Standard name | |
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Human Ortholog | |
Description | Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 22 | 12 | 96 | 108 | 85 | 66 | 78 | 76 | – | 42 | 26 | 38 | 72 | 77 | 45 | 10 | 20 | 8 | 3 | 4 | 4 | 3 | 7 | 14 |
Bud | 4 | 0 | 15 | 8 | 8 | 18 | 42 | 63 | – | 51 | 28 | 41 | 12 | 8 | 6 | 10 | 5 | 0 | 2 | 0 | 2 | 3 | 2 | 5 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | – | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 3 | 1 | 6 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 14 | – | 7 | 3 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 139 | 53 | 217 | 208 | 243 | 139 | 132 | 98 | – | 62 | 53 | 53 | 318 | 423 | 330 | 159 | 307 | 107 | 135 | 79 | 244 | 236 | 378 | 370 |
Cytoplasm | 28 | 8 | 29 | 31 | 57 | 88 | 169 | 253 | – | 289 | 191 | 248 | 45 | 37 | 38 | 42 | 82 | 32 | 8 | 6 | 3 | 3 | 6 | 9 |
Endoplasmic Reticulum | 3 | 5 | 3 | 5 | 53 | 25 | 49 | 25 | – | 5 | 6 | 7 | 17 | 19 | 18 | 7 | 11 | 3 | 11 | 9 | 10 | 20 | 39 | 53 |
Endosome | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | – | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | – | 0 | 0 | 0 | 4 | 22 | 11 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 1 | 0 | 2 | 1 | 1 | 5 | 8 | 23 | – | 52 | 42 | 52 | 0 | 0 | 2 | 6 | 3 | 4 | 1 | 0 | 5 | 2 | 5 | 4 |
Nucleus | 1 | 1 | 0 | 0 | 1 | 1 | 8 | 9 | – | 5 | 1 | 4 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 21 | – | 10 | 6 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | – | 1 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 1 | – | 1 | 1 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
SpindlePole | 0 | 0 | 1 | 0 | 2 | 4 | 19 | 34 | – | 9 | 6 | 12 | 0 | 3 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 0 | 0 | 0 | 3 | 9 | 36 | 72 | – | 33 | 10 | 26 | 1 | 3 | 2 | 0 | 0 | 2 | 1 | 1 | 1 | 9 | 8 | 16 |
Unique Cell Count | 155 | 60 | 250 | 239 | 339 | 252 | 425 | 521 | 441 | 279 | 378 | 367 | 482 | 386 | 186 | 362 | 133 | 168 | 105 | 279 | 288 | 454 | 486 | |
Labelled Cell Count | 198 | 79 | 366 | 361 | 453 | 359 | 553 | 692 | 567 | 373 | 494 | 473 | 593 | 457 | 235 | 431 | 156 | 168 | 105 | 279 | 288 | 454 | 486 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 23.8 | 30.0 | 19.8 | 21.3 | 17.6 | 11.4 | 9.9 | 9.0 | – | 6.1 | 6.0 | 5.6 | 30.7 | 30.5 | 28.4 | 28.4 | 34.4 | 40.7 | 23.7 | 21.3 | 20.1 |
Std Deviation (1e-4) | 7.1 | 8.7 | 6.2 | 6.5 | 5.6 | 4.9 | 4.8 | 4.3 | – | 3.2 | 3.0 | 2.9 | 7.9 | 8.2 | 8.5 | 7.0 | 9.6 | 13.0 | 7.4 | 5.3 | 5.8 |
