Standard name | |
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Human Ortholog | |
Description | Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 1 | – | 4 | 3 | 5 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 1 | 0 | 5 | 1 | 0 | 0 | – | 1 | 0 | 1 | 0 | 6 | 0 | 1 | 1 | 0 | 1 | 0 | 2 | 3 | 0 | 0 | 2 | 3 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 0 | 2 | 1 | 1 | 6 | – | 14 | 14 | 15 | 7 | 11 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 538 | 363 | 160 | 259 | 411 | 369 | – | 466 | 488 | 405 | 304 | 335 | 171 | 309 | 342 | 105 | 119 | 83 | 507 | 326 | 137 | 82 | 189 | 173 |
Endoplasmic Reticulum | 0 | 2 | 0 | 0 | 2 | 0 | – | 33 | 31 | 22 | 27 | 23 | 0 | 4 | 6 | 7 | 6 | 6 | 0 | 2 | 0 | 0 | 1 | 1 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 1 | 0 | 0 | 0 | 0 | 0 | – | 3 | 3 | 1 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 1 | 1 | 0 | 0 | 0 | – | 1 | 2 | 4 | 11 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | – | 4 | 3 | 2 | 1 | 8 | 0 | 0 | 1 | 0 | 0 | 0 | 10 | 12 | 9 | 3 | 13 | 20 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | – | 2 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 1 | 0 | 0 | 1 | 9 | 4 | – | 52 | 16 | 7 | 20 | 14 | 2 | 6 | 8 | 1 | 2 | 1 | 3 | 3 | 1 | 0 | 5 | 8 |
Unique Cell Count | 540 | 366 | 162 | 261 | 422 | 374 | 564 | 549 | 443 | 368 | 396 | 172 | 320 | 354 | 107 | 121 | 84 | 532 | 354 | 152 | 89 | 217 | 213 | |
Labelled Cell Count | 542 | 366 | 168 | 262 | 423 | 380 | 580 | 560 | 462 | 376 | 416 | 174 | 321 | 359 | 113 | 128 | 90 | 532 | 354 | 152 | 89 | 217 | 213 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 63.8 | 74.7 | 32.5 | 49.4 | 49.5 | 38.1 | – | 31.7 | 31.5 | 29.5 | 26.8 | 26.6 | 70.5 | 71.4 | 63.4 | 125.4 | 100.2 | 116.9 | 66.8 | 72.8 | 68.1 |
Std Deviation (1e-4) | 13.2 | 14.5 | 8.4 | 12.7 | 12.6 | 9.5 | – | 8.7 | 8.1 | 7.3 | 7.4 | 8.2 | 17.6 | 18.9 | 19.0 | 44.0 | 40.1 | 39.5 | 17.6 | 17.1 | 20.4 |
Intensity Change (Log2) | – | – | – | 0.61 | 0.61 | 0.23 | – | -0.03 | -0.04 | -0.14 | -0.27 | -0.29 | 1.12 | 1.14 | 0.97 | 1.95 | 1.63 | 1.85 | 1.04 | 1.17 | 1.07 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.5 | -1.0 | -0.1 | – | -5.3 | -3.9 | -3.2 | -5.2 | -4.8 | 0.6 | -1.4 | -1.4 | -0.4 | -0.3 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | – | 3.2 | 3.1 | 2.9 | 3.5 | 3.1 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | – | 4.0 | 0 | 0 | 3.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 70.5503 | 86.5009 | 73.4151 | 70.4774 | 87.8241 | 86.7633 | 71.3411 | 93.2722 | 72.7693 | 80.0655 | 83.8213 | 98.5792 | 84.7476 | 103.3714 | 85.5354 | 94.9664 | 73.2005 | 118.1652 |
Actin | 0.0061 | 0.0013 | 0.0015 | 0.0043 | 0.0002 | 0.0022 | 0.0038 | 0.0004 | 0.0017 | 0.0057 | 0.0001 | 0 | 0.0068 | 0.0001 | 0.004 | 0.0002 | 0.0007 | 0 |
Bud | 0.0005 | 0.0001 | 0.0002 | 0.0012 | 0.0004 | 0.0002 | 0.0019 | 0.0007 | 0.0009 | 0.0008 | 0.0002 | 0 | 0.0022 | 0.0001 | 0.0003 | 0 | 0.0004 | 0 |
Bud Neck | 0.0002 | 0.0002 | 0.0007 | 0.0004 | 0.0003 | 0.0005 | 0.0023 | 0.0002 | 0.0002 | 0.0002 | 0.0003 | 0.0004 | 0.002 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0002 |
Bud Periphery | 0.0003 | 0.0001 | 0.0001 | 0.0008 | 0.0004 | 0.0001 | 0.0012 | 0.0006 | 0.0007 | 0.0031 | 0.0001 | 0 | 0.0011 | 0 | 0.0001 | 0 | 0.0004 | 0 |
