Standard name
Human Ortholog
Description Ribosomal 60S subunit protein L37A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0.05 0.05 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 1.0 0.97 0.99 0.97 0.91 0.84 – 0.81 0.64 0.71 0.68 0.99 0.99 0.98 0.99 0.99 0.99 0.96 0.92 0.89 0.89 0.78 0.79
Endoplasmic Reticulum 0 0 0 0 0 0.07 0.13 – 0.15 0.28 0.21 0.24 0 0 0 0 0 0.05 0 0 0.05 0.07 0.17 0.15
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0.1 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 4 – 2 4 7 14 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 1 – 1 0 0 1 0 1 0 0 0 0 0 0 0 0 0 1
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 1 2 5 4 16 – 11 25 19 28 0 1 4 0 2 2 0 0 0 0 0 1
Cytoplasm 208 73 113 216 304 209 301 – 213 299 256 308 71 154 247 372 283 276 190 79 100 110 162 174
Endoplasmic Reticulum 0 0 3 4 9 16 46 – 38 131 77 110 0 0 4 15 6 14 2 2 5 8 35 33
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 1 0 14 – 5 46 24 20 1 0 0 3 2 1 0 0 0 0 0 1
Mitochondria 0 0 0 0 0 2 0 – 0 1 2 4 0 0 0 0 0 3 0 0 0 0 0 2
Nucleus 0 0 0 0 0 1 0 – 1 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Nucleolus 0 0 1 0 0 0 1 – 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 1 0 0 2 3 – 4 2 3 4 0 0 0 1 2 1 0 0 1 1 2 0
Unique Cell Count 209 73 117 218 313 229 360 262 466 363 456 72 155 251 375 286 278 198 86 113 124 209 221
Labelled Cell Count 209 73 119 222 319 234 386 275 509 389 489 72 156 255 391 295 297 198 86 113 124 209 221


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 122.3 119.7 100.1 96.1 80.6 47.9 56.0 – 43.2 47.4 40.2 42.0 121.9 98.2 123.3 153.6 160.0 157.0 116.4 122.7 124.6
Std Deviation (1e-4) 19.8 21.9 20.6 19.1 15.7 14.8 16.2 – 11.9 12.3 10.9 11.4 25.1 25.9 24.2 40.2 39.8 39.4 28.1 31.3 33.0
Intensity Change (Log2) – – – -0.06 -0.31 -1.06 -0.84 – -1.21 -1.08 -1.31 -1.25 0.28 -0.03 0.3 0.62 0.68 0.65 0.22 0.29 0.32


