Standard name | |
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Human Ortholog | |
Description | Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 |
Bud | 0 | 0 | 0 | 0 | 1 | 1 | 3 | – | 3 | 2 | 6 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 1 | 3 |
Bud Neck | 0 | 0 | 0 | 0 | 2 | 0 | 4 | – | 3 | 5 | 2 | 4 | 4 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 3 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 1 | 1 | – | 1 | 3 | 12 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 1 | 0 | 0 | – | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 37 | 24 | 2 | 37 | 102 | 117 | 214 | – | 128 | 127 | 102 | 127 | 14 | 54 | 70 | 81 | 119 | 107 | 26 | 21 | 18 | 13 | 75 | 62 |
Endoplasmic Reticulum | 1 | 0 | 0 | 1 | 0 | 0 | 0 | – | 0 | 4 | 0 | 3 | 0 | 1 | 0 | 14 | 9 | 20 | 0 | 0 | 0 | 0 | 1 | 1 |
Endosome | 0 | 0 | 0 | 3 | 11 | 1 | 4 | – | 2 | 1 | 2 | 2 | 0 | 14 | 27 | 18 | 29 | 24 | 1 | 1 | 0 | 0 | 2 | 2 |
Golgi | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 19 | 5 | 3 | 10 | 10 | 39 | 104 | – | 96 | 89 | 266 | 188 | 0 | 5 | 3 | 15 | 4 | 5 | 5 | 1 | 6 | 1 | 9 | 8 |
Nucleus | 25 | 34 | 11 | 29 | 27 | 36 | 64 | – | 60 | 70 | 49 | 85 | 17 | 51 | 20 | 33 | 48 | 27 | 44 | 39 | 26 | 18 | 33 | 21 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 1 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 3 | 5 | 1 | 4 | – | 8 | 8 | 6 | 4 | 11 | 24 | 16 | 1 | 3 | 1 | 5 | 2 | 3 | 0 | 6 | 9 |
Vac/Vac Membrane | 36 | 36 | 6 | 19 | 67 | 28 | 53 | – | 15 | 19 | 26 | 22 | 5 | 16 | 24 | 103 | 135 | 116 | 48 | 36 | 32 | 15 | 62 | 56 |
Unique Cell Count | 101 | 77 | 17 | 94 | 200 | 200 | 390 | 271 | 276 | 358 | 358 | 44 | 147 | 145 | 220 | 296 | 246 | 140 | 108 | 95 | 54 | 208 | 182 | |
Labelled Cell Count | 119 | 99 | 22 | 102 | 226 | 224 | 451 | 317 | 330 | 473 | 444 | 52 | 169 | 165 | 269 | 350 | 302 | 140 | 108 | 95 | 54 | 208 | 182 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.3 | 4.7 | 5.0 | 5.0 | 5.7 | 4.2 | 4.4 | – | 4.0 | 4.0 | 3.3 | 3.7 | 5.9 | 5.3 | 5.2 | 6.2 | 6.0 | 5.8 | – | 4.9 | 5.2 |
Std Deviation (1e-4) | 1.4 | 0.9 | 1.7 | 1.1 | 2.2 | 1.0 | 1.0 | – | 1.8 | 1.2 | 0.8 | 0.8 | 1.4 | 1.0 | 1.2 | 1.4 | 1.5 | 1.4 | – | 1.1 | 1.7 |
Intensity Change (Log2) | – | – | – | -0.02 | 0.17 | -0.26 | -0.2 | – | -0.33 | -0.32 | -0.6 | -0.44 | 0.23 | 0.07 | 0.04 | 0.31 | 0.26 | 0.2 | – | -0.04 | 0.05 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | 0.9 | 0.8 | 0.9 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | -1.0257 | -0.9441 | -0.7251 | -1.2426 | -1.1923 | -1.0434 | -0.1451 | -0.1691 | -0.3678 | 0.2457 | -0.4098 | -0.2503 | -1.6262 | -1.0871 | -1.2231 | -1.066 | -1.5869 | -1.3897 |
Actin | 0.0199 | 0.0003 | 0.0029 | 0.0077 | 0.0027 | 0.0009 | 0.0401 | 0.0003 | 0.0058 | 0.0361 | 0.0004 | 0.0044 | 0.0003 | 0.0004 | 0.0055 | 0.0002 | 0.0002 | 0.0003 |
Bud | 0.0005 | 0.0001 | 0.0002 | 0.0001 | 0.0003 | 0.0001 | 0.001 | 0.0001 | 0.0002 | 0.0004 | 0.0016 | 0.0002 | 0.0001 | 0.0021 | 0.0001 | 0 | 0 | 0.0001 |
Bud Neck | 0.0013 | 0.0007 | 0.0019 | 0.0018 | 0.0018 | 0.0023 | 0.0078 | 0.0006 | 0.0011 | 0.0022 | 0.0003 | 0.0044 | 0.0004 | 0.0008 | 0.0037 | 0.0005 | 0.0006 | 0.0027 |
Bud Periphery | 0.0009 | 0 | 0.0005 | 0.0001 | 0.0007 | 0.0001 | 0.0012 | 0.0001 | 0.0003 | 0.0006 | 0.0005 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0 | 0 | 0.0001 |
