Standard name | |
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Human Ortholog | |
Description | Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 2 |
Bud | 0 | 0 | 2 | 1 | 0 | 2 | 5 | 3 | 10 | 14 | 14 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 4 | 5 | 2 | 8 | 9 |
Bud Neck | 0 | 0 | 18 | 9 | 36 | 18 | 30 | 16 | 12 | 7 | 2 | 16 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 5 |
Bud Site | 0 | 0 | 0 | 0 | 1 | 1 | 6 | 3 | 11 | 7 | 6 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 0 | 5 | 1 | 1 | 0 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Cytoplasm | 95 | 66 | 188 | 254 | 351 | 339 | 423 | 310 | 251 | 250 | 211 | 172 | 48 | 147 | 135 | 60 | 40 | 32 | 86 | 55 | 140 | 43 | 91 | 126 |
Endoplasmic Reticulum | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 0 | 0 | 8 | 10 | 7 | 1 | 1 | 1 | 2 | 4 | 0 |
Endosome | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 15 | 5 | 17 | 10 | 11 | 7 | 1 | 1 | 0 | 3 | 4 |
Golgi | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 2 | 0 | 0 | 0 | 0 | 1 | 3 |
Mitochondria | 62 | 35 | 5 | 19 | 13 | 105 | 140 | 106 | 281 | 309 | 328 | 182 | 26 | 7 | 9 | 18 | 9 | 10 | 17 | 8 | 18 | 11 | 41 | 24 |
Nucleus | 65 | 42 | 102 | 112 | 102 | 96 | 156 | 125 | 144 | 157 | 123 | 170 | 32 | 51 | 44 | 155 | 77 | 96 | 83 | 54 | 102 | 19 | 51 | 56 |
Nuclear Periphery | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 1 |
Nucleolus | 2 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 2 | 2 | 1 | 2 | 6 | 2 | 1 | 0 | 0 | 4 | 0 | 0 | 1 | 2 | 3 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 4 | 0 | 4 | 5 | 12 | 10 | 19 | 20 | 11 | 7 | 3 | 15 | 1 | 7 | 5 | 1 | 1 | 2 | 18 | 5 | 21 | 4 | 11 | 15 |
Vac/Vac Membrane | 36 | 21 | 5 | 3 | 17 | 12 | 20 | 16 | 11 | 13 | 17 | 17 | 8 | 36 | 28 | 68 | 54 | 41 | 41 | 38 | 70 | 39 | 86 | 80 |
Unique Cell Count | 232 | 144 | 306 | 382 | 493 | 524 | 694 | 533 | 574 | 607 | 556 | 490 | 106 | 251 | 215 | 293 | 181 | 176 | 275 | 178 | 383 | 129 | 315 | 341 |
Labelled Cell Count | 269 | 164 | 331 | 405 | 537 | 585 | 801 | 600 | 734 | 768 | 706 | 584 | 119 | 270 | 228 | 332 | 204 | 201 | 275 | 178 | 383 | 129 | 315 | 341 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 3.9 | 3.7 | 4.6 | 4.1 | 4.7 | 3.6 | 3.8 | 4.2 | 3.4 | 3.4 | 3.2 | 3.8 | 4.1 | 4.2 | 4.1 | 6.4 | 6.7 | 6.9 | 3.9 | 4.0 | 4.3 |
