Standard name | |
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Human Ortholog | |
Description | Endosomal Rab family GTPase; required for vacuolar protein sorting, endocytosis and multivesicular body (MVB) biogenesis and sorting; required for localization of the CORVET complex to endosomes; involved in autophagy and ionic stress tolerance; similar to Vps21p and Ypt53p; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 5 | 6 | 0 | 4 | 2 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 7 | 0 | 2 | 7 | 5 | 6 | 13 | 16 | 11 | 21 | 7 | 1 | 1 | 3 | 7 | 6 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 102 | 262 | 249 | 194 | 304 | 299 | 250 | 470 | 301 | 202 | 266 | 299 | 167 | 251 | 285 | 240 | 286 | 172 | 97 | 255 | 231 | 115 | 129 | 180 |
Endoplasmic Reticulum | 0 | 1 | 4 | 1 | 4 | 4 | 9 | 22 | 22 | 9 | 14 | 14 | 0 | 1 | 4 | 2 | 2 | 2 | 0 | 1 | 3 | 1 | 2 | 1 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 2 | 0 | 0 | 1 | 0 | 1 | 0 |
Golgi | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Mitochondria | 0 | 0 | 1 | 0 | 5 | 1 | 13 | 13 | 33 | 16 | 42 | 26 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 3 | 2 | 8 | 1 | 1 | 1 | 0 | 0 | 2 | 2 | 2 | 0 | 0 | 2 | 0 | 0 | 1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 0 | 4 | 1 | 3 | 1 | 15 | 35 | 15 | 24 | 12 | 25 | 0 | 2 | 0 | 15 | 3 | 21 | 2 | 0 | 0 | 2 | 4 | 3 |
Unique Cell Count | 102 | 265 | 259 | 196 | 314 | 307 | 289 | 544 | 372 | 259 | 332 | 362 | 168 | 253 | 289 | 256 | 290 | 191 | 102 | 262 | 246 | 125 | 140 | 192 |
Labelled Cell Count | 103 | 271 | 259 | 198 | 325 | 311 | 298 | 564 | 395 | 270 | 360 | 378 | 170 | 255 | 292 | 272 | 300 | 203 | 102 | 262 | 246 | 125 | 140 | 192 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 21.3 | 21.2 | 15.5 | 15.9 | 15.3 | 14.5 | 14.3 | 14.8 | 14.9 | 13.5 | 14.6 | 15.3 | 21.4 | 21.0 | 22.1 | 20.1 | 19.3 | 17.5 | 22.5 | 22.2 | 23.4 |
Std Deviation (1e-4) | 4.2 | 3.3 | 3.5 | 3.2 | 2.8 | 3.0 | 3.1 | 3.6 | 3.8 | 4.9 | 4.2 | 4.6 | 3.3 | 3.4 | 3.5 | 5.8 | 5.4 | 6.2 | 4.7 | 4.2 | 4.4 |
Intensity Change (Log2) | – | – | – | 0.04 | -0.02 | -0.1 | -0.12 | -0.07 | -0.06 | -0.2 | -0.09 | -0.02 | 0.46 | 0.44 | 0.51 | 0.37 | 0.31 | 0.17 | 0.54 | 0.52 | 0.59 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 3.4 | 3.4 | 4.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1.9 | 0.4 | 0.8 | -3.9 | -4.2 | -5.6 | -6.2 | -5.8 | -5.2 | 2.1 | 2.3 | 1.8 | -1.2 | 1.8 | -2.6 |
Endoplasmic Reticulum | 0 | 0 | 0 | 1.2 | 1.9 | 2.7 | 1.4 | 1.9 | 1.7 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 3.0 | 0 | 4.6 | 3.7 | 5.7 | 4.1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 2.3 | 3.0 | 1.8 | 3.9 | 1.5 | 3.1 | 0 | 0 | 0 | 2.6 | 0 | 4.3 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 14.2356 | 17.21 | 15.7399 | 14.3292 | 11.2199 | 15.4482 | 18.0469 | 22.1259 | 18.8725 | 17.9881 | 14.3984 | 18.7902 | 12.196 | 20.1706 | 18.4444 | 15.8042 | 18.8082 | 19.6009 |
Actin | 0.005 | 0.0002 | 0.0095 | 0.0207 | 0.0626 | 0.0002 | 0.0078 | 0.0002 | 0.0006 | 0.0001 | 0.0223 | 0.0002 | 0.0016 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 |
Bud | 0.0008 | 0.0002 | 0.0007 | 0.0002 | 0.0007 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0004 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 |
