Standard name | |
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Human Ortholog | |
Description | Subunit of the anaphase-promoting complex/cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; relocalizes to the cytosol in response to hypoxia |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 1 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Bud | 0 | 2 | 0 | 0 | 1 | 0 | 4 | – | 2 | 6 | 2 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 5 | 0 | 2 | 6 | 11 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 2 | – | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 2 |
Bud Site | 0 | 0 | 2 | 0 | 0 | 0 | 5 | – | 8 | 6 | 1 | 4 | 0 | 0 | 0 | 0 | 1 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 3 | 4 | 2 | 1 | 1 | 6 | 4 | – | 7 | 9 | 12 | 4 | 20 | 30 | 45 | 5 | 5 | 7 | 0 | 2 | 0 | 3 | 1 | 1 |
Endoplasmic Reticulum | 0 | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 2 | 3 |
Endosome | 1 | 5 | 1 | 0 | 3 | 1 | 0 | – | 0 | 0 | 1 | 0 | 4 | 10 | 12 | 4 | 0 | 2 | 3 | 9 | 0 | 2 | 9 | 18 |
Golgi | 0 | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3 |
Mitochondria | 9 | 30 | 6 | 4 | 5 | 14 | 41 | – | 64 | 87 | 51 | 16 | 29 | 4 | 13 | 5 | 4 | 1 | 0 | 2 | 1 | 2 | 6 | 8 |
Nucleus | 156 | 398 | 67 | 37 | 31 | 36 | 67 | – | 72 | 79 | 42 | 31 | 211 | 214 | 195 | 37 | 29 | 21 | 158 | 380 | 71 | 184 | 249 | 227 |
Nuclear Periphery | 2 | 4 | 0 | 0 | 2 | 0 | 0 | – | 1 | 0 | 1 | 0 | 4 | 7 | 4 | 1 | 0 | 1 | 0 | 2 | 0 | 0 | 1 | 9 |
Nucleolus | 9 | 33 | 4 | 9 | 17 | 14 | 19 | – | 23 | 15 | 7 | 2 | 30 | 65 | 60 | 5 | 4 | 3 | 9 | 45 | 6 | 15 | 42 | 42 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 3 | 1 | 0 | 13 | 5 | 6 | – | 2 | 2 | 2 | 2 | 2 | 3 | 8 | 0 | 1 | 0 | 3 | 11 | 1 | 3 | 9 | 13 |
Vac/Vac Membrane | 1 | 17 | 0 | 0 | 1 | 0 | 1 | – | 1 | 2 | 1 | 0 | 4 | 3 | 11 | 4 | 5 | 6 | 6 | 34 | 4 | 25 | 65 | 79 |
Unique Cell Count | 167 | 458 | 71 | 45 | 53 | 58 | 104 | 116 | 133 | 85 | 40 | 268 | 302 | 317 | 57 | 41 | 35 | 185 | 498 | 89 | 245 | 408 | 432 | |
Labelled Cell Count | 181 | 498 | 84 | 51 | 74 | 76 | 149 | 181 | 207 | 120 | 60 | 306 | 337 | 352 | 65 | 50 | 44 | 185 | 498 | 89 | 245 | 408 | 432 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 6.1 | 6.1 | 5.5 | 5.0 | 6.3 | 4.5 | 4.6 | – | 4.1 | 3.9 | 3.8 | 4.3 | 5.9 | 6.0 | 5.9 | 7.6 | 7.6 | 7.7 | 5.7 | 5.4 | 5.9 |
