Standard name | |
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Human Ortholog | |
Description | Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; role in stationary phase survival; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4 |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 7 | 23 | 74 | 70 | 39 | 73 | 76 | 36 | 23 | 18 | 10 | 14 | 18 | 12 | 9 | 3 | 0 | 2 | 48 | 30 | 70 | 34 | 86 | 68 |
Bud | 5 | 4 | 10 | 8 | 5 | 7 | 9 | 9 | 5 | 5 | 3 | 5 | 6 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 5 | 1 | 1 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 7 | 2 | 3 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 7 | 6 | 12 | 12 | 16 | 10 | 10 | 12 | 4 | 8 | 10 | 8 | 1 | 6 | 6 | 6 | 3 | 2 | 0 | 2 | 8 | 1 | 0 | 0 |
Endoplasmic Reticulum | 39 | 53 | 164 | 76 | 140 | 105 | 32 | 5 | 2 | 14 | 12 | 5 | 37 | 16 | 8 | 15 | 12 | 5 | 33 | 10 | 72 | 16 | 13 | 7 |
Endosome | 0 | 0 | 1 | 3 | 0 | 2 | 2 | 0 | 3 | 1 | 0 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 49 | 56 | 143 | 24 | 68 | 56 |
Golgi | 74 | 134 | 245 | 274 | 302 | 306 | 328 | 422 | 44 | 172 | 135 | 203 | 110 | 119 | 72 | 128 | 96 | 71 | 147 | 144 | 134 | 82 | 155 | 164 |
Mitochondria | 43 | 40 | 6 | 21 | 8 | 72 | 348 | 282 | 555 | 630 | 724 | 524 | 48 | 69 | 117 | 28 | 10 | 18 | 1 | 0 | 3 | 0 | 1 | 3 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 2 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 1 | 0 | 1 | 2 | 5 | 4 | 7 | 15 | 25 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 7 | 0 | 1 | 1 |
Nucleolus | 97 | 58 | 40 | 48 | 50 | 81 | 237 | 290 | 206 | 229 | 241 | 265 | 70 | 135 | 177 | 73 | 52 | 42 | 0 | 1 | 0 | 0 | 0 | 1 |
Peroxisomes | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 19 | 15 | 16 | 17 | 56 | 60 |
SpindlePole | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 2 | 0 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 6 | 9 | 4 | 3 | 5 |
Vac/Vac Membrane | 4 | 12 | 28 | 27 | 27 | 46 | 29 | 59 | 21 | 50 | 23 | 68 | 1 | 8 | 17 | 23 | 8 | 10 | 1 | 4 | 6 | 3 | 3 | 2 |
Unique Cell Count | 222 | 241 | 419 | 387 | 449 | 529 | 779 | 871 | 676 | 878 | 912 | 887 | 223 | 281 | 316 | 197 | 143 | 104 | 314 | 281 | 484 | 193 | 397 | 375 |
Labelled Cell Count | 277 | 331 | 589 | 542 | 592 | 704 | 1078 | 1127 | 872 | 1146 | 1193 | 1124 | 293 | 366 | 409 | 277 | 181 | 150 | 314 | 281 | 484 | 193 | 397 | 375 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 45.1 | 42.4 | 35.1 | 34.6 | 34.0 | 31.1 | 30.1 | 31.4 | 28.0 | 30.6 | 27.5 | 29.4 | 47.6 | 45.5 | 45.0 | 71.9 | 72.1 | 67.1 | 41.6 | 41.4 | 42.6 |
Std Deviation (1e-4) | 9.7 | 9.0 | 6.7 | 7.1 | 6.6 | 6.0 | 6.4 | 7.6 | 6.5 | 9.5 | 8.8 | 9.5 | 9.2 | 10.5 | 9.9 | 20.9 | 20.0 | 18.3 | 8.7 | 9.1 | 10.1 |
