Standard name
Human Ortholog
Description Protein of unknown function; component of the Swr1p complex that incorporates Htz1p into chromatin

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0.05 0.07 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.11 0.06 0.1 0.08 0.07 0.06 0.06 0.08 0.07 0.09 0.14 0.16 0.13 0.24 0.17 0 0 0.05 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0.06 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.3 0.05 0.62 0.64 0.27 0.63 0.54 0.72 0.68 0.69 0.81 0.06 0.07 0 0.09 0.06 0.06 0 0 0 0 0 0
Nucleus 0.93 0.91 0.74 0.77 0.79 0.63 0.68 0.58 0.61 0.64 0.57 0.86 0.81 0.79 0.45 0.46 0.57 0.84 0.8 0.74 0.65 0.61 0.62
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0.07 0 0.06 0.05 0.07 0.05 0.09 0.06 0.07 0.05 0.06 0.05 0.06 0 0 0 0.06 0.09 0.06 0.15 0.15 0.11
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0.05
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.3 0.18 0.26 0 0 0.07 0.06 0.09 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0
Bud 0 0 0 1 0 0 6 2 2 2 3 0 0 1 0 0 0 5 1 0 1 5 10
Bud Neck 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 4
Bud Site 2 0 0 1 2 8 9 8 20 6 10 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 6 3 9 7 18 16 22 11 17 12 17 27 59 73 11 20 18 0 2 3 0 5 11
Endoplasmic Reticulum 1 0 0 0 0 0 0 0 0 0 0 3 1 0 3 5 6 0 0 0 0 2 0
Endosome 0 0 0 0 2 0 0 0 0 0 1 1 1 8 6 3 6 5 0 1 2 5 7
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 1 0 0 0 0 0 2 1
Mitochondria 143 6 52 70 49 125 170 124 182 106 188 19 29 9 7 5 6 6 2 1 1 5 7
Nucleus 449 106 62 85 145 125 215 101 164 99 132 263 341 358 37 38 59 426 100 60 71 212 253
Nuclear Periphery 0 1 0 1 0 1 2 1 2 0 0 1 1 3 0 1 0 0 0 0 0 0 1
Nucleolus 12 8 1 7 10 14 15 16 15 11 11 18 22 29 3 2 2 30 11 4 15 52 46
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
SpindlePole 4 1 0 2 3 0 2 2 4 1 1 6 3 14 1 1 0 7 0 0 5 16 22
Vac/Vac Membrane 3 0 1 1 0 5 4 2 5 1 4 3 3 3 25 15 27 21 4 5 6 32 33
Unique Cell Count 484 116 84 110 184 197 314 173 267 154 233 306 421 454 82 82 104 508 125 81 109 347 409
Labelled Cell Count 620 125 125 175 229 294 446 267 411 238 367 341 462 499 94 91 124 508 125 81 109 347 409


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.6 5.5 3.9 4.3 4.7 3.7 4.0 3.5 3.6 3.6 3.5 5.5 5.5 5.8 8.0 8.3 8.5 5.0 5.5 5.4
Std Deviation (1e-4) 0.6 0.8 1.9 2.4 1.4 1.3 1.6 1.7 1.2 1.7 1.5 1.9 1.5 2.0 1.9 2.3 1.7 1.4 1.6 1.8
Intensity Change (Log2) 0.14 0.26 -0.07 0.04 -0.18 -0.1 -0.13 -0.17 0.49 0.5 0.56 1.03 1.09 1.12 0.34 0.48 0.47


