Standard name | |
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Human Ortholog | |
Description | Subunit of the Snt2C complex; physically associates with Snt2p and Rpd3p; along with Snt2p, recruits Rpd3p to a small number of promoters; also colocalizes with Snt2p, independently of Rpd3p, to promoters of stress response genes in response to oxidative stress; contains ATP/GTP-binding site motif A; null mutant exhibits increased cellular volume, large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 5 |
Bud | 2 | 1 | 0 | 3 | 3 | 3 | 3 | 7 | 5 | 6 | 5 | 8 | 0 | 1 | 3 | 0 | 0 | 0 | 2 | 1 | 0 | 1 | 4 | 7 |
Bud Neck | 0 | 0 | 0 | 0 | 1 | 3 | 4 | 2 | 2 | 0 | 1 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 5 | 5 |
Bud Site | 0 | 0 | 0 | 1 | 1 | 1 | 7 | 10 | 2 | 4 | 7 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 37 | 29 | 42 | 75 | 133 | 87 | 191 | 124 | 70 | 93 | 50 | 87 | 22 | 97 | 124 | 145 | 131 | 149 | 30 | 32 | 35 | 29 | 86 | 107 |
Endoplasmic Reticulum | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 13 | 8 | 11 | 1 | 1 | 0 | 0 | 1 | 2 |
Endosome | 7 | 2 | 0 | 0 | 7 | 1 | 3 | 1 | 0 | 0 | 0 | 0 | 5 | 12 | 3 | 3 | 1 | 5 | 13 | 0 | 4 | 0 | 3 | 10 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 2 |
Mitochondria | 47 | 33 | 37 | 93 | 86 | 137 | 216 | 168 | 143 | 213 | 144 | 239 | 10 | 15 | 78 | 10 | 5 | 4 | 24 | 8 | 13 | 2 | 10 | 23 |
Nucleus | 36 | 6 | 1 | 10 | 9 | 15 | 30 | 32 | 17 | 28 | 21 | 39 | 9 | 30 | 14 | 2 | 5 | 1 | 57 | 24 | 7 | 25 | 28 | 23 |
Nuclear Periphery | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 |
Peroxisomes | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 1 | 0 | 1 | 1 | 2 | 3 | 3 | 3 | 1 | 3 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 20 | 4 | 3 | 6 | 14 | 19 |
Vac/Vac Membrane | 38 | 40 | 4 | 0 | 21 | 12 | 16 | 6 | 4 | 7 | 5 | 20 | 23 | 41 | 49 | 26 | 23 | 29 | 57 | 27 | 28 | 30 | 53 | 83 |
Unique Cell Count | 148 | 86 | 79 | 155 | 225 | 216 | 383 | 294 | 204 | 278 | 183 | 309 | 65 | 180 | 233 | 169 | 149 | 176 | 228 | 107 | 101 | 101 | 217 | 307 |
Labelled Cell Count | 168 | 114 | 87 | 184 | 264 | 263 | 475 | 354 | 244 | 356 | 235 | 418 | 70 | 198 | 271 | 201 | 173 | 200 | 228 | 107 | 101 | 101 | 217 | 307 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.2 | 3.9 | 3.2 | 3.2 | 3.6 | 3.2 | 3.2 | 3.2 | 2.7 | 2.8 | 2.9 | 2.8 | 4.5 | 4.3 | 3.7 | 5.0 | 5.2 | 5.8 | 4.1 | 4.2 | 4.6 |
Std Deviation (1e-4) | 1.0 | 1.5 | 0.6 | 1.3 | 1.8 | 1.5 | 1.8 | 1.5 | 1.3 | 1.7 | 1.1 | 1.7 | 1.2 | 0.8 | 1.0 | 1.1 | 0.9 | 1.8 | 0.8 | 1.4 | 1.5 |
Intensity Change (Log2) | – | – | – | 0.01 | 0.16 | -0.01 | -0.0 | -0.0 | -0.23 | -0.2 | -0.17 | -0.21 | 0.5 | 0.41 | 0.19 | 0.65 | 0.68 | 0.84 | 0.35 | 0.4 | 0.52 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | 2.3 | 2.3 | 2.5 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Actin | 0.0275 | 0.0002 | 0.0086 | 0.0223 | 0.083 | 0.0147 | 0.0338 | 0.0121 | 0.0219 | 0.0024 | 0.0003 | 0.0042 | 0.0001 | 0.0002 | 0.0002 | 0.0007 | 0.0001 | 0.0004 |
Bud | 0.0002 | 0.0001 | 0.0003 | 0.0003 | 0.0008 | 0.0012 | 0.0037 | 0.0007 | 0.0009 | 0.0003 | 0.0001 | 0.0014 | 0 | 0.0002 | 0 | 0 | 0 | 0.0002 |
Bud Neck | 0.002 | 0.0003 | 0.0006 | 0.0008 | 0.0035 | 0.0074 | 0.0008 | 0.0003 | 0.0005 | 0.0007 | 0.0001 | 0.0033 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0009 |
Bud Periphery | 0.0002 | 0.0001 | 0.0004 | 0.0005 | 0.0026 | 0.0012 | 0.0036 | 0.0006 | 0.0013 | 0.0003 | 0 | 0.0027 | 0 | 0.0002 | 0 | 0 | 0 | 0.0001 |
