Standard name | |
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Human Ortholog | |
Description | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35 |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 4 | 22 | 14 | 24 | 21 | 18 | 18 | 26 | 17 | 30 | 10 | 23 | 4 | 18 | 21 | 14 | 15 | 14 | 1 | 6 | 5 | 5 | 5 | 5 |
Bud | 1 | 2 | 0 | 1 | 1 | 1 | 3 | 1 | 5 | 10 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 3 | 7 | 9 | 13 | 15 | 12 | 10 | 20 | 13 | 23 | 7 | 15 | 8 | 55 | 67 | 45 | 27 | 39 | 0 | 0 | 1 | 1 | 3 | 7 |
Cytoplasm | 10 | 35 | 9 | 12 | 22 | 26 | 37 | 32 | 25 | 42 | 28 | 44 | 4 | 19 | 13 | 29 | 18 | 26 | 2 | 12 | 1 | 1 | 4 | 3 |
Endoplasmic Reticulum | 189 | 258 | 174 | 137 | 215 | 178 | 226 | 175 | 159 | 252 | 112 | 179 | 95 | 237 | 242 | 4 | 4 | 2 | 202 | 287 | 176 | 149 | 239 | 277 |
Endosome | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 5 | 3 | 23 | 16 | 29 | 2 | 4 | 13 | 1 | 6 | 0 | 8 | 5 | 4 | 5 | 27 | 16 | 17 | 0 | 2 | 0 | 0 | 1 | 5 |
Mitochondria | 2 | 1 | 12 | 18 | 22 | 25 | 48 | 37 | 55 | 70 | 47 | 45 | 0 | 0 | 2 | 11 | 10 | 19 | 3 | 4 | 3 | 1 | 4 | 9 |
Nucleus | 0 | 1 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 2 | 2 | 11 | 9 | 4 | 5 | 9 | 9 | 14 | 16 | 8 | 12 | 4 | 2 | 2 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 2 | 8 | 4 | 3 | 8 | 14 | 43 | 53 | 21 | 52 | 23 | 48 | 2 | 0 | 5 | 80 | 32 | 53 | 3 | 7 | 0 | 2 | 4 | 5 |
Unique Cell Count | 200 | 298 | 187 | 168 | 253 | 232 | 328 | 299 | 232 | 396 | 184 | 308 | 108 | 283 | 296 | 170 | 104 | 139 | 218 | 328 | 192 | 167 | 267 | 325 |
Labelled Cell Count | 218 | 339 | 257 | 233 | 338 | 282 | 401 | 368 | 313 | 502 | 240 | 379 | 125 | 336 | 358 | 211 | 125 | 174 | 218 | 328 | 192 | 167 | 267 | 325 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 16.7 | 16.4 | 17.5 | 17.0 | 15.6 | 13.1 | 12.3 | 13.7 | 12.5 | 12.5 | 12.0 | 12.3 | 17.2 | 17.2 | 17.5 | 13.8 | 13.8 | 13.9 | 15.8 | 15.8 | 17.0 |
Std Deviation (1e-4) | 2.9 | 2.8 | 3.0 | 2.7 | 2.8 | 2.5 | 2.3 | 2.8 | 2.8 | 2.5 | 2.6 | 2.9 | 3.2 | 2.9 | 2.7 | 5.4 | 5.4 | 5.3 | 2.5 | 2.7 | 2.9 |
Intensity Change (Log2) | – | – | – | -0.04 | -0.17 | -0.42 | -0.51 | -0.35 | -0.49 | -0.48 | -0.55 | -0.51 | -0.03 | -0.03 | -0.0 | -0.34 | -0.34 | -0.33 | -0.15 | -0.15 | -0.04 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 2.1 | 0.3 | 0.1 | -0.9 | 0.5 | -0.1 | 0 | -0.8 | 0 | -1.3 | -0.5 | -0.2 | 0.3 | 1.9 | 0.8 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 1.1 | 0.5 | 0.2 | -1.0 | 0.8 | 0.4 | 0.5 | -0.5 | 0 | 0.9 | 4.5 | 5.2 | 5.7 | 5.3 | 5.9 |