Intensity Change (Log2) | – | – | – | -0.02 | -0.04 | -0.17 | -0.22 | -0.16 | -0.33 | -0.2 | -0.35 | -0.26 | 0.44 | 0.38 | 0.36 | 1.03 | 1.04 | 0.94 | 0.25 | 0.24 | 0.28 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0.2 | -3.9 | -1.6 | -3.9 | -8.1 | -8.1 | -10.2 | -11.5 | -10.8 | -3.3 | -5.3 | -6.3 | -5.6 | -5.4 | -4.1 |
Bud | -0.3 | -1.4 | -1.2 | -1.6 | -1.9 | -2.3 | 0 | 0 | 0 | 0.2 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.2 | 0.6 | -1.0 | -1.9 | -1.9 | -3.0 | -2.7 | -2.3 | -2.7 | 0 | -0.6 | -0.8 | 0.1 | 0 | 0 |
Endoplasmic Reticulum | -6.0 | -2.5 | -6.5 | -15.6 | -19.2 | -17.4 | -18.4 | -18.9 | -19.4 | -5.9 | -9.9 | -11.6 | -8.0 | -6.8 | -6.7 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 3.7 | 2.7 | -0.2 | -5.4 | -3.4 | -19.0 | -14.0 | -16.4 | -12.6 | -2.2 | -4.2 | -9.7 | 1.5 | 1.8 | 1.8 |
Mitochondria | 3.1 | 0.4 | 6.8 | 15.6 | 12.5 | 26.0 | 23.7 | 26.5 | 19.8 | 8.7 | 9.7 | 12.8 | 6.5 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 2.2 | 3.1 | 2.4 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 1.3 | 0.8 | 2.6 | 8.2 | 9.2 | 8.1 | 6.9 | 7.0 | 8.1 | 7.0 | 11.5 | 13.7 | 8.2 | 7.5 | 7.7 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0.2 | -0.4 | 1.1 | -2.3 | 0.1 | -2.8 | -0.7 | -3.7 | 0.6 | -3.6 | -2.3 | -0.7 | 2.1 | -0.5 | 1.0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 27.44 | 32.855 | 29.6751 | 28.7229 | 24.3076 | 31.3537 | 37.8464 | 42.431 | 39.8078 | 38.2886 | 35.2203 | 39.562 | 30.2762 | 42.1382 | 39.7067 | 41.0374 | 25.4427 | 38.3103 |
Actin | 0.0108 | 0.0077 | 0.0113 | 0.0009 | 0.0369 | 0.0154 | 0.0163 | 0.0057 | 0.0178 | 0.0061 | 0.0034 | 0.0021 | 0.0361 | 0.0179 | 0.0337 | 0.0061 | 0.1639 | 0.0103 |
Bud | 0.0004 | 0.0001 | 0.0001 | 0.0001 | 0.001 | 0.0002 | 0.0003 | 0 | 0.0001 | 0 | 0 | 0 | 0.0014 | 0.0003 | 0.0005 | 0 | 0.0006 | 0.0001 |
Bud Neck | 0.0009 | 0.0002 | 0.0003 | 0.0001 | 0.0009 | 0.0007 | 0.0003 | 0.0001 | 0.0004 | 0.0002 | 0.0001 | 0.0001 | 0.0011 | 0.0025 | 0.0004 | 0.0001 | 0.0003 | 0.0004 |
Bud Periphery | 0.0006 | 0.0001 | 0.0002 | 0.0003 | 0.0017 | 0.0004 | 0.0004 | 0 | 0.0001 | 0 | 0 | 0 | 0.0022 | 0.0005 | 0.0006 | 0 | 0.0014 | 0.0001 |
Bud Site | 0.002 | 0.0006 | 0.0005 | 0.0006 | 0.0038 | 0.0001 | 0.0018 | 0.0001 | 0.0008 | 0.0001 | 0 | 0 | 0.0093 | 0.0037 | 0.0007 | 0 | 0.0008 | 0.0001 |
Cell Periphery | 0.0014 | 0.0012 | 0.0007 | 0.0007 | 0.0004 | 0.0007 | 0.0017 | 0.0005 | 0.0011 | 0.0004 | 0.0003 | 0.0005 | 0.0016 | 0.0019 | 0.0016 | 0.0002 | 0.0004 | 0.0005 |
Cytoplasm | 0.0032 | 0.0005 | 0.0028 | 0.0007 | 0.0007 | 0.0005 | 0.0009 | 0.0002 | 0.0013 | 0.0002 | 0.0006 | 0.0006 | 0.0049 | 0.0008 | 0.0182 | 0.0002 | 0.0071 | 0.0038 |
Cytoplasmic Foci | 0.0725 | 0.0476 | 0.057 | 0.0265 | 0.0531 | 0.0289 | 0.0327 | 0.0321 | 0.0325 | 0.0294 | 0.0411 | 0.0208 | 0.0245 | 0.0272 | 0.0311 | 0.0145 | 0.0108 | 0.0222 |
