Standard name | |
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Human Ortholog | |
Description | Karyopherin beta; forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 1 | 1 | 0 | 1 | 13 | 22 | 20 | – | 19 | 20 | 21 | 33 | 5 | 3 | 3 | 4 | 1 | 0 | 2 | 3 | 3 | 1 | 1 | 2 |
Bud | 1 | 5 | 2 | 1 | 2 | 3 | 7 | – | 0 | 8 | 1 | 3 | 7 | 0 | 2 | 1 | 3 | 1 | 3 | 7 | 5 | 2 | 1 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 3 | 0 | 0 | 0 | 2 | – | 3 | 4 | 3 | 5 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 215 | 179 | 144 | 95 | 93 | 112 | 147 | – | 110 | 134 | 63 | 94 | 144 | 191 | 218 | 83 | 62 | 78 | 118 | 160 | 130 | 67 | 115 | 142 |
Endoplasmic Reticulum | 74 | 38 | 59 | 40 | 53 | 63 | 88 | – | 71 | 65 | 32 | 74 | 84 | 57 | 74 | 4 | 3 | 3 | 129 | 22 | 74 | 59 | 88 | 93 |
Endosome | 0 | 0 | 1 | 0 | 2 | 8 | 5 | – | 0 | 1 | 0 | 2 | 1 | 0 | 10 | 0 | 2 | 2 | 12 | 26 | 12 | 7 | 12 | 24 |
Golgi | 12 | 1 | 6 | 18 | 71 | 105 | 61 | – | 42 | 52 | 23 | 63 | 19 | 26 | 46 | 98 | 69 | 51 | 6 | 1 | 1 | 4 | 16 | 29 |
Mitochondria | 0 | 2 | 0 | 0 | 1 | 2 | 2 | – | 13 | 6 | 13 | 8 | 0 | 1 | 0 | 7 | 1 | 1 | 1 | 1 | 1 | 0 | 2 | 2 |
Nucleus | 1 | 1 | 1 | 1 | 0 | 0 | 0 | – | 1 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 17 | 4 | 0 | 1 | 1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 100 | 51 | 33 | 11 | 10 | 13 |
Nucleolus | 8 | 4 | 3 | 0 | 11 | 17 | 21 | – | 10 | 11 | 8 | 10 | 5 | 5 | 19 | 16 | 15 | 6 | 1 | 2 | 0 | 1 | 0 | 0 |
Peroxisomes | 0 | 0 | 1 | 0 | 1 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 |
SpindlePole | 0 | 0 | 2 | 1 | 1 | 2 | 1 | – | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 1 | 0 | 7 | 5 | 3 | 3 | 5 | 5 |
Vac/Vac Membrane | 37 | 42 | 58 | 33 | 68 | 64 | 64 | – | 33 | 62 | 62 | 66 | 21 | 28 | 56 | 80 | 66 | 65 | 40 | 68 | 42 | 10 | 22 | 31 |
Unique Cell Count | 326 | 264 | 253 | 178 | 268 | 340 | 363 | 263 | 329 | 206 | 295 | 258 | 293 | 401 | 252 | 186 | 179 | 438 | 380 | 322 | 181 | 289 | 358 | |
Labelled Cell Count | 349 | 273 | 280 | 190 | 316 | 398 | 418 | 302 | 364 | 232 | 359 | 286 | 311 | 429 | 299 | 223 | 207 | 438 | 380 | 322 | 181 | 289 | 358 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 39.8 | 31.1 | 32.9 | 30.9 | 31.5 | 31.3 | 28.8 | – | 27.8 | 26.4 | 24.2 | 27.0 | 34.8 | 37.5 | 34.3 | 47.0 | 52.1 | 45.6 | 34.0 | 34.8 | 35.5 |
Std Deviation (1e-4) | 8.5 | 8.4 | 8.1 | 5.8 | 5.8 | 6.5 | 6.9 | – | 6.6 | 6.3 | 6.7 | 7.1 | 7.2 | 8.1 | 8.1 | 15.6 | 15.6 | 15.0 | 6.9 | 7.1 | 8.3 |
