Standard name | |
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Human Ortholog | |
Description | Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form high-molecular weight chaperone complex under oxidative stress; chaperone activity essential for growth in zinc deficiency; required for telomere length maintenance; binds and modulates Cdc19p activity; protein abundance increases, forms cytoplasmic foci during DNA replication stress; TSA1 has a paralog, TSA2, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 18 |
Bud | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 3 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 0 | 3 | 3 | 8 | 6 | 9 | 8 | 13 | 20 | 11 | 17 | 2 | 6 | 8 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 240 | 195 | 153 | 237 | 281 | 186 | 297 | 351 | 291 | 346 | 286 | 312 | 291 | 508 | 506 | 151 | 67 | 54 | 220 | 173 | 144 | 246 | 354 | 280 |
Endoplasmic Reticulum | 0 | 0 | 1 | 0 | 0 | 2 | 7 | 19 | 11 | 14 | 17 | 34 | 0 | 4 | 0 | 9 | 4 | 8 | 1 | 0 | 0 | 4 | 11 | 21 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 14 | 31 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 12 | 38 |
Mitochondria | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 3 |
Nucleolus | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 2 | 4 | 3 | 5 | 2 | 5 | 0 | 0 | 0 | 0 | 1 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 8 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 6 |
Vac/Vac Membrane | 0 | 1 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 2 | 1 | 1 | 3 | 2 | 4 |
Unique Cell Count | 240 | 197 | 155 | 237 | 285 | 190 | 316 | 376 | 310 | 370 | 314 | 361 | 294 | 515 | 512 | 160 | 73 | 59 | 229 | 183 | 153 | 268 | 423 | 440 |
Labelled Cell Count | 241 | 197 | 158 | 240 | 291 | 196 | 320 | 381 | 317 | 381 | 317 | 365 | 296 | 523 | 519 | 168 | 77 | 70 | 229 | 183 | 153 | 268 | 423 | 440 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 254.6 | 235.2 | 210.1 | 221.5 | 244.0 | 180.2 | 217.7 | 205.2 | 207.8 | 205.7 | 179.9 | 197.7 | 303.6 | 332.8 | 360.4 | 307.3 | 281.5 | 316.5 | 247.8 | 268.9 | 288.8 |
Std Deviation (1e-4) | 41.3 | 70.1 | 40.9 | 38.1 | 55.6 | 63.6 | 63.2 | 56.0 | 53.9 | 57.8 | 60.7 | 51.0 | 61.1 | 72.9 | 74.5 | 96.1 | 101.5 | 110.5 | 51.7 | 64.2 | 75.9 |
Intensity Change (Log2) | – | – | – | 0.08 | 0.22 | -0.22 | 0.05 | -0.03 | -0.02 | -0.03 | -0.22 | -0.09 | 0.53 | 0.66 | 0.78 | 0.55 | 0.42 | 0.59 | 0.24 | 0.36 | 0.46 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 1.3 | 1.8 | 0 | 1.5 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1.8 | -0.1 | -0.6 | -2.3 | -2.6 | -2.4 | -2.5 | -3.2 | -4.3 | 0.3 | -0.1 | 0.1 | -2.1 | -2.7 | -2.6 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 2.4 | 0 | 0 | 2.5 | 3.6 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 180.2293 | 226.7762 | 207.6726 | 210.7903 | 174.4542 | 200.4486 | 230.5451 | 300.7082 | 280.2147 | 259.5823 | 255.9507 | 245.1615 | 252.085 | 308.4401 | 274.5539 | 248.7656 | 266.2584 | 237.4361 |
Actin | 0.0065 | 0.0002 | 0.0001 | 0.0001 | 0.0009 | 0.0001 | 0.006 | 0.0002 | 0.001 | 0.0001 | 0.0003 | 0.0002 | 0.0003 | 0.0024 | 0.0059 | 0.0006 | 0.0001 | 0.0003 |
Bud | 0.0007 | 0 | 0.0001 | 0 | 0.0029 | 0 | 0.0008 | 0.0009 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0004 | 0.0009 | 0 | 0.0002 |
Bud Neck | 0.0007 | 0.0001 | 0.0002 | 0.0002 | 0.0004 | 0.0004 | 0.0005 | 0.0001 | 0.0001 | 0.0002 | 0.0003 | 0.001 | 0.0001 | 0.0001 | 0.0002 | 0.0002 | 0.0002 | 0.0003 |