Std Deviation (1e-4) | 0.5 | 0.7 | 0.6 | 0.7 | 0.9 | 0.9 | 0.9 | 0.8 | 1.1 | 1.0 | 0.9 | 1.0 | 1.3 | 1.1 | 0.8 | 1.5 | 1.8 | 1.8 | 1.1 | 0.9 | 1.2 |
Intensity Change (Log2) | – | – | – | -0.17 | 0.02 | -0.35 | -0.27 | -0.15 | -0.44 | -0.45 | -0.52 | -0.27 | -0.16 | -0.12 | -0.19 | 0.48 | 0.54 | 0.58 | -0.24 | -0.21 | -0.11 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | 8.1 | 9.2 | 7.8 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 0.2373 | -0.4076 | -0.8385 | -0.4886 | -0.4848 | -0.5713 | -0.6411 | -0.4307 | -0.7756 | -0.4685 | -0.4967 | -0.5578 | -0.2684 | -0.4089 | -0.6448 | -0.6589 | -0.573 | -0.3246 |
Actin | 0.0389 | 0.0018 | 0.0055 | 0.0095 | 0.0696 | 0.005 | 0.0233 | 0.0002 | 0.0059 | 0.0028 | 0.0079 | 0.0035 | 0.1072 | 0.0003 | 0.0001 | 0.0593 | 0.0014 | 0.0058 |
Bud | 0.001 | 0.0008 | 0.0002 | 0.0002 | 0.0005 | 0.0006 | 0.0006 | 0.0001 | 0.0005 | 0.0014 | 0.0014 | 0.0005 | 0.0007 | 0.0001 | 0.0002 | 0.0003 | 0.0003 | 0.0001 |
Bud Neck | 0.0047 | 0.0005 | 0.0023 | 0.0008 | 0.0017 | 0.0058 | 0.0031 | 0.0005 | 0.0007 | 0.0015 | 0.0015 | 0.0023 | 0.0048 | 0.0005 | 0.0006 | 0.0032 | 0.0004 | 0.0025 |
Bud Periphery | 0.0018 | 0.0007 | 0.0002 | 0.0002 | 0.0006 | 0.0008 | 0.001 | 0 | 0.0006 | 0.0011 | 0.0015 | 0.0013 | 0.0009 | 0.0001 | 0.0001 | 0.0002 | 0.0005 | 0.0002 |
Bud Site | 0.0097 | 0.0043 | 0.0011 | 0.0004 | 0.0011 | 0.0008 | 0.0131 | 0.0009 | 0.0016 | 0.0047 | 0.0022 | 0.0003 | 0.0074 | 0.0021 | 0.0005 | 0.0007 | 0.0011 | 0.0002 |
Cell Periphery | 0.0013 | 0.0001 | 0.0001 | 0 | 0.0002 | 0.0002 | 0.0003 | 0 | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0.0005 | 0.0001 | 0 | 0.0001 | 0.0003 | 0.0001 |
Cytoplasm | 0.0798 | 0.0695 | 0.0878 | 0.0405 | 0.0471 | 0.06 | 0.0812 | 0.0834 | 0.0895 | 0.0756 | 0.0512 | 0.0579 | 0.1143 | 0.1088 | 0.1152 | 0.0978 | 0.1626 | 0.1134 |
Cytoplasmic Foci | 0.0376 | 0.0083 | 0.0073 | 0.0112 | 0.0368 | 0.0057 | 0.0398 | 0.0104 | 0.004 | 0.0262 | 0.0271 | 0.0115 | 0.0329 | 0.0037 | 0.0128 | 0.0045 | 0.0049 | 0.0044 |
Eisosomes | 0.0008 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0 | 0.0003 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.001 | 0 | 0 | 0.0002 | 0.0002 | 0.0001 |
Endoplasmic Reticulum | 0.0226 | 0.0052 | 0.0032 | 0.0007 | 0.0021 | 0.0034 | 0.0059 | 0.0024 | 0.0045 | 0.0027 | 0.0026 | 0.0016 | 0.012 | 0.0083 | 0.0027 | 0.0012 | 0.0017 | 0.0053 |