Intensity Change (Log2) | – | – | – | -0.09 | -0.06 | -0.07 | -0.19 | – | -0.25 | -0.32 | -0.44 | -0.28 | 0.08 | 0.19 | 0.06 | 0.52 | 0.66 | 0.47 | 0.05 | 0.08 | 0.11 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 3.5 | 4.1 | 3.8 | – | 4.4 | 4.0 | 5.2 | 5.5 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -0.7 | -5.1 | -5.8 | -4.0 | – | -3.4 | -3.9 | -5.6 | -5.9 | -0.3 | 2.0 | -0.6 | -5.4 | -4.9 | -2.7 |
Endoplasmic Reticulum | -0.2 | -1.0 | -1.4 | 0.3 | – | 1.0 | -1.0 | -2.1 | 0.5 | 2.3 | -1.1 | -1.5 | -7.4 | -6.5 | -6.3 |
Endosome | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 3.5 | 7.8 | 8.8 | 5.7 | – | 5.3 | 5.4 | 3.9 | 6.7 | 2.6 | 3.2 | 4.2 | 10.1 | 9.6 | 7.9 |
Mitochondria | 0 | 0 | 0 | 0 | – | 3.6 | 0 | 4.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 2.1 | 2.5 | 2.9 | – | 1.9 | 1.7 | 0 | 1.7 | 0 | 0 | 2.5 | 3.0 | 3.6 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | -1.1 | 0.7 | -1.2 | -1.6 | – | -3.1 | -1.2 | 1.7 | -0.2 | -4.6 | -4.3 | -2.9 | 2.2 | 2.9 | 3.0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 27.268 | 40.2542 | 33.4087 | 32.715 | 34.5504 | 35.6133 | 30.698 | 43.6043 | 38.6632 | 34.8645 | 37.6641 | 38.5315 | 31.3159 | 45.3247 | 39.8152 | 37.5641 | 29.9672 | 40.6356 |
Actin | 0.019 | 0.0103 | 0.009 | 0.0011 | 0.0016 | 0.0005 | 0.0219 | 0.0005 | 0.004 | 0.0137 | 0.0006 | 0.0086 | 0.0159 | 0.0003 | 0.0162 | 0.0039 | 0.0231 | 0.0016 |
Bud | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0003 | 0 | 0.0001 | 0.0006 | 0.0001 | 0.0001 | 0.0002 | 0 | 0.0002 | 0.0001 | 0.0002 | 0.0001 |
Bud Neck | 0.0007 | 0.0001 | 0.0002 | 0.0002 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0004 | 0.0053 | 0.0001 | 0.0003 | 0.0001 | 0.0003 | 0.0005 |
Bud Periphery | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0.0003 | 0 | 0.0001 | 0.0009 | 0.0001 | 0.0001 | 0.0002 | 0 | 0.0004 | 0.0002 | 0.0002 | 0 |
Bud Site | 0.0014 | 0.0004 | 0.0008 | 0.0001 | 0.0001 | 0 | 0.0015 | 0 | 0.0004 | 0.0008 | 0 | 0.0001 | 0.0027 | 0 | 0.0009 | 0.0002 | 0.0006 | 0 |
Cell Periphery | 0.0002 | 0.0002 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0002 | 0.0001 |
Cytoplasm | 0.0567 | 0.0709 | 0.0499 | 0.1523 | 0.0627 | 0.0367 | 0.0397 | 0.1138 | 0.0611 | 0.0945 | 0.1073 | 0.0711 | 0.0449 | 0.0836 | 0.0917 | 0.2052 | 0.0597 | 0.1315 |
Cytoplasmic Foci | 0.0156 | 0.0104 | 0.0121 | 0.0485 | 0.0357 | 0.0208 | 0.0136 | 0.0104 | 0.013 | 0.015 | 0.0342 | 0.0145 | 0.0161 | 0.0063 | 0.0157 | 0.0093 | 0.0551 | 0.0071 |
Eisosomes | 0.0003 | 0 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0 | 0.0002 | 0 | 0.0004 | 0 | 0.0006 | 0 |
Endoplasmic Reticulum | 0.0469 | 0.0351 | 0.0293 | 0.0819 | 0.054 | 0.0261 | 0.0163 | 0.0205 | 0.0148 | 0.0501 | 0.0093 | 0.0292 | 0.0092 | 0.0142 | 0.0093 | 0.0175 | 0.0121 | 0.0159 |