Intensity Change (Log2) | – | – | – | 0.11 | -0.17 | -0.79 | -1.0 | -1.14 | – | -1.7 | -1.72 | -1.83 | 0.64 | 0.62 | 0.52 | 0.52 | 0.8 | 1.04 | 0.26 | 0.11 | 0.03 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 1.5 | -3.5 | -2.9 | -5.8 | -7.4 | – | -9.1 | -7.9 | -8.5 | -5.1 | -6.8 | -7.9 | -8.0 | -10.2 | -6.8 |
Bud | -1.4 | -2.3 | 0.5 | 1.8 | 2.6 | – | 2.4 | 1.7 | 2.1 | -1.6 | -3.2 | -3.1 | -0.3 | -3.2 | -2.9 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0.1 | -4.4 | -7.8 | -14.0 | -18.0 | – | -18.7 | -15.6 | -18.0 | -0.1 | 0.4 | -0.5 | -0.4 | -0.7 | -1.6 |
Cytoplasm | 0.5 | 1.8 | 6.2 | 7.8 | 10.0 | – | 13.7 | 13.2 | 13.3 | 0.2 | -1.8 | -0.7 | 3.1 | 3.5 | 3.2 |
Endoplasmic Reticulum | 0 | 5.9 | 4.3 | 4.9 | 2.5 | – | 0 | 0 | 0 | 2.4 | 2.1 | 2.4 | 0 | 1.5 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 3.1 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 2.7 | – | 5.2 | 5.9 | 5.7 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 2.8 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 3.0 | 3.8 | – | 0 | 0 | 2.4 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 4.7 | 6.2 | – | 4.4 | 0 | 4.2 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 23.524 | 45.1951 | 38.9789 | 40.0712 | 32.1268 | 42.3026 | 33.3188 | 51.9674 | 43.5783 | 41.3195 | 42.6743 | 48.6523 | 25.2411 | 48.9716 | 46.0002 | 40.1442 | 43.4317 | 42.5765 |
Actin | 0.0236 | 0 | 0.0004 | 0.0002 | 0.0011 | 0.0003 | 0.0092 | 0 | 0.0053 | 0.004 | 0.0012 | 0.0001 | 0.0203 | 0 | 0.0149 | 0.0023 | 0.0001 | 0 |
Bud | 0.0042 | 0.0001 | 0.0004 | 0.0003 | 0.0049 | 0.0002 | 0.0013 | 0.0001 | 0.0011 | 0.0022 | 0.0005 | 0.0002 | 0.0008 | 0.0002 | 0.0003 | 0.0003 | 0.0009 | 0.0002 |
Bud Neck | 0.0021 | 0.0002 | 0.0009 | 0.0005 | 0.0027 | 0.0013 | 0.0014 | 0.0001 | 0.0004 | 0.0009 | 0.0147 | 0.0011 | 0.0011 | 0.0005 | 0.0006 | 0.003 | 0.0021 | 0.0008 |
Bud Periphery | 0.0278 | 0.0006 | 0.0044 | 0.0053 | 0.0314 | 0.0026 | 0.0038 | 0.0006 | 0.0055 | 0.0107 | 0.0041 | 0.0053 | 0.0014 | 0.0013 | 0.0027 | 0.0046 | 0.0152 | 0.0063 |
Bud Site | 0.0062 | 0.0018 | 0.0029 | 0.0005 | 0.0043 | 0.0009 | 0.0041 | 0.0044 | 0.004 | 0.006 | 0.0025 | 0.0001 | 0.008 | 0.0046 | 0.0025 | 0.0005 | 0.0012 | 0.0002 |
Cell Periphery | 0.6272 | 0.786 | 0.7628 | 0.6638 | 0.627 | 0.7664 | 0.7518 | 0.8598 | 0.7989 | 0.7704 | 0.7512 | 0.8092 | 0.5545 | 0.8712 | 0.8248 | 0.6586 | 0.846 | 0.8498 |
Cytoplasm | 0.0224 | 0.0386 | 0.0229 | 0.0097 | 0.0317 | 0.0123 | 0.0101 | 0.0058 | 0.0063 | 0.0018 | 0.0032 | 0.0027 | 0.0152 | 0.0104 | 0.0101 | 0.0022 | 0.0035 | 0.0037 |
Cytoplasmic Foci | 0.0016 | 0 | 0.0027 | 0 | 0.0002 | 0.0013 | 0.0132 | 0 | 0.0018 | 0.0002 | 0.0029 | 0 | 0.1067 | 0 | 0.0057 | 0 | 0 | 0 |