Bud Neck | 0.0028 | 0.0002 | 0.0009 | 0.0004 | 0.003 | 0.0008 | 0.0002 | 0.0001 | 0.0002 | 0.0002 | 0.0008 | 0.0005 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0002 | 0.0003 |
Bud Periphery | 0.0006 | 0 | 0.0009 | 0.0003 | 0.001 | 0 | 0 | 0 | 0 | 0 | 0.0005 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0.0014 | 0.0002 | 0.009 | 0.0003 | 0.0034 | 0 | 0.0001 | 0.0001 | 0.0003 | 0 | 0.0008 | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0.0001 | 0 | 0.0002 | 0.0001 | 0.0003 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.8382 | 0.9828 | 0.9033 | 0.8865 | 0.6854 | 0.945 | 0.961 | 0.9922 | 0.981 | 0.9895 | 0.7959 | 0.9826 | 0.7779 | 0.9972 | 0.9964 | 0.9963 | 0.998 | 0.9962 |
Cytoplasmic Foci | 0.0321 | 0.001 | 0.016 | 0.0057 | 0.0366 | 0.007 | 0.0024 | 0.0006 | 0.0031 | 0.0003 | 0.0265 | 0.0014 | 0.0013 | 0.0001 | 0.0001 | 0.0003 | 0.0002 | 0.0002 |
Eisosomes | 0.0001 | 0 | 0.0001 | 0.0002 | 0.0007 | 0 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0052 | 0.0006 | 0.0024 | 0.0072 | 0.0098 | 0.0024 | 0.0046 | 0.0005 | 0.0014 | 0.0005 | 0.0062 | 0.0026 | 0.0119 | 0 | 0.0001 | 0 | 0 | 0.0001 |
Endosome | 0.024 | 0.0004 | 0.0149 | 0.0147 | 0.0764 | 0.007 | 0.0042 | 0.0002 | 0.0013 | 0.0001 | 0.0287 | 0.001 | 0.0063 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0.0051 | 0 | 0.0038 | 0.0047 | 0.0123 | 0.0003 | 0.0015 | 0 | 0.0008 | 0 | 0.0081 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Lipid Particles | 0.0119 | 0 | 0.0033 | 0.0138 | 0.0125 | 0.0004 | 0.0021 | 0 | 0.0007 | 0 | 0.0318 | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0.0066 | 0.0001 | 0.0034 | 0.0055 | 0.0098 | 0.0002 | 0.0004 | 0 | 0.0014 | 0 | 0.0034 | 0.0001 | 0.0006 | 0 | 0 | 0 | 0 | 0 |
None | 0.0035 | 0.0007 | 0.0019 | 0.0077 | 0.0078 | 0.0006 | 0.0026 | 0.0006 | 0.0005 | 0.0004 | 0.004 | 0.0006 | 0.009 | 0.0005 | 0.0003 | 0.0007 | 0.0004 | 0.0003 |
Nuclear Periphery | 0.0094 | 0.0016 | 0.0027 | 0.0065 | 0.0183 | 0.0038 | 0.0035 | 0.0007 | 0.0007 | 0.001 | 0.0138 | 0.0018 | 0.1026 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0002 |
Nucleolus | 0.0005 | 0 | 0.0003 | 0.0002 | 0.0008 | 0 | 0 | 0 | 0 | 0 | 0.0005 | 0 | 0.0003 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0.0324 | 0.0111 | 0.0145 | 0.0192 | 0.0112 | 0.0293 | 0.0067 | 0.004 | 0.0055 | 0.0076 | 0.0083 | 0.0086 | 0.0771 | 0.0017 | 0.0026 | 0.0019 | 0.0009 | 0.0024 |
Peroxisomes | 0.0063 | 0 | 0.0045 | 0.0007 | 0.0094 | 0.0002 | 0.0006 | 0 | 0.0021 | 0 | 0.0253 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Punctate Nuclear | 0.0107 | 0.0004 | 0.0031 | 0.0011 | 0.0236 | 0.0006 | 0.0012 | 0.0002 | 0.0001 | 0.0001 | 0.021 | 0.0002 | 0.0079 | 0 | 0 | 0 | 0 | 0.0001 |
Vacuole | 0.0027 | 0.0004 | 0.0039 | 0.0032 | 0.0113 | 0.0016 | 0.0006 | 0.0001 | 0.0002 | 0.0002 | 0.0009 | 0.0002 | 0.0013 | 0 | 0 | 0 | 0 | 0 |
Vacuole Periphery | 0.0008 | 0.0001 | 0.0007 | 0.0011 | 0.0033 | 0.0003 | 0.0002 | 0 | 0.0001 | 0 | 0.0006 | 0.0001 | 0.0013 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 45.3883 | 46.1708 | 35.2989 | 61.3066 | 49.7163 | 53.1844 | 51.9882 | 72.564 | 65.5386 | 57.0815 |
Translational Efficiency | 2.7648 | 2.0259 | 2.6557 | 1.8649 | 1.7571 | 2.2322 | 2.1798 | 1.3731 | 1.8636 | 1.7947 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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