Bud Site | 0.0004 | 0.0002 | 0.0003 | 0.0017 | 0.0001 | 0.0001 | 0.0026 | 0.0005 | 0.0051 | 0.0003 | 0.0001 | 0 | 0.0021 | 0 | 0.0001 | 0 | 0.0004 | 0 |
Cell Periphery | 0.0003 | 0.0002 | 0.0002 | 0.0002 | 0.0021 | 0.0001 | 0.0004 | 0.0002 | 0.0004 | 0.0001 | 0.0001 | 0 | 0.0005 | 0 | 0.0001 | 0 | 0.0005 | 0 |
Cytoplasm | 0.8564 | 0.9654 | 0.9221 | 0.8795 | 0.9505 | 0.8985 | 0.855 | 0.964 | 0.8816 | 0.8843 | 0.9525 | 0.9577 | 0.8766 | 0.9884 | 0.9283 | 0.9368 | 0.7646 | 0.9819 |
Cytoplasmic Foci | 0.012 | 0.0003 | 0.0094 | 0.0081 | 0.0052 | 0.0014 | 0.0054 | 0.0012 | 0.0143 | 0.0032 | 0.0042 | 0.0001 | 0.0124 | 0.0001 | 0.0022 | 0.0041 | 0.0789 | 0.0001 |
Eisosomes | 0.0002 | 0.0002 | 0.0001 | 0.0002 | 0 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0 | 0 | 0.0003 | 0 | 0.0001 | 0 | 0.0002 | 0 |
Endoplasmic Reticulum | 0.0032 | 0.0014 | 0.0008 | 0.0044 | 0.0002 | 0.0004 | 0.001 | 0.0001 | 0.001 | 0.0014 | 0.0006 | 0.0001 | 0.0009 | 0 | 0.0004 | 0 | 0.0046 | 0 |
Endosome | 0.0082 | 0.0006 | 0.0019 | 0.0021 | 0.0005 | 0.0049 | 0.0056 | 0.0001 | 0.0036 | 0.0238 | 0.0001 | 0 | 0.0042 | 0 | 0.0027 | 0.0003 | 0.0115 | 0 |
Golgi | 0.0044 | 0.0006 | 0.0004 | 0.0006 | 0.0001 | 0.0085 | 0.0015 | 0 | 0.0021 | 0.0124 | 0 | 0 | 0.0024 | 0 | 0.0033 | 0.0006 | 0.001 | 0 |
Lipid Particles | 0.0095 | 0.0006 | 0.0028 | 0.0024 | 0.0045 | 0.0044 | 0.003 | 0.0002 | 0.007 | 0.0075 | 0.0001 | 0 | 0.0043 | 0 | 0.0079 | 0.0029 | 0.0314 | 0 |
Mitochondria | 0.0032 | 0.0067 | 0.0009 | 0.0041 | 0.0016 | 0.0019 | 0.008 | 0.001 | 0.0145 | 0.0114 | 0.0004 | 0 | 0.0053 | 0.0001 | 0.0031 | 0.0007 | 0.0186 | 0 |
None | 0.0071 | 0.0004 | 0.0035 | 0.0081 | 0.0004 | 0.0018 | 0.0028 | 0.0002 | 0.0047 | 0.0003 | 0.0087 | 0.0001 | 0.0047 | 0.0001 | 0.0012 | 0.0001 | 0.0154 | 0 |
Nuclear Periphery | 0.016 | 0.0021 | 0.0047 | 0.0167 | 0.0032 | 0.0069 | 0.0104 | 0.0023 | 0.0055 | 0.0047 | 0.0046 | 0.0037 | 0.0063 | 0.0009 | 0.0031 | 0.0019 | 0.0122 | 0.001 |
Nucleolus | 0.002 | 0 | 0.0012 | 0.0023 | 0.0011 | 0.0023 | 0.0018 | 0.0003 | 0.0037 | 0.0001 | 0.0004 | 0 | 0.0032 | 0.0001 | 0.0009 | 0 | 0.0051 | 0 |
Nucleus | 0.0599 | 0.0184 | 0.0456 | 0.0404 | 0.018 | 0.0634 | 0.0834 | 0.0267 | 0.0434 | 0.0181 | 0.0261 | 0.0375 | 0.0467 | 0.0098 | 0.034 | 0.024 | 0.0162 | 0.0166 |
Peroxisomes | 0.0016 | 0.0005 | 0.0003 | 0.0006 | 0.0004 | 0.0002 | 0.0009 | 0.0002 | 0.002 | 0.0011 | 0 | 0 | 0.009 | 0 | 0.0036 | 0.0281 | 0.003 | 0 |
Punctate Nuclear | 0.004 | 0.0002 | 0.0009 | 0.0181 | 0.0001 | 0.0009 | 0.0033 | 0.0001 | 0.0027 | 0.0004 | 0.0003 | 0.0001 | 0.0019 | 0.0001 | 0.0004 | 0.0001 | 0.0031 | 0 |
Vacuole | 0.0027 | 0.0003 | 0.0018 | 0.0024 | 0.0093 | 0.0009 | 0.0042 | 0.0007 | 0.0029 | 0.0102 | 0.0009 | 0.0001 | 0.0048 | 0.0001 | 0.0029 | 0 | 0.0196 | 0.0001 |
Vacuole Periphery | 0.0019 | 0.0002 | 0.0006 | 0.0015 | 0.0016 | 0.0004 | 0.0013 | 0.0002 | 0.0018 | 0.0107 | 0.0001 | 0.0001 | 0.0021 | 0.0001 | 0.0011 | 0 | 0.0121 | 0 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 182.1493 | 657.5841 | 550.693 | 282.6025 | 143.0612 | 203.0541 | 683.0877 | 550.2542 | 363.0787 | 196.2865 |
Translational Efficiency | 3.1444 | 3.5942 | 3.1034 | 4.3525 | 4.1961 | 3.4862 | 3.09 | 4.4725 | 3.4488 | 3.1036 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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