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.1 -0.2 -0.7 -1.1 -1.2 -1.3 -0.8 -1.0 -0.5 0.8 1.3 0.5 2.3 1.3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 -11.7 -12.5 -15.9 -7.2 -7.6 -8.3
Nucleus 0.6 0.9 -1.7 -0.9 -2.4 -2.1 -1.5 -2.8 2.6 1.5 1.0 -3.8 -3.6 -2.4
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 5.2 3.7 4.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.2331 1.3817 1.4456 0.6803 1.0906 1.0894 1.0963 1.0275 1.2378 0.9945 1.2036 0.938 1.9789 2.3091 2.2694 2.0043 2.5235 2.1621
Actin 0.015 0 0.002 0.0011 0.0046 0.0004 0.0221 0 0.0023 0.0038 0.0045 0.0002 0.0303 0 0.0086 0.0021 0.0081 0.0074
Bud 0.0006 0.0001 0.0002 0.0001 0.0044 0.0001 0.0008 0 0.0002 0.0002 0.0006 0.0001 0.0003 0 0.0001 0.0001 0.0003 0.0001
Bud Neck 0.0027 0.0002 0.0006 0.0005 0.0049 0.0014 0.0067 0.0001 0.0007 0.0004 0.0024 0.0011 0.0026 0.0001 0.0004 0.0002 0.0022 0.0027
Bud Periphery 0.0019 0.0001 0.0005 0.0003 0.0103 0.0003 0.0017 0 0.0003 0.0006 0.0014 0.0003 0.0005 0 0.0003 0.0001 0.0008 0.0001
Bud Site 0.0055 0.0003 0.0038 0.0004 0.0227 0.0002 0.0098 0.0001 0.0016 0.0003 0.0019 0.0003 0.0012 0.0001 0.0003 0.0002 0.001 0.0002
Cell Periphery 0.0005 0 0.0002 0.0001 0.0012 0.0001 0.0012 0 0.0001 0.0004 0.0001 0 0.0001 0 0 0 0.0001 0
Cytoplasm 0.0097 0.0002 0.0015 0.0001 0.0016 0.0001 0.0025 0.0008 0.0012 0.0015 0.0012 0.0004 0.0067 0.0003 0.0002 0.0027 0.0024 0.0002
Cytoplasmic Foci 0.0216 0.0003 0.004 0.0102 0.019 0.0003 0.0134 0 0.0046 0.0016 0.0236 0.0006 0.0135 0 0.0023 0.001 0.0047 0.0005
Eisosomes 0.0001 0 0.0001 0 0.0002 0 0.0004 0 0 0.0003 0.0001 0 0.0003 0 0.0001 0 0.0001 0.0001
Endoplasmic Reticulum 0.0011 0 0.0009 0.0001 0.001 0.0001 0.0042 0 0.0006 0.0013 0.001 0.0004 0.0019 0 0.0003 0.0015 0.0017 0.0004
Endosome 0.0215 0.0002 0.0103 0.0107 0.0274 0.001 0.0211 0 0.0057 0.0093 0.0335 0.0058 0.0153 0 0.0028 0.0104 0.0105 0.0024
Golgi 0.0075 0.0002 0.0041 0.0079 0.016 0.0007 0.0074 0 0.0028 0.011 0.016 0.0012 0.0051 0 0.0016 0.0006 0.002 0.001
Lipid Particles 0.026 0.0066 0.0089 0.0335 0.0456 0.0027 0.0154 0 0.0185 0.0118 0.0128 0.0031 0.0175 0 0.0065 0.0007 0.0183 0.0016
Mitochondria 0.0074 0.0012 0.0063 0.0318 0.0505 0.0118 0.013 0.0001 0.0032 0.0408 0.0481 0.002 0.0039 0.0001 0.0012 0.0019 0.0102 0.0003
None 0.001 0.0001 0.0008 0.0001 0.0006 0 0.0013 0.0022 0.0002 0.0216 0.0008 0.0001 0.0087 0 0.0003 0.0012 0.0023 0.0006
Nuclear Periphery 0.0074 0.002 0.004 0.0003 0.0036 0.0092 0.0161 0.0015 0.0016 0.0017 0.0146 0.0013 0.0174 0.002 0.0008 0.0284 0.0222 0.0038
Nucleolus 0.0329 0.0196 0.0141 0.0094 0.0978 0.0528 0.0302 0.0148 0.0169 0.0231 0.0947 0.0663 0.0179 0.0112 0.016 0.015 0.0623 0.0577
Nucleus 0.8022 0.9611 0.9271 0.8722 0.6467 0.9144 0.7949 0.9751 0.9268 0.8623 0.6887 0.9127 0.815 0.9838 0.9493 0.9224 0.8215 0.9136
Peroxisomes 0.0138 0.0006 0.002 0.0167 0.0094 0.0003 0.0144 0 0.0071 0.0011 0.0116 0.0007 0.023 0 0.007 0.0002 0.0179 0.0019
Punctate Nuclear 0.0084 0.0068 0.0059 0.0009 0.0071 0.0032 0.0157 0.0051 0.0037 0.001 0.0392 0.0024 0.0167 0.0021 0.0016 0.0095 0.0097 0.0048
Vacuole 0.0113 0.0001 0.002 0.0021 0.0198 0.0005 0.0051 0 0.0014 0.004 0.0016 0.0007 0.001 0.0001 0.0003 0.0007 0.0009 0.0002
Vacuole Periphery 0.0018 0.0001 0.0008 0.0015 0.0057 0.0004 0.0025 0 0.0003 0.0019 0.0015 0.0005 0.001 0 0.0002 0.0009 0.001 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 23.5061 9.8885 3.6688 10.5591 14.342 11.0556 12.4978 9.2787 6.6046 17.0548
Translational Efficiency 1.0232 1.2039 2.4544 0.6435 0.7289 2.4439 0.6843 0.5047 1.1301 0.9507

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency
Standard name
Human Ortholog
Description Protein of unknown function; component of the Swr1p complex that incorporates Htz1p into chromatin
Localization
Cell Percentages nucleus (94%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Swc7

Swc7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Swc7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available