Standard name | |
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Human Ortholog | |
Description | Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 2 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 5 | 0 | 1 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 10 | 5 | 2 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 2 | 4 | 8 | 12 | 9 | 5 | 9 | 9 | 3 | 15 | 2 | 2 | 5 | 24 | 31 | 26 | 15 | 10 | 0 | 0 | 3 | 1 | 1 | 2 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6 | 4 | 5 | 0 | 0 | 0 | 0 | 1 | 0 |
Endosome | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 3 | 2 | 0 | 2 | 0 | 2 | 2 | 1 | 0 | 2 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
Mitochondria | 4 | 92 | 1 | 1 | 1 | 7 | 12 | 17 | 90 | 38 | 57 | 59 | 2 | 4 | 3 | 13 | 2 | 2 | 0 | 1 | 0 | 1 | 2 | 4 |
Nucleus | 69 | 319 | 200 | 155 | 258 | 93 | 170 | 199 | 218 | 237 | 182 | 259 | 162 | 247 | 260 | 241 | 213 | 195 | 86 | 318 | 203 | 156 | 196 | 162 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 5 | 4 | 1 | 1 | 0 | 2 | 2 | 4 | 2 | 2 | 0 | 0 | 0 | 1 | 1 | 0 |
Nucleolus | 4 | 5 | 0 | 2 | 3 | 10 | 6 | 8 | 31 | 23 | 36 | 31 | 3 | 3 | 7 | 4 | 8 | 5 | 0 | 1 | 1 | 3 | 6 | 16 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 3 | 0 | 2 | 0 | 3 | 0 | 3 | 6 | 2 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 2 |
Vac/Vac Membrane | 0 | 2 | 2 | 2 | 4 | 1 | 2 | 4 | 2 | 3 | 4 | 3 | 0 | 3 | 4 | 8 | 16 | 14 | 0 | 8 | 3 | 11 | 14 | 30 |
Unique Cell Count | 73 | 340 | 211 | 168 | 273 | 109 | 183 | 221 | 272 | 282 | 220 | 297 | 169 | 280 | 305 | 283 | 245 | 226 | 90 | 338 | 221 | 190 | 229 | 230 |
Labelled Cell Count | 79 | 422 | 213 | 173 | 281 | 117 | 200 | 246 | 360 | 329 | 287 | 372 | 172 | 290 | 319 | 307 | 261 | 238 | 90 | 338 | 221 | 190 | 229 | 230 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 7.1 | 5.2 | 7.9 | 7.7 | 8.0 | 6.1 | 6.1 | 6.5 | 5.4 | 6.1 | 5.2 | 5.6 | 6.8 | 7.3 | 7.2 | 6.5 | 8.4 | 8.5 | 7.6 | 8.3 | 8.4 |
Std Deviation (1e-4) | 1.1 | 0.8 | 1.3 | 1.7 | 1.5 | 1.3 | 1.2 | 1.4 | 1.5 | 1.8 | 1.0 | 1.1 | 1.4 | 1.5 | 1.8 | 1.8 | 2.4 | 2.6 | 1.6 | 1.5 | 1.7 |
Intensity Change (Log2) | – | – | – | -0.03 | 0.02 | -0.38 | -0.36 | -0.27 | -0.54 | -0.37 | -0.6 | -0.5 | -0.22 | -0.11 | -0.13 | -0.27 | 0.09 | 0.11 | -0.05 | 0.08 | 0.1 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1.4 | -0.3 | 0 | 0.5 | 0.2 | 0 | 0.8 | 0 | 0 | -0.4 | 2.1 | 2.7 | 2.3 | 1.1 | 0.3 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 3.4 | 3.8 | 9.1 | 5.3 | 7.7 | 6.7 | 0 | 0 | 0 | 2.7 | 0 | 0 |
Nucleus | -1.0 | -0.1 | -2.9 | -0.8 | -1.9 | -4.7 | -3.7 | -3.9 | -2.9 | 0.5 | -2.5 | -3.4 | -3.4 | -2.9 | -3.0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 5.1 | 4.2 | 6.1 | 4.8 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.1 | 2.9 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 6.4747 | 6.1738 | 6.6766 | 5.8774 | 5.6319 | 6.3118 | 5.7097 | 6.8806 | 5.8929 | 6.8236 | 5.496 | 5.8395 | 2.8806 | 3.4857 | 3.0929 | 3.2214 | 2.223 | 2.9407 |
Actin | 0.023 | 0.0001 | 0.0131 | 0.0001 | 0.004 | 0.0004 | 0.0021 | 0.0009 | 0.0011 | 0.0435 | 0.0001 | 0.0115 | 0.0424 | 0 | 0.0061 | 0 | 0.0009 | 0.0017 |
Bud | 0.0005 | 0 | 0.0003 | 0 | 0.0009 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0 | 0.0001 | 0.0005 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 |
Bud Neck | 0.0034 | 0.0001 | 0.0016 | 0.0001 | 0.0008 | 0.0016 | 0.0002 | 0.0001 | 0.0023 | 0.0001 | 0.0002 | 0.0006 | 0.0032 | 0 | 0.0042 | 0.0001 | 0.002 | 0.0009 |