Endosome | 0.0429 | 0.0078 | 0.0168 | 0.0072 | 0.0655 | 0.0121 | 0.0345 | 0.0078 | 0.0062 | 0.0456 | 0.0463 | 0.0058 | 0.0281 | 0.004 | 0.004 | 0.0017 | 0.0467 | 0.0066 |
Golgi | 0.0101 | 0.0013 | 0.0048 | 0.0145 | 0.03 | 0.0028 | 0.0093 | 0.0002 | 0.0016 | 0.027 | 0.046 | 0.0033 | 0.0124 | 0.0001 | 0.0002 | 0.0022 | 0.0133 | 0.0025 |
Lipid Particles | 0.0173 | 0.001 | 0.0015 | 0.0051 | 0.0178 | 0.0031 | 0.0294 | 0.0007 | 0.0016 | 0.0157 | 0.0302 | 0.0065 | 0.0176 | 0.0015 | 0.0007 | 0.0009 | 0.0189 | 0.0087 |
Mitochondria | 0.0266 | 0.0014 | 0.0174 | 0.0024 | 0.0097 | 0.0052 | 0.0141 | 0.0004 | 0.0081 | 0.0243 | 0.0692 | 0.0211 | 0.0047 | 0.0005 | 0.0003 | 0.0009 | 0.0334 | 0.0061 |
None | 0.1339 | 0.2106 | 0.2343 | 0.2619 | 0.2473 | 0.0988 | 0.0678 | 0.0665 | 0.1309 | 0.1365 | 0.1312 | 0.0912 | 0.163 | 0.088 | 0.235 | 0.2009 | 0.1137 | 0.111 |
Nuclear Periphery | 0.0479 | 0.0357 | 0.0271 | 0.0077 | 0.03 | 0.0104 | 0.0311 | 0.0307 | 0.0369 | 0.0168 | 0.0227 | 0.0165 | 0.0328 | 0.0238 | 0.0167 | 0.0067 | 0.0038 | 0.0218 |
Nucleolus | 0.0055 | 0.0069 | 0.0088 | 0.0047 | 0.0054 | 0.0204 | 0.0053 | 0.0096 | 0.0068 | 0.0041 | 0.0045 | 0.0117 | 0.0057 | 0.0044 | 0.0047 | 0.0023 | 0.0023 | 0.0064 |
Nucleus | 0.4211 | 0.6129 | 0.5289 | 0.5787 | 0.3948 | 0.7177 | 0.5857 | 0.738 | 0.6506 | 0.5797 | 0.4843 | 0.7323 | 0.3964 | 0.7107 | 0.5316 | 0.6039 | 0.5722 | 0.6609 |
Peroxisomes | 0.0236 | 0.0015 | 0.0026 | 0.0033 | 0.0116 | 0.0011 | 0.0244 | 0.0001 | 0.0004 | 0.0065 | 0.0142 | 0.0012 | 0.0139 | 0.0001 | 0.0002 | 0.0013 | 0.0012 | 0.0085 |
Punctate Nuclear | 0.063 | 0.0248 | 0.0462 | 0.0505 | 0.017 | 0.0383 | 0.0215 | 0.0445 | 0.0458 | 0.0218 | 0.0518 | 0.0289 | 0.0361 | 0.0401 | 0.072 | 0.0108 | 0.0022 | 0.0338 |
Vacuole | 0.0061 | 0.0038 | 0.0026 | 0.0004 | 0.0073 | 0.0062 | 0.006 | 0.0031 | 0.0025 | 0.0042 | 0.0025 | 0.0019 | 0.0059 | 0.0021 | 0.0018 | 0.0008 | 0.0099 | 0.0012 |
Vacuole Periphery | 0.0037 | 0.001 | 0.0012 | 0.0002 | 0.0036 | 0.0015 | 0.0024 | 0.0005 | 0.0009 | 0.0015 | 0.0013 | 0.0007 | 0.0017 | 0.0006 | 0.0004 | 0.0002 | 0.0091 | 0.0004 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 7.6957 | 11.8612 | 10.5618 | 9.751 | 6.8813 | 11.1393 | 7.4356 | 10.5227 | 11.4925 | 10.4966 |
Translational Efficiency | 0.8834 | 0.3686 | 0.5407 | 0.6955 | 0.6992 | 0.511 | 0.7398 | 0.561 | 0.6654 | 0.5831 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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