.1 | 2.8 | 2.9 | 2.6 | 2.6 | 2.5 | 1.1 | 1.1 | 1.3 |
Intensity Change (Log2) | – | – | – | – | 0.16 | 0.05 | 0.07 | 0.27 | 0.11 | 0.07 | 0.11 | -0.07 | 0.5 | 0.54 | 0.55 | 0.73 | 0.68 | 0.73 | 0.14 | 0.13 | 0.2 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | – | 0 | 0 | 0 | 0 | 0 | 0.6 | 0 | 0.6 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | – | -0.6 | 0 | 0.4 | 0.1 | 0 | 0.9 | 0.7 | 1.0 | 3.4 | 1.8 | 1.8 | 1.7 | 1.8 | 2.3 |
Nuclear Periphery | – | 0 | 0.8 | 1.0 | 0 | 0 | 0 | 0 | 0.6 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | – | 0 | -1.2 | -0.5 | 0 | 0.1 | -0.4 | 0 | -0.7 | -1.2 | -0.6 | -1.0 | -1.2 | 0 | 0 |
Peroxisomes | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | – | 0 | 2.4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.3359 | 2.5313 | 3.4684 | 2.707 | 2.5282 | 2.4124 | 3.6083 | 4.489 | 4.8305 | 3.7291 | 3.6129 | 4.0436 | 2.4969 | 3.2437 | 3.4629 | 3.2504 | 3.2378 | 2.8545 |
Actin | 0.0003 | 0.0003 | 0.0001 | 0.0001 | 0.001 | 0.0004 | 0.0204 | 0.0001 | 0.0029 | 0.0392 | 0.0279 | 0.0037 | 0.0143 | 0.0001 | 0.0004 | 0 | 0.0014 | 0.001 |
Bud | 0.0001 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0.0003 | 0 | 0.0001 | 0.0002 | 0.0002 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0.0003 | 0.0001 |
Bud Neck | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.001 | 0.0016 | 0.0001 | 0.0002 | 0.0027 | 0.0005 | 0.0011 | 0.0011 | 0.0001 | 0.0002 | 0.0003 | 0.0013 | 0.0015 |
Bud Periphery | 0.0001 | 0.0001 | 0 | 0 | 0.0001 | 0.0002 | 0.0005 | 0 | 0.0001 | 0.0003 | 0.0003 | 0.0002 | 0.0003 | 0 | 0.0001 | 0 | 0.0026 | 0.0004 |
Bud Site | 0.0001 | 0.0003 | 0 | 0 | 0.0001 | 0 | 0.0011 | 0.0001 | 0.0002 | 0.0028 | 0.0003 | 0 | 0.0008 | 0 | 0.0001 | 0 | 0.0007 | 0.0001 |
Cell Periphery | 0 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0.0002 | 0 | 0 | 0.0002 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0.0005 | 0.0001 |
Cytoplasm | 0.0004 | 0.0085 | 0 | 0 | 0.0002 | 0.0001 | 0.0096 | 0.0007 | 0.001 | 0.0011 | 0.0007 | 0.0001 | 0.0124 | 0 | 0.0002 | 0.0001 | 0.0005 | 0.0002 |
Cytoplasmic Foci | 0.0001 | 0.0012 | 0 | 0 | 0 | 0 | 0.0048 | 0 | 0.0046 | 0.0088 | 0.0043 | 0.0001 | 0.0097 | 0 | 0 | 0 | 0.0014 | 0 |
Eisosomes | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0.0002 | 0 | 0.0001 | 0.0005 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0002 | 0.0006 | 0 | 0 | 0.0002 | 0.0002 | 0.0013 | 0.0002 | 0.0006 | 0.0019 | 0.001 | 0.0004 | 0.001 | 0 | 0.0003 | 0 | 0.0011 | 0.0005 |