Bud Site | 0.0019 | 0.0011 | 0.0022 | 0.0018 | 0.0055 | 0.0007 | 0.0084 | 0.0014 | 0.0068 | 0.0012 | 0.0001 | 0.0003 | 0.0005 | 0.0001 | 0.0002 | 0 | 0.0001 | 0.0001 |
Cell Periphery | 0.0001 | 0.0002 | 0.0002 | 0.0003 | 0.0002 | 0.0001 | 0.0007 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.1064 | 0.2813 | 0.1669 | 0.1837 | 0.1614 | 0.2708 | 0.1907 | 0.3558 | 0.3259 | 0.2319 | 0.2295 | 0.4098 | 0.0278 | 0.0219 | 0.1545 | 0.0895 | 0.0504 | 0.2266 |
Cytoplasmic Foci | 0.0274 | 0.0111 | 0.009 | 0.006 | 0.01 | 0.0101 | 0.0434 | 0.0114 | 0.0121 | 0.0179 | 0.0041 | 0.0106 | 0.0031 | 0.0063 | 0.0042 | 0.0015 | 0.004 | 0.0117 |
Eisosomes | 0.0008 | 0.0001 | 0.0005 | 0.0007 | 0.0003 | 0.0002 | 0.0007 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0003 | 0.0002 | 0.0001 | 0.0001 | 0 | 0 |
Endoplasmic Reticulum | 0.0029 | 0.0081 | 0.0048 | 0.0064 | 0.0034 | 0.0036 | 0.0112 | 0.0048 | 0.0038 | 0.0019 | 0.0046 | 0.0034 | 0.0005 | 0.0007 | 0.0035 | 0.0021 | 0.0006 | 0.0028 |
Endosome | 0.0073 | 0.0035 | 0.0044 | 0.0068 | 0.0084 | 0.0033 | 0.0159 | 0.0032 | 0.0065 | 0.0289 | 0.0026 | 0.0032 | 0.0004 | 0.0003 | 0.0021 | 0.0009 | 0.001 | 0.0034 |
Golgi | 0.003 | 0.0002 | 0.0011 | 0.0032 | 0.0027 | 0.0006 | 0.0063 | 0.0002 | 0.0057 | 0.007 | 0.0001 | 0.0007 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 |
Lipid Particles | 0.0216 | 0.0007 | 0.0048 | 0.0025 | 0.0044 | 0.0008 | 0.0094 | 0.0005 | 0.0022 | 0.005 | 0.0001 | 0.0018 | 0.0005 | 0.0005 | 0.0003 | 0.0002 | 0.0001 | 0.0003 |
Mitochondria | 0.001 | 0.0004 | 0.0013 | 0.006 | 0.0111 | 0.0007 | 0.0577 | 0.0006 | 0.0153 | 0.0103 | 0.0005 | 0.0081 | 0.0004 | 0.0003 | 0.0005 | 0.001 | 0.0006 | 0.0005 |
None | 0.6451 | 0.5695 | 0.6106 | 0.6209 | 0.4866 | 0.4914 | 0.427 | 0.4795 | 0.4053 | 0.4855 | 0.6353 | 0.3422 | 0.9027 | 0.9646 | 0.7549 | 0.8679 | 0.6976 | 0.6328 |
Nuclear Periphery | 0.0046 | 0.0201 | 0.011 | 0.007 | 0.0323 | 0.0053 | 0.0275 | 0.0058 | 0.0086 | 0.0034 | 0.0084 | 0.0118 | 0.0016 | 0.0007 | 0.0054 | 0.0062 | 0.0011 | 0.0046 |
Nucleolus | 0.002 | 0.0017 | 0.0034 | 0.0028 | 0.0044 | 0.0018 | 0.0038 | 0.0008 | 0.0014 | 0.0009 | 0.0003 | 0.0012 | 0.008 | 0.0003 | 0.0021 | 0.0005 | 0.0014 | 0.001 |
Nucleus | 0.114 | 0.0741 | 0.147 | 0.1113 | 0.1244 | 0.1663 | 0.0911 | 0.1041 | 0.1432 | 0.1779 | 0.1101 | 0.1757 | 0.0329 | 0.0006 | 0.0612 | 0.0253 | 0.2405 | 0.0847 |
Peroxisomes | 0.0148 | 0.0002 | 0.0058 | 0.0007 | 0.0293 | 0.0005 | 0.0139 | 0.0007 | 0.0038 | 0.0064 | 0.0001 | 0.0011 | 0.0001 | 0.0003 | 0.0001 | 0.0001 | 0.0001 | 0.0002 |
Punctate Nuclear | 0.0157 | 0.0235 | 0.0149 | 0.0133 | 0.0209 | 0.0172 | 0.0322 | 0.0155 | 0.0253 | 0.0102 | 0.0023 | 0.0163 | 0.02 | 0.0021 | 0.0088 | 0.0029 | 0.0014 | 0.0283 |
Vacuole | 0.0011 | 0.0031 | 0.002 | 0.0022 | 0.0026 | 0.0016 | 0.0112 | 0.0018 | 0.0086 | 0.0052 | 0.001 | 0.0015 | 0.0007 | 0.0003 | 0.0013 | 0.0004 | 0.0005 | 0.0013 |
Vacuole Periphery | 0.0002 | 0.0003 | 0.0004 | 0.0006 | 0.0024 | 0.0002 | 0.0068 | 0.0002 | 0.0007 | 0.0026 | 0.0003 | 0.0005 | 0.0001 | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0.0002 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 9.1169 | 7.6842 | 12.4408 | 10.765 | 9.6252 | 6.2481 | 10.5948 | 11.8385 | 11.9859 | 14.4302 |
Translational Efficiency | – | – | – | – | – | – | – | – | – | – |
Dataset | Hit |
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Protein Concentration | – |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | – |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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