Endosome | 0.0239 | 0.0353 | 0.0312 | 0.0672 | 0.0599 | 0.0395 | 0.0202 | 0.0127 | 0.0233 | 0.1043 | 0.1266 | 0.0305 | 0.0146 | 0.0087 | 0.02 | 0.0239 | 0.0523 | 0.0184 |
Golgi | 0.0057 | 0.004 | 0.0057 | 0.0086 | 0.0038 | 0.0089 | 0.007 | 0.0035 | 0.0061 | 0.0171 | 0.0138 | 0.0089 | 0.0058 | 0.0007 | 0.0033 | 0.0144 | 0.0314 | 0.0012 |
Lipid Particles | 0.0313 | 0.0431 | 0.0332 | 0.0659 | 0.0171 | 0.0418 | 0.0149 | 0.0265 | 0.0586 | 0.0348 | 0.0219 | 0.0144 | 0.028 | 0.0123 | 0.0101 | 0.0275 | 0.1461 | 0.0067 |
Mitochondria | 0.005 | 0.0002 | 0.0014 | 0.0011 | 0.0025 | 0.0003 | 0.0037 | 0.0002 | 0.0029 | 0.0377 | 0.0009 | 0.0009 | 0.0055 | 0.0001 | 0.0029 | 0.0253 | 0.0245 | 0.0003 |
None | 0.0127 | 0.0002 | 0.0013 | 0.003 | 0.0005 | 0.0003 | 0.0008 | 0.0003 | 0.0003 | 0.0005 | 0.0003 | 0.0003 | 0.0027 | 0.0002 | 0.0026 | 0.0005 | 0.0052 | 0.0003 |
Nuclear Periphery | 0.6786 | 0.7282 | 0.7574 | 0.4888 | 0.6852 | 0.7514 | 0.7843 | 0.7456 | 0.7431 | 0.5567 | 0.6179 | 0.757 | 0.7692 | 0.7749 | 0.7458 | 0.6264 | 0.4826 | 0.6986 |
Nucleolus | 0.0028 | 0.0004 | 0.0009 | 0.0016 | 0.0137 | 0.0006 | 0.0007 | 0.0025 | 0.0076 | 0.0003 | 0.0007 | 0.0004 | 0.0013 | 0.0034 | 0.0007 | 0.0004 | 0.0014 | 0.0002 |
Nucleus | 0.0384 | 0.0251 | 0.0282 | 0.0196 | 0.024 | 0.0351 | 0.0373 | 0.0373 | 0.0288 | 0.0173 | 0.0282 | 0.0283 | 0.0533 | 0.0735 | 0.0427 | 0.02 | 0.0698 | 0.0908 |
Peroxisomes | 0.0193 | 0.0002 | 0.0021 | 0.0003 | 0.0013 | 0.0002 | 0.0042 | 0.0001 | 0.0004 | 0.0006 | 0.0001 | 0.0004 | 0.0033 | 0.0001 | 0.0023 | 0.0008 | 0.0074 | 0.0001 |
Punctate Nuclear | 0.0118 | 0.0044 | 0.0044 | 0.0128 | 0.0034 | 0.005 | 0.0106 | 0.011 | 0.01 | 0.0023 | 0.0029 | 0.0049 | 0.01 | 0.0091 | 0.0174 | 0.0033 | 0.011 | 0.009 |
Vacuole | 0.0093 | 0.0087 | 0.0086 | 0.0264 | 0.0096 | 0.0083 | 0.0065 | 0.0033 | 0.0066 | 0.0163 | 0.0096 | 0.0091 | 0.0029 | 0.0025 | 0.0041 | 0.0044 | 0.0028 | 0.0056 |
Vacuole Periphery | 0.0202 | 0.0228 | 0.0235 | 0.0203 | 0.0246 | 0.0243 | 0.0158 | 0.0115 | 0.0184 | 0.0358 | 0.0251 | 0.0206 | 0.0086 | 0.0098 | 0.0131 | 0.0164 | 0.0133 | 0.012 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 81.9233 | 79.3373 | 75.2878 | 86.3277 | 86.8546 | 66.5258 | 67.8766 | 71.3212 | 70.6537 | 83.7971 |
Translational Efficiency | 1.2881 | 1.2735 | 1.244 | 1.0377 | 1.1174 | 1.3059 | 1.2378 | 1.0725 | 1.0774 | 1.0035 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✔ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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