Eisosomes | 0.0056 | 0.0002 | 0.0009 | 0.0003 | 0.0002 | 0.0004 | 0.001 | 0.0002 | 0.0011 | 0.0007 | 0.0014 | 0.0004 | 0.0023 | 0.0002 | 0.0002 | 0.0004 | 0.0001 | 0.0001 |
Endoplasmic Reticulum | 0.0708 | 0.053 | 0.0546 | 0.1555 | 0.082 | 0.0499 | 0.0432 | 0.0284 | 0.0405 | 0.0459 | 0.054 | 0.062 | 0.0271 | 0.015 | 0.0228 | 0.0867 | 0.0123 | 0.0397 |
Endosome | 0.0091 | 0 | 0.0048 | 0.0002 | 0.0014 | 0.0002 | 0.0097 | 0 | 0.0036 | 0.0007 | 0.011 | 0 | 0.0202 | 0 | 0.0091 | 0.0001 | 0 | 0 |
Golgi | 0.0023 | 0 | 0.0011 | 0.0001 | 0.0002 | 0.0001 | 0.0027 | 0 | 0.0058 | 0.0006 | 0.0076 | 0 | 0.0109 | 0 | 0.0059 | 0.0001 | 0 | 0 |
Lipid Particles | 0.0062 | 0.0063 | 0.0053 | 0.0032 | 0.0075 | 0.0037 | 0.0083 | 0.0009 | 0.0038 | 0.0019 | 0.0074 | 0.0013 | 0.0181 | 0.0008 | 0.0054 | 0.0011 | 0.0014 | 0.0008 |
Mitochondria | 0.0163 | 0 | 0.0019 | 0.0001 | 0.0038 | 0.0005 | 0.0057 | 0 | 0.0133 | 0.0089 | 0.0054 | 0 | 0.0044 | 0.0001 | 0.0003 | 0.0016 | 0 | 0 |
None | 0.0072 | 0 | 0.0085 | 0.0001 | 0.0006 | 0.0033 | 0.0082 | 0 | 0.0002 | 0.0001 | 0.0001 | 0 | 0.0236 | 0 | 0.0004 | 0.0002 | 0 | 0 |
Nuclear Periphery | 0.0225 | 0.0133 | 0.0147 | 0.0146 | 0.0117 | 0.007 | 0.0262 | 0.014 | 0.0176 | 0.0135 | 0.0113 | 0.0154 | 0.0271 | 0.011 | 0.0123 | 0.1294 | 0.0079 | 0.0071 |
Nucleolus | 0.0046 | 0.0001 | 0.001 | 0.0001 | 0.0045 | 0.0017 | 0.0013 | 0.0001 | 0.0003 | 0.0006 | 0.0011 | 0.0001 | 0.0022 | 0.0002 | 0.0002 | 0.0006 | 0.0003 | 0.0001 |
Nucleus | 0.0049 | 0.0002 | 0.0008 | 0.0004 | 0.0105 | 0.0014 | 0.0024 | 0.0003 | 0.0005 | 0.0008 | 0.001 | 0.0003 | 0.003 | 0.0005 | 0.0006 | 0.0041 | 0.0006 | 0.0003 |
Peroxisomes | 0.0016 | 0 | 0.0004 | 0 | 0.0001 | 0.0001 | 0.0048 | 0 | 0.0017 | 0.0001 | 0.0015 | 0 | 0.0619 | 0 | 0.0002 | 0 | 0 | 0 |
Punctate Nuclear | 0.0018 | 0 | 0.0009 | 0 | 0.0001 | 0.0011 | 0.0052 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0.025 | 0 | 0.0002 | 0.0002 | 0 | 0 |
Vacuole | 0.1283 | 0.0991 | 0.1066 | 0.1444 | 0.168 | 0.1447 | 0.0849 | 0.085 | 0.0873 | 0.1274 | 0.1162 | 0.1008 | 0.0645 | 0.0835 | 0.08 | 0.097 | 0.106 | 0.0901 |
Vacuole Periphery | 0.0038 | 0.0002 | 0.001 | 0.0008 | 0.0058 | 0.0005 | 0.0015 | 0.0003 | 0.0008 | 0.0026 | 0.0015 | 0.001 | 0.0015 | 0.0005 | 0.0009 | 0.0071 | 0.0021 | 0.0009 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 10.1603 | 12.1102 | 11.6822 | 15.5482 | 12.295 | 20.9863 | 20.3567 | 21.2805 | 22.9715 | 18.0777 |
Translational Efficiency | 1.0165 | 0.8941 | 0.9667 | 0.5248 | 0.4454 | 0.8829 | 0.868 | 0.6679 | 0.7248 | 0.5294 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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