Standard name | |
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Human Ortholog | |
Description | Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress; human homolog, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Bud | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 2 | 1 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 4 | 1 | 0 | 0 | 5 | 0 | 1 |
Bud Neck | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 5 | 5 | 1 | 3 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Bud Site | 1 | 1 | 1 | 2 | 2 | 5 | 8 | 20 | 25 | 19 | 16 | 34 | 0 | 0 | 0 | 1 | 5 | 8 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 9 | 1 | 5 | 5 | 7 | 13 | 20 | 5 | 11 | 6 | 4 | 2 | 19 | 46 | 44 | 29 | 25 | 7 | 0 | 0 | 1 | 4 | 2 | 1 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 2 | 0 | 2 | 3 | 4 | 1 | 2 | 1 | 0 | 4 | 1 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 0 | 2 | 0 |
Mitochondria | 3 | 1 | 5 | 8 | 12 | 31 | 52 | 24 | 38 | 63 | 37 | 43 | 1 | 0 | 0 | 8 | 29 | 27 | 0 | 0 | 2 | 0 | 0 | 1 |
Nucleus | 100 | 88 | 273 | 203 | 229 | 242 | 329 | 298 | 284 | 261 | 264 | 263 | 185 | 331 | 300 | 322 | 396 | 313 | 88 | 90 | 220 | 183 | 169 | 188 |
Nuclear Periphery | 1 | 0 | 3 | 1 | 0 | 6 | 3 | 6 | 4 | 4 | 5 | 1 | 0 | 1 | 1 | 5 | 6 | 11 | 0 | 0 | 0 | 0 | 0 | 2 |
Nucleolus | 74 | 70 | 176 | 134 | 128 | 198 | 260 | 278 | 302 | 304 | 287 | 290 | 74 | 85 | 76 | 111 | 142 | 104 | 41 | 32 | 130 | 53 | 64 | 131 |
Peroxisomes | 0 | 0 | 1 | 0 | 1 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 1 | 1 | 0 | 0 | 1 | 0 | 2 | 1 | 2 | 0 | 3 | 0 | 3 | 12 | 6 | 4 | 2 | 1 | 0 | 0 | 1 | 3 | 5 | 6 |
Vac/Vac Membrane | 1 | 2 | 4 | 0 | 0 | 3 | 0 | 0 | 1 | 1 | 2 | 1 | 0 | 8 | 7 | 7 | 9 | 5 | 2 | 3 | 6 | 6 | 8 | 11 |
Unique Cell Count | 137 | 116 | 349 | 262 | 305 | 352 | 507 | 457 | 487 | 463 | 442 | 456 | 231 | 418 | 383 | 408 | 503 | 378 | 136 | 130 | 371 | 263 | 262 | 351 |
Labelled Cell Count | 190 | 165 | 470 | 354 | 383 | 499 | 679 | 641 | 674 | 665 | 622 | 636 | 283 | 485 | 435 | 492 | 626 | 487 | 136 | 130 | 371 | 263 | 262 | 351 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 10.9 | 11.9 | 10.7 | 9.2 | 9.9 | 8.0 | 8.5 | 8.7 | 8.0 | 8.0 | 7.9 | 7.7 | 12.4 | 12.7 | 12.2 | 13.8 | 13.3 | 12.5 | 12.3 | 13.6 | 15.3 |
Std Deviation (1e-4) | 4.2 | 3.7 | 3.3 | 2.9 | 3.0 | 2.2 | 3.0 | 2.7 | 2.7 | 2.7 | 2.5 | 2.5 | 4.7 | 4.4 | 4.2 | 5.6 | 5.6 | 5.4 | 4.0 | 3.7 | 3.8 |
Intensity Change (Log2) | – | – | – | -0.22 | -0.12 | -0.42 | -0.34 | -0.31 | -0.43 | -0.43 | -0.45 | -0.47 | 0.21 | 0.24 | 0.18 | 0.36 | 0.31 | 0.22 | 0.2 | 0.34 | 0.51 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 3.6 | 4.0 | 3.5 | 3.2 | 4.9 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 0.8 | 1.9 | 2.1 | 0 | 0.9 | 0 | 0 | 0 | 4.0 | 5.3 | 5.4 | 3.8 | 2.8 | 0.4 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 1.4 | 2.0 | 4.4 | 5.1 | 2.9 | 4.1 | 6.2 | 4.3 | 4.7 | 0 | 0 | 0 | 0.6 | 3.2 | 3.7 |
Nucleus | -0.2 | -0.9 | -2.8 | -4.2 | -4.0 | -6.0 | -6.5 | -5.5 | -6.1 | 0.5 | 0.3 | 0 | 0.2 | 0.2 | 1.6 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.0 |
Nucleolus | 0.2 | -2.2 | 1.5 | 0.2 | 3.0 | 3.3 | 4.4 | 4.1 | 3.7 | -4.4 | -8.8 | -8.7 | -6.6 | -6.6 | -6.3 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.2 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.9 | 0.8 | 0.7 | 0.8 | 0 |
R1 | R2 | R3 | ||||||||||||||||
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G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 11.4897 | 9.0921 | 9.4992 | 8.6371 | 8.5349 | 8.5387 | 11.726 | 9.891 | 9.8414 | 8.8935 | 9.9418 | 9.3332 | 10.124 | 8.8187 | 8.8587 | 8.5096 | 8.3057 | 8.2311 |
Actin | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0.0003 | 0.0005 | 0 | 0 | 0 | 0 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0 | 0.0001 | 0.0001 |
Bud Periphery | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0002 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 |
Cytoplasm | 0 | 0 | 0 | 0 | 0 | 0 | 0.0028 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasmic Foci | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Eisosomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0.0004 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lipid Particles | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0.0001 | 0 | 0 | 0 | 0.0019 | 0 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0.0003 | 0 | 0 | 0 | 0.0028 | 0 |
None | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0.0005 | 0.0004 | 0.0001 | 0.0016 | 0.0001 | 0.0007 | 0.0003 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0004 | 0.0001 | 0 | 0.0008 | 0 |
Nucleolus | 0.0735 | 0.0534 | 0.0504 | 0.0654 | 0.3602 | 0.2544 | 0.0506 | 0.0567 | 0.0325 | 0.049 | 0.2535 | 0.1758 | 0.0787 | 0.0572 | 0.0597 | 0.0477 | 0.3593 | 0.1816 |
Nucleus | 0.9263 | 0.9447 | 0.9489 | 0.9341 | 0.6285 | 0.7434 | 0.945 | 0.9412 | 0.9671 | 0.9503 | 0.7447 | 0.8238 | 0.9207 | 0.9421 | 0.9401 | 0.9512 | 0.6353 | 0.8181 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Punctate Nuclear | 0.0001 | 0.0013 | 0.0002 | 0.0004 | 0.0067 | 0.0014 | 0.0001 | 0.0016 | 0.0002 | 0.0004 | 0.0014 | 0.0001 | 0 | 0.0003 | 0.0001 | 0.0009 | 0.0008 | 0.0001 |
Vacuole | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0002 | 0 |
Vacuole Periphery | 0 | 0 | 0 | 0 | 0.0003 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0002 | 0 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 21.9374 | 22.5314 | 18.577 | 29.6471 | 33.2841 | 18.6598 | 25.7347 | 31.0367 | 26.1593 | 29.3312 |
Translational Efficiency | 2.6361 | 2.5088 | 3.1357 | 1.7059 | 1.8557 | 3.1328 | 2.3115 | 1.8625 | 2.1264 | 2.0533 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
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37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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