Bud Periphery | 0.0007 | 0 | 0 | 0 | 0.0041 | 0 | 0.0007 | 0.0002 | 0.0001 | 0 | 0 | 0 | 0 | 0.0001 | 0.0003 | 0.0008 | 0 | 0 |
Bud Site | 0.0014 | 0 | 0 | 0 | 0.0004 | 0 | 0.0015 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0 | 0 | 0 | 0.0004 | 0.0002 | 0 | 0 |
Cell Periphery | 0.001 | 0.0001 | 0.0003 | 0 | 0.0005 | 0 | 0.0007 | 0.0001 | 0.0002 | 0.0006 | 0.0004 | 0.0008 | 0.0004 | 0 | 0.0003 | 0.0006 | 0 | 0.0001 |
Cytoplasm | 0.8719 | 0.9902 | 0.9794 | 0.9769 | 0.8529 | 0.9889 | 0.9073 | 0.9836 | 0.972 | 0.9478 | 0.8774 | 0.9767 | 0.938 | 0.9899 | 0.9622 | 0.9578 | 0.9934 | 0.9685 |
Cytoplasmic Foci | 0.0075 | 0.0001 | 0.0003 | 0.0001 | 0.0136 | 0.0001 | 0.0039 | 0.0036 | 0.0007 | 0.0082 | 0.0506 | 0.0007 | 0.0046 | 0.0001 | 0.0045 | 0.0008 | 0.0001 | 0.0002 |
Eisosomes | 0.0005 | 0 | 0 | 0 | 0.0004 | 0 | 0.0009 | 0 | 0.0004 | 0.0007 | 0.001 | 0 | 0.0003 | 0 | 0.0002 | 0.0001 | 0 | 0 |
Endoplasmic Reticulum | 0.0004 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0007 | 0 | 0.0012 | 0.0001 | 0.0002 | 0.0005 | 0.0003 | 0 | 0.0004 | 0.0003 | 0 | 0.0002 |
Endosome | 0.0007 | 0 | 0 | 0 | 0.0003 | 0 | 0.005 | 0 | 0.0009 | 0.0001 | 0.0003 | 0 | 0.0003 | 0 | 0.0017 | 0.0001 | 0 | 0.0001 |
Golgi | 0.0005 | 0 | 0 | 0 | 0.0001 | 0 | 0.001 | 0 | 0.0004 | 0 | 0.0004 | 0 | 0 | 0 | 0.0007 | 0 | 0 | 0 |
Lipid Particles | 0.0034 | 0 | 0.0001 | 0 | 0.0023 | 0 | 0.0025 | 0.0001 | 0.0004 | 0.0018 | 0.0104 | 0.0002 | 0.0005 | 0 | 0.0029 | 0.0001 | 0 | 0 |
Mitochondria | 0.0051 | 0.0001 | 0.0003 | 0.0001 | 0.0519 | 0 | 0.0052 | 0.0006 | 0.0014 | 0.0062 | 0.0062 | 0.0002 | 0.0013 | 0.0028 | 0.0039 | 0.0026 | 0 | 0.0004 |
None | 0.0056 | 0.0002 | 0.0006 | 0.0001 | 0.003 | 0.0001 | 0.0056 | 0.0004 | 0.0016 | 0.0142 | 0.0187 | 0.0011 | 0.0032 | 0.0003 | 0.0022 | 0.0055 | 0.0002 | 0.0003 |
Nuclear Periphery | 0.0084 | 0.0019 | 0.0024 | 0.0036 | 0.0066 | 0.0016 | 0.008 | 0.0007 | 0.0052 | 0.002 | 0.0021 | 0.0085 | 0.0088 | 0.0008 | 0.0012 | 0.005 | 0.0007 | 0.0061 |
Nucleolus | 0.0176 | 0.0001 | 0.0025 | 0 | 0.0301 | 0 | 0.0109 | 0.0011 | 0.0001 | 0.0052 | 0.0172 | 0.0003 | 0.004 | 0 | 0.0037 | 0.0006 | 0 | 0.0003 |
Nucleus | 0.0576 | 0.0067 | 0.0122 | 0.0177 | 0.0227 | 0.0084 | 0.0287 | 0.0077 | 0.0132 | 0.0085 | 0.0088 | 0.008 | 0.0359 | 0.0029 | 0.0059 | 0.0222 | 0.005 | 0.0217 |
Peroxisomes | 0.0019 | 0 | 0 | 0 | 0.0021 | 0 | 0.0007 | 0 | 0 | 0.0005 | 0.0011 | 0 | 0.0001 | 0.0001 | 0.0004 | 0.0001 | 0 | 0 |
Punctate Nuclear | 0.0014 | 0.0001 | 0.0001 | 0 | 0.0009 | 0.0001 | 0.0049 | 0.0001 | 0.0003 | 0.0003 | 0.002 | 0.0004 | 0.0005 | 0 | 0.0005 | 0.0002 | 0.0001 | 0.0002 |
Vacuole | 0.0038 | 0.0001 | 0.0008 | 0.0007 | 0.0021 | 0.0001 | 0.0028 | 0.0003 | 0.0004 | 0.0017 | 0.001 | 0.0009 | 0.0007 | 0 | 0.0011 | 0.0011 | 0.0001 | 0.0006 |
Vacuole Periphery | 0.0025 | 0 | 0.0003 | 0.0003 | 0.0018 | 0 | 0.0019 | 0.0002 | 0.0003 | 0.0015 | 0.0014 | 0.0002 | 0.0004 | 0.0001 | 0.0009 | 0.0004 | 0.0001 | 0.0005 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 1439.4667 | 1573.8625 | 2237.9089 | 2099.6179 | 2058.7743 | 1778.278 | 1838.5523 | 1862.2026 | 2239.2927 | 1839.3815 |
Translational Efficiency | 2.0467 | 2.0417 | 1.8024 | 2.1604 | 2.1139 | 1.9637 | 2.0668 | 2.491 | 2.0771 | 2.3203 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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