Eisosomes | 0.0002 | 0 | 0.0002 | 0.0001 | 0.0003 | 0.0006 | 0.0009 | 0.0001 | 0.0003 | 0.0001 | 0 | 0.0001 | 0.0006 | 0.0003 | 0.0002 | 0.0003 | 0.0006 | 0.0001 |
Endoplasmic Reticulum | 0.0024 | 0.0006 | 0.001 | 0.001 | 0.0009 | 0.0025 | 0.0014 | 0.0002 | 0.0027 | 0.0005 | 0.0009 | 0.0004 | 0.0051 | 0.0005 | 0.0016 | 0.0019 | 0.0027 | 0.0039 |
Endosome | 0.0352 | 0.0225 | 0.0276 | 0.0134 | 0.0575 | 0.0177 | 0.0241 | 0.014 | 0.0143 | 0.0346 | 0.0339 | 0.0198 | 0.0424 | 0.0174 | 0.0156 | 0.0169 | 0.0324 | 0.0169 |
Golgi | 0.0773 | 0.0884 | 0.1611 | 0.0817 | 0.2908 | 0.1409 | 0.1024 | 0.0632 | 0.1658 | 0.1997 | 0.1554 | 0.2053 | 0.1026 | 0.0692 | 0.0882 | 0.1183 | 0.0932 | 0.1246 |
Lipid Particles | 0.6902 | 0.7947 | 0.6865 | 0.8231 | 0.4726 | 0.7689 | 0.77 | 0.8668 | 0.7335 | 0.7145 | 0.7548 | 0.725 | 0.6478 | 0.755 | 0.752 | 0.8173 | 0.4834 | 0.7591 |
Mitochondria | 0.02 | 0.0012 | 0.011 | 0.0065 | 0.0381 | 0.0021 | 0.0174 | 0.0005 | 0.0043 | 0.0056 | 0.0023 | 0.0123 | 0.019 | 0.0078 | 0.0232 | 0.0132 | 0.042 | 0.0019 |
None | 0.001 | 0 | 0.0007 | 0.0009 | 0.0002 | 0.0001 | 0.0004 | 0 | 0.001 | 0.0001 | 0 | 0.0002 | 0.0274 | 0.0001 | 0.0015 | 0 | 0.0018 | 0.0001 |
Nuclear Periphery | 0.0052 | 0.0035 | 0.0037 | 0.0073 | 0.0009 | 0.0021 | 0.0052 | 0.0011 | 0.0026 | 0.0005 | 0.0008 | 0.0051 | 0.0202 | 0.0036 | 0.006 | 0.0027 | 0.0271 | 0.0146 |
Nucleolus | 0.0254 | 0.0119 | 0.0175 | 0.0109 | 0.0009 | 0.0084 | 0.0106 | 0.0016 | 0.0057 | 0.0001 | 0.0002 | 0.0003 | 0.012 | 0.0614 | 0.0072 | 0.0002 | 0.002 | 0.0035 |
Nucleus | 0.0118 | 0.0006 | 0.0025 | 0.007 | 0.0008 | 0.0011 | 0.0009 | 0.0003 | 0.0007 | 0 | 0 | 0.0001 | 0.005 | 0.0063 | 0.0011 | 0.0001 | 0.0981 | 0.0006 |
Peroxisomes | 0.0067 | 0.006 | 0.0067 | 0.0033 | 0.024 | 0.0015 | 0.004 | 0.0011 | 0.0049 | 0.0025 | 0.0015 | 0.001 | 0.005 | 0.0039 | 0.0045 | 0.0026 | 0.0058 | 0.0013 |
Punctate Nuclear | 0.0077 | 0.0007 | 0.0019 | 0.0016 | 0.0004 | 0.0005 | 0.001 | 0.0034 | 0.0022 | 0.0002 | 0.0002 | 0.0003 | 0.0029 | 0.006 | 0.0011 | 0.0005 | 0.0027 | 0.0312 |
Vacuole | 0.0086 | 0.0034 | 0.002 | 0.0032 | 0.0094 | 0.0024 | 0.0027 | 0.0032 | 0.0023 | 0.001 | 0.0012 | 0.0014 | 0.0143 | 0.0073 | 0.0023 | 0.0007 | 0.0065 | 0.0006 |
Vacuole Periphery | 0.0164 | 0.0084 | 0.0047 | 0.0099 | 0.0045 | 0.0044 | 0.0047 | 0.0059 | 0.0055 | 0.0042 | 0.0034 | 0.0046 | 0.0147 | 0.0064 | 0.0086 | 0.0041 | 0.0166 | 0.0042 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 105.5775 | 76.6393 | 86.7087 | 77.8548 | 111.8416 | 87.2714 | 44.2458 | 36.4812 | 39.6867 | 76.0783 |
Translational Efficiency | 1.3012 | 1.2672 | 1.1529 | 1.4697 | 1.2567 | 1.1831 | 1.0694 | 1.1719 | 1.0664 | 1.1142 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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