Std Deviation (1e-4) | 1.1 | 1.1 | 0.7 | 0.8 | 1.0 | 0.8 | 1.1 | – | 1.0 | 1.0 | 1.0 | 1.1 | 1.4 | 1.4 | 1.6 | 1.5 | 1.5 | 1.6 | 1.5 | 1.1 | 1.9 |
Intensity Change (Log2) | – | – | – | -0.14 | 0.19 | -0.29 | -0.24 | – | -0.41 | -0.48 | -0.53 | -0.36 | 0.1 | 0.13 | 0.11 | 0.48 | 0.47 | 0.49 | 0.05 | -0.01 | 0.12 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 0 | 0 | 0 | – | 0 | 0 | 2.5 | 0 | 0 | 1.9 | 2.7 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0.6 | 0 | 0 | 0 | 0 | 0 |
Nucleus | -2.1 | -4.9 | -4.5 | -4.6 | – | -4.9 | -5.3 | -6.1 | -2.7 | -3.0 | -4.1 | -5.3 | -4.2 | -3.4 | -4.4 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 2.4 | 3.9 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1.4 | 3.1 | 2.7 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 4.0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.173 | 4.8839 | 4.6572 | 3.9679 | 4.7187 | 4.4152 | 2.5733 | 3.1018 | 2.5959 | 2.4485 | 2.2933 | 2.6185 | 1.1838 | 2.2568 | 1.8404 | 1.4037 | 1.5851 | 1.1816 |
Actin | 0.0264 | 0.0001 | 0.0057 | 0 | 0.0152 | 0.0001 | 0.0147 | 0 | 0.0087 | 0 | 0.0078 | 0.0008 | 0.0075 | 0 | 0.018 | 0.008 | 0 | 0.0363 |
Bud | 0.0004 | 0 | 0.0001 | 0 | 0.0005 | 0 | 0.0005 | 0 | 0.0003 | 0 | 0.0011 | 0.0003 | 0.0001 | 0.0001 | 0 | 0.0009 | 0 | 0.0001 |
Bud Neck | 0.0023 | 0.0002 | 0.0009 | 0.0004 | 0.0007 | 0.0013 | 0.009 | 0.0001 | 0.0046 | 0.0001 | 0.0026 | 0.0034 | 0.0007 | 0.0001 | 0.0004 | 0.0022 | 0.0005 | 0.001 |
Bud Periphery | 0.001 | 0.0003 | 0.0002 | 0 | 0.0009 | 0.0002 | 0.0013 | 0 | 0.001 | 0 | 0.0019 | 0.0009 | 0.0004 | 0.0004 | 0.0001 | 0.0014 | 0.0001 | 0.0001 |
Bud Site | 0.0058 | 0.0001 | 0.0008 | 0 | 0.0008 | 0.0001 | 0.0042 | 0 | 0.0017 | 0 | 0.0011 | 0.001 | 0.0008 | 0.0003 | 0.0002 | 0.0104 | 0.0001 | 0.0001 |
Cell Periphery | 0.0004 | 0.0001 | 0.0001 | 0 | 0.0002 | 0 | 0.0005 | 0 | 0.0003 | 0 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0002 | 0 | 0 |
Cytoplasm | 0.0081 | 0.0001 | 0.0019 | 0.0001 | 0.0028 | 0.0001 | 0.0109 | 0.0001 | 0.0011 | 0 | 0.0014 | 0.004 | 0.0005 | 0.0004 | 0.0003 | 0.0003 | 0 | 0.0002 |
Cytoplasmic Foci | 0.0063 | 0 | 0.0048 | 0 | 0.0325 | 0.0001 | 0.0032 | 0 | 0.0014 | 0 | 0.0028 | 0.0004 | 0.0141 | 0 | 0.0003 | 0.0061 | 0 | 0.0003 |
Eisosomes | 0.0004 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0.0002 | 0 | 0.0003 |
Endoplasmic Reticulum | 0.0026 | 0.0001 | 0.0023 | 0 | 0.0109 | 0.0003 | 0.0087 | 0 | 0.001 | 0 | 0.0008 | 0.0007 | 0.0014 | 0 | 0.0002 | 0.0002 | 0 | 0.001 |