Cytoplasm | 0.9 | 1.6 | 2.4 | 2.5 | 2.3 | 2.2 | 2.3 | 3.3 | 3.3 | 0 | 0.9 | -0.2 | 3.7 | 3.5 | 4.0 |
Endoplasmic Reticulum | -3.3 | -2.6 | -4.5 | -6.3 | -8.2 | -6.2 | -7.5 | -7.4 | -8.3 | -1.5 | -3.0 | -3.5 | -17.1 | -15.0 | -16.4 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | -0.8 | -0.3 | -4.9 | -5.4 | -3.3 | -5.2 | -5.6 | -4.9 | -4.3 | -2.2 | -5.0 | -4.9 | 1.0 | 0.7 | 0 |
Mitochondria | 1.5 | 0.9 | 1.6 | 2.8 | 2.1 | 4.8 | 3.7 | 5.0 | 2.8 | 0 | 0 | -3.7 | 0 | 1.0 | 2.2 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | -0.2 | -2.5 | -2.0 | -1.8 | -1.6 | 0.1 | -1.0 | -0.7 | -1.0 | -0.8 | -3.3 | -3.4 | -3.2 | 0 | -2.0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0.7 | 2.0 | 4.2 | 5.2 | 3.0 | 4.2 | 3.8 | 4.7 | 0 | 0 | 0 | 10.0 | 7.1 | 8.5 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 12.4041 | 11.0448 | 11.3515 | 9.9678 | 11.2468 | 10.8605 | 13.6691 | 14.4624 | 13.1252 | 12.1436 | 10.6418 | 13.5536 | 9.749 | 13.6203 | 10.5922 | 10.7434 | 9.552 | 11.0576 |
Actin | 0.0093 | 0.0133 | 0.0015 | 0.0008 | 0.0014 | 0.0011 | 0.0181 | 0.0001 | 0.0101 | 0.0032 | 0.0388 | 0.0017 | 0.0396 | 0.0011 | 0.0014 | 0 | 0.0086 | 0.0003 |
Bud | 0 | 0.0002 | 0.0002 | 0 | 0 | 0 | 0.0003 | 0 | 0.0003 | 0.0002 | 0.0002 | 0 | 0.0007 | 0 | 0 | 0 | 0.0003 | 0 |
Bud Neck | 0.0001 | 0.0012 | 0.0007 | 0.0002 | 0.0004 | 0.0006 | 0.0004 | 0.0001 | 0.0018 | 0.0012 | 0.0003 | 0.0006 | 0.0009 | 0.0003 | 0.0001 | 0 | 0.0005 | 0.0004 |
Bud Periphery | 0.0001 | 0.0006 | 0.0005 | 0.0001 | 0 | 0.0002 | 0.0003 | 0 | 0.0005 | 0.001 | 0.0004 | 0.0001 | 0.0008 | 0 | 0.0001 | 0 | 0.0003 | 0 |
Bud Site | 0.0001 | 0.0034 | 0.0004 | 0 | 0 | 0 | 0.004 | 0 | 0.0014 | 0.0009 | 0.0008 | 0 | 0.0128 | 0.0002 | 0 | 0 | 0.0006 | 0 |
Cell Periphery | 0.0018 | 0.0149 | 0.0044 | 0.0017 | 0.0007 | 0.0012 | 0.001 | 0.0021 | 0.0011 | 0.0041 | 0.0008 | 0.0004 | 0.0012 | 0.0029 | 0.0014 | 0.0008 | 0.0002 | 0.0006 |
Cytoplasm | 0.0109 | 0.0373 | 0.0153 | 0.004 | 0.0029 | 0.0054 | 0.0103 | 0.0061 | 0.0034 | 0.002 | 0.0021 | 0.007 | 0.0085 | 0.1013 | 0.0078 | 0.001 | 0.0025 | 0.0018 |
Cytoplasmic Foci | 0.002 | 0.002 | 0.0006 | 0.0015 | 0.001 | 0.0003 | 0.0081 | 0.0003 | 0.0033 | 0.0014 | 0.0071 | 0.0038 | 0.0082 | 0.0025 | 0.0009 | 0.0001 | 0.0113 | 0.0002 |
Eisosomes | 0.0001 | 0.0008 | 0.0002 | 0.0001 | 0 | 0 | 0.0001 | 0.0001 | 0.0003 | 0.0006 | 0.0004 | 0 | 0.0002 | 0 | 0 | 0 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.9102 | 0.8855 | 0.9596 | 0.9319 | 0.9625 | 0.9663 | 0.8987 | 0.9813 | 0.9364 | 0.924 | 0.8328 | 0.9522 | 0.8025 | 0.8629 | 0.949 | 0.9918 | 0.7903 | 0.9823 |