Bud Periphery | 0.0005 | 0 | 0.0006 | 0 | 0.0023 | 0.0007 | 0.0003 | 0.0001 | 0.0003 | 0.0004 | 0.0001 | 0.0001 | 0.0014 | 0 | 0.0002 | 0 | 0.0001 | 0.0003 |
Bud Site | 0.0063 | 0.0004 | 0.002 | 0 | 0.0009 | 0.0004 | 0.0002 | 0.0005 | 0.0128 | 0.0005 | 0.0001 | 0.0001 | 0.0045 | 0 | 0.0007 | 0 | 0.0002 | 0.0001 |
Cell Periphery | 0.0001 | 0 | 0.0004 | 0 | 0.0002 | 0.0002 | 0.0001 | 0 | 0.0007 | 0 | 0 | 0 | 0.0007 | 0 | 0.0002 | 0 | 0 | 0.0001 |
Cytoplasm | 0.0045 | 0.0061 | 0.0008 | 0.0002 | 0.0022 | 0.0002 | 0.0048 | 0.0314 | 0.0015 | 0.0001 | 0.0246 | 0.0074 | 0.0113 | 0 | 0.0001 | 0 | 0.0008 | 0.0004 |
Cytoplasmic Foci | 0.0133 | 0.0002 | 0.0036 | 0.0088 | 0.0046 | 0.0004 | 0.0161 | 0.0064 | 0.0004 | 0.0044 | 0.0111 | 0.0041 | 0.0152 | 0 | 0.0017 | 0.0016 | 0.013 | 0.0015 |
Eisosomes | 0.0002 | 0 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0.0002 | 0 | 0 | 0.0004 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0013 | 0.0008 | 0.0006 | 0 | 0.0016 | 0.0002 | 0.0044 | 0.0002 | 0.0007 | 0.0002 | 0.0031 | 0.0005 | 0.0029 | 0 | 0.0002 | 0 | 0.0006 | 0.0007 |
Endosome | 0.0149 | 0.0003 | 0.0048 | 0.0002 | 0.0046 | 0.0017 | 0.0244 | 0.0016 | 0.0029 | 0.0064 | 0.0234 | 0.0044 | 0.0226 | 0 | 0.005 | 0.0022 | 0.0292 | 0.0061 |
Golgi | 0.0106 | 0 | 0.0042 | 0.0003 | 0.0016 | 0.0007 | 0.0023 | 0.0018 | 0.0002 | 0.0251 | 0.001 | 0.0014 | 0.0065 | 0 | 0.0076 | 0.0017 | 0.0153 | 0.0027 |
Lipid Particles | 0.0099 | 0.0001 | 0.0027 | 0.0005 | 0.002 | 0.001 | 0.0164 | 0.0054 | 0.0003 | 0.0059 | 0.0009 | 0.0034 | 0.0172 | 0 | 0.0091 | 0.0142 | 0.0156 | 0.0027 |
Mitochondria | 0.0048 | 0.0001 | 0.0039 | 0.0002 | 0.0052 | 0.0073 | 0.008 | 0.0003 | 0.0004 | 0.025 | 0.0007 | 0.0007 | 0.0146 | 0.0001 | 0.0026 | 0.0012 | 0.0014 | 0.0033 |
None | 0.0019 | 0.0001 | 0.0002 | 0.0001 | 0.0002 | 0 | 0.0051 | 0.0008 | 0.0012 | 0.0002 | 0.0093 | 0.0029 | 0.0123 | 0 | 0 | 0 | 0.0001 | 0.0002 |
Nuclear Periphery | 0.0052 | 0.0019 | 0.0033 | 0.0013 | 0.0098 | 0.0029 | 0.0548 | 0.0004 | 0.0075 | 0.0006 | 0.0015 | 0.0007 | 0.0088 | 0.0003 | 0.0021 | 0.0008 | 0.0017 | 0.0033 |
Nucleolus | 0.0072 | 0.0054 | 0.007 | 0.0039 | 0.0209 | 0.0273 | 0.0051 | 0.0048 | 0.0083 | 0.0011 | 0.0233 | 0.0145 | 0.0092 | 0.0048 | 0.0041 | 0.0066 | 0.0284 | 0.0233 |
Nucleus | 0.8604 | 0.9835 | 0.9435 | 0.95 | 0.8789 | 0.9493 | 0.8463 | 0.9301 | 0.9572 | 0.8734 | 0.8984 | 0.9349 | 0.796 | 0.9947 | 0.9534 | 0.9674 | 0.8863 | 0.9461 |
Peroxisomes | 0.0103 | 0 | 0.0035 | 0.0336 | 0.0471 | 0.0012 | 0.0021 | 0.0129 | 0.0001 | 0.012 | 0.0003 | 0.0021 | 0.0082 | 0 | 0.0014 | 0.0031 | 0.0021 | 0.0002 |
Punctate Nuclear | 0.0194 | 0.0006 | 0.0022 | 0.0003 | 0.0007 | 0.0004 | 0.0033 | 0.0022 | 0.001 | 0.0003 | 0.0012 | 0.0101 | 0.0092 | 0.0001 | 0.0003 | 0.0002 | 0.0008 | 0.0043 |
Vacuole | 0.0015 | 0.0003 | 0.0012 | 0.0002 | 0.0081 | 0.003 | 0.0011 | 0.0001 | 0.0007 | 0.0001 | 0.0005 | 0.0002 | 0.0083 | 0 | 0.0006 | 0.0002 | 0.0007 | 0.001 |
Vacuole Periphery | 0.0006 | 0 | 0.0004 | 0.0001 | 0.0032 | 0.0008 | 0.0028 | 0 | 0.0003 | 0.0002 | 0.0003 | 0.0001 | 0.0046 | 0 | 0.0003 | 0.0004 | 0.0006 | 0.0008 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 13.0031 | 8.8564 | 4.9288 | 13.2954 | 9.6338 | 12.377 | 13.1521 | 15.4872 | 11.6333 | 13.4311 |
Translational Efficiency | 1.0436 | 2.0107 | 2.7234 | 0.8241 | 1.1516 | 1.1209 | 1.5129 | 1.0566 | 1.2465 | 0.9352 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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