Bud Site | 0.0026 | 0.0016 | 0.002 | 0.0005 | 0.001 | 0.0002 | 0.0135 | 0.0012 | 0.0046 | 0.0019 | 0.0006 | 0.0003 | 0.0003 | 0.0028 | 0.0007 | 0.0001 | 0.0001 | 0.0001 |
Cell Periphery | 0.0003 | 0.0001 | 0.0004 | 0.0002 | 0.0002 | 0 | 0.0005 | 0.0001 | 0.0002 | 0.0002 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.1885 | 0.2413 | 0.132 | 0.1907 | 0.2238 | 0.1473 | 0.1607 | 0.1337 | 0.1183 | 0.1746 | 0.1496 | 0.1207 | 0.1012 | 0.1291 | 0.0579 | 0.0907 | 0.1022 | 0.0683 |
Cytoplasmic Foci | 0.0267 | 0.0171 | 0.0097 | 0.0138 | 0.0067 | 0.0063 | 0.0325 | 0.0036 | 0.0078 | 0.0147 | 0.0144 | 0.0074 | 0.0053 | 0.0054 | 0.0024 | 0.001 | 0.0033 | 0.0051 |
Eisosomes | 0.0004 | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0005 | 0.0002 | 0.0001 | 0.0004 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0091 | 0.0114 | 0.0102 | 0.0095 | 0.0109 | 0.0031 | 0.0057 | 0.0047 | 0.003 | 0.005 | 0.0027 | 0.0034 | 0.0034 | 0.0072 | 0.0012 | 0.0009 | 0.002 | 0.0013 |
Endosome | 0.0375 | 0.0055 | 0.0181 | 0.0083 | 0.0155 | 0.0112 | 0.0353 | 0.0042 | 0.0068 | 0.0427 | 0.0681 | 0.0073 | 0.0039 | 0.0091 | 0.0031 | 0.0014 | 0.0041 | 0.0036 |
Golgi | 0.0151 | 0.0002 | 0.0058 | 0.0019 | 0.0054 | 0.0065 | 0.0073 | 0.0001 | 0.0011 | 0.0216 | 0.0031 | 0.0023 | 0.0002 | 0.0005 | 0.0001 | 0 | 0.0001 | 0.0001 |
Lipid Particles | 0.0127 | 0.0039 | 0.0145 | 0.0066 | 0.0846 | 0.0161 | 0.0118 | 0.0004 | 0.0015 | 0.0567 | 0.0006 | 0.0082 | 0.0013 | 0.0008 | 0.0005 | 0.0001 | 0.0001 | 0.0005 |
Mitochondria | 0.0186 | 0.0005 | 0.0102 | 0.0009 | 0.0034 | 0.0021 | 0.0061 | 0.001 | 0.0014 | 0.0192 | 0.0021 | 0.0014 | 0.0025 | 0.0013 | 0.0009 | 0.0008 | 0.0006 | 0.0006 |
None | 0.234 | 0.269 | 0.3691 | 0.1626 | 0.3657 | 0.2328 | 0.2568 | 0.3941 | 0.334 | 0.4396 | 0.3398 | 0.1141 | 0.2503 | 0.222 | 0.2396 | 0.2506 | 0.2244 | 0.1398 |
Nuclear Periphery | 0.0388 | 0.0198 | 0.0419 | 0.0594 | 0.0376 | 0.0142 | 0.0269 | 0.0205 | 0.0279 | 0.015 | 0.0121 | 0.0226 | 0.0241 | 0.0261 | 0.0228 | 0.0151 | 0.0174 | 0.0183 |
Nucleolus | 0.0035 | 0.0041 | 0.0152 | 0.0021 | 0.0058 | 0.0049 | 0.0144 | 0.0061 | 0.0183 | 0.0024 | 0.005 | 0.0112 | 0.0102 | 0.0079 | 0.0098 | 0.0054 | 0.0077 | 0.0117 |
Nucleus | 0.3393 | 0.397 | 0.3278 | 0.5001 | 0.2007 | 0.5151 | 0.3105 | 0.3977 | 0.3993 | 0.1233 | 0.3631 | 0.649 | 0.5377 | 0.5384 | 0.5918 | 0.61 | 0.5905 | 0.6795 |
Peroxisomes | 0.0137 | 0.0003 | 0.0131 | 0.0009 | 0.0013 | 0.0016 | 0.0046 | 0.0001 | 0.0004 | 0.0106 | 0.0002 | 0.003 | 0.0031 | 0.0002 | 0.0003 | 0.0001 | 0.0003 | 0.0002 |
Punctate Nuclear | 0.0256 | 0.0225 | 0.0154 | 0.0293 | 0.0277 | 0.0338 | 0.0509 | 0.0276 | 0.0631 | 0.0218 | 0.0306 | 0.0369 | 0.0526 | 0.0425 | 0.0576 | 0.022 | 0.0443 | 0.0664 |
Vacuole | 0.0084 | 0.0041 | 0.0071 | 0.0023 | 0.0027 | 0.0012 | 0.0089 | 0.0031 | 0.0043 | 0.0083 | 0.0037 | 0.0021 | 0.0025 | 0.0024 | 0.0014 | 0.0007 | 0.0015 | 0.001 |
Vacuole Periphery | 0.0026 | 0.0004 | 0.0019 | 0.0009 | 0.0015 | 0.0003 | 0.0032 | 0.0006 | 0.0007 | 0.0028 | 0.0015 | 0.0007 | 0.0006 | 0.0006 | 0.0004 | 0.0003 | 0.0003 | 0.0003 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 3.0558 | 3.9733 | 2.5798 | 4.3176 | 1.4407 | 3.3317 | 3.5152 | 5.423 | 4.5115 | 5.4645 |
Translational Efficiency | – | – | – | – | – | – | – | – | – | – |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | – |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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