Endosome | 0.0083 | 0.0001 | 0.0121 | 0 | 0.0549 | 0.0019 | 0.0195 | 0 | 0.0037 | 0 | 0.0173 | 0.002 | 0.0029 | 0.0001 | 0.0003 | 0.0066 | 0 | 0.0019 |
Golgi | 0.0067 | 0 | 0.0115 | 0 | 0.0103 | 0.0005 | 0.0047 | 0 | 0.0017 | 0 | 0.0053 | 0.0021 | 0.0012 | 0 | 0.0003 | 0.0056 | 0 | 0.0029 |
Lipid Particles | 0.0245 | 0.0001 | 0.0043 | 0 | 0.0198 | 0.0008 | 0.0069 | 0 | 0.0026 | 0 | 0.005 | 0.0025 | 0.005 | 0 | 0.0001 | 0.0083 | 0 | 0.0007 |
Mitochondria | 0.0252 | 0.0002 | 0.0064 | 0.0001 | 0.0098 | 0.0098 | 0.0129 | 0.0001 | 0.0206 | 0.0001 | 0.0462 | 0.0086 | 0.0024 | 0.0004 | 0.0004 | 0.0034 | 0.0002 | 0.001 |
None | 0.0062 | 0 | 0.0102 | 0 | 0.0016 | 0.0001 | 0.0111 | 0 | 0.0004 | 0 | 0.0007 | 0.0001 | 0.0004 | 0.0002 | 0.0002 | 0.0004 | 0 | 0.0005 |
Nuclear Periphery | 0.0075 | 0.0078 | 0.0141 | 0.0064 | 0.0603 | 0.0079 | 0.0398 | 0.0087 | 0.0109 | 0.0022 | 0.0115 | 0.0022 | 0.0263 | 0.0058 | 0.02 | 0.0012 | 0.0004 | 0.0046 |
Nucleolus | 0.0281 | 0.0261 | 0.0402 | 0.0173 | 0.0241 | 0.0446 | 0.0276 | 0.0257 | 0.0369 | 0.0276 | 0.0385 | 0.0513 | 0.0335 | 0.0221 | 0.0336 | 0.0478 | 0.067 | 0.0249 |
Nucleus | 0.8136 | 0.9556 | 0.8572 | 0.9731 | 0.6989 | 0.9176 | 0.7953 | 0.9498 | 0.8768 | 0.9676 | 0.841 | 0.9126 | 0.8668 | 0.9442 | 0.8798 | 0.8195 | 0.9306 | 0.9022 |
Peroxisomes | 0.0135 | 0 | 0.0026 | 0 | 0.025 | 0 | 0.0019 | 0 | 0.0014 | 0 | 0.0023 | 0.0009 | 0.0077 | 0 | 0.0001 | 0.0058 | 0 | 0.0005 |
Punctate Nuclear | 0.0074 | 0.0084 | 0.0233 | 0.0024 | 0.0228 | 0.0128 | 0.0173 | 0.0153 | 0.0217 | 0.002 | 0.0069 | 0.0046 | 0.0262 | 0.0249 | 0.045 | 0.0699 | 0.001 | 0.0212 |
Vacuole | 0.003 | 0.0004 | 0.0008 | 0 | 0.0049 | 0.0006 | 0.0054 | 0 | 0.0018 | 0.0001 | 0.0035 | 0.0011 | 0.0009 | 0.0005 | 0.0001 | 0.0011 | 0.0001 | 0.0001 |
Vacuole Periphery | 0.0024 | 0.0005 | 0.0004 | 0 | 0.0031 | 0.0009 | 0.0045 | 0 | 0.0011 | 0.0001 | 0.002 | 0.0004 | 0.0007 | 0.0002 | 0.0004 | 0.0003 | 0 | 0.0002 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 9.6214 | 13.2924 | 15.0854 | 15.127 | 12.4746 | 11.8016 | 16.7999 | 14.8072 | 15.6674 | 16.6245 |
Translational Efficiency | 1.1896 | 1.0267 | 0.7625 | 0.8531 | 0.8742 | 0.991 | 0.8325 | 0.7741 | 0.7772 | 0.7718 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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