Endosome | 0.0003 | 0.0015 | 0 | 0 | 0.0005 | 0.0003 | 0.0055 | 0.0002 | 0.0072 | 0.0146 | 0.0088 | 0.001 | 0.0037 | 0 | 0.0003 | 0 | 0.0044 | 0.0004 |
Golgi | 0 | 0.0001 | 0 | 0 | 0.0001 | 0.0001 | 0.0031 | 0 | 0.003 | 0.0081 | 0.0077 | 0.0003 | 0.0014 | 0 | 0 | 0 | 0.0007 | 0.0001 |
Lipid Particles | 0.0001 | 0.0015 | 0.0001 | 0 | 0.0002 | 0.0004 | 0.0067 | 0 | 0.0067 | 0.0304 | 0.0057 | 0.0005 | 0.0128 | 0 | 0.0001 | 0 | 0.0081 | 0.0007 |
Mitochondria | 0.001 | 0.0006 | 0.0002 | 0.0002 | 0.0014 | 0.0009 | 0.0033 | 0.0002 | 0.0049 | 0.0215 | 0.0037 | 0.0006 | 0.0026 | 0.0004 | 0.0004 | 0.0002 | 0.0137 | 0.0012 |
None | 0.0002 | 0.0406 | 0 | 0 | 0.0002 | 0.0001 | 0.0064 | 0.0001 | 0.0016 | 0.001 | 0.0016 | 0.0002 | 0.0039 | 0 | 0.0001 | 0 | 0.001 | 0.0002 |
Nuclear Periphery | 0.1812 | 0.1534 | 0.0401 | 0.0035 | 0.2735 | 0.3396 | 0.2392 | 0.064 | 0.0408 | 0.0044 | 0.2938 | 0.4026 | 0.2281 | 0.0467 | 0.0453 | 0.0037 | 0.3887 | 0.3399 |
Nucleolus | 0.0481 | 0.0444 | 0.106 | 0.0974 | 0.0223 | 0.0921 | 0.042 | 0.0442 | 0.0786 | 0.0491 | 0.075 | 0.0779 | 0.0372 | 0.0414 | 0.0872 | 0.0368 | 0.0801 | 0.0788 |
Nucleus | 0.7529 | 0.7239 | 0.8286 | 0.8951 | 0.6924 | 0.5468 | 0.6176 | 0.8758 | 0.8143 | 0.7589 | 0.5308 | 0.4968 | 0.6481 | 0.9087 | 0.8554 | 0.9573 | 0.4609 | 0.5639 |
Peroxisomes | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0.005 | 0 | 0.0019 | 0.0168 | 0.0033 | 0.0001 | 0.0036 | 0 | 0 | 0 | 0.0007 | 0.0001 |
Punctate Nuclear | 0.0123 | 0.0183 | 0.024 | 0.0033 | 0.0042 | 0.0118 | 0.0278 | 0.0134 | 0.0289 | 0.0335 | 0.0295 | 0.0107 | 0.0131 | 0.0019 | 0.0092 | 0.0013 | 0.0121 | 0.0054 |
Vacuole | 0.0004 | 0.002 | 0.0001 | 0 | 0.0002 | 0.0007 | 0.0006 | 0.0002 | 0.0007 | 0.0019 | 0.0006 | 0.0005 | 0.0008 | 0.0001 | 0.0001 | 0 | 0.0056 | 0.0007 |
Vacuole Periphery | 0.0019 | 0.002 | 0.0003 | 0.0001 | 0.0031 | 0.0051 | 0.003 | 0.0006 | 0.0013 | 0.0019 | 0.0043 | 0.003 | 0.0049 | 0.0004 | 0.0005 | 0.0001 | 0.0138 | 0.0046 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 64.8685 | 17.1395 | 7.419 | 21.1583 | 35.8378 | 54.9321 | 16.5354 | 12.7685 | 17.0443 | 46.4305 |
Translational Efficiency | 0.9077 | 0.6534 | 0.6684 | 0.663 | 0.8521 | 1.0729 | 0.6744 | 0.4805 | 0.5801 | 0.6899 |
Dataset | Hit |
---|---|
Protein Concentration | ✔ |
Protein Localization | ✔ |
Gene Expression | ✔ |
Translational Efficiency | ✔ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
---|
Gene | Images |
---|
Gene | Images |
---|