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 2.1 0 2.3 0 0 0 0 0 0
Cytoplasm 1.6 0.3 -1.8 -3.6 – -4.0 -6.9 -5.8 -6.3 0.8 1.7 1.1 2.1 1.7 2.0
Endoplasmic Reticulum 0 0 1.7 3.2 – 3.5 5.9 4.7 5.2 0 0 0 0 0 1.1
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 3.5 2.9 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 96.9691 124.3366 112.0482 92.0377 104.2955 119.8016 119.3947 148.7511 132.2063 115.7462 110.1879 131.3648 120.208 148.38 134.62 129.4439 124.2781 133.1319
Actin 0.0072 0.0005 0.0008 0.0044 0.0008 0.0013 0.0102 0.0008 0.0107 0.0015 0.0011 0.0056 0.009 0.0002 0.0127 0.0076 0.0015 0.0017
Bud 0.0024 0.0005 0.0019 0.0021 0.0011 0.002 0.0024 0.0013 0.0022 0.0033 0.0029 0.0082 0.0031 0.0008 0.0025 0.0022 0.0031 0.0021
Bud Neck 0.0012 0.0011 0.0017 0.002 0.0017 0.0024 0.0015 0.0013 0.0013 0.0018 0.0013 0.0025 0.0011 0.0006 0.0018 0.0009 0.0008 0.0009
Bud Periphery 0.0049 0.0003 0.0018 0.0014 0.0006 0.0019 0.0035 0.001 0.0023 0.0027 0.0013 0.0044 0.0047 0.0004 0.0015 0.0012 0.0015 0.0007
Bud Site 0.002 0.0005 0.0015 0.0009 0.0011 0.0004 0.0013 0.0012 0.0027 0.0009 0.0016 0.0009 0.0012 0.0005 0.0025 0.0021 0.0006 0.0002
Cell Periphery 0.0428 0.0113 0.0232 0.0168 0.0199 0.0198 0.0401 0.0326 0.032 0.0392 0.0082 0.0227 0.0422 0.0064 0.0194 0.0226 0.0119 0.001
Cytoplasm 0.6021 0.8942 0.7305 0.4689 0.6286 0.7559 0.5938 0.8704 0.7505 0.5668 0.6663 0.5967 0.5859 0.9195 0.7412 0.6049 0.6725 0.7965
Cytoplasmic Foci 0.011 0.0019 0.0027 0.0053 0.0426 0.0044 0.0019 0.0011 0.0036 0.0071 0.0058 0.0073 0.0065 0.0009 0.0098 0.012 0.0223 0.0082
Eisosomes 0.0007 0 0.0001 0.0001 0.0013 0.0001 0.0002 0.0001 0.0002 0.0036 0.0001 0.0011 0.0007 0 0.0004 0.0003 0.0004 0
Endoplasmic Reticulum 0.042 0.0171 0.0121 0.0045 0.0051 0.0362 0.0392 0.0082 0.0167 0.0053 0.0193 0.0265 0.0596 0.0071 0.0162 0.0029 0.0029 0.0271
Endosome 0.0248 0.0056 0.0078 0.095 0.0146 0.0213 0.0178 0.0023 0.0163 0.0162 0.0289 0.0707 0.0072 0.0028 0.0072 0.0108 0.0127 0.0446
Golgi 0.0044 0.0016 0.0012 0.0226 0.0016 0.0029 0.0061 0.0006 0.0039 0.0014 0.0017 0.0332 0.0015 0.0002 0.0018 0.0014 0.0019 0.0061
Lipid Particles 0.0049 0.0006 0.0019 0.0036 0.0203 0.004 0.002 0.0018 0.0023 0.014 0.0014 0.0017 0.0033 0.0004 0.0056 0.0042 0.0261 0.0005
Mitochondria 0.0136 0.0005 0.0068 0.0389 0.0219 0.0032 0.0104 0.0008 0.0063 0.0268 0.005 0.0254 0.0146 0.0004 0.0055 0.0012 0.0133 0.0131
None 0.0075 0.0001 0.0027 0.0004 0.0119 0.001 0.0012 0.0004 0.001 0.0058 0.0045 0.0015 0.003 0.0002 0.0057 0.0016 0.0072 0.001
Nuclear Periphery 0.0319 0.0043 0.0081 0.0105 0.0138 0.0279 0.0361 0.0065 0.0124 0.0082 0.0662 0.0209 0.0637 0.0035 0.0149 0.0107 0.0074 0.0282
Nucleolus 0.0038 0.0001 0.0048 0.0015 0.0309 0.0005 0.0008 0.0011 0.001 0.0077 0.0032 0.0013 0.0071 0.0001 0.005 0.0049 0.0049 0.0006
Nucleus 0.0115 0.0021 0.0075 0.0077 0.0073 0.0046 0.01 0.0026 0.0055 0.0063 0.0139 0.0091 0.0143 0.0024 0.0066 0.0082 0.0084 0.0111
Peroxisomes 0.0006 0 0.0002 0.0003 0.0022 0.0002 0.0001 0.0001 0.0003 0.0012 0.0002 0.0004 0.0006 0 0.0007 0.0025 0.0013 0.0002
Punctate Nuclear 0.0015 0 0.0001 0.0003 0.0017 0.0001 0.0002 0 0.0002 0.0003 0.0004 0.0002 0.0004 0 0.0019 0.0022 0.0007 0.0002
Vacuole 0.1435 0.0519 0.1488 0.2685 0.1319 0.0701 0.181 0.0601 0.1116 0.2162 0.1029 0.089 0.1335 0.0481 0.1121 0.2258 0.1403 0.0271
Vacuole Periphery 0.0357 0.0057 0.0338 0.0442 0.039 0.04 0.0403 0.0056 0.017 0.0636 0.0636 0.0707 0.0368 0.0051 0.0252 0.0701 0.0584 0.0292

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 2045.6375 2216.5757 2305.454 2139.1166 2459.3669 1738.8618 1957.2949 1762.2299 1900.2743 1787.5579
Translational Efficiency 1.9726 1.9178 1.9468 1.827 1.9268 2.2802 1.8155 2.2586 1.8454 1.9103

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘
Standard name
Human Ortholog
Description Ribosomal 60S subunit protein L37A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-2

Rpl37a

Rpl37a


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rpl37a-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available