Endosome | 0.0054 | 0.0048 | 0.0023 | 0.0045 | 0.0128 | 0.0051 | 0.0164 | 0.0007 | 0.0096 | 0.008 | 0.0276 | 0.0069 | 0.0426 | 0.0032 | 0.0068 | 0.0009 | 0.0607 | 0.0019 |
Golgi | 0.0017 | 0.0063 | 0.0013 | 0.0024 | 0.0055 | 0.0012 | 0.0046 | 0.0016 | 0.0049 | 0.0057 | 0.0289 | 0.0046 | 0.0239 | 0.0008 | 0.0215 | 0.0019 | 0.0839 | 0.0006 |
Lipid Particles | 0.0024 | 0.0143 | 0.002 | 0.0231 | 0.0007 | 0.0014 | 0.0108 | 0.004 | 0.0034 | 0.0106 | 0.0077 | 0.0027 | 0.0098 | 0.0093 | 0.0005 | 0.0003 | 0.0013 | 0.0005 |
Mitochondria | 0.0002 | 0.0032 | 0.0006 | 0.0002 | 0.0003 | 0.0002 | 0.0007 | 0 | 0.0146 | 0.0252 | 0.0162 | 0.0013 | 0.0068 | 0 | 0.0015 | 0.0001 | 0.0299 | 0.0001 |
None | 0.0007 | 0.0004 | 0.0004 | 0.0003 | 0.0001 | 0.0001 | 0.0012 | 0 | 0.0002 | 0.0002 | 0.001 | 0.0048 | 0.0012 | 0.0001 | 0 | 0 | 0.0001 | 0 |
Nuclear Periphery | 0.036 | 0.0071 | 0.0061 | 0.0258 | 0.0097 | 0.0129 | 0.012 | 0.0024 | 0.0037 | 0.0031 | 0.0093 | 0.0071 | 0.0239 | 0.0089 | 0.0064 | 0.0019 | 0.0053 | 0.0076 |
Nucleolus | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0.0002 | 0.0002 | 0.0001 | 0 | 0.0006 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0.0077 | 0.0008 | 0.0005 | 0.0007 | 0.0002 | 0.0006 | 0.0006 | 0.0001 | 0.0003 | 0.0003 | 0.0005 | 0.0004 | 0.0063 | 0.0006 | 0.0002 | 0 | 0.0002 | 0.0003 |
Peroxisomes | 0.0049 | 0.0001 | 0 | 0 | 0 | 0 | 0.0074 | 0 | 0.0005 | 0.0006 | 0.0205 | 0.0032 | 0.0016 | 0 | 0 | 0 | 0.0006 | 0 |
Punctate Nuclear | 0.0005 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0007 | 0 | 0.0004 | 0.0001 | 0.0005 | 0.0003 | 0.0038 | 0.0002 | 0 | 0 | 0.0001 | 0 |
Vacuole | 0.0045 | 0.003 | 0.0029 | 0.0016 | 0.0012 | 0.0028 | 0.0029 | 0.001 | 0.003 | 0.0059 | 0.0018 | 0.002 | 0.0029 | 0.0054 | 0.0017 | 0.0008 | 0.0012 | 0.0028 |
Vacuole Periphery | 0.0012 | 0.0005 | 0.0006 | 0.0007 | 0.0005 | 0.0006 | 0.0011 | 0.0001 | 0.0007 | 0.0014 | 0.0022 | 0.0008 | 0.0014 | 0.0003 | 0.0006 | 0.0001 | 0.0019 | 0.0004 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 47.0736 | 42.642 | 42.4671 | 53.8511 | 59.4054 | 37.638 | 48.7883 | 55.5195 | 68.9542 | 54.9252 |
Translational Efficiency | 1.7203 | 2.0105 | 2.0736 | 2.1407 | 1.4193 | 1.9603 | 1.9628 | 1.9062 | 1.3424 | 1.4656 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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